%PDF-1.4
%
52 0 obj
<>/Metadata 49 0 R/PageLabels 46 0 R/Pages 48 0 R/Type/Catalog>>
endobj
49 0 obj
<>stream
Acrobat Distiller 7.0 (Windows)
11th February 2012
2022-09-13T01:13:02-07:00
0-00-00T00:00:20+02:00
Arbortext Advanced Print Publisher 9.1.510/W Unicode
2022-09-13T01:13:02-07:00
application/pdf
bmjopen-2011-000626 1..8
uuid:2426ccbc-327b-437f-89be-9e71c2b5e692
uuid:2262355f-1dd2-11b2-0a00-900048a68fff
11th February 2012
endstream
endobj
46 0 obj
<>
endobj
48 0 obj
<>
endobj
53 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>>>/Rotate 0/Type/Page>>
endobj
1 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
4 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
7 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
16 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
19 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
24 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
27 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/Type/Page>>
endobj
98 0 obj
<>
endobj
99 0 obj
<>
endobj
143 0 obj
<>stream
/GS1 gs
BT
/TT2 1 Tf
0 8.4675 -8.4675 0 66.9 395.94 Tm
0 g
0 Tc
0 Tw
( )Tj
/TT4 1 Tf
0 9.427 -9.427 0 550.6799 53.34 Tm
( )Tj
/TT6 1 Tf
0 48.4225 TD
.0013 Tc
[(Resu)9.7(lts )]TJ
ET
79.2 48.06 .48 .41998 re
f
79.2 48.06 .48 706.86 re
f
79.2 754.44 .48 .48004 re
f
79.68 48.06 17.16 .41998 re
f
79.68 662.94 17.16 .48004 re
f
79.68 754.44 17.16 .48004 re
f
BT
/TT10 1 Tf
0 9.427 -9.427 0 108.54 53.34 Tm
-.0019 Tc
.005 Tw
[(Part)-4.3(icipa)-6.6(n)1.6(ts)-11.8( )-5677.3(1)-4.2(3)-4.2(*)6.1( )-1132.9(\()-4.2(a)-.2(\))-4.2( Rep)8(o)-2.8(rt numbers )6.4(of individuals at)-4.3( each s)-5.4(t)2.1(a)-6.6(g)]TJ
32.1989 0 TD
-.0008 Tc
.0038 Tw
[(e of )6.3(study)-5.7(e).3(g nu)9(mb)9.1(ers )-6.4(potentially el)5.9(ig)-7.4(i)5.9(b)2.7(le)-6.1(, )6.3(exami)5.9(n)2.7(e)-6(d)-3.7( for eli)5.9(g)-7.4(i)5.9(b)2.7(i)]TJ
25.9043 0 TD
-.0025 Tc
.0119 Tw
[(lity, confirme)-7.8(d )]TJ
-44.5146 -1.5021 TD
-.001 Tc
.0041 Tw
[(eli)5.7(g)-7.6(ib)8.9(le, included in )6.4(the study)-6.6(,)6.7( co)]TJ
13.2831 0 TD
-.0046 Tc
.0077 Tw
[(mp)-7.5(le)-3.5(t)-7(i)-4.2(ng)-4.9( f)-4.9(o)-5.5(ll)-4.2(o)-5.5(w)-2.6(-)-4(u)-7.5(p,)-3.3( an)-7.5(d )6.4(a)-9.3(n)-1.1(al)-4.2(yse)-9.8(d)-7.5( )]TJ
38.3536 1.5021 TD
-.004 Tc
0 Tw
(8 )Tj
ET
96.84 48.06 .42 128.52 re
