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Since this stud)3.8(y)-7.1( is )5.5(fundam)8.4(e)2.3(ntally)]TJ 21.9563 0 TD .0007 Tc .0007 Tw [( a preventio)3.4(n stud)3.4(y)-7.5(,)4.8( an ap)3.4(propriate alternative for )]TJ -21.9563 -1.153 TD .0011 Tc .0003 Tw [(prospective subjects is to sim)8.4(p)-1.6(ly)-7.1( )5.5(do )5.5(not)5.7(hing. )]TJ /TT2 1 Tf 10.02 0 0 10.02 256.2 524.88 Tm 0 Tc 0 Tw ( )Tj -19.8204 -1.1796 TD ( )Tj 1 0 0 rg 0 -1.3952 TD ( )Tj ET 0 g 56.1 510.42 499.8 .47998 re f 56.1 509.46 499.8 .48001 re f BT 10.02 0 0 10.02 57.6 487.56 Tm -.0011 Tc -.0013 Tw (SECTION 9: CONFIDENTIALITY )Tj 0 -1.1437 TD 0 Tc 0 Tw ( )Tj /TT4 1 Tf 10.98 0 0 10.98 57.6 463.74 Tm .0015 Tc -.0001 Tw [(Main stud)4.2(y)-6.7( a)8.2(nd Contr)6.6(o)-1.2(l-R4 sam)8.8(p)-1.2(le )]TJ ET 57.6 462 155.22 .54001 re f BT 10.98 0 0 10.98 57.6 451.08 Tm .0008 Tc .0006 Tw [(Study)-7.4( )5.5(participants will be identified )]TJ 14.612 0 TD .0006 Tc .0008 Tw [(by)-7.6( )5.5(a unique and )5.5(confidential study)-7.6( ID. )]TJ 15.6448 0 TD [( Part)5.2(icipant names will not be )5.5(used )]TJ -30.2568 -1.153 TD .0004 Tc .001 Tw [(on any)-7.8( study)-7.8(-)5.5(r).1(elated data or speci)-5.9(mens, and the study )5.5(te)]TJ 22.4153 0 TD .0007 Tc .0007 Tw [(am)8( will foll)-5.6(ow all confidentiality)-7.5( )5.5(proc)7.4(edures that are )]TJ -22.4153 -1.153 TD [(followed by)-7.5( t)5.3(h)-2(e Ifakara investigators and field team)8( )]TJ 20.9727 0 TD [(involved i)5.3(n)-2( DSS resear)-5.1(ch. 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The st)]TJ 22.5902 0 TD .0004 Tc .001 Tw [(udy)-7.8( team)7.7( will not share laboratory)-7.8( test results with )]TJ -22.5902 -1.153 TD .0009 Tc .0005 Tw [(anyone, inclu)3.6(d)-1.8(ing )5.5(partner\(s\) or parents o)3.6(r).6( friends. In )]TJ 21.2568 0 TD .0007 Tc .0007 Tw [(li)5.3(ne with the National VCT Guidelines, participants )]TJ -21.2568 -1.153 TD .0009 Tc .0005 Tw [(who test posit)5.5(ive for HIV or any STI will)5.5( be urged to)3.6( )]TJ 21.5902 0 TD .0005 Tc .0009 Tw [(notify)-7.7( their partner\(s\) so they can also see)-3.7(k testing and )]TJ -21.5902 -1.1475 TD .0001 Tc 0 Tw [(treat)-6.2(ment. )]TJ -1.6393 -1.153 TD 0 Tc ( )Tj /F1 1 Tf .3279 -1.224 TD ()Tj /TT2 1 Tf .459 0 TD ( )Tj /TT4 1 Tf .8525 0 TD .0005 Tc .0009 Tw [(The study)-7.7( team)7.8( )-5.4(will also not share information rega)]TJ 20.694 0 TD .001 Tc .0004 Tw [(rding study group assignm)8.3(en)-7.2(t )]TJ 12.1366 0 TD (\(e.g., control group, high-)Tj -32.8306 -1.153 TD .0004 Tc .001 Tw [(value cash group, etc.\) wit)5(h)-2.3( any)-7.8(one )5.5(outs)7(i)-.5(de of the study)-7.8( team)7.7(.)-6.4( )]TJ -1.6393 -1.153 TD 0 Tc 0 Tw ( )Tj T* ( )Tj T* .0006 Tc .0008 Tw (Qualitative sub-study )Tj ET 57.6 181.32 94.38 .53999 re f BT 10.98 0 0 10.98 57.6 170.4601 Tm .0011 Tc .0003 Tw [(In order to )5.5(pr)6.2(otect against risks to priva)7.8(c)2.3(y)-7.1( of)6.2( indi)5.7(vi)]TJ 20.4481 0 TD .0008 Tc .0006 Tw [(duals or confidentiality)-7.4( )5.5(of da)7.5(ta, no persona)7.5(l identif)5.9(y)-7.4(i)-.1(ng )]TJ -20.4481 -1.153 TD .0011 Tc .0003 Tw [(inform)8.4(ation will be included in the audi)5.7(o recording )5.5(of )]TJ 21.8361 0 TD .0005 Tc .0009 Tw [(the interview. 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Al)5.2(though HIV testing is sporadically)-7.6( avail)5.2(a)1.8(ble in these co)-7.6(mm)7.9(unities,)-6.2( it is t)5.2(y)-7.6(picall)5.2(y)-2.1( )]TJ 0 -1.153 TD .0008 Tc .0006 Tw [(conducted by a local health worker who l)5.4(i)-.1(ves in the )]TJ 20.9235 0 TD .0004 Tc .001 Tw [(study)-7.8( area, and participants have expressed)-7.8( concern )]TJ -20.9235 -1.153 TD .0011 Tc .0003 Tw [(about lack of )5.5(confidentialit)5.7(y, thus )]TJ 13.7432 0 TD .0009 Tc .0005 Tw [(often )5.5(have been unwilling to )5.5(be tested in the community)-7.3(.)5( B)6.7(y)-1.8( contrast, )]TJ -13.7432 -1.153 TD .0006 Tc .0008 Tw [(since our study em)7.9(ploy)-7.6(s personnel from)7.9( )-5.4(outside the area,)]TJ 22.8415 0 TD .0005 Tc .0009 Tw [( subjects h)-7.7(a)1.7(ve expressed)-7.7( a high )5.5(degree of interest )]TJ -22.8415 -1.153 TD .0016 Tc -.0002 Tw [(in testing thr)6.7(o)4.3(ugh )5.5(our