%PDF-1.3 % 6 0 obj << /FormType 1 /Subtype /Form /Resources << /Font << /F3 7 0 R /F2 8 0 R >> /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] >> /Type /XObject /BBox [0 0 841 595] /Filter /FlateDecode /Length 549 /Matrix [1 0 0 1 0 0] >> stream xTۊA }ﯨ$T `u^D|+Ȃ'5:΂`=I%I*~O/mǗq~0 op7~H)ZTmaT/9԰_yNhUk6[Ka[5|6M-szm,8A<"F{!wsi7{d"%b3.[w6fƦcU ;YN(38UHfxl1Abc^ekGT\S66$rnيrELђ ?bBeB抽-o jyLz)mӗJY1d-y5j1[~&3$" `'2< KCX%Q< oڊ$UR1y3ir4vEx+$8ߣ@GiY>o &hxTsĵ~M=S% QBʪa]X{ 8 ww;``D+ 8: ~Xl*>jݫ&bhjͤ:R,X.Ike> /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] >> /Type /XObject /BBox [0 0 841 595] /Filter /FlateDecode /Length 549 /Matrix [1 0 0 1 0 0] >> stream xTۊA }ﯨ$T `u^D|+Ȃ'5:΂`=I%I*~O/mǗq~0 op7~H)ZTmaT/9԰_yNhUk6[Ka[5|6M-szm,8A<"F{!wsi7{d"%b3.[w6fƦcU ;YN(38UHfxl1Abc^ekGT\S66$rnيrELђ ?bBeB抽-o jyLz)mӗJY1d-y5j1[~&3$" `'2< KCX%Q< oڊ$UR1y3ir4vEx+$8ߣ@GiY>o &hxTsĵ~M=S% QBʪa]X{ 8 ww;``D+ 8: ~Xl*>jݫ&bhjͤ:R,X.Ike> /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] >> /Type /XObject /BBox [0 0 841 595] /Filter /FlateDecode /Length 549 /Matrix [1 0 0 1 0 0] >> stream xTۊA }ﯨ$T `u^D|+Ȃ'5:΂`=I%I*~O/mǗq~0 op7~H)ZTmaT/9԰_yNhUk6[Ka[5|6M-szm,8A<"F{!wsi7{d"%b3.[w6fƦcU ;YN(38UHfxl1Abc^ekGT\S66$rnيrELђ ?bBeB抽-o jyLz)mӗJY1d-y5j1[~&3$" `'2< KCX%Q< oڊ$UR1y3ir4vEx+$8ߣ@GiY>o &hxTsĵ~M=S% QBʪa]X{ 8 ww;``D+ 8: ~Xl*>jݫ&bhjͤ:R,X.Ike> /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] >> /Type /XObject /BBox [0 0 841 595] /Filter /FlateDecode /Length 549 /Matrix [1 0 0 1 0 0] >> stream xTۊA }ﯨ$T `u^D|+Ȃ'5:΂`=I%I*~O/mǗq~0 op7~H)ZTmaT/9԰_yNhUk6[Ka[5|6M-szm,8A<"F{!wsi7{d"%b3.[w6fƦcU ;YN(38UHfxl1Abc^ekGT\S66$rnيrELђ ?bBeB抽-o jyLz)mӗJY1d-y5j1[~&3$" `'2< KCX%Q< oڊ$UR1y3ir4vEx+$8ߣ@GiY>o &hxTsĵ~M=S% QBʪa]X{ 8 ww;``D+ 8: ~Xl*>jݫ&bhjͤ:R,X.Ike> /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] >> /Type /XObject /BBox [0 0 841 595] /Filter /FlateDecode /Length 549 /Matrix [1 0 0 1 0 0] >> stream xTۊA }ﯨ$T `u^D|+Ȃ'5:΂`=I%I*~O/mǗq~0 op7~H)ZTmaT/9԰_yNhUk6[Ka[5|6M-szm,8A<"F{!wsi7{d"%b3.[w6fƦcU ;YN(38UHfxl1Abc^ekGT\S66$rnيrELђ ?bBeB抽-o jyLz)mӗJY1d-y5j1[~&3$" `'2< KCX%Q< oڊ$UR1y3ir4vEx+$8ߣ@GiY>o &hxTsĵ~M=S% QBʪa]X{ 8 ww;``D+ 8: ~Xl*>jݫ&bhjͤ:R,X.Ike> /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] >> /Type /XObject /BBox [0 0 841 595] /Filter /FlateDecode /Length 549 /Matrix [1 0 0 1 0 0] >> stream xTۊA }ﯨ$T `u^D|+Ȃ'5:΂`=I%I*~O/mǗq~0 op7~H)ZTmaT/9԰_yNhUk6[Ka[5|6M-szm,8A<"F{!wsi7{d"%b3.[w6fƦcU ;YN(38UHfxl1Abc^ekGT\S66$rnيrELђ ?bBeB抽-o jyLz)mӗJY1d-y5j1[~&3$" `'2< KCX%Q< oڊ$UR1y3ir4vEx+$8ߣ@GiY>o &hxTsĵ~M=S% QBʪa]X{ 8 ww;``D+ 8: ~Xl*>jݫ&bhjͤ:R,X.Ike> endobj 8 0 obj << /Encoding /WinAnsiEncoding /Subtype /Type1 /Type /Font /BaseFont /Times-Roman >> endobj 9 0 obj << /Filter /FlateDecode /Length 10 >> stream x+| endstream endobj 10 0 obj << /Filter /FlateDecode /Length 44 >> stream xS**T0T0B g`hndd'*Gd*+rrW endstream endobj 11 0 obj << /Filter /FlateDecode /Length 10 >> stream x+| endstream endobj 12 0 obj << /Filter /FlateDecode /Length 44 >> stream xS**T0T0B g`hndd'*Gd(+rrV endstream endobj 13 0 obj << /Filter /FlateDecode /Length 10 >> stream x+| endstream endobj 14 0 obj << /Filter /FlateDecode /Length 44 >> stream xS**T0T0B g`hndd'*Gd++rrU endstream endobj 15 0 obj << /Filter /FlateDecode /Length 10 >> stream x+| endstream endobj 16 0 obj << /Filter /FlateDecode /Length 44 >> stream xS**T0T0B g`hndd'*Gd)+rr|T endstream endobj 17 0 obj << /Filter /FlateDecode /Length 10 >> stream x+| endstream endobj 18 0 obj << /Filter /FlateDecode /Length 44 >> stream xS**T0T0B g`hndd'*Gd*+rrsS endstream endobj 19 0 obj << /Filter /FlateDecode /Length 10 >> stream x+| endstream endobj 20 0 obj << /Filter /FlateDecode /Length 44 >> stream xS**T0T0B g`hndd'*Gd(+rrjR