f
1 i
q 1 0 0 1 96.84 176.58 cm 0 0 m
0 486.36 l
.42 486.36 l
.42 0 l
f
Q
96.84 662.94 .42 91.98 re
f
97.26 48.06 28.26 .41998 re
f
97.26 146.46 28.26 .42 re
f
97.26 176.1 28.26 .48 re
f
97.26 662.94 28.26 .48004 re
f
97.26 754.44 28.26 .48004 re
f
BT
0 9.427 -9.427 0 137.22 53.34 Tm
.0004 Tc
-.0037 Tw
[( )-11252.7( )-1890.3(\(b)3.9(\) Give reas)3.3(o)5.8(n)3.9(s)3.3( )-6.4(for)5.3( )-6.4(n)3.9(o)-.5(n)3.9(-)-5.3(p)10.3(a)]TJ
24.6377 0 TD
-.0009 Tc
.004 Tw
[(rticipation)8.9( at each stage )-30601.4(8 )]TJ
ET
125.52 48.06 .42 128.52 re
f
q 1 0 0 1 125.52 176.58 cm 0 0 m
0 486.36 l
.42 486.36 l
.42 0 l
f
Q
125.52 662.94 .42 91.98 re
f
125.94 48.06 14.1 .41998 re
f
125.94 146.46 14.1 .42 re
f
125.94 176.1 14.1 .48 re
f
125.94 662.94 14.1 .48004 re
f
125.94 754.44 14.1 .48004 re
f
BT
0 9.427 -9.427 0 151.86 53.34 Tm
.0011 Tc
.002 Tw
[( )-11246.3( )-1883.9(\(c)3.9(\) )6.4(Con)4.6(s)4(id)4.6(er)6( u)4.6(s)-2.4(e of )6.4(a )12.8(flow d)11(i)1.5(agr)6(a)-3.6(m)4.3( )]TJ
65.2253 0 TD
0 Tc
0 Tw
( )Tj
ET
140.04 48.06 .48 128.52 re
f
q 1 0 0 1 140.04 176.58 cm 0 0 m
0 486.36 l
.48 486.36 l
.48 0 l
f
Q
140.04 662.94 .48 91.98 re
f
140.52 48.06 14.16 .41998 re
f
140.52 146.46 14.16 .42 re
f
140.52 176.1 14.16 .48 re
f
140.52 662.94 14.16 .48004 re
f
140.52 754.44 14.16 .48004 re
f
BT
0 9.427 -9.427 0 166.44 53.34 Tm
.0013 Tc
.0018 Tw
[(Des)4.2(c)4.1(ri)8(p)4.8(t)-1.1(iv)7.4(e )-6.3(d)4.8(a)3(ta )-3914.2(14*)9.3( )-1132.9(\(a\) Gi)8(ve c)4.1(h)11.2(ar)6.2(ac)10.4(teris)4.2(t)5.3(ic)4.1(s)4.2( of )6.4(st)5.3(ud)4.8(y)8.4( p)4.8(a)3(rtic)4.1(ip)4.8(an)]TJ
30.595 0 TD
-.0011 Tc
.0042 Tw
[(ts)-11( )6.4(\(eg d)8.7(e)0(mog)-7.7(r)3.8(a)-5.8(p)8.8(hic)-4.7(,)6.6( cl)-7.1(ini)-7.1(c)1.7(al,)6.6( so)-8.4(cial\) )6.4(a)-5.8(n)2.4(d)8.7( information )6.4(on expos)]TJ
24.7459 0 TD
-.002 Tc
.0051 Tw
[(ures and pot)-4.4(e)-.9(ntial )]TJ
-41.7523 -1.4957 TD
-.0014 Tc
0 Tw
[(confou)-4.3(nders)-4.9( )]TJ
51.6367 1.4957 TD
-.004 Tc
[(8)-6.3(-)-3.4(10 )]TJ
ET
154.68 48.06 .48 128.52 re
f
q 1 0 0 1 154.68 176.58 cm 0 0 m
0 486.36 l
.48 486.36 l
.48 0 l
f
Q
154.68 662.94 .48 91.98 re
f
155.16 48.06 28.2 .41998 re
f
155.16 146.46 28.2 .42 re
f
155.16 176.1 28.2 .48 re
f
155.16 662.94 28.2 .48004 re
f
155.16 754.44 28.2 .48004 re
f
BT
0 9.427 -9.427 0 195.12 53.34 Tm
