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Abstract
ObjectivesThe aim was to identify predictors of electronic cigarette (e-cigarette) use among teenagers.
Design and settingA prospective population-based cohort study of schoolchildren in northern Sweden.
參與者In 2006, a cohort study about asthma and allergic diseases among schoolchildren started within the Obstructive Lung Disease in Northern Sweden studies. The study sample (n=2185) was recruited at age 7–8 years, and participated in questionnaire surveys at age 14–15 and 19 years. The questionnaire included questions about respiratory symptoms, living conditions, upper secondary education, physical activity, diet, health-related quality of life, parental smoking and parental occupation. Questions about tobacco use were included at age 14–15 and 19 years.
Primary outcomeE-cigarette use at age 19 years.
ResultsAt age 19 years, 21.4% had ever tried e-cigarettes and 4.2% were current users. Among those who were daily tobacco smokers at age 14–15 years, 60.9% had tried e-cigarettes at age 19 years compared with 19.1% of never-smokers and 34.0% of occasional smokers (p<0.001). Among those who had tried e-cigarettes, 28.1% were never smokers both at age 14–15 and 19 years, and 14.4% were never smokers among the current e-cigarette users. In unadjusted analyses, e-cigarette use was associated with daily smoking, use of snus and having a smoking father at age 14–15 years, as well as with attending vocational education, physical inactivity and unhealthy diet. In adjusted analyses, current e-cigarette use was associated with daily tobacco smoking at age 14–15 years (OR 6.27; 95% CI 3.12 to 12.58), attending a vocational art programme (OR 2.22; 95% CI 1.04 to 4.77) and inversely associated with eating a healthy diet (OR 0.74; 95% CI 0.59 to 0.92).
ConclusionsE-cigarette use was associated with personal and parental tobacco use, as well as with physical inactivity, unhealthy diet and attending vocational upper secondary education. Importantly, almost one-third of those who had tried e-cigarettes at age 19 years had never been tobacco smokers.
- public health
- epidemiology
- preventive medicine
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Strengths and limitations of this study
This paper presents data from a prospective cohort study with high response rates and few participants lost to follow-up.
Self-reported use of tobacco or e-cigarettes was not validated by objective measures.
E-cigarette use was measured only at the last follow-up.
Introduction
In the last 10 years, the use of electronic cigarettes (e-cigarettes) has increased rapidly among teenagers,1–3but the increase seems to level off in some countries including England1and Sweden.4One explanation for their popularity may be that they are perceived as less harmful and less addictive than tobacco cigarettes.5–7Although the levels are considerably lower than in conventional cigarette smoke, e-cigarette aerosol does contain carcinogenic and toxic substances8 9and they can deliver similar nicotine levels as conventional cigarettes, and thereby cause nicotine addiction.10 11
Because e-cigarettes are portrayed as an alternative to tobacco smoking, studies of predictors for e-cigarette use have mostly evaluated the association with smoking conventional cigarettes.12 13For instance, e-cigarette use was more common among current smokers than former smokers14 15and younger smokers appear to be more prone to start using e-cigarettes than older smokers.15 16關於電子煙是一個主要問題y also seem to appeal to non-smoking teenagers17 18and might serve as a gateway to initiation of tobacco smoking as well as other drugs.11 17 19然而,另一種解釋為協會between e-cigarette use and tobacco smoking may be that these behaviours share many risk factors such as social disadvantage, addictive behaviours, low academic achievement, and having family members or friends that smoke.20–24These shared characteristics may serve as a common liability for any tobacco or nicotine product,25 26which implies that the sequential order of product initiation is of less importance. Nevertheless, predictors of e-cigarette use need to be identified both among smoking and non-smoking teenagers, but prospective studies are lacking. In Sweden, smoking is more common among women, while the use of snus (smokeless, moist, grounded tobacco placed under the upper lip) and e-cigarettes is more common among men14 27–29; but there are no epidemiological studies on sex differences in e-cigarette use among Swedish teenagers.4
The aim of the present study was to identify predictors of e-cigarette use in a prospective population-based cohort study of teenagers in Sweden followed from 14–15 to 19 years of age.
Methods
Study sample
Within the Obstructive Lung Disease in Northern Sweden studies, a population-based paediatric cohort study has been ongoing since 2006. The starting point was a parental questionnaire survey inviting all children in first and second grade (age 7–8 years) in three municipalities of northern Sweden: Luleå, Piteå and Kiruna.30–32The cohort was followed up at age 14–15 years and 19 years. At age 19 years, the study sample consists of the 2185 individuals who participated in all surveys, corresponding to 82% of the invited and 78% of the original cohort (n=2819).