endstream endobj 21 0 obj << /Type /Catalog /Pages 22 0 R >> endobj 22 0 obj << /Kids [23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R] /Type /Pages /Count 6 >> endobj 23 0 obj << /Annots [29 0 R 30 0 R] /Resources << /Font 31 0 R /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] /XObject 32 0 R /ExtGState 33 0 R >> /Rotate 0 /Contents [19 0 R 34 0 R 20 0 R] /Parent 22 0 R /Type /Page /MediaBox [0 0 841.6 595.4] >> endobj 34 0 obj << /Filter /FlateDecode /Length 2943 >> stream x\Ksϯ3[OOTr9TVҬ7+֥4H<d19RF>Vfk[|2k*es(X]=\Wo_U^ .oW5zU#i`:l_**Ù[p/ ]2W;<[; , Ypi1dPT/Ӈvf7fM.mnjiM'̓wpxSqt;!ixSjumVm εv{E~o}J9]U;Δ~rJm͛^ XB|y&zoFQYkr44`~I᪩-1M5[Zkfv.6߼.zNJۡ~#Դ |l%F$XI3K. O;^$^ aaH i15@TU׎idjl%ۖ(| `31ހM Ds@F2mo2& nZ]EPI+gh3'-ˤ+ݜx^,θ P ˶#?_ /YER4-ysʰTA@h7m 5Zz,|nXڇ&)Μ*'E9׷!tݼVf[Lc< nj!@sSI.*. *thLFNײ(dOШIfzmr/{ OF DQ)pU !258LZ Hk:r Ej1 vHY*R 6ˏ{Jts:<@fͽa\ oI%(SD~ YQ<}8quNݩ s'f88`'-3$*򉧰 k*d:4v01"jkȏw"}t=NbO4x/ :-%f: o1&=uuF ["((\PSZnb.aRvܟG}yL#Kr!TO>=HN0l  %j`b%ItQ(cnr Cg3xg(`d/6u>Ma` H,EsO{=R%:0d::W^yh ;؂r ёƆՒ,%'"&9NKZNء,0⺊j}UsĄn3l{CodSl7NXPt5JoJiL#dUiFչW=cSt`_k-dE"j(ۜM/"le߰f *Zze_rͧxrDxQZZ},FY+sO墔 =!)gA$GRU:>cql^֬G P_Rޛ Š7Vb:hvYZQ?PJ8]w.MˑiNkׅqkTMk'`!ki?u\ endstream endobj 35 0 obj << /OPM 1 /Type /ExtGState >> endobj 36 0 obj << /Encoding /WinAnsiEncoding /Widths [278 0 0 0 0 0 667 0 333 333 389 0 278 333 278 278 556 556 556 556 556 556 556 556 556 556 278 278 0 0 0 0 0 667 667 722 722 667 611 778 722 278 0 0 0 833 722 778 667 0 722 667 611 722 0 944 0 0 0 0 0 0 0 0 0 556 556 500 556 556 278 556 556 222 222 500 222 833 556 556 556 556 333 500 278 556 500 722 500 500 500] /Subtype /Type1 /Type /Font /FirstChar 32 /LastChar 122 /FontDescriptor 37 0 R /BaseFont /EVGZZR+Helvetica >> endobj 37 0 obj << /Descent -218 /StemV 104 /FontName /EVGZZR+Helvetica /Ascent 741 /ItalicAngle 0 /CharSet (/A/B/C/D/E/F/G/H/I/M/N/O/P/R/S/T/U/W/a/ampersand/asterisk/b/c/colon/comma/d/e/eight/f/five/four/g/h/hyphen/i/j/k/l/m/n/nine/o/one/p/parenleft/parenright/period/q/r/s/semicolon/seven/six/slash/space/t/three/two/u/v/w/x/y/z/zero) /FontBBox [-18 -218 929 741] /Type /FontDescriptor /CapHeight 741 /MissingWidth 278 /Flags 34 /FontFile3 38 0 R /XHeight 539 >> endobj 39 0 obj << /Encoding /WinAnsiEncoding /Widths [278 0 0 0 0 0 0 0 333 333 0 0 278 0 0 278 0 0 0 0 0 0 0 0 0 0 333 0 0 0 0 0 0 722 0 0 722 667 0 0 0 278 0 0 0 833 722 0 667 0 0 667 0 0 0 944 0 0 0 0 0 0 0 0 0 556 0 556 611 556 333 611 611 278 0 0 278 889 611 611 611 0 389 556 333 611 556 0 0 556] /Subtype /Type1 /Type /Font /FirstChar 32 /LastChar 121 /FontDescriptor 40 0 R /BaseFont /OMGNEV+Helvetica-Bold >> endobj 40 0 obj << /Descent -219 /StemV 139 /FontName /OMGNEV+Helvetica-Bold /Ascent 741 /ItalicAngle 0 /CharSet (/A/D/E/I/M/N/P/S/W/a/c/colon/comma/d/e/f/g/h/i/l/m/n/o/p/parenleft/parenright/r/s/slash/space/t/u/v/y) /FontBBox [0 -219 932 741] /Type /FontDescriptor /CapHeight 741 /MissingWidth 278 /Flags 32 /FontFile3 41 0 R /XHeight 549 >> endobj 42 0 obj << /Subtype /Image /DecodeParms << /Colors 3 /Predictor 15 /Columns 949 >> /Width 949 /Filter /FlateDecode /Height 196 /BitsPerComponent 8 /Length 15136 /ColorSpace /DeviceRGB >> stream x xE;<]Q @P (:qAf]T@dq$" B@!*"D a-,-7wg6eTz;U˩>+79S[ݿJ H@~ @1D~ @1D~ @1H8tNJJ$˕c(}?7a1H&h}W49v9쭶m}*-c̚9/d{9 ^9Tiخ3r~ ~ o57\j"u{?ıs]P;²ㅾ ?SR)yG:~ o1s.YʯMc ~ ⃅~%^_@ߘ9y@=t·K7_'M)\QcnĬק9Ա%cVN?8 4Ա%cJطC[?Cr1qj.K{ӡ?k ~SYOŊ^<$C|4 $]uYY(fvZTO+V|BHϋ,DWo]a94iF!3-߂$QHd?$ 4Â3e&Ѩ ٖb9%!!ar^$ҢMb`"R&&}ͅ*Ǘ%c.v/l]_"ua"#+-lNI"Ja-c6!=lqŒ%%I/,MT1Bm)8 &LS%E+@a /[*sE{9 c1[@`̚9eg'nFs3?~LÏ ~|;s;vo{??zEC?UXFTRZ[ֺMIT6 vkchnf c1[pׯ~$}O9wYr%˕-]Vo([~տ4:|KfX /鳗l~O\VᦔJ.Ѵy]_^2Z)Nt>_7^%*_Oז\CJU*sg[Pc'džA .Gs3?~LÏb;^w~8rQ%f2>H^*;5oѺNLb`k#c{bҽNUزujJ0rޓAZ2W(ؔK01+  .