-.003 Tc
.0061 Tw
[( )-11246.3( )-1883.9(\()-5.3(b).5(\))-5.3( )12.8(I)-12(ndica)-7.7(te n)-5.9(u)-5.9(m).2(ber of p)6.9(a)-7.7(rt)-5.4(icipant)-5.4(s)-.1( wit)-5.4(h).5( mi)]TJ
31.0215 0 TD
.0002 Tc
-.0035 Tw
[(ssin)10(g)-6.4( )-6.4(d)10.1(a)-4.5(t)4.2(a)-4.5( for each vari)6.9(abl)6.9(e)1.3( )-6.4(of )-6.4(i)6.9(n)3.7(terest )-18489.4( )]TJ
ET
183.36 48.06 .42 128.52 re
f
q 1 0 0 1 183.36 176.58 cm 0 0 m
0 486.36 l
.42 486.36 l
.42 0 l
f
Q
183.36 662.94 .42 91.98 re
f
183.78 48.06 14.16 .41998 re
f
183.78 146.46 14.16 .42 re
f
183.78 176.1 14.16 .48 re
f
183.78 662.94 14.16 .48004 re
f
183.78 754.44 14.16 .48004 re
f
BT
0 9.427 -9.427 0 209.7 53.34 Tm
.0014 Tc
.0017 Tw
[( )-11246.3( )-1883.9(\(c)4.2(\) )6.4(Su)4.9(m)4.6(m)4.6(a)3.1(ris)4.3(e)2.5( fo)6.8(llow-u)11.3(p)4.9( ti)8.1(me )6.4(\(eg,)9.1( avera)9.4(g)1.1(e a)9.4(n)4.9(d)4.9( to)6.8(tal am)4.6(oun)4.9(t)5.4(\) )-26661.6(8)5.4( )]TJ
ET
197.94 48.06 .42001 128.52 re
f
q 1 0 0 1 197.94 176.58 cm 0 0 m
0 486.36 l
.42 486.36 l
.42 0 l
f
Q
197.94 662.94 .42001 91.98 re
f
198.36 48.06 14.16 .41998 re
f
198.36 146.46 14.16 .42 re
f
198.36 176.1 14.16 .48 re
f
198.36 662.94 14.16 .48004 re
f
198.36 754.44 14.16 .48004 re
f
BT
0 9.427 -9.427 0 224.28 53.34 Tm
.0021 Tc
.001 Tw
[(Ou)11.9(tc)4.9(om)5.3(e d)5.6(a)3.8(t)6.1(a)-2.6( )-4684.4(15*)10.1( )-1132.9(Rep)12(o)1.2(rt )6.4(nu)5.6(m)5.3(b)5.6(er)]TJ
19.7942 0 TD
-.0002 Tc
.0033 Tw
[(s )6.4(of outcome even)9.7(ts )]TJ
8.4459 0 TD
.0019 Tc
.0012 Tw
[(or)6.8( s)4.8(u)5.4(mm)5.1(ar)6.8(y m)5.1(e)3(as)4.8(u)5.4(r).5(es)4.8( o)7.3(v)1.7(er )6.4(tim)5.1(e)3( )-23587.5(11,)9.6( 1)5.9(4)5.9( )]TJ
ET
212.52 48.06 .48 128.52 re
f
q 1 0 0 1 212.52 176.58 cm 0 0 m
0 486.36 l
.48 486.36 l
.48 0 l
f
Q
212.52 662.94 .48 91.98 re
f
213 48.06 14.1 .41998 re
f
213 146.46 14.1 .42 re
f
213 176.1 14.1 .48 re
f
213 662.94 14.1 .48004 re
f
213 754.44 14.1 .48004 re
f
BT
0 9.427 -9.427 0 238.86 53.34 Tm
-.0007 Tc
-.0026 Tw
[(Main results )-5721.8(16 )-1387.5(\()]TJ
/TT12 1 Tf
13.8941 0 TD
0 Tc
0 Tw
(a)Tj
/TT10 1 Tf
.5155 0 TD
-.0027 Tc
.0058 Tw
[(\) Give u)7.2(n).8(adj)-11.7(u).8(st)-5.1(ed )6.4(es)-6.2(timat)-5.1(e)-8(s and, )6.4(if ap)-5.6(pli)-8.7(c)-6.3(able, co)-10(nfou)-5.6(nd)-5.6(er)]TJ
23.6066 0 TD
-.0023 Tc
.0054 Tw