stud)4.3(y)4.3(.).2( )]TJ /F1 1 Tf -1.6393 -1.224 TD 0 Tc 0 Tw ()Tj /TT2 1 Tf .459 0 TD ( )Tj /TT4 1 Tf 1.1803 0 TD .0007 Tc .0007 Tw [(Participants who are found to be i)5.3(n)-2(fected with one or)]TJ 21.2787 0 TD .0008 Tc [( m)8.1(o)-1.9(re of the treatable STIs \(CT, GC, syphilis, M.Gen, )]TJ -21.2787 -1.153 TD .0005 Tc .0009 Tw [(and trich\) will receive free treat)-5.8(ment that will cure them)]TJ 22.4372 0 TD .0007 Tc .0007 Tw ( of the infection. Participants whose test results )Tj -22.4372 -1.1475 TD .0003 Tc .0011 Tw [(indicate that they)-7.9( are infect)4.9(ed with HIV will be referr)]TJ 21.388 0 TD .0007 Tc .0007 Tw (ed to the VCT clinic for further evaluation. The VCT )Tj -21.388 -1.153 TD .0008 Tc [(clinic onl)5.4(y)-7.4( )5.5(provides testing, and then ref)5.9(e)2(rs the positives )]TJ 22.8689 0 TD [(to the Chr)5.9(onic Care Cli)-5.5(n)-1.9(ic run out of)5.9( the district )]TJ -22.8689 -1.153 TD [(hospital. All )5.5(HIV positives are regularly m)8.1(onitored for CD)]TJ 23.8142 0 TD .001 Tc .0004 Tw [(4 count)5.6( and viral loa)7.7(d)-1.7(. Note that t)5.6(h)-1.7(e VCT clinic )]TJ -23.8142 -1.153 TD .0007 Tc .0007 Tw [(provides free treat)-5.6(ment to all HIV-positive indivi)5.3(dual)5.3(s)1.9(, but m)8(a)1.9(y)-7.5( not begin treatment until a pat)5.3(i)-.2(ent has )]TJ T* .0001 Tc .0013 Tw [(passed a spe)-4.1(c)-4.1(i)-.8(fic clinic sta)-4.1(g)-2.6(e of disease.)-6.7( )]TJ /F1 1 Tf -1.6393 -1.2186 TD 0 Tc 0 Tw ()Tj /TT2 1 Tf .459 0 TD ( )Tj /TT4 1 Tf 1.1803 0 TD .0005 Tc .0009 Tw (Free condoms will be available to all particip)Tj 18.1093 0 TD .0003 Tc .0011 Tw [(ants each)-7.9( time they)-7.9( vis)6.9(it the study)-7.9( st)4.9(ation )]TJ /F1 1 Tf -19.7486 -1.224 TD 0 Tc 0 Tw ()Tj /TT2 1 Tf .459 0 TD ( )Tj /TT4 1 Tf 1.1803 0 TD .0006 Tc .0008 Tw (Participants will have access to trained counselors )Tj 20.3333 0 TD .0008 Tc .0006 Tw [(who will assist with any)-7.4( ques)7.4(tions or conc)7.5(erns )]TJ -20.3333 -1.153 TD .0006 Tc .0008 Tw [(participants may)-7.6( have about this )]TJ 13.2186 0 TD .0005 Tc .0009 Tw (testing, their sexual health, etc. )Tj /TT2 1 Tf -14.8579 -1.1639 TD 0 Tc 0 Tw ( )Tj /TT10 1 Tf 0 -1.1475 TD .0008 Tc .0006 Tw [(Im)3.2(portance )-5.4(of knowledg)3.5(e)2( to be gaine)7.5(d \(Control-R4 sam)3.2(p)-.4(le\))]TJ /TT4 1 Tf 25.3989 0 TD 0 Tc 0 Tw ( )Tj -25.3989 -1.1475 TD ( )Tj 0 -1.153 TD .0007 Tc .0007 Tw [(The Control-)5.8(R4 sam)8(p)-2(le wi)-5.6(ll allow testing of the eff)]TJ 20.5902 0 TD .0008 Tw [(ects of the extensive access to)-7.6( counseling, t)5.2(esting and )]TJ -20.5902 -1.1475 TD .0009 Tc .0005 Tw [(treatment pro)3.6(v)-1.8(ided to C)6.7(ont)5.5(rol-R1 subjects in the m)8.2(a)2.1(in)-7.3( st)]TJ 22.5902 0 TD .0007 Tc .0007 Tw [(ud)3.4(y)-7.5(.)-.7( T)5(h)-2(e )5.5(main study was designed to test the effects of )]TJ -22.5902 -1.153 TD .0005 Tc .0009 Tw [(cash rewards,)-6.3( over and above the effects )-5.4(of such couns)7.1(e)]TJ 22.4208 0 TD .0007 Tc .0007 Tw [(ling/testing/t)5.3(r).4(eat)-5.6(ment, thus the Control-)5.8(R1 group itself )]TJ -22.4208 -1.153 TD .0008 Tc [(received exte)-3.4(nsive intervention. )5.5( This)]TJ 15.0546 0 TD .0005 Tc .0009 Tw ( Control-R1 intervention has so far )Tj 14.2404 0 TD .0009 Tc .0005 Tw [(included baseline, 4-)-4.9(m)8.2(onth, and )5.5(8-)]TJ -29.2951 -1.153 TD .0004 Tc .001 Tw [(m)7.7(onth counseling/testing/treat)-5.9(ment, as w)-4.2(e)1.6(ll as a y)-7.8(ear of m)]TJ 23.3333 0 TD .0011 Tc .0003 Tw [(onthly)-7.1( )5.5(gro)3.8(up counselin)3.8(g)3.8(.)-.3( This package of services to )]TJ -23.3333 -1.153 TD .0005 Tc .0009 Tw (baseline participants is expected to)Tj 13.9617 0 TD .0003 Tc .0011 Tw [( result in decreased)-7.9( STI incidence based)]TJ 16.0765 0 TD .0006 Tc .0008 Tw [( on prior research, but the extent )5.5(of )]TJ -30.0383 -1.153 TD [(that prior research is li)-5.7(m)7.9(ite)-3.6(d, thus there is considerable)]TJ 21.9454 0 TD .0005 Tc .0009 Tw [( scientific va)-3.7(lue in quantify)-7.7(i)5.1(ng the STI )5.5(benefits of this )]TJ -21.9454 -1.1475 TD .0008 Tc .0006 Tw [(precise package of preventi)5.4(ve efforts. 