%PDF-1.3 % 1 0 obj << /FormType 1 /Subtype /Form /Resources << /Font << /F3 2 0 R /F2 3 0 R >> /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] >> /Type /XObject /BBox [0 0 595 841] /Filter /FlateDecode /Length 554 /Matrix [1 0 0 1 0 0] >> stream xTۊA}wò V|P"q2+ȂUɚ2sR 2vx|y:wC ݍ_ovj!\+J ƣTfn.y[,RLufUNjX u6kӝﳊ2oâ!N kztȊ:;=;`eIq.,(sT>b3'\P1# k{B"~;;3w}Xc54ZpNB6$ui8鰿gVߍtc,i,i o[Ia{d92NNBVe\Y̮B/Y94 D8j;BwT*$|]E YU9*:uOXDF$Qx!wO o˳뭶譹0V u~}(Ej鋓J1A#XUA`G{uՃeJRZ-GLيԊ nc6YiL endstream endobj 2 0 obj << /Encoding /WinAnsiEncoding /Subtype /Type1 /Type /Font /BaseFont /Times-Italic >> endobj 3 0 obj << /Encoding /WinAnsiEncoding /Subtype /Type1 /Type /Font /BaseFont /Times-Roman >> endobj 4 0 obj << /Filter /FlateDecode /Length 10 >> stream x+| endstream endobj 5 0 obj << /Filter /FlateDecode /Length 43 >> stream xS**T0T0B0g`jb`iO endstream endobj 6 0 obj << /Type /Catalog /Pages 7 0 R >> endobj 7 0 obj << /Kids [8 0 R] /Type /Pages /Count 1 >> endobj 8 0 obj << /Resources << /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] /XObject 9 0 R /ExtGState 10 0 R >> /Contents [4 0 R 11 0 R 5 0 R] /Parent 7 0 R /Type /Page /MediaBox [0 0 595.53 841.86] /CropBox [0 0 595.532 841.86] >> endobj 11 0 obj << /Filter /FlateDecode /Length 68 >> stream x+T03T0A(˥d^U`jljgn 775737Q02337U06г(Pp Bc endstream endobj 12 0 obj << /OPM 1 /Type /ExtGState >> endobj 13 0 obj << /Subtype /Image /Width 411 /Filter /DCTDecode /Height 581 /BitsPerComponent 8 /Length 18233 /ColorSpace /DeviceRGB >> stream JFIFExifMM*>F(iNC      C  E" ]  !"1AQ29BUaqv#RbdhST 3W57r$%4CDfµ4!1Aq3RSa"Q#2B ?ǒ|n▫qI̱YYT٭ҩ"ELV|PC_qUhg^XjYO]$j db;Zjmj+y"U?+UU |539+UઊC n-xfѶ#Tk4~AxPk aff:J{_!sr^p}=w _QtVUEem\Ζj_E$r9UUʪ<<UN}fC4Qhx[GGv⾧֗}ަptY%t+[pN:}nϡEt*v^:&je=QwPW9zEܸn"7 YӍg]ֽY7QcֽY7Qg.HüֽY7Qc־YNkm=G~-)+Rb]qQU2Zk.sU#cDk2ǚ]־Y7QcֽY7QfҊʖ{\ YEmW$OsޫQN_6N+aȜHsتQ!J.I'#_4Dr.syyѽk%suf=k%sufl=#ƙ8g}}RUʞ-cVyPH>4ߺ6noUQ0sGc-UKlg:84{S B.bGcGyyk%suf=k%sufw{|jjlR-GY?G UrHDvcEn Nݪ]JլTWSn.