[(-adjust)-4.7(e)-1.2(d est)-11(i)4.4(ma)-7(tes)-5.8( )6.4(a)-7(n)7.5(d t)-4.7(h)1.2(e)-7.6(i)4.4(r preci)-8.3(s).6(ion \()-4.6(e)-1.2(g, 9)-4.6(5)-4.6(%)-.3( )6.4(confidence )]TJ
-24.4277 -1.4957 TD
-.0022 Tc
.0053 Tw
[(in)7.7(t)-4.6(e)-1.1(rva)-6.9(l)4.5(\))-4.5(.)-10.7( Make cle)-7.5(a)-.5(r which c)-5.8(o)-3.1(nfoun)-5.1(d)1.3(ers)-5.7( )6.4(we)-7.5(re adj)-4.8(u)7.6(s)-5.7(t)1.8(ed for and wh)7.6(y t)-4.6(h)1.3(ey )-6.3(were include)-7.4(d)-5.1( )]TJ
51.6367 1.4957 TD
.0023 Tc
0 Tw
[(12-)9.3(13)6.3( )]TJ
ET
227.1 48.06 .48001 128.52 re
f
q 1 0 0 1 227.1 176.58 cm 0 0 m
0 486.36 l
.48 486.36 l
.48 0 l
f
Q
227.1 662.94 .48001 91.98 re
f
227.58 48.06 28.2 .41998 re
f
227.58 146.46 28.2 .42 re
f
227.58 176.1 28.2 .48 re
f
227.58 662.94 28.2 .48004 re
f
227.58 754.44 28.2 .48004 re
f
BT
0 9.427 -9.427 0 267.6 53.34 Tm
11.2494 Tc
[( )9362.4(\()]TJ
/TT12 1 Tf
13.8941 0 TD
0 Tc
(b)Tj
/TT10 1 Tf
.5155 0 TD
-.0019 Tc
.0049 Tw
[(\) Report cat)-4.3(e)-.8(gory bou)7.9(n)-4.8(dari)-7.9(es wh)7.9(en co)-9.2(nti)-7.9(nuous varia)-6.6(b)1.6(les were c)7.2(a)-6.6(teg)-8.5(o)-2.8(r)9.4(ized)-4.8( )-20437.1(1)-4.2(2)2.1( )]TJ
ET
255.78 48.06 .48001 128.52 re
f
q 1 0 0 1 255.78 176.58 cm 0 0 m
0 486.36 l
.48 486.36 l
.48 0 l
f
Q
255.78 662.94 .48001 91.98 re
f
256.26 48.06 14.16 .41998 re
f
256.26 146.46 14.16 .42 re
f
256.26 176.1 14.16 .48 re
f
256.26 662.94 14.16 .48004 re
f
256.26 754.44 14.16 .48004 re
f
BT
0 9.427 -9.427 0 282.12 53.34 Tm
11.2494 Tc
0 Tw
[( )9362.4(\()]TJ
/TT12 1 Tf
13.8941 0 TD
0 Tc
(c)Tj
/TT10 1 Tf
.4137 0 TD
-.0028 Tc
.0059 Tw
[(\))-5.1( )6.4(I)-5.4(f)-3.1( relevant)-5.2(, con)7.1(s)-6.3(ider)-4.2( tr)-4.2(ansl)-8.8(at)-5.2(ing)-9.4( )6.4(e)-8(s).1(tima)-7.5(tes of relat)-5.2(i)-2.4(ve)-8( )]TJ
21.9072 0 TD
-.0018 Tc
.0049 Tw
[(risk)7.3( into absol)-7.8(u)1.7(te)-7.1( risk for a meaningful )6.4(t)-4.2(i)-1.4(me )-6.3(p)-4.7(e)-.7(riod)-4.7( )-8267.7( )]TJ
ET
270.42 48.06 .41998 128.52 re
f
q 1 0 0 1 270.42 176.58 cm 0 0 m
0 486.36 l
.42 486.36 l
.42 0 l
f
Q
270.42 662.94 .41998 91.98 re
f
270.84 48.06 14.1 .41998 re
f
270.84 146.46 14.1 .42 re
f
270.84 176.1 14.1 .48 re
f
270.84 662.94 14.1 .48004 re
f
270.84 754.44 14.1 .48004 re
f
BT
0 9.427 -9.427 0 296.7 53.34 Tm
-.0015 Tc
-.0018 Tw