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Additiona)]TJ 22.4699 0 TD .0004 Tc .001 Tw [(lly)-7.8(, )5.5(in an effort to prevent negative im)7.7(p)-7.8(acts of )]TJ -22.4699 -1.153 TD [(discussing these sensitive issues, the interviewer will )-5.4(pref)]TJ 23.0874 0 TD .0006 Tc .0008 Tw (ace this set of questions as potentially sensitive and )Tj -23.0874 -1.153 TD .0007 Tw [(rem)8(i)-.2(nd participants that they)-7.5( are under no obligation )5.5(to )]TJ 22.3388 0 TD .0004 Tc .001 Tw [(answer and can feel free )-5.4(to stop the interview at any )]TJ -22.3388 -1.153 TD .0002 Tc .0012 Tw [(time. The participant may)-8( f)5.3(eel threatened)-8( by)-8( the i)4.8(n)-2.5(terv)]TJ 21.8361 0 TD .0005 Tc .0009 Tw [(i)5.1(e)1.7(wer. 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Throughout)5.6( the)7.7( study)-7.2(,)]TJ 24.4863 0 TD .0009 Tc .0005 Tw [( )5.5(participants will be rem)8.2(i)0(nded that the intention )5.5(of )]TJ -24.4863 -1.153 TD .0004 Tc .001 Tw [(the cash is to reward saf)-5.4(e sexual behaviors, and that ne)]TJ 21.9454 0 TD .0006 Tc .0008 Tw (gative test results are no guarantee that they will not )Tj -21.9454 -1.1475 TD .0009 Tc .0005 Tw [(beco)-7.3(m)8.2(e)2.1( infected if the)7.6(y)-7.3( co)3.6(ntinue to)3.6( eng)3.6(a)2.1(ge in risk)3.6(y)-7.3( b)3.6(e)2.1(haviors. )]TJ 0 -1.153 TD 0 Tc 0 Tw ( )Tj /TT8 1 Tf 0 -1.1585 TD .0008 Tc .0006 Tw [(iii\) A few participants who do not receive a cash pay)7.5(ment)]TJ 23.0929 0 TD .0007 Tc [( because of positive results may seek out alternat)5.3(e )]TJ -23.0929 -1.1475 TD .0009 Tc .0005 Tw [(ways of obtaining/earning )5.5(cash in order to )]TJ 17.3989 0 TD .0002 Tc .0012 Tw [(deliver the cash expecte)-4(d)-2.5( by household members.)]TJ /TT4 1 Tf 19.765 0 TD .0003 Tc .0011 Tw [( S)-6.4(u)-2.4(ch alternate )]TJ -37.1639 -1.153 TD 0 Tc .0014 Tw [(way)-8.2(s)1.2( may)-8.2( involve commer)-5.8(c)1.2(ial sex work, st)]TJ 17.3279 0 TD .0002 Tc .0012 Tw [(ealing, or other risky)-8( enterprises. )-5.4( )]TJ -17.3279 -1.1475 TD 0 Tc 0 Tw ( )Tj 0 -1.153 TD .0006 Tc .0008 Tw [(We will resp)-7.6(ond t)5.2(o)-2.1( the ris)7.2(k)-2.1( of such abuse in the )]TJ 19.3388 0 TD .0005 Tc .0009 Tw [(same way)-7.7(s)1.7( as listed above for t)5.1(h)-2.2(e abuse stemming fro)-7.7(m)7.8( )]TJ -19.3388 -1.153 TD [(HIV/STI test )-5.4(result reporting. )5.5( )]TJ T* 0 Tc 0 Tw ( )Tj /TT8 1 Tf 0 -1.1585 TD .0005 Tc .0009 Tw [(iv\) Small risk that participants could )5.5(be )5.5(target)]TJ 18.8033 0 TD .0009 Tc .0005 Tw (ed \(e.g., robbery, theft\))Tj 9.2678 0 TD .0002 Tc .0012 Tw ( because of the cash. )Tj -28.071 -1.153 TD 0 Tc 0 Tw ( )Tj /TT10 1 Tf 0 -1.1475 TD .0005 Tc .0009 Tw (Psychological/social risks )Tj /TT8 1 Tf 0 -1.153 TD 0 Tc 0 Tw ( )Tj /TT4 1 Tf 0 -1.1475 TD .0005 Tc .0009 Tw [(i\) Feel a loss of privac)7.2(y)-7.7(.)4.6( )]TJ 0 -1.153 TD .0006 Tc .0008 Tw [(ii\) Create con)-7.6(f).3(lict and tension in t)5.2(h)-2.1(e househol)]TJ 18.2787 0 TD .0004 Tc .001 Tw [(d that does not lead to phy)-7.8(s)1.6(ical abuse. )]TJ -18.2787 -1.153 TD .0007 Tc .0007 Tw [(iii\) Feel that the cash creat)-5.6(es a sense of coercion to engage in certain behaviors. )]TJ 12 0 0 12 57.6 128.64 Tm 0 Tc 0 Tw ( )Tj 0 -1.15 TD ( )Tj 10.98 0 0 10.98 57.6 101.94 Tm .0006 Tc .0008 Tw (Qualitative sub-study )Tj ET 57.6 100.2 94.38 .54001 re f BT /TT2 1 Tf 10.98 0 0 10.98 57.6 89.16 Tm 0 Tc 0 Tw ( )Tj /TT4 1 Tf 0 -1.1421 TD .0006 Tc .0008 Tw [(The prim)7.9(a)-3.6(r).3(y)-7.6( )5.5(potential risk )5.5(to subjects is a loss of confid)]TJ 22.3169 0 TD .0001 Tc .0013 Tw [(entiality)-8.1( with regard to interview respo)-8.1(n)-2.6(ses, HIV st)-6.2(a)-4.1(t)-.8(us, )]TJ -22.3169 -1.153 TD .0008 Tc .0006 Tw [(or identit)5.4(y and the im)8.1(pact )-5.4(of discussing )5.5(sensitive subject)]TJ 22.6448 0 TD .0004 Tc .001 Tw [( )-5.4(m)7.7(a)1.6(tt)-5.9(er ab)-7.8(out HIV status, partners HIV status, the )]TJ -22.6448 -1.153 TD .0011 Tc .0003 Tw [(decision to ha)7.8(ve or not)5.7( to have children, and power d)]TJ 21.2842 0 TD .0008 Tc .0006 Tw [(ynam)8.1(i)-.1(cs in sex)-7.4(ual relationships. 