}ɦkwŔc䖛[qK'U cK+ǶjX?V!9ZaG?~L';{i_8Dgl1E?I~['| 3(7m\-&U? ɱW ?&Џ_Z5Y{bhƄkqBO*JR2]Z E'.co)Sf''v~, ?W??Ӄ{"oR*)VYJV0l%K?;}ùΜxylZU\rd_{\xnaJ%K%sEm|l~- 5x}" ?&Տ_x\\ZVQ7U@geLL*b[6áCڵؑc]VďE#;+ v8yLzsW.X4-r=ķ8x=ǽ2fŀߙwڡSA zܔrY<) ~,4caq\ ^VMfMtmjEΏB;{Uo=ǖ.1)~l T}[_ZJfkݲK.򵗅R$g6>CcQgn|Pl?~Lǟ矿,ݳ~rӵ ;?f !v?u ׺1+%^1 fL2o-Z*$I1 |Y&|'o֔L;"Ï&fnNxůx˭<*2,f|z{d՚ x<-g%c9ʱfNY~7} ~, ?3?>vs24At95桺 K?vEީO۲;IʘA`rv8C1~BV!3n];t}%;96_[O8:% ?~LǙϙ"+&BW~?BS?v͐V. ߼"yP*ҥ٧,Ɍ4Gݧ,ɻ]c~LǙ?shڶب0c99s W@W\:yP*iEiF\u2#8qcy7}ŗc_|9cdEiUcа<ÏnUg%<媕ʃR}=o@H?NduNlߑlҤ>Ҋ4Woc?ڱK`ů5eK3yBۇJܭ3ѮOfJA`4o#02# 8aqݣͰ~LǓybP犎=ٿ['rv>6V[LP*JChdo{1`f'&l7 3MVYdCr 㭛L&”iRn*?wwP*JCܸa Y% fFq0IVSGSO0c8n8se^ʛxUfM*Bv9RyP*Dx;!A?N4r*8 >Q~(/ pO!K)Ht ff'hVSP!~LǍZi_߻~(WH+.{*H{'QchWqqyÇZ!zpv4_<( e،y 8A-upqq=DN2eKÏ`#{s9!RyP*icDyq׮[١q K?#&JA`(c:#/~Qk1~~4svl~q_.+s)^c[ 8DsyT*JC\Ѹa%=C?|N|T:n{qq{W%_1JWU~#*dP*JI<~C$ic/>y(Ms}/2#Xyc\eKmv'aya?&ɏuN\ G߻?ӷl=̿(ʃ: BX9N?Q'3r qF?j SS*%/hn!~LǙ;rakW-ԳT:WH ~]H0Y9OcסmɳLfeA΃ ѻGar\ĕo!~LǙO#T?vDGC7,ʃ d_ڤ%r5_Ι*d c,|g44Xgn|s/q/?=xoGnt_gH쬜^^A(J!H?i J3{0Rb썯yAФa k?c8X?5g)o}]AW?Gt#'S*1 &gG᳅F֣41R$=>$/ (/˖\1~q\i˳h^SnǴU_?DtNͻĔCLx꫋*\*sy=+JUcOMb !~9֙4O48 xcW^?4s;lf4cK$tӼJL<LY뾗6c*e[& & Ǟk瑮$9^ZZH=~q/ǍYtLjF=N&yOK.w،{6"y,YnۺoƔ&ǚb$+&$Ǟa~q//G|_nMڴk4Dc99<}L<ӺEuו!?7m^no١{ԹO9҉)AʱX5I? B8cH?c8>叽͙7^ӡC㮽1~w*з{{F) ˉ)`9& 9 1 DzBr{>-?&?-_%<́%zE'nub ӧ~,:Ze޼=43+'&$c(_3T5I?BXʱ1~ ~kDZO>vGf)M?v9T0=?'JUco៶0{;qljǤڬ=H~d^mc>[3gW)RT+٧Ej~9Ӆ؍b!*ǚ1~h~rݸ%W |[S Igg,`ͷ[>+0ԌO/5OLKu}EEj~9Ӆ{ Kte 8 cɦ=Kdxven[ծS/nS}?9h pX4Jj'&̘T5I?B Jȱ1~~LbڴA Yr׼4Oj&)vJ[h J:'&[cJUc?.vG٧ C?Np?&19Џ#G=Үc$8JL)mnr x;"*JUc\<ս{6D1~ ?7;{7g]~܏S*%O>n+J3\rnlٺA޽Aj~Ӆ4iXeâ+o@7?&lq Yr~ 8 c1[II_ss;yt=xJ/3[JP0%x3 Aj~+ Yb" خ3Tqc8K?&>xyn?%;u*VMnlJh0BEo>z<_[^].ǺשUAjkaJ`&͘'5 l(P$t!3U%?&lq~lQZKe@߻ H])N_9RC:U<͚R=0e0r/C1R$80fMɜ237%Nlx~1-Υ,95)5N~!J`:ܔ JUXk{a>s``D~1-s?W_D~!J`N巽Sf]S$(J C?yVm=z&CʃOEw& 1E=zV!~LÏ<N>Y~!J`&͘Zy_j~[,gSg~1-s?mt&Cʃt휾E|F1Mw& 10^JRg~1-+ k0y:>}k8XIq1̨73[ՎmHC?܏1?(u~d+WÎJUc 8 c1[~1YҸޢTf̩3>V{B' gpRN8 J!u{I/JrWaءT5I?C?ŹO-ڭB+x=wӵ ={Rya0y9\#r)UM'?&̏9s\\.I=`ZQV KCluR$p?c8M'O^Zv5nU݊xgٛjRK.Uj^Tb̄]+EՋyf\?C?3?^f[sֱM=L7_ZRF*W)_ O6[m4̚տY˚LD<L[bJţ|zWO̸~ 81~g~X[x+*puק\ e6"۾;[g˿nEjδFRN ~B0y>fAqG' Zl1 )6nXnmc sckjsvpUIT$dkҴ /:?,Xxx0զMO_~0eukW8HB+b?Ey$'ncڼE@>~n=d 9h֪]g V}#~6N&;BW3Wxc,C N?8z'O=j6~v]V:ݛ̐A A_.<7b$Yk,8%|4yO3z;14~,s/Op=[2wm»Z?~) ,xt p:Q^s 4l.]뷹6ԼE{;F]X+xB`Zjڡ)d΀W痫+۷m%GXAZ`+N_n=)vo*1=Jk+.Ki{8rc8\ZÍOsBX1*}a?λQovCCwo{e8kxN)u-}uv[j6 30TzV~УYb"s!Ke1d@__|Ip`f_b Cx{ߵO5BR44~AO،e]9|B$,j9 OG}..Ku8=y0+,]rxB`b[t1i?<-}0h0A]Byoaph_Xi.܌m,M69Cϟ$X޵m ~Kɑ3+~nwp1>#3_ m`ڴ:]^zcl&MlyF}V׷<ܘMg~,W,~γd\a2 :N/B=t>EXϞ=%4Qts>/,ݧѫrpҏ/_䥫(qroMoJCïs`~,TxEȏ X v/Hi{Oc#gVv!y{B5 }VFr~L[h`Za-ҷ]4<kB,Ԙ,緼ޏbc+,䂛>'# $pa8cC*ˑx^lFҏ٣ -=-7<Z&ǖD>j+y{<L4_cv\wiy_rǫ4zRM/^cˣfgvrߔȃfuߔ>9Oo+~ܧr\٫Uo\8q.ǚ}S(}S8 LC_b'>45/> /BS << /W 0 >> >> endobj 30 0 obj << /Subtype /Link /File 4 /Type /Annot /F 4 /Rect [650.25 294.84 703.269 308.34] /A << /URI (https://clinicaltrials.gov/ct2/show/NCT04631302) /Type /Action /S /URI >> /BS << /W 0 >> >> endobj 33 0 obj << /R7 35 0 R >> endobj 32 0 obj << /R12 42 0 R /Xi0 1 0 R >> endobj 31 0 obj << /R8 36 0 R /R10 39 0 R >> endobj 24 0 obj << /Resources << /Font 43 0 R /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] /XObject << /Xi1 2 0 R >> /ExtGState 44 0 R >> /Rotate 0 /Contents [17 0 R 45 0 R 18 0 R] /Parent 22 0 R /Type /Page /MediaBox [0 0 841.6 595.4] >> endobj 45 0 obj << /Filter /FlateDecode /Length 3729 >> stream x\KsW8ċstSI%U:=F~]Y70<*q頑 4uд7 _}i޾\}aF7Xf{mSڲoEx6o(?ф_w];뇫eޘpKWf{WߺWF*˜DL 薩N5lgio6b5lS?Kؾu FucBuǬiTf \I-yث?זFw u}%̎z)uPΚ !5tyvXVl;Z.Uyݹ5[.6[߿lw?e͏[ut'/">iiO }~Z}ݧ3szi8+==|>}L j L#@I\#="R;]}`pT]oJL# 0\YyC _7[xU7E]#um3iyXӂ)Qlidf7xQRU ˄1!np۶=D#P-g*Z,%l0d쏞 =nq|1O_;j$@$ .md?aؑ3"qZ (W6@m3PbфCф3phT-̄3o 6q}/y}R9E~:l_a@c&6@޿_]GߎTX hNo{353ͧt7ǰWO4` |=M=Gh[3 1N 2K;d aA v:,Y'U2"Z% 1y2ql€7@xL/̷ JV}3 vt$pM'hPrkpy[A r|)2e&(mu3aq;n.X84mG'*&hl,pU;A@{ZQ( }p9n.