[(O)-7.7(t)2.5(her a)-6.2(n)2(aly)5.6(s)1.4(es)-11.4( )-4709.9(17 )-1387.5(Rep)8.4(o)-2.4(rt other )-6.4(analyses )-12.7(done)-6.8(eg)-8.1( )-6.4(analy)5.6(s)1.4(e)-6.7(s)1.4( of)]TJ
31.3652 0 TD
-.0026 Tc
.0057 Tw
[( subgroups a)-7.3(nd int)-5(e)-1.5(ractions)-6.1(, )6.4(a)-7.3(n)7.2(d se)-7.8(nsit)-5(iv)-9.2(ity analys)-6.1(es)-6.1( )-12423.8(1)-4.9(1)-4.9(,)5.1( 14 )]TJ
ET
284.94 48.06 .48001 128.52 re
f
q 1 0 0 1 284.94 176.58 cm 0 0 m
0 486.36 l
.48 486.36 l
.48 0 l
f
Q
284.94 662.94 .48001 91.98 re
f
285.42 48.06 14.1 .41998 re
f
285.42 146.46 14.1 .42 re
f
285.42 176.1 14.1 .48 re
f
285.42 662.94 14.1 .48004 re
f
285.42 754.44 14.1 .48004 re
f
BT
/TT6 1 Tf
0 9.427 -9.427 0 314.58 53.34 Tm
.001 Tc
0 Tw
[(Di)4.7(scussio)10.3(n)3( )]TJ
/TT10 1 Tf
11.4755 .3437 TD
1.887 Tc
( )Tj
53.7498 0 TD
0 Tc
( )Tj
ET
299.52 48.06 .48001 128.52 re
f
q 1 0 0 1 299.52 176.58 cm 0 0 m
0 486.36 l
.48 486.36 l
.48 0 l
f
Q
299.52 662.94 .48001 91.98 re
f
300 48.06 17.16 .41998 re
f
300 146.46 17.16 .42 re
f
300 176.1 17.16 .48 re
f
300 662.94 17.16 .48004 re
f
300 754.44 17.16 .48004 re
f
BT
0 9.427 -9.427 0 328.92 53.34 Tm
-.0025 Tc
.0056 Tw
[(K)-4.9(e)-1.4(y )6.4(results)-12.4( )-6326.4(1)-4.8(8)1.5( )-1381.1(Summa)-7.2(rise ke)-7.8(y re)-7.8(sult)-4.9(s wit)-4.9(h)1( refe)-7.8(rence to st)-4.9(udy ob)7.3(j)-5.1(e)-1.4(ct)-4.9(ives)-6( )-28271.9(1)-4.8(5)-4.8(-)4.5(1)-4.8(6)1.5( )]TJ
ET
317.16 48.06 .41998 128.52 re
f
q 1 0 0 1 317.16 176.58 cm 0 0 m
0 486.36 l
.42 486.36 l
.42 0 l
f
Q
317.16 662.94 .41998 91.98 re
f
317.58 48.06 14.16 .41998 re
f
317.58 146.46 14.16 .42 re
f
317.58 176.1 14.16 .48 re
f
317.58 662.94 14.16 .48004 re
f
317.58 754.44 14.16 .48004 re
f
BT
/TT6 1 Tf
0 9.427 -9.427 0 343.5 53.34 Tm
-.0037 Tc
0 Tw
[(Li)-6.3(mi)-6.3(ta)-6.5(t)5.7(i)-6.3(o)-7.1(n)4.7(s)]TJ
/TT10 1 Tf
4.6208 0 TD
6.6287 Tc
[( )4741.7( )]TJ
60.6045 0 TD
0 Tc
( )Tj
ET
331.74 48.06 .48001 128.52 re
f
q 1 0 0 1 331.74 176.58 cm 0 0 m
0 486.36 l
.48 486.36 l
.48 0 l
f
Q
331.74 662.94 .48001 91.98 re
f
332.22 48.06 14.1 .41998 re
f
332.22 146.46 14.1 .42 re
f
332.22 176.1 14.1 .48 re
f
332.22 662.94 14.1 .48004 re
f
332.22 754.44 14.1 .48004 re
f
BT
0 9.427 -9.427 0 358.08 53.34 Tm
.0007 Tc
.0024 Tw
[(I)-8.3(n)10.6(terp)4.2(r)5.6(e)1.8(tatio)6.1(n)4.2( )-4989.9(20)4.7( )-1381.1(Gi)7.4(ve a c)3.5(a)2.4(u)4.2(t)4.7(ious)3.6( ov)6.8(erall)7.4( in)4.2(ter)5.6(p)-2.2(ret)4.7(a)-4(t)4.7(i)1.1(on)4.2( )6.4(of re)]TJ