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Stud)3.8(y )]TJ -22.3115 -1.153 TD .0008 Tc .0006 Tw [(counselors will receive additional training through t)5.4(h)-1.9(is)7.4( stud)]TJ 23.8361 0 TD .0004 Tc .001 Tw [(y)-7.8( to enable them)7.7( to effectively)-7.8( counsel participants )]TJ -23.8361 -1.153 TD .0009 Tc .0005 Tw [(through the s)7.5(p)-1.8(ecific study)-7.3(-)6(r).6(elated issues. 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The lab has effective procedures in )]TJ -22.3279 -1.153 TD .0005 Tc .0009 Tw (place to for maintaining participan)Tj 13.8525 0 TD .0003 Tc .0011 Tw [(t confidentiality)-7.9( for )5.5(all speci)-6(mens)-4(.)]TJ /TT2 1 Tf 10.02 0 0 10.02 360.3 458.4 Tm 0 Tc 0 Tw ( )Tj /TT4 1 Tf 10.98 0 0 10.98 57.6 445.74 Tm ( )Tj 0 -1.153 TD .0006 Tc .0008 Tw (Qualitative sub-study )Tj ET 57.6 431.34 94.38 .54001 re f BT 10.98 0 0 10.98 57.6 420.42 Tm .0007 Tw [(Interviews will be conduct)5.3(e)1.9(d in Swahili )5.5(by)-7.5( a Tanzan)]TJ 21.0874 0 TD .0011 Tc .0003 Tw [(ian trained in )5.5(qualitative int)5.7(e)2.3(rviewing techniques. )5.5( )]TJ -21.0874 -1.153 TD 0 Tc 0 Tw ( )Tj 0 -1.1475 TD .0009 Tc .0005 Tw (Conversational diarists )Tj ET 57.6 393.42 101.16 .53998 re f BT 10.98 0 0 10.98 57.6 382.5 Tm .0003 Tc .0011 Tw [(Ten local community)-7.9( residents \(each in a separate )-5.4(st)]TJ 20.9781 0 TD .0008 Tc .0006 Tw [(udy)-7.4( )5.5(village\) will be hired )]TJ 10.3825 0 TD .0007 Tc [(to anony)-7.5(m)8(ously record )]TJ -31.3607 -1.153 TD .0009 Tc .0005 Tw [(conversations overheard in )5.5(the villa)]TJ 14.3005 0 TD .0007 Tc .0007 Tw [(ge regarding t)5.3(h)-2(e study)-7.5(.)-.7( )5.5( The in)]TJ 12.2732 0 TD .0011 Tc .0003 Tw [(te)7.8(rviewers will )-5.4(undergo )5.5(training in )]TJ -26.5738 -1.153 TD [(appropriate techniques for r)6.1(ecording data and ensuring)3.7( )]TJ 22.1749 0 TD [(confidentialit)5.7(y of the ano)3.8(n)3.8(y)-7.1(m)8.4(ous conve)7.8(rsations recorded. )]TJ /TT2 1 Tf 10.02 0 0 10.02 57.6 345.36 Tm 0 Tc 0 Tw ( )Tj /TT4 1 Tf 10.98 0 0 10.98 57.6 333.06 Tm .0014 Tc [(Round )5.5(4 Con)4.1(t).5(rol Group \()8.1(Control-R4\) )]TJ ET 57.6 331.32 174.78 .53998 re f BT 10.98 0 0 10.98 57.6 320.4 Tm .0002 Tc .0012 Tw [(The Control-R4 study)-8( activities will take place at the )-5.4(sa)]TJ 22.2842 0 TD .0005 Tc .0009 Tw [(me study)-7.7( station as for the )-5.4(m)7.8(a)1.7(in enrollees, during the )]TJ -22.2842 -1.153 TD .0006 Tc .0008 Tw [(same weeks, with the sam)7.9(e)-3.6( study)-7.6( pers)]TJ 15.2186 0 TD (onnel. We anticipate that the initial )Tj 14.5792 0 TD .0005 Tc .0009 Tw [(visit wi)5.1(ll take approxi)-5.8(m)7.8(ately)-7.7( 2 hours, )]TJ -29.7978 -1.153 TD .0007 Tc .0007 Tw [(and the second visit to )5.5(pick up resu)]TJ 14.1093 0 TD .0003 Tc .0011 Tw (lts will take less than one hour. )Tj /TT2 1 Tf 10.02 0 0 10.02 57.6 283.2601 Tm 0 Tc 0 Tw ( )Tj 0 -1.1437 TD ( )Tj 0 -1.1497 TD -.0007 Tc -.0017 Tw [(Data Collecti)7.7(on Instruments: )]TJ 1 0 0 rg 1.7964 -1.1437 TD 0 Tc 0 Tw ( )Tj /TT4 1 Tf 10.98 0 0 10.98 57.6 236.4601 Tm 0 g .0014 Tc [(Main stud)4.1(y )]TJ ET 57.6 234.72 49.8 .54001 re f BT /TT2 1 Tf 10.02 0 0 10.02 57.6 224.64 Tm 1 0 0 rg 0 Tc ( )Tj /TT8 1 Tf 10.98 0 0 10.98 57.6 212.28 Tm 0 g .0014 Tw [(Baseline surv)-4.2(ey)]TJ /TT12 1 Tf 6.3115 0 TD .0003 Tc .0011 Tw (: )Tj /TT4 1 Tf .8361 0 TD .0005 Tc .0009 Tw [(During the first visit to )5.5(the study)-7.7( stati)5.1(on at)]TJ 16.9727 0 TD .0004 Tc .001 Tw [( baseline, study)-7.8( couns)7(elors will interview all )]TJ -24.1202 -1.1475 TD .0007 Tc .0007 Tw (participants using a structured baseline questionnaire. Pa)Tj 22.7322 0 TD .0008 Tw (rticipants will be asked a series of questions regarding )Tj -22.7322 -1.153 TD .0012 Tc .0002 Tw [(dem)8.5(ographics, sexual behavior, econom)8.5(ic)]TJ 16.8251 0 TD .0007 Tc .0007 Tw [( activity)-7.5(, )5.5(knowledge and )5.5(beliefs a)]TJ 13.459 0 TD .0005 Tc .0009 Tw [(bout HIV & STIs, )-5.4(etc. during a f)5.6(ace-)]TJ -30.2842 -1.153 TD .0002 Tc .0012 Tw [(to-face interview with a study)-8( counselor. )]TJ /TT10 1 Tf 0 -1.1585 TD 0 Tc 0 Tw ( )Tj /TT8 1 Tf 0 -1.1475 TD .0003 Tc .0011 Tw (Short surveys)Tj /TT12 1 Tf 5.4262 0 TD 0 Tw (: )Tj /TT10 1 Tf .5847 0 TD 0 Tc ( )Tj /TT4 1 Tf .2514 0 TD .0016 Tc -.0002 Tw [(During the )5.5(4-m)8.9(onth and 8-m)8.9(onth intervention )]TJ 18.6503 0 