%PDF-1.3 % 3 0 obj << /FormType 1 /Subtype /Form /Resources << /Font << /F3 4 0 R /F2 5 0 R >> /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] >> /Type /XObject /BBox [0 0 612 792] /Filter /FlateDecode /Length 554 /Matrix [1 0 0 1 0 0] >> stream xUۊA}ꪚ+>yŇ8XdASfcDŽ:U!,ap=9}> Cځݷ.qj,搅45>fSeOIZתbF:X{:bhDb[)iiv짌1vߵy/V>]-)ب:[D6~ν,(86awݽuIՌ#(UՄ]FBWsT)`g)l4x= TqZqcJS]X%m<QۺR"ǹc.7̠&~/V- 0 "$:KV,gN4ᙙYi^u!C#'2F!"I}D%^f{SLZM ԦH^ kO,D TkFj.X 5ZE)M%m4xGzJjoh9 MnrBu4NF[fw|ݥ(ǥX]"Rb^Us#$>q,Ri$}OXB@ endstream endobj 2 0 obj << /FormType 1 /Subtype /Form /Resources << /Font << /F3 4 0 R /F2 5 0 R >> /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] >> /Type /XObject /BBox [0 0 612 792] /Filter /FlateDecode /Length 554 /Matrix [1 0 0 1 0 0] >> stream xUۊA}ꪚ+>yŇ8XdASfcDŽ:U!,ap=9}> Cځݷ.qj,搅45>fSeOIZתbF:X{:bhDb[)iiv짌1vߵy/V>]-)ب:[D6~ν,(86awݽuIՌ#(UՄ]FBWsT)`g)l4x= TqZqcJS]X%m<QۺR"ǹc.7̠&~/V- 0 "$:KV,gN4ᙙYi^u!C#'2F!"I}D%^f{SLZM ԦH^ kO,D TkFj.X 5ZE)M%m4xGzJjoh9 MnrBu4NF[fw|ݥ(ǥX]"Rb^Us#$>q,Ri$}OXB@ endstream endobj 1 0 obj << /FormType 1 /Subtype /Form /Resources << /Font << /F3 4 0 R /F2 5 0 R >> /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] >> /Type /XObject /BBox [0 0 612 792] /Filter /FlateDecode /Length 554 /Matrix [1 0 0 1 0 0] >> stream xUۊA}ꪚ+>yŇ8XdASfcDŽ:U!,ap=9}> Cځݷ.qj,搅45>fSeOIZתbF:X{:bhDb[)iiv짌1vߵy/V>]-)ب:[D6~ν,(86awݽuIՌ#(UՄ]FBWsT)`g)l4x= TqZqcJS]X%m<QۺR"ǹc.7̠&~/V- 0 "$:KV,gN4ᙙYi^u!C#'2F!"I}D%^f{SLZM ԦH^ kO,D TkFj.X 5ZE)M%m4xGzJjoh9 MnrBu4NF[fw|ݥ(ǥX]"Rb^Us#$>q,Ri$}OXB@ endstream endobj 4 0 obj << /Encoding /WinAnsiEncoding /Subtype /Type1 /Type /Font /BaseFont /Times-Italic >> endobj 5 0 obj << /Encoding /WinAnsiEncoding /Subtype /Type1 /Type /Font /BaseFont /Times-Roman >> endobj 6 0 obj << /Filter /FlateDecode /Length 10 >> stream x+ | endstream endobj 7 0 obj << /Filter /FlateDecode /Length 36 >> stream xS**T0T0 Bi yJ% endstream endobj 8 0 obj << /Filter /FlateDecode /Length 10 >> stream x+ | endstream endobj 9 0 obj << /Filter /FlateDecode /Length 36 >> stream xS**T0T0 Bi yA$ endstream endobj 10 0 obj << /Filter /FlateDecode /Length 10 >> stream x+ | endstream endobj 11 0 obj << /Filter /FlateDecode /Length 36 >> stream xS**T0T0 Bi y8# endstream endobj 12 0 obj << /Type /Catalog /Pages 13 0 R /Outlines 14 0 R >> endobj 13 0 obj << /Kids [15 0 R 16 0 R 17 0 R] /Type /Pages /Count 3 >> endobj 15 0 obj << /Resources << /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] /XObject 18 0 R /ExtGState 19 0 R >> /Contents [10 0 R 20 0 R 11 0 R] /Parent 13 0 R /Type /Page /MediaBox [0 0 612 792] >> endobj 14 0 obj << /Last 21 0 R /First 22 0 R /Count 2 >> endobj 22 0 obj << /Parent 14 0 R /Title ( M o d e l s o f t h e t a r g e t a n d a c t u a l s a m p l e s i z e) /Last 23 0 R /Next 21 0 R /First 24 0 R /Dest [15 0 R /XYZ 72.0 583.892 null] /Count -2 >> endobj 24 0 obj << /Parent 22 0 R /Title ( a \) A N Z C T R) /Next 23 0 R /Dest [15 0 R /XYZ 72.0 563.51 null] >> endobj 16 0 obj << /Resources << /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] /XObject 25 0 R /ExtGState 26 0 R >> /Contents [8 0 R 27 0 R 9 0 R] /Parent 13 0 R /Type /Page /MediaBox [0 0 612 792] >> endobj 23 0 obj << /Parent 22 0 R /Title ( b \) c l i n t r i a l s . g o v) /Prev 24 0 R /Dest [16 0 R /XYZ 72.0 721.993 null] >> endobj 17 0 obj << /Resources << /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] /XObject 28 0 R /ExtGState 29 0 R >> /Contents [6 0 R 30 0 R 7 0 R] /Parent 13 0 R /Type /Page /MediaBox [0 0 612 792] >> endobj 21 0 obj << /Parent 14 0 R /Title ( M o d e l s o f t h e t a r g e t t o a c t u a l s a m p l e s i z e r a t i o) /Last 31 0 R /Prev 22 0 R /First 32 0 R /Dest [17 0 R /XYZ 72.0 723.985 null] /Count -2 >> endobj 32 0 obj << /Parent 21 0 R /Title ( a \) A N Z C T R) /Next 31 0 R /Dest [17 0 R /XYZ 72.0 703.603 null] >> endobj 31 0 obj << /Parent 21 0 R /Title ( b \) c l i n i c a l t r i a l s . g o v) /Prev 32 0 R /Dest [17 0 R /XYZ 72.0 382.421 null] >> endobj 20 0 obj << /Filter /FlateDecode /Length 53 >> stream x+T03T0 A(˥dh^U`fhS5DK>W ^ endstream endobj 33 0 obj << /OPM 1 /TR /Identity /Type /ExtGState >> endobj 34 0 obj << /Subtype /Image /DecodeParms << /Colors 3 /Predictor 15 /Columns 6120 >> /Width 6120 /Filter /FlateDecode /Height 7920 /BitsPerComponent 8 /Length 403640 /ColorSpace /DeviceRGB >> stream xA 0 ?! q ܉{ @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { @ @ q = { |vX `H 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` !vX `H = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` A q = 0{ ` @mUAF {pF @ p = @ p = @ p = @ p = @ p = @ p = @ p = @ p = @ p = @ p = @ p = @ p = @ p = @ p = @ p = @ p = @ p = @ p = @ p = <ۿu p & T=