30.8178 0 TD
-.0015 Tc
.0046 Tw
[(sul)5.2(t)-3.9(s consi)5.2(d)2(er)-9.3(ing)-8.1( )6.4(objectives,)6.2( li)-7.5(mi)]TJ
13.0667 0 TD
-.0008 Tc
.0039 Tw
[(tations,)6.9( mul)-6.8(t)3.2(iplicity)6.3( of anal)-6.8(y)6.3(s)]TJ
11.6537 0 TD
-.0004 Tc
.0035 Tw
[(es,)7.3( re)-5.6(su)9.4(lts from )]TJ
-41.9496 -1.4957 TD
-.0026 Tc
.0057 Tw
[(simila)-7.3(r st)-5(u)-5.5(d)7.3(ies)-6.1(,)-7.7( and )6.4(ot)-5(her relevant)-5( evide)-7.9(n).9(ce)-7.9( )]TJ
51.6367 1.4957 TD
.0023 Tc
0 Tw
[(16-)9.3(17)6.3( )]TJ
ET
346.32 48.06 .48001 128.52 re
f
q 1 0 0 1 346.32 176.58 cm 0 0 m
0 486.36 l
.48 486.36 l
.48 0 l
f
Q
346.32 662.94 .48001 91.98 re
f
346.8 48.06 28.2 .41998 re
f
346.8 146.46 28.2 .42 re
f
346.8 176.1 28.2 .48 re
f
346.8 662.94 28.2 .48004 re
f
346.8 754.44 28.2 .48004 re
f
BT
0 9.427 -9.427 0 386.82 53.34 Tm
-.0011 Tc
4.4467 Tw
[(Genera)-5.8(l)5.6(i)-.7(sa)-12.2(b)8.8(ility 21 )3061.4(Discu)8.8(s)-4.6(s )4448.9(the )4442.5(generalisabil)5.6(ity)6( )]TJ
24.7077 0 TD
-.0002 Tc
.0033 Tw
[(\()-8.8(e).9(xte)-5.4(r)4.7(nal v)5.9(a)-4.9(l)6.5(i).2(dity\) of )]TJ
8.395 0 TD
-.0006 Tc
-.0027 Tw
[(the study results )-25165.9(15-)6.4(16 )]TJ
ET
375 48.06 .48001 128.52 re
f
q 1 0 0 1 375 176.58 cm 0 0 m
0 486.36 l
.48 486.36 l
.48 0 l
f
Q
375 662.94 .48001 91.98 re
f
375.48 48.06 14.16 .41998 re
f
375.48 146.46 14.16 .42 re
f
375.48 176.1 14.16 .48 re
f
375.48 662.94 14.16 .48004 re
f
375.48 754.44 14.16 .48004 re
f
BT
/TT6 1 Tf
0 9.427 -9.427 0 404.64 53.34 Tm
.0002 Tc
.0029 Tw
[(Other in)8.6(formation )]TJ
/TT10 1 Tf
11.4755 .3501 TD
1.887 Tc
0 Tw
( )Tj
53.7498 0 TD
0 Tc
( )Tj
ET
389.64 48.06 .41998 128.52 re
f
q 1 0 0 1 389.64 176.58 cm 0 0 m
0 486.36 l
.42 486.36 l
.42 0 l
f
Q
389.64 662.94 .41998 91.98 re
f
390.06 48.06 17.1 .41998 re
f
390.06 146.46 17.1 .42 re
f
390.06 176.1 17.1 .48 re
f
390.06 662.94 17.1 .48004 re
f
390.06 754.44 17.1 .48004 re
f
BT
0 9.427 -9.427 0 418.98 53.34 Tm
-.0018 Tc
.0049 Tw
[(F)-6.9(u)8(nd)-4.7(ing)-8.4( )-7478.5(2)-4.1(2)2.2( )-1381.1(Give the source of fun)8.1(d)1.7(ing an)-4.7(d the role of )6.4(t)-4.2(h)1.7(e fund)]TJ
34.1784 0 TD
-.0012 Tc
-.0021 Tw
[(ers )-6.4(for )-6.4(the present study a)-5.9(nd, if)]TJ
12.7676 0 TD
-.0009 Tc
.004 Tw