TD .0007 Tc .0007 Tw [(r)5.8(ounds \(Rounds 2-)5.8(3\), study counselors will )]TJ -24.9126 -1.1475 TD .0008 Tc [(interview all participants using a structured short que)7.5(s)]TJ 21.6721 0 TD .0007 Tc (tionnaire. This short survey)Tj 11.0219 0 TD .0009 Tc .0005 Tw [( will take 10-15 m)8.2(i)0(nutes to )]TJ -32.694 -1.153 TD .0007 Tc .0007 Tw [(co)-7.5(m)8(p)-2(lete and will contain )5.5(questions that)5.3( enable us to )5.5(m)]TJ 22.2131 0 TD [(onitor for adverse events \(e.g., reporte)7.4(d phy)-7.5(s)1.9(ical abuse\) )]TJ -22.2131 -1.153 TD .0009 Tc .0005 Tw [(or study)-7.3( im)8.2(plem)8.2(entation problems \(e.g., STI treat)-5.4(m)8.2(e)2.1(nt)-5.4( av)]TJ 23.0383 0 TD .0007 Tc .0007 Tw [(ailability)-7.5(\))5.8( )5.5(as well as changes in sexual behavior and )]TJ -23.0383 -1.153 TD .0015 Tc -.0001 Tw [(econom)8.8(ic activit)6.1(y)-6.7(.)5.6( )]TJ T* 0 Tc 0 Tw ( )Tj /TT8 1 Tf T* .0005 Tc .0009 Tw [(Follow-up survey)-3.7(s)]TJ /TT12 1 Tf 7.4262 0 TD 0 Tc 0 Tw (:)Tj /TT8 1 Tf .3333 0 TD .0014 Tc ( )Tj /TT4 1 Tf .5027 0 TD .0012 Tc .0002 Tw [(During the 12-m)8.5(onth and 24-m)8.5(o)-7(n)-1.5(th foll)5.8(ow-up )]TJ 18.7596 0 TD .0007 Tc .0007 Tw [(rounds, st)5.3(udy counselors )5.5(will interview all )]TJ -27.0219 -1.1475 TD .0009 Tc .0005 Tw [(participants using a structured follow-up questionnair)6(e. Pa)]TJ 23.3989 0 TD .0007 Tc .0007 Tw [(rticipants will be asked a series of questions sim)8(ilar to )]TJ ET endstream endobj 208 0 obj <>/Font<>/ProcSet[/PDF/Text]>> endobj 205 0 obj <>stream /GS1 gs BT /TT2 1 Tf 7.98 0 0 7.98 57.6 748.62 Tm 0 g 0 Tc 0 Tw ( )Tj 0 -89.9774 TD -.0001 Tc .0005 Tw [( )-29045.1(Page 20 )-7.5(of 29)]TJ /TT4 1 Tf 12 0 0 12 342.72 30.6 Tm 14.24 Tc 0 Tw ( )Tj 10.98 0 0 10.98 57.6 736.6801 Tm .0008 Tc .0006 Tw [(In the context)5.4( of the RCT, j)5.4(ournalists will be instructed to)]TJ 23.1803 0 TD ( capture all conversations and )Tj 12.1585 0 TD .0006 Tc .0008 Tw (events that relate to the )Tj -35.3388 -1.153 TD [(study)-7.6(,)-.8( the res)7.2(earcher)-5.2(s, the incentive, and )5.5(sexual behavi)]TJ 21.9727 0 TD .0008 Tc .0006 Tw [(or and partne)7.5(rships generally. Data collected fro)-7.4(m)8.1( the )]TJ -21.9727 -1.153 TD .0009 Tc .0005 Tw [(conversational journals will)5.5( not incl)5.5(ude n)3.6(a)-3.3(m)8.2(e)-3.3(s or identify)-7.3(i)]TJ 23.3989 0 TD .0011 Tc .0003 Tw [(ng i)5.7(n)-1.6(formation of an)3.8(yo)3.8(ne that the di)5.7(arists are writing )]TJ -23.3989 -1.153 TD .0007 Tc .0007 Tw [(about. If t)5.3(h)-2(e diarists )-5.4(m)8(i)-.2(stakenl)5.3(y)-7.5( include names in thei)]TJ 21.4536 0 TD .0008 Tc [(r notebooks, )5.5(nam)8.1(es )-5.4(will be re)]TJ 11.7924 0 TD .0006 Tc .0008 Tw (dacted upon review of the )Tj -33.2459 -1.153 TD .0011 Tc .0003 Tw [(journals. )5.5( )]TJ 0 -1.1475 TD 0 Tc 0 Tw ( )Tj 0 -1.153 TD ( )Tj T* .0014 Tc [(Round )5.5(4 Con)4.1(t).5(rol Group \()8.1(Control-R4\) )]TJ ET 57.6 646.38 174.78 .54004 re f BT 10.98 0 0 10.98 57.6 635.46 Tm .0001 Tw [(The Control-)6.4(R4 sam)8.6(p)-1.4(le group will be e)8(n)-1.4(rolled for )5.5(only one)]TJ 23.7377 0 TD .001 Tc .0004 Tw [( round )5.5(of the study \()6.1(r).7(ound )5.5(4\), thus for onl)5.6(y)-7.2( )5.5(3 w)7.3(eeks. )]TJ -23.7377 -1.153 TD [(During that r)6.2(ound, study procedures for recruitm)8.4(ent, enrollm)]TJ 24.3934 0 TD .0012 Tc .0002 Tw [(ent, an)-7(d inform)8.5(ed consent )]TJ 10.6667 0 TD .0005 Tc .0009 Tw (will be identical to those )Tj -35.0601 -1.1475 TD .0008 Tc .0006 Tw [(at round )5.5(1 for)5.9( the main sample described elsewher)-5(e)2( \(note )]TJ 23.1967 0 TD .0005 Tc .0009 Tw [(that since all are enrolled in the same group, t)5.1(h)-2.2(ere will )]TJ -23.1967 -1.153 TD .0008 Tc .0006 Tw (be no randomization step\). After informed consent,)Tj 20.7814 0 TD .0009 Tc .0005 Tw [( the round )5.5(4 procedures for the Control-R4 )5.5(group will )5.5(be )]TJ -20.7814 -1.153 TD .0005 Tc .0009 Tw [(identical to those described)-7.7( above fo)]TJ 14.6667 0 TD .0011 Tc .0003 Tw [(r the)7.8( main control )5.5(group \(Contr)6.2(ol-R1\): )]TJ /F1 1 Tf -14.6667 -1.224 TD 0 Tc 0 Tw ()Tj /TT2 1 Tf .459 0 TD ( )Tj /TT4 1 Tf 1.1803 0 TD .0005 Tc .0009 Tw [(As described )-5.4(in