(H#9ߛ3\si~X}=}=KpL׺d%V*1؋JEc/ǹ翳ǹϳ?i&met'P$9y'j/yr}Ҳ{.FʘnHccp3-Ø+i앗y.s6zʎr 9xHNK&bbESTNZgGُZgEٟWQkMe}$m!TQwuv/WLٯWwZgGُZgGٟDzd<^,{1_y,4?ٚMyH]Eo)KaVOߢɩ%ǪƬ!V;\Q_jUCj=OC#tt DUzZQ~tטOyyk%suf=k%suflz_+MAAMCq]tWOUUOH-ֿt-s:qx;Jkuzˍ%SmlQ$r#ՌinE2Gyy=k%sufO}vͧ>U5inttPU:r;~H0O,)[mJԂ*%|pIҪF56+UTvrKz׾K>?z׾K>?C +^^m މ"lmc~g4s"x&ꃼ<_y,5fO}fϡ5FȨU{g#*zOΟ4#ܸ+y&2?LeߗZcGُZkEٟ"ZAUR{;\r7T?NN&6cc?Ǒ)!iT-s^S -.ݸ۵T'v0P;.v'㫕Ur'Sݎs""m޲7rړ$t{Ӟ\^avP]nbEe;Љ`/mR|=@#ʱo ?b,v-,yx}=ngiN54D$lr|{U3Cs Y&PqrjZGkMS*z9N9t;txʦSZ4c }EFITeT',fԵVۤ5S+XUDφU Z8UUyW xoy+A>LҷPѬ7U[YZ)&UvSEU. ~(jKNIIosJ5˔F{\gEMqIj*-MY; j,k܍ETL',qI&5p[e4*~ڊ/3QSo%jQv8W&v+a⾎z֕_QBVGEGʵ1vr8xSAShG[EW~V tGf]+^-ɩ< %e]єz畔-c4nđTt/[ɳl\[NӺ?EMqPݦ}K &ed> ѪΉ#Q誈r ZXߵkq~_.m{[,rlUȩ7TG#UEE*ù;F'mQ]mt5 vT=J=XΕڈ.U\Mt5WzwZm1PQJ+ؚW"ZF*ai飵?T^+[[ϩPBݐIdhzz1s1~\~Sn5TCd. DCFɕr"n؎^NVj E^m/ TzjeEkZڋTޖF5\eƱbeʪt&w BS71UU>N~~ Ye.9npcTQNS%m[Povbo9's*"3T!{LMUEڪ]):mmOy cWU5uzjzmloWR71wb>w5®ϷECt}PDGY mʜ3؈gkNڪ?*{mt5;Plƫbb*۳ڞ*)- #Ʊ+c*/YZ$M;'? ,=GQ%%~ziEQQ_^ͫ#n6iECk-J+idb,*O0vN\ 8ik 6ډ:{覧WȜL, x5lڮ5GQM%tcڽ*f,rGa}p7 /4jnzHF;8 w 5-\1Z-=@zGrx{Q:ZzEL;(LlZR^.,v?j%I JUEG9[YU^ޯiuMhesrWBldcsQr"vzn].\n.8*cZFJ]z\sԜ:5%Efכ <~RIQ UCjꜳkU#UcZ\`kE-p}SCYC,5{]#asQ("ZN8GuGdQ dg=FEjFOvMv.!\ Zu5JR- tLy&|4S z3 ]^DNN.ka/[㥡eXNZ#sdS9wdm<6ڣ>^f 0+F`V;H4P#k 'ID˰NǧkF VGm2L;N%;T]%!38Q 6/<@#ʿkQ71R{MLP|~y"jm}}[kXv⬠.mzxFIumkUm`'N¿gbs,teқPRiZSj(Q?٣ד>6-%%5 J8OK Djv" ;$o}ۨh #"DkȅCm'/?ɭ33DDkp 5\KFASCFۅpک_'Fjgz1݅Ǣ3_9~-w.VՏ{`^mrv\-7XMgi75}Ҋ7RFfF˾7"97")X=Ckin6Z*zE%4+UJd}4(梽YsD{U{L5C'votGj/;CTGGU;b5XtK_/76TˉfڮEcy"&:U]n"]$m~9ss h#;}hę4}Gitײ9]ޝ^9ʉ˗2⫉1K}[nT\|͊mTLev:țmT;Qi4曤VL"G3j{CZqRXtLbMc۪jk/d5#2"_[ڍrֵ{qno:G\؝N]o^G-?kvvsQX3pܸBix4H-#\d ؊u\PHx%M;AguʪHٶ*rU9&2ߵK.$Vܮ|I&&7F?NijR}{KoT2#jK^NQ S[EpuYg4kgHWt{ym@}΢z}1,nWڸl/vw(ye\cW %d:rZ)Et9ȊD*~3+3P^ Ӿ :jZhQD~#&QZ\vUi2jUiS]$Ӿ6ze6zI͝ +Eͧ"ibs܋\9m\C׋႖*us:Y]ꨈbU]ϖT⛉lLKgltQVMQY$ɘ汏D\W$oÌZqrW-'Ut}W5YzW,Mgk.