[( applicable)-6.1(, )6.4(for the original st)]TJ
11.8129 0 TD
-.0076 Tc
.0107 Tw
[(ud)-10.5(y)-6.9( on)-4.1( )]TJ
-45.1702 -1.4957 TD
-.0016 Tc
.0047 Tw
[(whi)5.1(c)-5.2(h the present arti)5.1(cle is ba)-6.3(sed )]TJ
51.6367 1.4957 TD
.0023 Tc
0 Tw
[(18)6.3( )]TJ
ET
407.16 48.06 .48001 128.52 re
f
q 1 0 0 1 407.16 176.58 cm 0 0 m
0 486.36 l
.48 486.36 l
.48 0 l
f
Q
407.16 662.94 .48001 91.98 re
f
407.64 48.06 28.74 .41998 re
f
435.9 48.06 .48001 98.4 re
f
407.64 146.46 28.74 .42 re
f
435.9 146.88 .48001 29.22 re
f
407.64 176.1 28.74 .48 re
f
q 1 0 0 1 435.9 176.58 cm 0 0 m
0 486.36 l
.48 486.36 l
.48 0 l
f
Q
407.64 662.94 28.74 .48004 re
f
435.9 663.42 .48001 91.02 re
f
407.64 754.44 28.74 .48004 re
f
435.9 754.44 .48001 .48004 re
f
BT
0 9.427 -9.427 0 447.66 53.34 Tm
0 Tc
( )Tj
0 -1.4957 TD
-.0012 Tc
.0043 Tw
[(*Giv)4.9(e informa)-5.9(t)-3.6(ion )6.4(se)-6.5(p)8.6(a)-5.9(rately for )6.4(cases and )6.4(controls i)5.5(n)2.3( case)-6.4(-contr)]TJ
26.3371 0 TD
-.0022 Tc
.0053 Tw
[(ol st)-4.6(u)-5.1(d)1.3(ie)-7.5(s)-5.7( )6.4(a)-6.9(n)1.3(d)7.6(,)-.9( if ap)-5.1(pli)-8.2(c).6(a)-6.9(b)7.7(le, for exp)7.7(o)-3.1(s)-5.7(e)-1.1(d and unex)-8.3(p)1.3(osed group)]TJ
25.2933 0 TD
-.0018 Tc
.0049 Tw
[(s i)-7.8(n)8( c)-5.4(o)-2.7(hort)-4.2( )6.4(a)-6.5(n)1.7(d)8.1( cros)-5.3(s)-5.3(-)-1.2(sectional st)-4.2(u)-4.7(d)1.7(ies. )]TJ
-51.6303 -1.4957 TD
0 Tc
0 Tw
( )Tj
/TT6 1 Tf
0 -1.5021 TD
-.0024 Tc
(Note:)Tj
/TT10 1 Tf
2.3104 0 TD
-.0009 Tc
.004 Tw
[( An Expla)-12(n)8.9(a)-5.6(t)3.1(ion and)9( Elaboration )]TJ
13.2194 0 TD
-.0024 Tc
.0055 Tw
[(articl)-8.4(e )6.4(disc)-6(usses eac)-6(h)1.1( che)-7.7(c)6.7(k)-6.1(l)-2(is)-5.9(t ite)-14(m).8( )6.4(a)-7.1(n)1.1(d)7.5( gives )]TJ
18.7185 0 TD
[(met)-4.8(h)7.4(odolog)-9(ic)6.7(a)-7.1(l)4.3( )-6.3(bac)-6(k).3(groun)-5.3(d)1.1( an)-5.3(d)7.5( pu)-5.3(bli)-8.4(s).5(he)-7.7(d example)]TJ
20.9525 0 TD
.002 Tc
.0011 Tw
[(s)4.9( o)7.4(f)1.7( tr)6.9(an)11.8(sp)5.5(ar)6.9(en)5.5(t r)6.9(e)3.1(p)5.5(o)1.1(rt)6(in)5.5(g.)-6.5( )12.8(T)-7.1(h)11.9(e )6.4(STROB)11.3(E).2( )]TJ
-55.2009 -1.4957 TD
-.0021 Tc
.0052 Tw
[(chec)-5.7(k)7(l)-8.1(ist)-4.5( )6.4(is bes)-5.6(t)-4.5( )6.4(use)-7.4(d)7.8( in )6.4(co)-9.4(nj)-4.7(unct)-4.5(i)-1.7(on with t)-4.5(h)7.7(i)-8.1(s).8( art)-4.5(i)4.6(cle \()-4.4(f)-2.4(reely )]TJ
24.0458 0 TD