the Section 7 Overview above, the Contro)]TJ 23.3169 0 TD .0008 Tc .0006 Tw [(l-R4 parti)5.4(c)2(ipants will have two visits to the study )]TJ -23.3169 -1.153 TD .0007 Tc [(station. At the initial enrol)5.3(m)2.6(ent visit they will com)8(p)]TJ 21.0273 0 TD .0008 Tc [(lete a 30-m)8.1(i)-.1(nut)-5.5(e interview, have individual pre-test )]TJ -21.0273 -1.153 TD .0011 Tc .0003 Tw [(counseling, a)7.8(nd provide a )5.5(blood and uri)5.7(n)-1.6(e sam)8.4(p)-1.6(le. At )]TJ 21.9235 0 TD .0004 Tc .001 Tw [(the second visit 2-3 weeks later they)-7.8( wil)5(l)-.5( receive their)-5.4( )]TJ -21.9235 -1.153 TD .0008 Tc .0006 Tw [(test results, post-test counseling, and fre)7.5(e treatment vouchers. )]TJ /F1 1 Tf -1.6393 -1.2186 TD 0 Tc 0 Tw ()Tj /TT2 1 Tf .459 0 TD ( )Tj /TT4 1 Tf 1.1803 0 TD .0007 Tc .0007 Tw [(The pre and post-test counseling will be i)5.3(d)-2(entical to )]TJ 21.0055 0 TD [(that described above \(the gr)5.8(oup counseling sessions in )]TJ -21.0055 -1.153 TD .0008 Tw [(the village will have finished by)-7.6( round )5.5(4, so Contro)]TJ 20.6503 0 TD .001 Tc .0004 Tw [(l-)6.1(R4 participants will not be )5.5(involved in a)7.7(n)3.7(y)-7.2( group )]TJ -20.6503 -1.153 TD [(counseling\). )5.5( )]TJ /F1 1 Tf -1.6393 -1.224 TD 0 Tc 0 Tw ()Tj /TT2 1 Tf .459 0 TD ( )Tj /TT4 1 Tf 1.1803 0 TD .0008 Tc .0006 Tw [(The blood and urine specimen collectio)-7.4(n procedur)]TJ 20.1475 0 TD .0005 Tc .0009 Tw [(es will be identi)5.1(cal to those described above. )]TJ /F1 1 Tf -21.7869 -1.224 TD 0 Tc 0 Tw ()Tj /TT2 1 Tf .459 0 TD ( )Tj /TT4 1 Tf 1.1803 0 TD .0007 Tc .0007 Tw [(The STIs tested for will be identical to t)]TJ 15.9727 0 TD (hose listed above at r)Tj 8.459 0 TD .0019 Tc -.006 Tw [(ound 4 )-5.5(\(includi)6.5(ng HIV\). )]TJ /F1 1 Tf -26.071 -1.224 TD 0 Tc 0 Tw ()Tj /TT2 1 Tf .459 0 TD ( )Tj /TT4 1 Tf 1.1803 0 TD .0007 Tc .0007 Tw [(The laboratory testing proc)7.4(edures will be identical to those described above. )]TJ /F1 1 Tf -1.6393 -1.224 TD 0 Tc 0 Tw ()Tj /TT2 1 Tf .459 0 TD ( )Tj /TT4 1 Tf 1.1803 0 TD .0004 Tc .001 Tw [(The inconvenience fees an)-7.8(d inclusion in the lotter)5.5(y)-7.8( wi)]TJ 21.6995 0 TD .0009 Tc .0005 Tw [(ll be identical to those described above f)6(o)-1.8(r control )]TJ -21.6995 -1.153 TD [(group enr)6(o)-1.8(llees.)-5.9( )]TJ /F1 1 Tf -1.6393 -1.224 TD 0 Tc 0 Tw ()Tj /TT2 1 Tf .459 0 TD ( )Tj /TT4 1 Tf 1.1803 0 TD .0006 Tc .0008 Tw [(Free STI treat)-5.7(ment vouchers will be identical to that described above. )]TJ /F1 1 Tf -1.6393 -1.224 TD 0 Tc 0 Tw ()Tj /TT2 1 Tf .459 0 TD ( )Tj /TT4 1 Tf 1.1803 0 TD .001 Tc .0004 Tw [(The round 4 s)7.6(u)-1.7(rve)7.7(y)-7.2( questionnaire for the)7.7( Control-R4 e)7.7(n)]TJ 22.3661 0 TD .0006 Tc .0008 Tw (rollees will be identical to )Tj 10.6557 0 TD .0004 Tc .001 Tw (that used for the main )Tj -33.0219 -1.153 TD .0007 Tc .0007 Tw [(study)-7.5( enrolle)7.4(es at round 4 )5.5(\(except that sections U a)]TJ 20.4426 0 TD [(nd W will be omitted for the Control-R4 e)7.4(n)-2(rollees, as )]TJ -20.4426 -1.1475 TD .0008 Tc [(indicated b)3.5(y)-7.4( t)5.4(h)-1.9(e questionna)7.5(ire skip patterns\). )]TJ /F1 1 Tf -1.6393 -1.224 TD 0 Tc 0 Tw ()Tj /TT2 1 Tf .459 0 TD ( )Tj /TT4 1 Tf 1.1803 0 TD .0007 Tc .0007 Tw [(Control-R4 e)7.4(n)-2(rollees will not be invited to particip)]TJ 20.3388 0 TD .0008 Tw [(ate in any)-7.6( supple)7.3(m)2.5(ental studies \(such as qualitative sub-)]TJ -20.3388 -1.153 TD -.0014 Tc 0 Tw [(study)-9.6(\))-1.7(. )]TJ -1.6393 -1.153 TD 0 Tc ( )Tj T* ( )Tj /TT10 1 Tf 0 -1.1585 TD .0004 Tc .001 Tw [(Desc)-3.8(ription of locations for interventi)-5.9(on/study activities )]TJ /TT4 1 Tf 0 -1.1421 TD 0 Tc 0 Tw ( )Tj /TT8 1 Tf 0 -1.1585 TD .0006 Tc .0008 Tw [(Enrollment, STI testing, basic counseling, and survey)-3.6(s )]TJ /TT4 1 Tf 0 -1.1475 TD .0005 Tc .0009 Tw [(Study)-7.7( stations)-5.3( will be te)7.2(m)7.8(porary)-7.7( structures set up )]TJ 20.6995 0 TD (in each village that will serve as the location where )Tj -20.6995 -1.153 TD .0006 Tc .0008 Tw [(intervention/s)7.2(t)-.3(udy)-7.6( activitie)7.3(s take place, i)-5.7(n)-2.1(cluding enrollm)]TJ 23.0874 0 TD .0007 Tw [(ent, speci)-5.6(men collectio)-7.5(n, test result and cash pa)7.4(y)-7.5(m)2.6(ent )]TJ -23.0874 -1.153 TD .0008 Tc [(distribution, s)7.4(u)-1.9(rve)7.5(y)-7.4( adm)8.1(i)-.1(nistration, etc. Dedicated areas )]TJ 22.612 0 TD .0007 Tc [(will be set )-5.4(up within )5.5(the )5.5(stations that allow for priva)7.4(c)1.9(y)-7.5( )]TJ -22.612 -1.153 TD [(during specimen collectio)-7.5(n, results distribution and c)7.4(ounse)]TJ 23.5683 0 TD .0008 Tw [(ling, and surve)7.3(y)-7.6( administration. 