Patient and public involvement
Patients and/or the public were not involved in the design, or conduct, or reporting or dissemination plans of this research.
Questionnaire
The questionnaire surveys at age 14–15 years and 19 years were performed at school. The questionnaire included the International Study of Asthma and Allergies in Childhood core questionnaire33with additional questions about asthma and allergic diseases including physician diagnoses, symptoms, use of medicine and heredity.30Other questions included possible risk factors such as living conditions, physical activity, diet, parental smoking and parental occupation. In the questionnaire at the age of 14–15 years, questions about smoking and use of snus were included34; and at age 19 years, questions about e-cigarettes were added. At age 14–15 years, health-related quality of life (HRQoL) was assessed using the KIDSCREEN-10 questionnaire which consists of 10 items with responses on a 5-point ordinal scale.35The crude values were transformed into a single score and poor HRQoL was defined as a value lower than the group mean score minus 0.5 SD.
Definitions
At age 14–15 years and 19 years, respectively, tobacco use was defined based on the questions ‘Do you smoke/use snus?’ asNeverif they smoked/used snus ‘Never’;Occasional,if they smoked/used snus ‘Almost never’, ‘Monthly’ or ‘Weekly’; andDailyif they smoked/used snus ‘Almost daily’ or ‘Daily’. At age 19 years, the category Former smoker was also included in the analyses. Former smoker was defined as either self-reported former smoker in the questionnaire at age 19 years, or reporting being an occasional or daily smoker at age 14–15 years and non-smoker at age 19 years.
At age 19 years, e-cigarette use was defined based on the question ‘Do you use e-cigarettes?’ asEver tried e-cigarettesif they responded ‘No, have quit’, ‘Have only tried’, ‘Use sometimes’ or ‘Use daily’; andCurrent e-cigarette userif they responded ‘Use sometimes’ or ‘Use daily’.
In Sweden, the upper secondary school education offers 3-year programmes that are vocational or preparatory for higher education (eg, economics, natural science, social science or technology). The programme is chosen at age 15 years and they attend the programme until graduation at age 19 years. We divided the vocational programmes intowork shop(eg, building and construction, electricity, energy, vehicle, transport or industrial technology),service(eg, child and recreation, hotel and tourism, restaurant management, or health and social care) andart(theatre, dance or music).
Healthy dietwas defined based on a score between 0 and 4 with 1 point each for: eating fish every week; eating a fruit every day; eating fast food less than every week and drinking soda less than every week. These four items were chosen based on recommendations by the Swedish National Food Agency.
Physical activitywas defined as regular participation in sports or physical activity, not including physical education at school.
Parental socioeconomic status是基於父母的職業報告一樣嗎entally completed questionnaire at age 7–8 years, defined according to the socioeconomic classification by Statistics Sweden36and categorised into the following groups: manual workers in service, manual workers in industry, assistant non-manual employees, intermediate non-manual employees, self-employed, unemployed, and professionals and executives.
Statistical analyses
Analyses were performed using the IBM SPSS statistics V.24. Differences in proportions between groups were analysed by the Χ2test. A p value of <0.05 was considered statistically significant. Individuals with missing data in questions about exposure to parental smoking (2.7%), tobacco use at age 14–15 years (0.97%–1.1%) and 19 years (1.0%–1.7%), and e-cigarette use at age 19 years (1.8%) were excluded from the analyses. Factors significantly associated with e-cigarette use in unadjusted analyses were included in adjusted logistic regression models. Sex was also included in the analysis. The results were expressed as ORs with 95% CIs. The adjusted analyses were also performed among those who were never smokers and did not use snus at age 14–15 years. A representativeness analysis was performed comparing the n=2185 individuals who participated in the follow-up surveys both at 14–15 years and 19 years with the n=634 individuals who did not participate in the follow-up surveys. Participants and non-participants were compared regarding sex, parental smoking habits, single-parent household and prevalence of asthma at recruitment.
Results
The prevalence of tobacco use at ages 14–15 and 19 years
At age 14–15 years, the majority of the adolescents were never smokers, 90.0% (table 1). The prevalence of occasional smoking was 6.8% and 3.2% were daily smokers, with similar prevalence in girls and boys. Daily use of snus was significantly more common among boys than girls, 5.0% vs 0.8%, p<0.001.