&fA[4N؝^ΪF@sA8>)ɕtDJ3㨇t[ephMIVIRf yR}&82U=As(4tIM8&yZl0KR?@|macVϘT9xeaR˅-PaGx"Vz'D?6)g%ϫItS)w% l McRvыCbɋR.Eg:.%itgt. LtʰdsJh)S I'u F0-܃O z袓ٚ{.gsJ/+|gM"Ɖ6_"8V:,#LD5?u@G%,̈́uL=A2-JFpA3zmkE"eZBK4=.܍=8%cL>8H׎Q_8ro[=q°ゝ<@SQUzprKTXL3/2Dqar=^( vS1vJA. מFDZ e1/IC]Z =nN! ľ|#aF@:LhyiD(mV>E<߀+õyJiŬݖG\MR6Q2a8]#4#TW0se)_9i/vŖjϋǟvC̲3Oq!< '=]:2;o)~~ĝEETbAF=ɳ +^[zGgrnuY\spz,. JkoW| 8\8TPxB:-fZ^Orby61G{pț"S1ȊJ7-gpb 7,pglu=Se:SP0:bd(3g(pɸ1ښuI !ݤ֓&In hc蜀@|94 \^v}v<aqH`vP.gca<eޡ& d1JѓvHπ;ç #OwM;ޝٿeٙ%fl'/]j[J6#.cZC Yn0O%G0/NgK_-LHjԜ,\eHl#Oy6y0HdwY~2ptJg}Z<po5'85&h\1kOR@|K"k)o}xϖLFA53\ˁs.Y{Ck[ArEdib`u B:ӷW8rL endstream endobj 44 0 obj << /R7 35 0 R >> endobj 43 0 obj << /R8 36 0 R /R10 39 0 R >> endobj 25 0 obj << /Annots [46 0 R] /Resources << /Font 47 0 R /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] /XObject << /Xi2 3 0 R >> /ExtGState 48 0 R >> /Rotate 0 /Contents [15 0 R 49 0 R 16 0 R] /Parent 22 0 R /Type /Page /MediaBox [0 0 841.6 595.4] >> endobj 49 0 obj << /Filter /FlateDecode /Length 4736 >> stream x]KsܸWqf+b iSI*U[7A%YVVק9x59])44A<+dzwOggM+vRU?;t[;%U_u_wnwVnITWwvݰ93- *5hӢd.>w_~8{Eϴl$aT#wښ~?Rj껞^UE :?jjܵnyUVUݱg7ߝ4 iPNðktm"fbMAtG l+UU2CASU3V'Zq z[=v.^Fcl[u|T9 3BUzш8*m5 RχSר:9PfdB>}Wx5ofP]Kw/Q^*ú/LnhT[w<=6 ʄWϦhMHQlTCk$7ݡWiƿ2v{)uȉ!>c|_Z{?6O˸bPW|cUsVW^cU%a:oy6nX;oы>#|˵:gZ8 8ӬQ>??3혹c`^/'"\X{s84 2 ];y]$d/ 1QSMKŹ^ũ*MU# }u4CɁU+Q2Mc"lwB62v~6Qd6=tC6'dj6&adU@C:´)c^$mNdkئRM)if;dg*'a~zjć(+q!|g-q[@SXvWB "l8_-nn:}':1N <*@9,]ѕ3K$"%0(isܧdE(iE6ܱ((#R-kةvHHFGH(pB٘r1$5F>iţc~6n} #ӎP3WV)cZuXm i Jr̼6J?hPC3!=[0Eb$aos$f/$jH VѦtlPؑm(J5@!N9(NJ1w^] c(6Ct.[k'Ѐ&;"g8Eq ҨB_e|M4+s7S#"u1r*,gF,~3nFt`"(|8Mf=)! !Ȁ"7+SG ,p ( *0@4Dp" .>4Cςx|*9^gu+-,|i6iUf$~; D%~٤~D~43B$B́ZK/|C(^B=`5*e Lkj\M&$Z N"TI'>!EEYe`Jઌ48ޙ'KeN0Q9D 8?lRxLy9y2}012 5_g_SC5a6`wWi-q .X`gy*j WT+6#[vM/XB?fLV-TkP{SGȧl9OcnxӚ-EFd$'%[dOs$*)Z??38n q5zp_p P_BY~ʔEy\PON(''SS3ou]:@$3h=֣);%Ɠ56sIh:`Bc)j5a%F7mN54!Ș"2խd*+TwVjМddqm]!i >0a)c8@pS(YsM5oG,( 7m9P5id&/>M~7ACG"%`BLηtݔJH@a{z7cmJrE^ƙUe,w+.YsrgT7'ByOd=Q3qY+Tpmb@q6wj^&[-{<-e#~LΕaf&e)pfǔYQddaZ`ee^|ݝR~ZNrÊlCu U\1By`eʬxЬPޡ*;4:Ue#mB$jYI彐jkxAC6N;牢YxI_#:3O赕 V$Z 8O2c;rd_9|vZ,V۶mTi/N9srALIYCĿs[VJY0rK8v` r;a(.mp/f}NSJ9nu&qs@MϪ-3T.gAp]2}P0)ȯ/er)L zL(ìI^,:{ܤQmS;Ox$ѨȲ'\PT57u6)zԘx-[*UYhp{x/w | ۜ}=^949عWvəv2~B.ybnގǐ:o %u@vVnnoeI|d kKn,X:Qڥ.GIREea}ʗ|8 |6l` %ZrூܒK D>پQx nYUJ3[`w>.8`9KC%kg֚EYF$ϳ[OPG6DdbrVRbe!LE`_߼5}D%;p5j S95֣ǯf PxNWx^0ȭ,WĬP@6By d9m,DN&Ow/rrm%=0ZW\mIfN+_eَp\ևĎ͜z%c68 [>+0PrIc…; y! )n]`wEL nh~Mp![]Lx$H\pvkJKVK1Z"-Q{t-Dx>aL`5 ~B'a.A6:7cyKvv*ET `J)]T%dfۻ煜ԅԘŗDOxŠdΩ;HF=IYIp?2 /x/{sMׁAp+_(k/::irKs`Be_2~bp6OϩR?Y!?ˁG<*F(#u<)Np ӫB endstream endobj 46 0 obj << /Subtype /Link /File 4 /Type /Annot /F 4 /Rect [688.788 187.425 723.645 200.925] /A << /URI (https://github.com/mvainre/SWELL/blob/main/SWELL_RandomisationGenerator_final.R) /Type /Action /S /URI >> /BS << /W 0 >> >> endobj 48 0 obj << /R7 35 0 R >> endobj 47 0 obj << /R8 36 0 R /R10 39 0 R >> endobj 26 0 obj << /Resources << /Font 50 0 R /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] /XObject << /Xi3 4 0 R >> /ExtGState 51 0 R >> /Rotate 0 /Contents [13 0 R 52 0 R 14 0 R] /Parent 22 0 R /Type /Page /MediaBox [0 0 841.6 595.4] >> endobj 52 0 obj << /Filter /FlateDecode /Length 4594 >> stream x][sܶL+q7S@`I4Mu4$}eYŖorK8~HtwpV4|94kbAݨJK*wii@gh]Ng/ʮE7]P~j$TXqYԪ2дMhthdz8k!纪jχf~eDW!]쟅_]7nwh%peJ[YaoDeeMVk69yuU=JFݥ~f-+ˣXRG5H4R +sT|aTm\V#HUPD }r87U]Gyc?7x?u?k/.͗nu?|NC"蹼 ˜'l)ސx`  maf.Mdm}>n=|.ړ $[ [d\'lRޫx謙dPQ7PbSW+qN}9kٺ~-3Yx5,KZ_KU5JNL~!Qɒ ָkeCcbYhU#bUʒ̳ pZ5FSqՋ$/͒g߂ Brڶ;OLm :498rD9D {"#'FL`#eE޷#,,zx#/}6+gc|>{#b6?M`s r _Nپ150x^C(>;rMSmN^LR0^YrkTe?WK4ܹ<Ωnh#~=b6tH֎/s G]ĄKfSv'^{'L'YfOe0&Lդoy>G'8|>aj`+w6amMA;o9'֥Ht! 9dPP@ bka)ڪ=mhKЧ nyEQұU'ejTQK&_{a-Nk+_)HY*zvlL;²F>ႚAsTR|آ6%ŢB(QGBAC!Kr*ᙢ_{wkX˛A Ty 05ɍð"[7'[r;xW=hDJmrmv`)[fހ  gSy0Q !6h٬k-`|ҭj5i&}* %h 9Uw8*;kHj–mUv]`*5q9n$pDŽ%΃3].