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This is a FDA approved ELISA that utilizes puri)5.4(f).5(ied HSV recom)8.1(b)-1.9(inant glycoprotein G2 )]TJ 0 -1.153 TD .0005 Tc .0009 Tw [(antigens immobilized on )5.5(poly)-7.7(st)]TJ 12.6011 0 TD -.0159 Tc .0063 Tw [(y)-24.1(r)-16.2(e)-14.7(n)-18.6(e)-14.7( )-11(m)-8.6(i)-22.2(c)-14.7(r)-16.2(o)-18.6(w)-15(e)-14.7(l)-16.8(l)-16.8(s)-14.7(.)-17.3( )-16.4(Hig)-7.7(h)-2.2(e)-3.7(r).2( cut)-5.8( )5.4(poi)-5.8(nt)-5.8(s ne)-3.7(ed)-7.7(ed fo)-7.7(r s)-3.8(e)1.7(r)-5.3(a)1.7( fro)-13.2(m Af)-5.3(ri)-5.8(c)-3.7(a)1.7( wi)-5.8(ll)-5.8( )5.4(b)-7.7(e)1.7( )5.4(u)-7.7(s)-3.8(ed.)-6.3( )]TJ -12.6011 -1.153 TD .0009 Tc .0005 Tw [(Positive results do not)5.5( disti)5.5(nguish )5.5(between active or past infection. )]TJ /TT8 1 Tf 27.2678 0 TD .0018 Tc -.0004 Tw [(T. palli)6.4(dum)]TJ /TT4 1 Tf 4.623 0 TD .0007 Tc .0007 Tw [( )5.5(will be identi)5.3(fied using RP)4.9(R )]TJ -31.8907 -1.153 TD .0004 Tc .001 Tw [(with reactive )-5.4(tests confirmed by)-7.8( TPPA .)4.5( Active sy)-7.8(phi)5(lis )]TJ 22.5956 0 TD .0006 Tc .0008 Tw [(is defined as RPR+/TPP)-6.1(A+. For HIV,)-6.2( we will use rapid )]TJ -22.5956 -1.153 TD .0009 Tc .0005 Tw [(test for initial results, confirm)8.2(a)2.1(tion of positives, and tie-breaking. )]TJ T* 0 Tc 0 Tw ( )Tj 0 -1.1475 TD .0006 Tc .0008 Tw [(For each participant, specimens will be )-5.4(labeled with a da)]TJ 22.7541 0 TD .0005 Tc .0009 Tw [(ted barcode that will link their sam)7.8(p)-7.7(l)-.4(es \(and test r)-5.3(esults\) )]TJ -22.7541 -1.153 TD .0008 Tc .0006 Tw [(to their study )5.5(identification )5.5(code in the la)7.5(boratory)-7.4( computer)]TJ 23.9235 0 TD .0005 Tc .0009 Tw [( database. All laboratory)-7.7( test results will be stored in )]TJ -23.9235 -1.153 TD .0006 Tc .0008 Tw [(a password-protected data)-3.6(base on a com)7.9(puter in the )]TJ 20.9727 0 TD .0004 Tc .001 Tw [(laboratory)-7.8(,)-1( separate fro)-7.8(m)7.7( a)-3.8(ll other study )5.5(data. The )]TJ -20.9727 -1.153 TD .0006 Tc .0008 Tw [(laborator)5.7(y)-7.6( test result reports will be automatically)-7.6( gene)]TJ 22.1202 0 TD .0011 Tc .0003 Tw [(rated \(using standard laboratory)-7.1( m)8.4(a)2.3(nagem)8.4(e)2.3(nt software\) )]TJ -22.1202 -1.153 TD .0006 Tc .0008 Tw [(for each study participant )5.5(once all tests )-5.4(have been com)7.9(p)]TJ 22.388 0 TD [(l)-5.7(e)1.8(ted for their village in a given round. These reports )]TJ -22.388 -1.1475 TD .0003 Tc .0011 Tw [(will then be double-checked by)-7.9( laboratory)-7.9( staff for ac)7(cu)]TJ 22.4699 0 TD .0005 Tc .0009 Tw [(racy)-7.7( and t)5.1(h)3.2(en returned to study)-7.7( partici)5.1(p)-2.2(ants in a )]TJ -22.4699 -1.153 TD .0006 Tc .0008 Tw (standardized format. )Tj T* 0 Tc 0 Tw ( )Tj T* .0005 Tc .0009 Tw [(As part of the accuracy)-7.7( checking of STI )5.5(result reports ge)]TJ 22.694 0 TD .0003 Tc .0011 Tw [(nerated for study)-7.9( participan)]TJ 11.0437 0 TD [(ts, several )-5.4(procedures have )]TJ -33.7377 -1.153 TD .001 Tc .0004 Tw [(been im)8.3(ple)-3.2(m)-2.6(ented: )]TJ /F1 1 Tf 0 -1.2186 TD 0 Tc 0 Tw ()Tj /TT2 1 Tf .459 0 TD ( )Tj /TT4 1 Tf 1.1803 0 TD .0005 Tc .0009 Tw [(The com)7.8(puter)-5.3( program)7.8(s tha)-3.7(t)-.4( translate res)-3.8(u)-2.2(lts into)]TJ 19.6995 0 TD .0004 Tc .001 Tw [( reports have been extensively)-7.8( )5.5(bug-checked. )5.5( )]TJ /F1 1 Tf -21.3388 -1.224 TD 0 Tc 0 Tw ()Tj /TT2 1 Tf .459 0 TD ( )Tj /TT4 1 Tf 1.1803 0 TD .0006 Tc .0008 Tw [(The data entry interface has been )-5.4(m)7.9(odified so as to )]TJ 20.6393 0 TD .0007 Tw [(reduce the possibility)-7.5( )5.5(of results being entered into )]TJ -20.6393 -1.153 TD .0005 Tc .0009 Tw [(incorrect fiel)-5.8(ds, and also to prevent invalid res)]TJ 18.5792 0 