The prevalence of smoking and use of snus at age 14–15 years and 19 years, and e-cigarette use at age 19 years*
At age 19 years, 61.8% were never smokers and 8.3% daily smokers. Occasional smoking was more common among boys than girls, 31.3% vs 25.6%; while daily smoking was more common among girls than boys, 9.3% vs 7.4% (p=0.021). Daily use of snus had increased to 14.4% and was still more common among boys.
The prevalence of e-cigarette use at age 19 years
At age 19 years, 21.4% (n=460) of the cohort had ever tried e-cigarettes, with a higher prevalence among boys than girls, 27.6% vs 15.1%, p<0.001, and 4.2% (n=90) were current e-cigarette users. The prevalence of dual use of e-cigarettes and conventional cigarettes was 1.7% (n=36), dual use of e-cigarettes and snus was 1.3% (n=28); while 0.5% (n=10) used all three products.
E-cigarette use at age 19 years in relation to tobacco use at age 14–15 years
Among those who were daily tobacco smokers at age 14–15 years, 60.9% (n=39) had tried e-cigarettes at age 19 years, compared with 34.0% (n=50) among occasional smokers and 19.1% (n=364) among never smokers (p<0.001). Of the daily smokers at age 14–15 years, 28.1% (n=18) were current e-cigarette users compared with 7.5% (n=11) among occasional smokers and 3.2% (n=61) among never smokers (table 2). Of the current e-cigarette users at age 19 years, 14.4% reported being never smokers both at age 14–15 years and at 19 years (figure 1). Corresponding proportion of never smokers among those who had tried e-cigarettes was 28.5%. Among those who were former smokers at age 19 years, 24.1% (n=7) had tried e-cigarettes but only one individual was a current user. At age 19 years, there were 13 individuals reported having quit using e-cigarettes. Of them, 10 were occasional smokers, 2 daily smokers, 1 never smoker but none of them was a former smoker.
Smoking habits among e-cigarette users. The bars represent all those who had ever tried e-cigarettes and all current e-cigarette users at age 19 years, respectively. Never smoker, never smoker at age 14–15 and 19 years; ever occasional smoker, occasional smoker at age 14–15 or 19 years but not a daily smoker; former smoker, either self-reported former smoker at age 19 years or being a non-smoker or occasional smoker at 14–15 years and non-smoker at 19 years; ever daily smoker, daily smoker at 14–15 or 19 years. E-cigarettes, electronic cigarettes.
E-cigarette use at the age of 19 years in relation to smoking, use of snus and parental tobacco use at age 14–15 years*
The prevalence of e-cigarette use, as well as current smoking at age 19 years, increased with increasing number of tobacco smoking family members (figure 2). Among those with two or more smoking family members, 33.1% had ever tried e-cigarettes and 8.4% were current users, compared with 18.7% and 3.3% among those with no smoking family members (p<0.001).
The prevalence of ever and current e-cigarette use and current tobacco smoking at age 19 years in relation to number of smoking family members at age 14–15 years. E-cigarette, electronic cigarette.
Predictors of e-cigarette use
Unadjusted analyses are presented in theonline supplemental table E1. Current e-cigarette use at age 19 years was associated with occasional and daily smoking, and use of snus at age 14–15 years. Further, it was associated with the vocational programmes of work shop, service and art using preparatory programmes as reference category. E-cigarette use was also associated with poor HRQoL, having a smoking father and inversely associated with physical activity and eating a healthy diet.
Supplemental material
In the adjusted analyses, current e-cigarette use remained significantly associated with daily smoking (OR 6.27; 95% CI 3.12 to 12.58), the vocational programme of art (OR 2.22; 95% CI 1.04 to 4.77) and inversely associated with eating a healthy diet (OR 0.74; 95% CI 0.59 to 0.92) (figure 3).
當前的風險因素包括煙用19歲years, analysed in an adjusted logistic regression analysis (including all factors listed in the figure) with the result expressed as ORs with 95% CIs. *Entered as a continuous variable (score 0–4); **upper secondary education, reference category: preparatory education. E-cigarette, electronic cigarette; HRQoL, health-related quality of life.
In analyses stratified by sex, current e-cigarette use among the girls was associated with poor HRQoL at age 14–15 years (OR 2.92; 95% CI 1.25 to 6.81), the vocational programme of art (OR 3.13; 95% CI 1.17 to 8.34) and inversely associated with eating a healthy diet (OR 0.64; 95% CI 0.45 to 0.91). Among the boys current e-cigarette use was significantly associated only with daily smoking (OR 5.37; 95% CI 1.94 to 14.84).