@cYQܢҏd nH,҅@+;gaG ]PӉy8G>9Lq]ND@dboD&Cř1،JL !К &NX90=hǛ+?iS֣ m>#2YWbC_ju]B_ y .3Ը6]o1=Dn*74pJz[Ң%{657JK2HHZtНϒNS4%854TF3\gР_#3Uns Ei$ '}ؓ8&IŁ; MϊNFE q-2щ7'SqzmxDӬ[r0aBVYh4X 9'ub_OUN (351O4>$Z[4v-D%AsFGa%JV MZnQL[|L[j^/赻bJ>32ap?|p=fjƘ[c thHd?SH V^W<]ɖ5K@ O^_ͅy tB_*pz\#i4)$-4 Q[[\3KXO7^%|NuVvO ۤ$&/s,,VP\ bDZڧBWh(QB&X,&`q4#)$XdK꧞(ϑ#ʲh<_LxZC%h-4R>(TRцRj4ں]tux⌧|';Qo`9A^%Y6+ʼ̋;ka^pK`E3MՅpmΐ0a ӝQصUJwR &_[kf!؍i zMKʢ;fCsin(F%D u&l%, w덀5m71KXtSR"v_jYt/&i+ko]7:5^W6k+FHXqoBm,ߑUs}#UmZdJq*]RC sB3㜁faxDYxi <]Kؿ*ZU*|LhqiV ޫ1|&VL,~m[,yY/c<Y! UU2>!>ReU-|19\{%kK-_BoՂހ1yHA|ɵHkp׷L&pmpHRt lAёl(rl&F^?F (AQ8>guW${d'"ᣍ;6؉ D"n8?z&1[昄-B P;J<*Iű[&$,'*t\xZƦOexio9>wuu䈅Ʉ5${UJлJC3EskA3(`xGfR CGeߦ Uؿy-΋J+D\d[A6KdfOåd]4RWU`xV5q͜H0}q0⻆Ɠ8dӉ8zђ&7J۵ENKX DbYX@Q'G`jT endstream endobj 53 0 obj << /Ordering (Identity) /Registry (Adobe) /Supplement 0 >> endobj 54 0 obj << /Encoding /Identity-H /ToUnicode 55 0 R /Subtype /Type0 /Type /Font /DescendantFonts [56 0 R] /BaseFont /EJGXWU+ArialMT >> endobj 56 0 obj << /CIDSystemInfo 53 0 R /CIDToGIDMap /Identity /Subtype /CIDFontType2 /Type /Font /W [3 [278] 38 [722] 70 [500 556 556] 76 [222] 79 [222 833 556 556 556] 85 [333 500 278 556 500] 179 [333 333] 182 [222]] /FontDescriptor 57 0 R /DW 556 /BaseFont /EJGXWU+ArialMT >> endobj 57 0 obj << /StemV 300 /ItalicAngle 0 /Ascent 1039 /FontName /EJGXWU+ArialMT /Type /FontDescriptor /FontFile2 58 0 R /Flags 65568 /FontBBox [-664 -324 2000 1039] /CapHeight 1039 /Descent -324 /CIDSet 59 0 R >> endobj 51 0 obj << /R7 35 0 R >> endobj 50 0 obj << /R8 36 0 R /R33 54 0 R /R10 39 0 R >> endobj 27 0 obj << /Resources << /Font 60 0 R /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] /XObject << /Xi4 5 0 R >> /ExtGState 61 0 R >> /Rotate 0 /Contents [11 0 R 62 0 R 12 0 R] /Parent 22 0 R /Type /Page /MediaBox [0 0 841.6 595.4] >> endobj 62 0 obj << /Filter /FlateDecode /Length 3930 >> stream x\]sܶ}ׯn&B )iI:mh&IdKĶ,YN q=M<ֻ\}2޴?囋/ͫLFj`tǺFIeX<6?|ּhWVm47WW 2oԠu9蚫7fW_hf%a`JFk_vÖNmvN/ m🫿pۮZ;t[Fa\7pq}xo;qq\17YF)`&Ni&+ q2_ڹ f-ݰ׻{7Y{kvǛ=V@ П懚ՈNR;&%}mzOPS"cG=$O7`ܷifC'M }7+VsI#j/L+Ym"FyOlstK15Q⬓H͌;aBD3{6ڔ!m*ܔ(;K3c *Vr6j6Z&(n$˹˵h{^X1]h8vWm;vt|_ąUBL5HZ&M?<ΪDt+jκyQYibjA f|%mYU\Dkfе ~TuO8+R6<rױR rFyzm,(1_m%0:OKp"ro/7sVA7/c7o11~"unԐ}iD l3Xg0l5]1ZP a_cp]R ѹ]Y0ߜn2UoR<**z}X*ЗH)8Y@c*fo'>©[?@G-*i{hJaeLP^Tw4>mtJDBln mho/;4ܨHÃS/6*/ ȗr?ñp1㲝l}Ӟ_sȽ >= |E\$q݁MpYaXl0Fɕ]RgIDO?, wEPRL 2Q5氲Q#f𥳺azEA+i%-8t]FРwv4i0dGzbqD0IdG б^NnAH&MBY|9@Ox 29^ 5} _f;EI%90VcR(^(P佐3$s;a352 1!A@-Ȕ7.:̘AI1:Ø00f-KZ.[ƖY3PBP~aCaac 5K)?OBM"zZ*ldPRav^j9)%$ fC Q7o~ ӎ0fBȎkŘ,%xB=a(- dH~\/}4sc^3ɷվE9kp&,Z}Fs ;۞#Ś((pw#0F4dF0#&L FOn=Adzv[yj\T%+z%Z/)rtΧ=E[S3(?Ė[zd\ҩ^ k 0b)Q,q/]F m>ExZ7hO"YI~'2dW 4 TS*)TƤzB~o@~ƥ(S㴥 ĥ#꽷[GKQ0L;Ip{Xsv2]no7tX)d:dOv)+EDm2 mqdL]=U5RuE2eڗ $VЄ9D:^i>Y ~-`Aͮ$ vs'cܭvz2L@U6Wp YOTNGRDyg<,HB2x4tp*HOBX՚S48d>x)% y2x3.-:I\ ]"IyR$TA"wJ})s Ǵ@|pL^2&ku^ZMK'F*EN0pɓZ_W@IuBk\_sRiiD\GN*4fu@o|ȍ"O|k w-8 AG0HgJiuNt YodDX8{:WkC_`2S&~:au&t VRT _={"3¸[B'8>#=j#`1XBre '-S& Js*LvZcT;OIև3a[> UrBe )g/Sk_$S$S$CpfUh9:1d}?e+~ _ H P]mSN-D@ÒycOO 9n%^il_hn+'rywMذ֝Aɸ}| O""} &nh\2\곙Jd, %Iٸq/ۭ_pt"rZW~'ʜ ЂpV|rہ T >OhoDžs!,W#iH` ?gP064Do d_ڣwuvDj2.UB Z^OZ'd7uD]nAok$qc%"Zub(ꌝH}E3~kYR"Z;[PD\<ʺe[P:*1y'}HAGL5{bźv8J I5dP75TTԹCddYZG\qnzt$+g0~Ü4T!+w@E ۅA^ޗGقk2ńZ^>ېQ9=(qQ"[%) Щ]QOy&M'8lT*͗6ٵ z2b_ĈF/P} yfoAϩ3G853,JmR򺦺wu43NI*M!tjqODmˤ(MGvkk ~bJrAa5K q5ۉ~+f&oBpS#S/о.^ 1,~ z/ֿ&#'jZA;Ay%8pB|9[ ,hCZt%&Ђd2g G/ÚAٚRQ`V^}a'\HyPGGͺ=PXQr MӳЍ4lOO`UD61rA+1A $y vgK4Q: qZH]{r*g2ZZ18pF1_rtMsռ|5-vCLdZ_С"ּaR1(db MqxEQ>;|rA9oP:u;GM*`(A}#d=.!0ۅUbop oKrcK+*sI"> (+S%D nH So׊nsc5uS^S\L59`#!