֪E-K*i*-:* \$,XU{wb*rÚ%Y edZS;ڋOjm)Tz)[,h+qΑ۱;׳{@|PHfsdb;(3߂elvz>&T^JF8#c1FѰXsڵcq-%r\j:WC4p.iD@xtjk5HsG=TѪ~ܩ-.2k"+J\Dz&v.!]uVJHKJ$)؊*b!]uds]SG>cBc[؊ގ\.W>eQTͬ' e_rԖ?c{69˷s 5j Uz)6{9**;Pfˢmԗ>FO#mW1] Wm{&^^˦+%  +hm\|i RڸwȨ־\7kM\WԶҥĒ)d"bwmEWy[-}W\0SUQ\DUn(n*덪m;m=wEm-<X[2[.fXF+-L9qͬ LaMRkn\c*nS@XҘŪf64Sp@%|{O߈yV=T9 g E^xx|95u㋚*˭. vױ!sljTʱ\x(DZR|TE\YchQC]jwEj΍oLaQȽG⋥S2JSl ׮;ߛH7/%r9UZͧ-ZW|HTu]'ugkVLn**.{ *ERCGDΎ4n'cSvH5 #в9fؒ@c2D^EAym7kjm%mۡ-%=JC-DT&,hW eT5+ÞIƱg3j5iyih/U|{c^#$c"#{PWL[t~Zi)|I5DY$tJr˜w$D;81p(5 })Uk( ڨls\wga qIRŲX#?yC~\ܵ9*wpZ~hnݷLg9iWWEenf-!gG6mLr@1 \S((s-]KLx~Xe{]H_QIVJm{=ݞ$∫.s*5@# 0*20 TVW'c p F~]؎pm^lPUʜs̡U*gz045SRA5LSӵYOW6rQp_*ErŒ)RrNT'Op@#ªrzs?)psu~j!i 6sjt;Dܿv6R{^Eۗ<4VS>-jRʍM]o:8"$~6ܶmUNJoQxnWBrPrFܹwn9Qܬ}<YF5 lW Ö9 ֧AMai_-hu>^6*4pIrl]\Esn\* nY4BUWRM 6[X&TEMM2Yl6gUPy5ZďVdgJ^޷#4ʛ5e72jJ{kgO&}ϳqn׻Tڎ !{cuUs&]+/% Y -湶j8nP=*Z̹V :FUG75ٓ 䎭+jֹr s|K9Zf^)-I%gHLj ڎyZEsZKدSC^i=D)Ec724^N?Lpf> ÷]=Ʈ'Uw",SrY"N9ekyE;նsO=Mp#/<"*/o2{ QҲ.m#6HDpV%wuQݙ]RUtKSGD]\.U&&4i+dJܝʍUEm22|y kS؛WRpoWU^:V)um(ꉡGUw~;;Lfl-wo岻UUaH,raSo4UNK0U)ҳVCOW{*C"S1$dnti0TW7sWr"y]GV=@xk~-;b#6#S-!juysڪ[8citϽ9۪b7lilyehtmK:Jc5Q.]DW<[ l_dV68ryæN2ޮDU_G;ڛ%HZCUzJMEEG":#i-j\l|6TN1DNt/횲:}5b\FcqMs".nb]v6}֧jpY{P*rM%ue5U> z)1ݮO5^W)&$s"9\ۆƏkw""nvlŵS i}1 /&K^GV٩5aj&\*ZÚ :V5V -G5ls9%E.I; wtQ$tQߒDTn?*􆋫2o}#=zԥJ=q=?J8%cۍ%V:&9!sٳ{lnr7sk[8Om/m#ǎ4EsUM33i5Š,K.jܯTC*rU(llob"|r'dljU16 ʅLLNe$9s[PݵHbI3{mSTf'ۂJvmڨUOVqˆ㫔W*wVV/arT,}6ؕΉ?pK YUooaR=Ty9 g GcOψoYK7[]mYYuR:E|sze{9vzL"#2MS mʰ9)ܦiioT]NFLʮo'/ID9٭b5+@ԉ6<{{nz٨!)کн`]vc{i tuIѤIWnF"ztF;mWY ԳT,krٕȈFa?({[imh TSE{dF:>{U杅2LT_m[""ΈTTW#E[ o([10RdD^N1k4:ԓK)etTwU_mݪt), {Ӽ:41͍9]UEUUVtQ'Q9UQS ޥx=KWQXլlnN#G.뎳9G[_KNQ䓞'$\QjX#'#"Oj[xmn/mLM#;jrj52uW jj8_N#ۙTQLÆ[̠Q eGv[M6TbESdzV(TUk[u$Ujt ۢQjlFȲJW9=˚w6k+] 21RU׵n"*0u6 ' j4LT UUy+5;DuI馓tk[OGf,oo.Ag[˪c,*.ɻqy/0l}MaIUnBS)] D-n:Vɹl5UsSIuY)"|QE;=(Waљ5tŎWH $*މr.WrB#fn[k*$Z΃+LUrUy٪+)CM$ ]DD6;0E[rlPi ZV&UQ*nW 29ڡWMw A9QZ*'5B$ r[>H@"b\'.