Predictors of e-cigarette use among non-tobacco users
Adjusted analyses were also performed among those who were never smokers and did not use snus at age 14–15 years, n=1827. Current e-cigarette use at age 19 years was associated with male sex (OR 2.00; 95% CI 1.06 to 3.77) and having a smoking father (OR 2.28; 95% CI 1.19 to 4.39) (figure 4).
當前的風險因素包括煙用19歲years among the teenagers who were never smokers and did not use snus at age 14–15 years, analysed in an adjusted logistic regression analysis (including all factors listed in the figure) with the results expressed as ORs with 95% CIs. *Entered as a continuous variable (score 0–4); **upper secondary education, reference category: preparatory education. E-cigarette, electronic cigarette.
Analyses of representativeness
The sex distribution did not differ between participants (n=2185) and non-participants (n=634), male sex: 51.5% vs 54.6%, p=0.177. However, compared with the participants, the non-participants more often had a smoking mother (16.2% vs 26.7%, p<0.001), a smoking father (13.7% vs 21.3%, p<0.001), lived in a single-parent household (10.5% vs 19.7%, p<0.001) and reported having physician-diagnosed asthma (6.7% vs 10.4%, p=0.004) at recruitment. Further, a comparison between the n=2185 participants and the n=213 who participated at age 14–15 years but not at age 19 years showed a similar pattern in the characteristics.
Discussion
In this population-based cohort study, daily smoking, use of snus and having a smoking father at age 14–15 years predicted e-cigarette use at age 19 years. Furthermore, e-cigarette use was more common among boys and less common among teenagers who were physically active and ate a healthy diet. Among never smokers and non-snus users at age 14–15 years, male sex and having a smoking father predicted e-cigarette use at age 19 years. Importantly, almost one-third of those who had tried e-cigarettes at age 19 years had never been smokers.
Biologically, teenagers are particularly susceptible to nicotine addiction and it has been shown that occasional smoking at a young age is associated with greater likelihood of daily smoking and future nicotine dependence.37 38Even occasional smoking is sufficient to develop abstinence symptoms38and may increase the likelihood of trying new nicotine-delivery products out of curiosity.39 40Thus, we were not surprised that smoking conventional cigarettes and using snus predicted e-cigarette use in our study. Although the prevalence of dual use was low, other studies have shown that the use of multiple tobacco and nicotine products has become more common particularly among young adults.41The different properties and legislation of cigarettes, snus and e-cigarettes enable the user to choose product depending on the situation. We found that one-fifth of never smokers and never snus users, respectively, at age 14–15 years had tried e-cigarettes 4 years later. Moreover, almost one-third of e-cigarette users had never been a tobacco user, which is a cause for concern as it has been shown that e-cigarette use is a predictor of becoming a tobacco smoker.17Finally, the teenagers in this cohort did not seem to use e-cigarettes as a smoking cessation method, as only one former smoker was a current e-cigarette user. Thus, due to the appeal of e-cigarettes among never smokers, our findings further undermine the claim that e-cigarettes are a useful harm-reduction product.
One explanation for the strong appeal of e-cigarettes to non-smoking teenagers may be the plethora of flavours, including fruits, sweets and desserts.42 43In order to make e-cigarettes less appealing it has been suggested, for instance by the Food and Drug Administration in the USA that flavours other than tobacco, mint and menthol should be banned.44The prominent taste of conventional cigarettes and most varieties of Swedish snus may avert teenagers from use. Consequently, e-cigarettes seem to appeal to new users that may not have initiated tobacco use otherwise, supporting the gateway theory.19
In line with other studies, we found that e-cigarette use was more common in boys than girls.23 24 45One explanation may be that teenaged boys have a more risk-taking behaviour than girls and therefore are willing to try a new nicotine-delivery product. For a long time, tobacco smoking was more common among men than women in Sweden, but during the 1990s and 2000s it was more common among women.46It may be that e-cigarette use follows the same pattern as the traditional tobacco epidemic, with a higher uptake among men in the beginning followed by an increase among women. Among teenagers, social role modelling may contribute to the choice of tobacco product as smoking is more common among mothers and daughters, while snus use is more common among fathers and sons.28 29Unfortunately, we did not ask for parental e-cigarette use, but we did find that e-cigarette use was associated with having a smoking father and that it was more common the more family members who smoked, suggesting that parental smoking habits play an important role for e-cigarette uptake.