{ߵhx 3 t=d^0i՚+o¦5u[ly ۓdqm3^[hQL'K1*^p-?er<*nKw`u`N\Xm{ kۍwr? endstream endobj 61 0 obj << /R7 35 0 R >> endobj 60 0 obj << /R8 36 0 R /R10 39 0 R >> endobj 28 0 obj << /Annots [63 0 R] /Resources << /Font 64 0 R /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] /XObject << /Xi5 6 0 R >> /ExtGState 65 0 R >> /Rotate 0 /Contents [9 0 R 66 0 R 10 0 R] /Parent 22 0 R /Type /Page /MediaBox [0 0 841.6 595.4] >> endobj 66 0 obj << /Filter /FlateDecode /Length 3807 >> stream x\ےܶݪW̓kF $GٱcR6Ƀi%[ڕ^9D< 8Rfg@ӍYUB*Sa6VήLcjQXѮ߬duwZniα\]}qNU:y,WMgHiUߞWN:?}FrjtmhN4JJ+}gQRE_Y#hbk)R`ЫXVM+Y)S-]]M]-4M]ZTUgfsfD%uݭ6g}kMߴk M-U5HI?z}!˗×ޥ'/3畵lD !zmk.ˮ6C6BvB&W2M:B얝rnu:Vd%:[cSZ+ajٶd{]FT_;뺪ώ{Lw:NiG-|QHgӌ6͙tj͔j)-p4a _^2nbލף_GčnJl{{hqž܃Pq~Eb~Q[GӖ1oǵewSPdSGILn89y/&jrNf[wKpNjz6J2uOdٸH.%NҺCI R}s q&$9I0cVf%uy(q!AnYp -wd×ҠuƟ &}AdmG4Qτ4,b6yk(HF#Gת[C$#X(1)]Ւ,T>s i>vhy[|§"d jڻԍj;2 m#)G!HԿL%Z N+z`rF@;6rj b4j 60VFM;׉Qo[8Da0{W(*~bAu - ll@<ȍc@^f  :.j?Y *2m).>P)vPE Kl)mvg܆CR6w%i{RhYk?n1( 3!NI3/&@$A= 3Iĵm&?h&?h&?n+f`aLĊ&*s\7~1fЖm& ^0OA01Zފm +޲}o"9F#O_r/W0Ґ`#nVAPA$ed%PBJ+Mjl@m?"AǛO|.0 4e ERsdikܟzɰ@8ؑJbK.xp*,l;"ٟ-<ӚI5V B<JB|eXdaSya N@͑=oe wòKdp8YF|H ~O ჰa0Xڴ2(Ï0SR9S<9eGx9,zl(.\RVN> 09B{d&@y$嘁!XMLe@Oqe!Y\-N'2{s2xtl2yC0WEBL6}23Ae< B{5wd;0!#!ic` B'4Cq&BjwfʦN))q3f۲jAU9M+m+?n\R}A*ѡў-}[h$>{ 6@Gn&sGIS8j,87Xngn^$J2Y>mjVYimKHnRVPF,Fq=GX}.XcNu"nrg&((rD0w43/NF>m3~valKrӇ'd@懬؇^^9dEc%$R0,Z)JϮ"hf Y69 0x0{@^*g 1i&d+"uÛ׌?G)C)gcYF,c\#j?e_R5#KYJKe[-l7Qdϼf#A-564SNIŒ l0lr$-' ѣI0 a]M}ZR'& 1ZfRÏLu#j[&mVSG|RFhEϑÊ{®őݾȆ~ipsJc& 13Ʊ;cOq*&>A o5Q?{Z0zC-"208fά. AB$=+ײ H>f%>Űeq"sWָTx}_.0D]|[9A:zHm`yǂ;q rb^>`V2$Ѹ AD D|4-Z#eiVj݅JZU0WA6dӷàdCAv<Kg!\#!+xuH槡AFĉ:ZYј/3]]O6(hX QV0{ᶘ/.TsʠhX;|(-\_Q 9|W7~N߂=V8f6,I|Q`ȇĆ4Dǂoޭi(]󒪡,!~<.A5<8?aQU\_},@1[ O?kC,Yzfo,E #T$ i_a;muW'/iFrhkBSyVEA|ba tԕ9gϔ Y=}%JQKKLiϨ>eF0VaοL($}Ia4+{C5'G N~7vY](;1x1+Q\B8{Ś:ڬn8%=I}>%M*!ѿ$;9eŇNi;+!ęXyCĎmSS q ;~So j&V[5:ۖZ#]"ʸ^^Uz[mSYv8ϤM#ꞇIy$> endstream endobj 63 0 obj << /Subtype /Link /File 4 /Type /Annot /F 4 /Rect [140.706 166.365 367.587 179.865] /A << /URI (http://www.creativecommons.org/licenses/by-nc-nd/3.0/) /Type /Action /S /URI >> /BS << /W 0 >> >> endobj 65 0 obj << /R7 35 0 R >> endobj 64 0 obj << /R8 36 0 R /R33 54 0 R /R10 39 0 R >> endobj 41 0 obj << /Subtype /Type1C /Filter /FlateDecode /Length 2292 >> stream xViTTGPyڭ'AJ؄***.馉(Q VlzfTr_[휩㝮W{wA*0CN9#)a\ɐ,eFt;bbzheeNIuг` <9)+wEFZYG \7쌴LrR ,cJ9*Ø2[Uo@4BhLSVpȊl9 I3RRgg㵓}&fh ҡ4CŢ #?ƣP&p4E4E@!y~?EuD*479`qQrrVMU}'۟`\G|,B`PbMP<țK'^,qdȒ)ycdawrdN.2`2-A @뮮kkD[ vgNu\;$,O`6}&Q)B=Jz` o)+q.P*0vW׼WϺw; 6H~}&G AJ`x L==0J,f c(Cc.ÞiuCKJayTW]wm۲}-ªw{S`<'͂~#$(T"ø5!,'4\pUY-f .ֿ zjTa"([$'u!r'Ko@coEu`|ע͓}@KhI ޸@e'A}ӏJ5[=Ս@G}hنu<}^qSc6_;-ڳNGoS*BF.T #^F 9ba ކq _Hh" 1ޗ 2UpkW,IU|E葸:O "Kg Zi6pߔ|]YZZkKXY~wl᠕ûx,,zzz9P*B4?o@|%r.,^-CMi(H2~I~`7ȓTk uW{ʣi24'g&ϋ1MAZ&XtBþ2+L؝Yc<޴5TǷUh4烼|Dŷu,k4L|*CGX4WU,Ӕnw ܖ[Ze\{) 5T6E$+Y*:tD3SF;/bui> stream xWiXqaTAP&ʢlhX\qKĸō  h@ "8lqPn4jR=9{̽7?? ӧꭷP:(@aaNs:COԣMG鑰b%f Y6u4+u3RSM;03vcB\9Y&[/MN L޴dqTn}(7du=7xxoIݴ -=j̘ؠ5q! .I M/n8cɬs:[L(S*2"j BS%JMR2cʝ a2bՈMzzzzKz}+#F|7jʨQj[]Ou\3^'zKCj{W։VoADb!M9-Pr4pQ]w#_M*sɗJF{(` Mm@]XP ΩE9)+m X ҕnWbX\F#/S.:\q9FY )w-#/n@:#y(tv ##ƧV-Y{)`*X7 erUx,&$ nQ5 ~@!-y%m+vDSsRh83u+\Yѫ!F ۞%YBb ,AP0`Zs/3| %V޲|WCI]u9Vhz% 1|\6ċ RTBX]?IYB|Qhi1tm<Ǡb(2`PQnڙ8Npa%/18^+krB^!!Njo|~$Xbg97b`\ֺ4(,|cӤ[O|vBց>Dq[W4;+s:MiThTvb%bTVyaRqzx4kl{t4" Cs/ `uG!3"aCDla=YjbRxzAWfx: ̗62޶7qw3Z v;GСGmR6^3mhh Aml(̧sgrFRbqAԵR`k&xe ;C,D9j~!,U9~m,#-YBMxMhB+`3j2o%B2! [țkwhTޮEpuʸ{@#6d#)ǜkঘ8{."uaM޸>;/nHZ|X*H =z}?bsк) I? G_{}dGO?8Á'|`Y#zA,C\4@&>\I R "˛1kM #i3acdps˩*C?+'+cUO`K8;kMFV<2B8gN8it]8tsNdGH%k;._+N2g0͢fDfw[i0 OѬ*|XAZ9ǿ#Ex䁆h 6&-PB:h>ڄ[I@f=`'Ս`|mL 3(32ztZ*yRO>QњѼJdTI`([[aʡno)NvJ7BL:%`zGhřu/Wy؉خֲSE*]#uc)qLzFDF)5^+vX찛L/!le JRUS܏60l&u2{/FMd  8!;8ȠQ⫷*EX8Oڢ!XVF89-6  #Mj\m1L-è bg܅%KeS$V&1<)Im4jA?rZىZ#Y9?F7pr7l%9kƔ?sD s ?sKLBJ{SV. ŵT+*C"jve{ЊW(?