}Ss$&w_o*EU~(ܿ ZJ/cG߈yYWe3@"\/i<>r敩 3xmUm{vr9\vW@-K|ᬷmXXatk"<»=l(0r𞭕 Ta<,'D滢j;*˲]+ϗ+|~W=M[v9p4{坲'b5ja}S@H$EklNUgHڊ@ͯH\-Rmw&Q[,N98e:#X&NVez*UIV-v0u uY>uLUU$ 3ZGF+w79#rcu׸[UWOmsk55eMf$RyĸR"r|4bq' U5U]RI=cӫ#728ѰadGڎV[/R͚jYQPX'F޷"Dvrwf2s𞱶kK3]rK#Ek򈨙zz_f/<9QS$-QQ29jnasy8 z{6oAU;cתU""b""vc# HWt"U0,Yry;n mS'lrjҊ((I[2sݭjLrSiQ^w5rL]p' bxhࣕmZQW*ƨDrrv`V Ye)w FY5:m]ܣyvZ>WC }@+"tWv:5Nkߟx: nYTcc^{DݜsdFu35NJxoA"N«7a9{T;.Wq*#˝S 㽂5g[FI74Wz|]SA܅r &!I(vP.)|#ۿڵ8r+}c{RkOM<"K˛?"vw:>j'Yx∍">I Ur(A+A)Y{%L^hLoo37ψoyZU#/߈YF _,y;^iR%XM$:T:V]tlU7Sv*|v/ 1˩Ś"ҧjc/‘#U̙{݈SԪ2)[DEE\L"w&P_4jtCr9rT\rRR9{JI_HsA cyuspNI3ݪPIYvc,Mһ,7"evgY9t^R%¹{%hG*.̧d(^Ց('\>fso8'!v~nTw(IeN]e˕ &cO yJW@#ʱg 7a3v--yLJ5Q؟ rT߷}O "{BR x u x){ rA)2rzs?*vOUN~~ Ye.9npc@;O Zvkr;*ڪIoW*Er}"/[ P O 2{qے EVJqRQn~;U:o!ɵ+UDݞ㏵y c|@#ʱo ?b,-,yx}\;$IL %FSSNpτ\TO _%\/q Bo)r|@#ʱo ?b,v-,ySe<@2 x>z?GoU~G|&:i~̳ޤmުt[_j|'/"+;pʮC Jijs#SmBvsUUfܵUI,=_~뚯?տ>뚯?տ`8q8nW6K=u͋b,2N1Qr#ci>e'h}WުtWFOgIuU##]?O_)$ 7-gYb-]|>lK-ʶg=i+YR4.Jsz,5e'h}Wo4|?OVWOuW5~>ߕ?Wу}R).vɪ-8id~Xsy#M'̳|WOuU5~>YRzkU&5){0\NXfja7: ';>WܯO]91f"#}ߠ@=A4 "&5nỤ=EE]pDL1~TU9]cӦ f_LOg~eM]`Ե֩.Ulu;gΦzw#cTUU;;oMr45¢*_[FDTH置ؙ9.Ù3fuK *_X6jQ m a۫*l\9ENfGfI-RSIZvsݿ DƱMdu;3GN#֫ea?x[ӪfyYWY#m< $ZHU§d\gҦ cik͡(eJ"EFgS-$Ui3k>?:/ٿ#c~yX>>?:/ٿ#c~yX>>?:/ٿ#c~yX>>?:/ٿ#c~yX>>?_NzKJ۬^yROt{mg\d 'Rqrkc{تOGɋ ?5k?5&/^,|t~L_P)_L?Pʀي)_L?Pz/e@M)_L?Pz/e@E)_L?PGh۶8^V~k?5&/<tj>L_P ?5k?5&/^8aƭ}D z5!%4ϕ\jF5Oj` ?5k?5&/^,tj>L_Py|xYѨ1}AQbgFGɋ ?5k?5&/^,tj>L_Py|xYѨ1}AQbgFGɋ endstream endobj 10 0 obj << /R7 12 0 R >> endobj 9 0 obj << /R8 13 0 R /Xi0 1 0 R >> endobj 14 0 obj << /ModDate (D:20220718041754Z00'00') /CreationDate (D:20220718041754Z00'00') /Author (https://imagemagick.org) /Title (bmjopen-2021-059280supp001) /Producer (GPL Ghostscript 9.26) >> endobj xref 0 15 0000000000 65535 f 0000000015 00000 n 0000000825 00000 n 0000000927 00000 n 0000001028 00000 n 0000001112 00000 n 0000001229 00000 n 0000001280 00000 n 0000001339 00000 n 0000020193 00000 n 0000020158 00000 n 0000001576 00000 n 0000001719 00000 n 0000001767 00000 n 0000020238 00000 n trailer << /Info 14 0 R /ID [<7795cbd751bc320790db5bffc6e99442> <7795cbd751bc320790db5bffc6e99442>] /Root 6 0 R /Size 15 >> startxref 20469 %%EOF