.0013 Tc
.0018 Tw
[(av)7.4(ai)8(lab)4.8(l)1.7(e on)11.2( th)4.8(e Web)4.8( )6.4(si)8(tes)4.2( of P)8.7(L)1.6(oS )6.4(Med)4.8(i)1.7(c)10.4(i)1.7(ne at h)11.2(ttp)4.8(:/)5.7(/ww)9.7(w)3.3(.)-7.2(p)4.8(l)8(o).4(s)4.2(m)]TJ
26.7253 0 TD
-.0009 Tc
-.0024 Tw
[(e)-6.2(d)8.9(icine)-6.2(.)-3(or)10.4(g)-7.5(/)-2.9(,)6.7( A)-7.8(n)9(na)-5.6(l)5.8(s)2( )-12.7(of Internal )-6.4(Me)-6.2(d)9(i)-.5(cine a)-5.6(t)3.1( )]TJ
-50.7711 -1.4957 TD
-.0018 Tc
.0049 Tw
[(http:)-7.9(//www.an)8(na)-6.5(ls.)-10.3(o)-2.7(rg)-8.4(/,)5.9( and Epid)8.1(em)-4.9(iology )6.4(a)-6.5(t)]TJ
18.5021 0 TD
-.001 Tc
.0041 Tw
[( http://www.epidem.com/\).)-9.5( )6.4(Info)]TJ
13.2194 0 TD
-.0019 Tc
-.0014 Tw
[(rma)-6.6(t)2.1(ion on )-6.4(th)7.9(e)-7.1( S)-7(T)-4.7(ROBE Initiative)-7.1( is )-6.4(avai)-7.9(lable )-6.4(a)-6.6(t)2.1( )-6.4(www.s)]TJ
21.9836 0 TD
.0042 Tc
0 Tw
[(t)8.2(r)2.8(ob)14(e-)11.2(st)8.2(at)8.2(e)5.3(m)7.4(en)14(t.o)9.6(r)2.8(g)10.3(.)2( )]TJ
ET
endstream
endobj
144 0 obj
<>/Font<>/ProcSet[/PDF/Text]>>
endobj
146 0 obj
<>
endobj
147 0 obj
<>
endobj
148 0 obj
<>
endobj
149 0 obj
<>
endobj
150 0 obj
<>
endobj
155 0 obj
<>
endobj
156 0 obj
<>stream
hy\gf}XU`@@7F6ADAWp2 ESlSJ6:ful?Vd^Xq\~D|O;/}_u_2F$Q "j]iяD.Xgoi窩$ZrHix5({H9!"kD\t:E4((gY-3?RUM\G *HOD㞣=zA},TSO[v!/f |H杍Q^{;;}#|!Jy}w&D?{۾vzڣo}|9}yǥ'jAeǙmm#E(voioM-wy~#/Cֳ-o;S}r*9E=c$I9:mդJ:I=_
I
$˙%ޒ?QYB~RH)J,7x)AJEXQboY2mjD!JK)٥H@iTK6yAYGŴS&Ol_W;nl͘U*JKF:G6tHAsY)ɶ`sש,QVJmvlTqfYf=5gU55`0e-Y]l.ib]#lMVWj D&1-Qsˬ.ZX<u
Y,44"JvJ#$-!?P<֥t5Y4j}.?/<1fڙu㺮`ޜii2ѥQRѱʰ2+re]6tV=KlvL3--^>%gInB/MFKLcAӑqk伕[lr͢䀯$)JVJz7T7{.Z5ݚkSV<}\Y2[CQ坹9Ҍ'Pʱl%\yZo3WX1o+WNy(5>F;G8\ƙ] ͖FK5g5Y2>'jngUoom-J-CA0Kˊ-fm,䫆xk V"E4-$6%0$wLa?_keXgvqJ_n4(jY&bQ(MZz[uFmQpFsE(eR`E7Z~VU\+v۪;D6od
KSZZYVb[+:ZlU3;l,X7,
j$;{OIMZ[Ol|VچF,ɥ%M(k|JЬ
XEF410hf3$l>D3dl2l*M`n˭3\4I,.Tl#%FtJ2fa/bs{RG
,"vy<
,MFW@&~]h%(ת-blmRf4!l}J+ =x{@
G4jW!Zjmפs*mC0ܧ.U<(#ԖM,C bAkb'06h*ͨG^jeD5u&[Hⵔc`G+FX&[㭀gQjWz;(c5覮."bW`JU6no6_Fo'+)
]mKdg ,!lkRfv@x/^Hu|!aIsOKGmQNWay;ׅKi:ƝK:#Gf!KZ0rB^:!?P)':93LˠJh,4 Z{z"٥6c2]Sr7ՕN߃ϡDh[OZgAH_4|A;+!S_?+ sPRRNgKyTGJ:V+/sIVCQuSV\k_4x4Z4 `4fAa"7HSա-$tiDYj8Wsh3.9v)&
*+ 旓Ң>DWi
$2ϖ^EhFAijZ4QWC+V@Tbn13Rh>gΒ~FO_.ExUN~S)qn9[ڻQ+j6+] g@|h!JU!tl|-+Qʓj,c)Li+ij=4`>&S-M+Y by< ,.CP9$.gȮ?'":?'sYz&EBٲSWTZ)*r
5^t&Jht ҋ\C?SN!p
",d`*h8O@s`T)|`Snl@3ϲmfI_n6iJfh>V_W])aBɚh
z@}
}(!?ApʵriN%B,OT