ܞ2ɂKALtDŝygӎEXǕ1R1 W :gz4[AK^:L;i”׭F/ LQG9T'W;g# -q_`Aj5(ŤE'mJN[=9oӫ% f[y!ܻ3SZPV|DoqylÙ|T>-˦ekMZpPU0>\nMc/+|,S33۴jF!㤯6`B0v7V@@BIjp KLhSDO-tx]H٣9L CW;/,DX -~7\baf}YZC;J-{??+7?,^Њ^QiҤ3>y +'Oϡ3[Bf4s^G4IҌ a5/El~+y˙`=l,S6bA8  B(Z߻4{#},8Nخ>o>!(H&|igv́X*H~Mu5|W/6&D@DQj*q$,L߂'d $"5uNiӇWSjܯLUwryx5cyNzTIg:pClkiI1:mh'=͔Ocp&Bd@EShHCzZG;<֫80zf}*ľ305=}tu>Nj'Fz `bO*_-ˇpZ()?2Aw^# [فS']o., ~DI`4KlX+__fq/'2h]ЂsУm>CWIɎ.3olgt12pA @fAa_%?ޘ=)+@,ЎmDqvp"RɛqD=q5sK%\>+G46.iIjECftvTJIiAKa%Nbݧ^@6Xt9J-Q?\ҎƖYØGgb(~xmc8s)x+a$1%&!??<gh3I[ʣ *:ɠFF}~;pqFc#5m͕1ܧj|oo†?~tvppF \`~τ*ϽÇ`:{ %agDy]0Fv#9K3hs0Pro򸇪6w zfR엠#' hqjD~=zo<5 endstream endobj 58 0 obj << /Filter /FlateDecode /Length 13963 >> stream x} |SWvX-ٲdc ^0ˀఃb; $! ILqhڦI@iy 1~ef״ !MҖGi6[\i~ߗ3˽3Μ+@@N -9q@{ժW}g@Wnp[}?7_]Wcu p-[߼qL۰bz mZb ,|37lޒ,{0,Ooj@{)cxG .{,Z|П"Gd ,^B;`|7`'ha  k0ē2xźpĝ|n+x0A<wKWC oj3ٔ+ywa>=9 Gh#;W|nV:wa/$yEA>\}a6%4wowl]J&b-?j*2kZGmlŻ=p}? FɳR~ACu(1 Ji`79'!3AcԔkb$_$7Ix^fט9=22(~O:lq}/-%?LqD"m.Id3*yMҥ7S_NxFldO.#6|G=ZO+a!T~YYsv{CMCro0{M>A8A@4@$,&ףI$>l8y|HJ>^K}4MZ z q P% Na'ߋ^D9kQ gyHngF!@k焱bTx NI|~+EN?'k _D 7U觺;scrAU op%8x|lw4WiK9FvT!>] )$V~2%{D-, qBGr;\iE!,DM(1 J 8fcs b1jߋzBD9~)j_@v+4fZ@|ih,I>%wh;;%;3-rf:=MoBzEi'9 ]a!%H.F {,Yp la0CshwrO  2N|_2)c }h a7J!Һmbx1܁s7p<3}]cM7\~ݕk׬bU֦K͝S|Q5*+Ǎ-34Z2(. y~v9svUMFIZ(P mD-!FB3gf2Xіbu6^-8f k\͘Z36\(Z]lGd&j&Ns~6pބ|~>^lpL`Cb5ڦ vyt)td %\5p&vSЙS ohZCz V&ojo] SW' 4%a*07NMH4p{t~E+C+4%eͬ k۝p}Bonڴ3't5Ykg0o~Sfi> x- Oo뚎M߁Bl\فMٓR=rДꮵm84ޮ,.LoCkQS(?Q 5/v@ׂz=gdnŪ lI1FS&>\9^q %KXB# AISi '@׊ X ]3+qD$Sۺ,]ЄP므ȜemX+0djXhADc}UK駡F%l5O,C?1ߤhstIbVҙ.-Hf$tEqVOL]-o\j)Ֆm)|pYKا6 >Oʖ,dLah9WK:D%! m6Eɳ*],3v a\^-G!/NExXԔ83OL`KPdSYğJK:GNGE5=ֵ?ٹ<TB]鮍 mi'KLeL]b%]]+Ac31_7Lۛs͡h(?Ԏ=ڦ"GaJw#.i:dעJԶ)݅Xt0Kϥ,eD%hztRg~A.c!w>j]-]K\p4'8@`KAPMfu9Qw 5pѭlfBl0J$[HͻIIەbdrpr:#QcT5§l~b/9:\e{./ ˰\"0#ش\ [b^Ƥj)qUt-Q'TQx#8y`2 &4WZ;Xؔ_WW1] OxHBE -kg*fص&vKo*4eÉ+EIXl].𭨫Ȋx굠Ċ),Ռ7R+ì"^?hw?je+7"U$A# X,X(&hrKT>Wd^6y)J_噵4qhum\/}ͺ˺2!YuYuYuYuYuYuYuYuYuYuYuYuYu:' V}Q>u_.8r݃˺˺ϥC:K^Gݗ7ՉEA8f"LC"X.a>[`)2}ՍX W]5Z+B<`$M=<6qL'?ۄ`'6nfq+`}؁} w1ހ{5e> ?fOǺW |}*-歇YބAm4C\_v..p-Ɓceq0E0d̿w݋vRiB@ %PqI67/F܁O $FDs"!gR /zm9B+a H T|Û:#A:6 E:J\ (Eh߄D" RI~UEZi/c9nB:tWwW<]'ɖV콴YgWi&UcqQ,MNĎoĐgBH QAʉ H#DHd-iZBO{g?~#HM$9uH{ C:'џ@} ,M(CCZ$BǠC!Q; [|bho }JOuMADRL b\cs_|< FD `2T=q?wO@?}7 K_Ş- AyHmHȽЉiR Q/":E!C=L?=w_П %~;_%_8=y7`95 eX?-Vze i.RHZz &E`xǏ: "SAD&^{{#4>L rȱ rȱ ȱ XY9D,Eà~¢@+IBE)]Rt-Zc=%%(cQ%C)ҹt>H:I獤s;%(<#E'HܤEcҹtFHgt +xz60h2j G#Q'RbX)XV䱸NMX3x38 $3xg 됖" AJ"ivv|7-!!-E w  .c.Ku|.HA~6rUf ĒG%h58mVLӻnTcTޞ@}䉈︳ku֚Ӿ hK =ϝqaSOcNiNs>D1uɇlô?YtPL>lXӚI׃ OO^O4A]Z~^z,zz=y^뉄\0qa3̬bü^u^tv:ɼߏU W/P,U*r_c:c:ukI+Z{ڑ_~,ؽ9+VxY{9>-"4-= [XдnhiXk3)6!lZsy#ںmy_pyf_P\͊gY[լ-Pԭ)S[Ըdm/yS8cxRF!4]C9a MIX+2pMo;DM)m M薫7_ 5ftj&p5nGe6ohL,lL_-I)11g04'19e pEWTſST6 :^#[`sk\DQ#,JX!4Zp3{iruKbK*VK6E2옰omi7 2Gy,ƣ1q9BY :U 򴀤Hߵ9 "AW0 QrJ+bvЈ%N9E8ГpG󵃵ssky3 ƍͷ[҅ςg1 | AqiUw5h^\Rmzb]KI>A-e\M+`#l[rDž }ék5rBZfKs՚+sn_|Q0}*+[=5@,X\X>{Qz%b !pQMl0l4!HPGtF5i댬:OފwE>򝣜Gi;]w7`Qk({Ѣ(F/F;2=uQ[MYifҊBZUi+(]R$*YQ>^{g9=o'S)t?P:̧?#WKЙz)DJ'P BXޤ/%L%%59վ%ZK֚֔2:~緽?4 qx+>9\Xr,Ms乘h.X1spҒbqfi\][ƸcQkuJYa<^:j(:_f365'͚3f|8 @bOF.6'ԧ(9s(vh2aX0L|n>OfꧏKqw,OY`YH. Q˔eP$ϫ C)30 cd!_؟ cb[(<} ʙs\.f`.g}~zY\ FFG45>.'_Wsj8V3* }5ƅ YGG8 ZiO-G*؅3?yco޿ǿ ܴdc߲.1K}+=OWC`\j+64ͤrT/+JM~?xUM;wg\{2 8Ymn Hchis"25tK ;wsff>čTnGD@ӊ/ p8 8ZnqKXQ[bY۬V1cS%cjck(LYZlbYݼ?!VELX }d>cвN@ܺŖF-2q[$׊MI'$2͕)Oa;d"VSEW1:WEjb¡VU`'Lh׮^mt5;>}h/S'ө/?lFyPW qsbUӪ_lhlзt9l5F&q~~q+Mf{m-eeڭ9yNb1\m΍NQ)TQD_}Un p:vc.DaTҨGe3F0gbF12a"&oSH%df@ʁbx=PҖ*f+R24Rj*K 9Tqr !3 xf9y, 3)Zk;j [H+_IZҹN\ 4cSgĢd3S@PȢ=dWo6^ZVvd8* r$?—{C| q5b&'XqtqBm?$qC}$@b$Co }ZMyՏ0N/ %tG`qŽK >ד[j8JC5Y鎸dXmDkyLhrhr%E{JJǏ+n0jQQk+FvQ^3EVSOvJ ZzCLo9 wq2i$Hor>"+jsuҘ7oaeQUZZV *.TşdTƸk h *(cx%i:\Ҁte^YG,\Y<-LE\llFU25W}q[|)2֯Y4֜ݯA=%n,@u(umҮڟkNteUUaupԞW7Or.