We did not find any associations with parental socioeconomic status, but e-cigarette use was more common among teenagers in vocational than preparatory upper secondary education. In Sweden, the vocational programmes mainly lead to jobs within the industry and service, while many attending preparatory programmes continue on to higher education. It is well known that smoking conventional cigarettes is associated with lower educational level, while studies of e-cigarette use have shown inconsistent results.14 47Nevertheless, our results indicate that the associations between lower educational level and smoking conventional or electronic cigarettes seen among adults are present already in early teenage in the choice of education. Moreover, e-cigarette use was less common among the teenagers who were physically active and ate a healthy diet. Tobacco use, physical inactivity and unhealthy diet, as well as low educational level, are known risk factors for public health diseases, for instance cardiovascular disease, and regrettably, the same individuals often recur in all of these high-risk groups,48 49in accordance with the common liability theory.19 25Another interesting finding was that e-cigarette use was associated with poor HRQoL, particularly among the girls. An association between HRQoL and tobacco smoking has been demonstrated among teenagers.34Thus, the predictors for e-cigarette use were to a large extent the same as for conventional cigarettes, which implies that the already available successful tobacco prevention measures only need minor modifications to also include e-cigarette use. Supporting teenagers to choose a healthy lifestyle without any tobacco or nicotine products is an important public health effort.
The strengths of the study include the prospective study design, with high initial participation rates and few individuals lost to follow-up. Among those lost to follow-up, there was a higher proportion of children having smoking parents than among those who participated in the survey at age 19 years. As having smoking parents and initiation of tobacco use in teenage are strongly correlated, we may have underestimated the prevalence of tobacco and e-cigarette use. On the other hand, most likely we have not overestimated the significance of the associations.50Tobacco and e-cigarette use was based on self-reports and not verified by objective measures such as level of cotinine. However, the prevalence of smokers, snus and e-cigarette users was in line with the prevalence in corresponding ages reported in Swedish national surveys,4supporting the external validity of our results. Questions about diet and physical activity were included in the questionnaire at age 19 years and thus represent cross-sectional associations with e-cigarette use. Another limitation is that the main focus of this cohort study is asthma and allergic diseases, and therefore we did not include questions about personality traits related to tobacco or nicotine product initiation, sensation-seeking behaviour, alcohol intake or other risk-taking behaviour in the questionnaire.
總之,每天吸煙,使用鼻煙和having a smoking father at age 14–15 years predicted e-cigarette use at age 19 years. Furthermore, e-cigarette use was associated with male sex, physical inactivity, eating an unhealthy diet and attending vocational upper secondary education. Alarmingly, almost one-third of those who had tried e-cigarettes at age 19 years had never been smokers or used snus. Until the effects of e-cigarette use on respiratory and cardiovascular health have been fully elucidated, the rapid increase of e-cigarette use among teenagers needs to be curbed. In order to increase the efficacy of intervention efforts, the predictors and pattern of e-cigarette use among teenagers need to be studied in detail and our study contributes new knowledge in the field.
Acknowledgments
Sigrid Sundberg, Ann-Christin Jonsson, Chatrin Wahlgren and Zandra Lundgren are acknowledged for data collection.
References
Supplementary materials
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Supplementary Data
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Footnotes
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ContributorsLH participated in study design and data collection, performed the statistical analyses, drafted and revised the manuscript, and approved the final manuscript. HB, CS, ML and MA contributed to the analyses and interpretation of data, revised the manuscript for important intellectual content and approved the final manuscript. ER is responsible for study conception and study design, participated in data collection, contributed to the analyses and interpretation of data, revised the manuscript for important intellectual content and approved the final manuscript. All authors are accountable for all aspects of the work.
FundingThe Swedish Heart-Lung Foundation (20140264; 20170438; 20170696; 20180214), ALF—a regional agreement between Umeå University and Västerbotten County Council (RV-638731; RV-738451), the Swedish Asthma-Allergy Foundation (F2012-0036; F2012-0039), Visare Norr fund: Northern County Council’s Regional Federation (646191), and Norrbotten County Council (867371; 933163) are acknowledged for financial support.
Disclaimer沒有一個資助者在研究設計有什麼作用,analysis or interpretation of data, or writing of the manuscript.
Competing interestsNone declared.
Patient consent for publicationNot required.
Ethics approvalThe study was approved by the Regional Ethical Review Board in Umeå, Sweden. At recruitment the parents gave consent for their child to participate. The participants gave written informed consent at the follow-up at 19 years.
Provenance and peer reviewNot commissioned; externally peer reviewed.
Data availability statementNo data are available.
Supplemental materialThis content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.