\٫~yS_yO=röG6yW.NNj߼;lGǶ>.r< +w?9 *$U)b 2<+tFC5 G Tӫf(n c+z2'NL:c @b:xldeC&*|ض 9mX69N]+γNѹϙp&: rH&.S{gr'I1sX@Ll|s^FsrfsgZoަmz΍DUTUlU08YkfGL:@ D} 2Ȃ/[!*p ek3rhs;n'}W_9Z͡n};K;_x QkB@`;-2CC/SҌ6H{ \a.l/ ^L}qjH_H34#!3| 47S+mik2xqxC_׏g1!'ExV Ef1P9DuAt0YgE泘`'}pjUG(kxpWU]}}}⟏4G|N/ /dߣ9 WfɸYA*y\YcǩqADZ08&٫9bpV#45Fħ*v'r**(]a3H2Iqc!l ƪduާ}CLOium폐L`Pʙ˾-fg ޛg ޛCü)7g ޞa(-f)sqe ޔ<GןbpIl2,Oz'yMs>H]`HksE!mQa'/L.c%V| beg.+@#S@+[yFIk;mK[1S#>ޒo%o Ĭ%_|sEgdm'>lЊPPz /G<&ǁ::~ yZ)?KMs1_2UsC<~7Hck2uddr-c>pE7[9y a8Vr jzUbLVd/Dk- <-ڳu6GNGk>+o Z\ )^;:ᴡFNl2#L6s7l-47 N3p;0l3l`fv?V!fvqMAaW/gt{;pnV8sLoNYbSMf0Ĕ>>oq)[3Jx;ͷkͩe,ɂVXfȶJCm&ى46)Mzo0 sv>xmS侒+gnoLoj}/>Դ{bdx9flgouivyxM=ڙYwvNWLMtVF[ݢi/PZmzzJ$G՘.iɗ v<.(YQC:F5giὦw&$WJ,u/N8Ï3(+Ǣa,)RP%jJVI7AfNc˜:­9F3vl\psPӏV1liE #^HߗC~h전/#tD[G[[G⋟)צ4 5 5"im毢}zf]|)?T# o%!s+9۞-q^O >س֞;{u$^~_>ҋH;ֈ*׸bTF+)XLi 8-)ϝ1'k]flq4Qֻ _q~J)ǩdJ4JLg)Kw R VB `'Pa@2Q&wb*!&'30pT-Kff +hŅشJJfJ=iNkh{i8^b\wǀQHAKhŊF4҈U)vE>K>A B&n#EzY}PrUJT(n߾29;iAkDrLj\s1xޜ\\"}A}kv(R4VUV\vʣ5vU? %_[xOXku:|V|7 iϙq]q :+ ZTv~[˒UaCZ\*~7d ^'3"!@&TQv`(P@L_@*l p6k7INi$4 [j!?g>_Խxo]jz2s9mUMl] n2{wp>:>uEe˵By݂L0&l2YͲ/޲A,e] UkZL`xJo'*+ Һ;R/[gnun?𲗌9J;+-Q=6GeN uv؝\(pW:3l4gƾvw.tˣ/LQH?p<".eqͤn&IȾ˜QzٛaAO@ןԋ6R/%d*5=M~gQ^t﷍V5d1Q4::FtVcIv,д@B08ůNAPaδx u^`j&}oU݃w1]zٛ!DLW8]v5BOíKX9|X V·2I.dheuB5liʢoU<ӂZLJ'4 52[MԱRՋ1I2;WB1ܒ+ވX<XXkJ 38f]~YEµZznZy'Ionv߅{_?'nxN~^o˟9GvS.\-υlJ ¸[˟]ئ#fa8wL,oTx.h7(ѣQ((ŪeI e^/@)ZB#2:D+zHX,S}?=tj>Hc_18z[[ӧZ5PW2Տ1ѝ7;h3;=!c1;="~;+n;QN?}ttnuFuujlXkZ'be MnI}l2Z,[iHt@ 즄z?P 1UOU9kE Z9d&ja{A:R1#5.bQ_-;ZQv}!'TUY=ڥJyrrYY%:'vz\:nҀ&>(=hwKwWFitnaJAv&= jFqKPj 1[j("khb5]MP ("`_^婜oe;Z.S Qq2)N#9,Ɏ,Nv .'{h ҟ#͈'5ùtE\qYF^ޖhD?ԑͺb];N@ѢR""! ??zA?C: ;>H255{m_0_w)OiY.ό_Ns?ﲸmYYYYYYYYYYYYYYYYYzg% t'ZjΧE~˩| t1OU2 endstream endobj 55 0 obj << /Filter /FlateDecode /Length 288 >> stream x]n y *_Km/@SPao?[OR>,|Ifu_qJJF2=]T Sܞ3fOoaY 4=ܨtbZ@%DZCRulVJU?mߡ6XTv;V]JhE:<*G%8QEJ8Q kP @,*aŁ^b;JoEq: dtN%;*M+f%¬*Yz &>֕ RcJ=K2~K&' endstream endobj 59 0 obj << /Filter /FlateDecode /Length 28 >> stream x````b0(8 endstream endobj 67 0 obj << /ModDate (D:20220412025658Z00'00') /CreationDate (D:20220412025658Z00'00') /Author (JKitchen) /Title (Table 1 SPIRIT 2013 checklist: recommended items to address in a clinical trial protocol and related documents*) /Creator (Microsoft Word for Microsoft 365) /Producer (GPL Ghostscript 9.26) >> endobj xref 0 68 0000000000 65535 f 0000004040 00000 n 0000003235 00000 n 0000002430 00000 n 0000001625 00000 n 0000000820 00000 n 0000000015 00000 n 0000004845 00000 n 0000004947 00000 n 0000005048 00000 n 0000005132 00000 n 0000005251 00000 n 0000005336 00000 n 0000005455 00000 n 0000005540 00000 n 0000005659 00000 n 0000005744 00000 n 0000005863 00000 n 0000005948 00000 n 0000006067 00000 n 0000006152 00000 n 0000006271 00000 n 0000006324 00000 n 0000006420 00000 n 0000027350 00000 n 0000031482 00000 n 0000036878 00000 n 0000042610 00000 n 0000046943 00000 n 0000026811 00000 n 0000027016 00000 n 0000027303 00000 n 0000027256 00000 n 0000027221 00000 n 0000006677 00000 n 0000009697 00000 n 0000009745 00000 n 0000010225 00000 n 0000053781 00000 n 0000010692 00000 n 0000011113 00000 n 0000051395 00000 n 0000011458 00000 n 0000031435 00000 n 0000031400 00000 n 0000027594 00000 n 0000036556 00000 n 0000036831 00000 n 0000036796 00000 n 0000031743 00000 n 0000042551 00000 n 0000042516 00000 n 0000037122 00000 n 0000041793 00000 n 0000041870 00000 n 0000072273 00000 n 0000042014 00000 n 0000042297 00000 n 0000058232 00000 n 0000072637 00000 n 0000046896 00000 n 0000046861 00000 n 0000042854 00000 n 0000051087 00000 n 0000051336 00000 n 0000051301 00000 n 0000047203 00000 n 0000072740 00000 n trailer << /Info 67 0 R /ID [<3f86eca4ac2a87ce0df1607efe01c5e4> <3f86eca4ac2a87ce0df1607efe01c5e4>] /Root 21 0 R /Size 68 >> startxref 73092 %%EOF