TD .0008 Tc .0006 Tw [(ponses \(such as bla)-3.4(nk spaces\) fr)-5(om)8.1( being entered. )]TJ /F1 1 Tf 12 0 0 12 57.6 227.3401 Tm 0 Tc 0 Tw ()Tj /TT2 1 Tf .46 0 TD ( )Tj /TT4 1 Tf 10.98 0 0 10.98 75.6 227.3401 Tm .0009 Tc .0005 Tw [(In addition to lab staff double-checking any)-7.3( )5.5(da)]TJ 18.7268 0 TD .0008 Tc .0006 Tw [(ta entry for accuracy, the lab dire)7.5(ctor m)8.1(u)-1.9(st)]TJ 12 0 0 12 468.06 227.3401 Tm .0005 Tc -.0005 Tw [( ha)-5.6(nd-check )]TJ -32.705 -1.15 TD .0006 Tc -.0016 Tw [(every positive report ag)5.6(ainst a raw )]TJ 14.055 0 TD .0001 Tc -.0001 Tw [(printout of lab results, and sign a flow sheet each tim)7.9(e he does )]TJ -14.055 -1.15 TD .0002 Tc 0 Tw (so. )Tj /F1 1 Tf -1.5 -1.225 TD 0 Tc ()Tj /TT2 1 Tf .46 0 TD ( )Tj /TT4 1 Tf 1.04 0 TD .0008 Tc -.0015 Tw [(The local If)3.8(akara direc)4.6(t)-1.4(or)3.8( of)3.8( the If)3.8(akara Health )]TJ 18.995 0 TD .0009 Tc -.0009 Tw [(In)5.9(stitu)5.9(te will s)5.1(pot-che)4.7(ck th)5.9(e result pr)3.9(intouts f)3.9(o).9(r )]TJ -18.995 -1.145 TD .0006 Tc -.0013 Tw [(study participants agains)4.8(t raw resu)5.6(lt printou)5.6(t)-1.6(s. T)6.4(h).6(is)]TJ 20.72 0 TD -.0018 Tw [( will b)5.7(e)-.5( d)5.7(one prior to results being)5.7( delivered to)5.7( )]TJ -20.72 -1.15 TD .0001 Tc -.0001 Tw (subjects each week. )Tj 10.98 0 0 10.98 57.6 144.6001 Tm 0 Tc 0 Tw ( )Tj 0 -1.153 TD ( )Tj /TT12 1 Tf T* .0009 Tc .0005 Tw (HIV/STI post-counseling )Tj /TT10 1 Tf 10.6885 0 TD 0 Tc 0 Tw ( )Tj /TT4 1 Tf .2514 0 TD ( )Tj -10.9399 -1.1475 TD .0008 Tc .0006 Tw (Participants will be asked to return )Tj 14.1913 0 TD .0002 Tc .0012 Tw [(to the study)-8( station at a specified tim)]TJ 14.7049 0 TD .0008 Tc .0006 Tw (e to receive their test results and )Tj -28.8962 -1.153 TD .0006 Tc .0008 Tw [(HIV/STI post-test counseling. A trained )5.5(study)-7.6( counselor w)]TJ 23.5902 0 TD .0005 Tc .0009 Tw [(ill return )5.5(the results to the )]TJ 10.5738 0 TD .0007 Tc .0007 Tw (participant in a private, )Tj -34.1639 -1.153 TD .0011 Tc .0003 Tw [(soundpr)6.2(oof ar)6.2(ea of the study station. P)5.3(o)3.8(st-test counseling )]TJ 23.4317 0 TD .0006 Tc .0008 Tw [(will diffe)7.3(r depending on whether the result is negative )]TJ -23.4317 -1.153 TD .0008 Tc .0006 Tw [(or positive. H)7.1(o)-1.9(wever, all post-test counseli)]TJ 17.1639 0 TD .0006 Tc .0008 Tw [(ng will contain the following core elements: )-5.4( )]TJ -15.5246 -1.153 TD 0 Tc 0 Tw ( )Tj /TT2 1 Tf T* .0003 Tc (- )Tj /TT4 1 Tf 1.6393 0 TD .001 Tw [(Confirmation of participant)-5.4(s readiness to receive the HIV/STI test )-5.4(result )]TJ ET endstream endobj 240 0 obj <>/Font<>/ProcSet[/PDF/Text]>> endobj 237 0 obj <>stream /GS1 gs BT /TT2 1 Tf 7.98 0 0 7.98 57.6 748.62 Tm 0 g 0 Tc 0 Tw ( )Tj 0 -89.9774 TD -.0001 Tc .0005 Tw [( )-29045.1(Page 13 )-7.5(of 29)]TJ /TT4 1 Tf 12 0 0 12 342.72 30.6 Tm 14.24 Tc 0 Tw ( )Tj 10.98 0 0 10.98 57.6 736.6801 Tm .0004 Tc .001 Tw [(The battery)-7.8( )5.5(of HIV/STI tests that we intend to )5.5(use in t)5(h)]TJ 22.1148 0 TD [(e study)-7.8( have)7.1( been selecte)-3.8(d)-2.3( to ensure that only)-7.8( m)7.7(i)-.5(nimally)-7.8( )]TJ -22.1148 -1.153 TD .0007 Tc .0007 Tw [(invasive procedures are ne)-3.5(eded for speci)-5.6(m)8(e)1.9(n collecti)-5.6(on, )]TJ 22.7049 0 TD [(and )5.5(that collection proc)7.4(edures can be)-3.5( easily)-7.5( performed )]TJ -22.7049 -1.153 TD .0002 Tc .0012 Tw [(by)-8( field staff. )]TJ T* 0 Tc 0 Tw ( )Tj /TT12 1 Tf 0 -1.1585 TD .0009 Tc .0005 Tw (HIV/STI pre-counseling )Tj /TT10 1 Tf 10.3552 0 TD .0014 Tc 0 Tw ( )Tj /TT4 1 Tf -10.3552 -1.1421 TD .0006 Tc .0008 Tw [(All study)-7.6( part)5.2(icipants will be offered HIV/STI testing,)]TJ 21.7541 0 TD .0009 Tc .0005 Tw [( based on the)7.6( three C)-4.9(s \(inform)8.2(e)2.1(d con)-7.3(sent, counseling )]TJ -21.7541 -1.153 TD .001 Tc .0004 Tw [(and confident)5.6(i).1(ality)-7.2(\).)5.1( This )5.5(expanded HIV/STI pre-te)]TJ 20.8907 0 TD .0009 Tc .0005 Tw [(st counseling )5.5(builds on the )5.5(reco)-7.3(mmendations of the )]TJ -20.8907 -1.153 TD .0005 Tc .0009 Tw [(Tanzanian Ministry of Health and Social )5.5(Welfare)-5.3(s )]TJ 20.776 0 TD .0009 Tc .0005 Tw [(National AIDS Control Pro)3.6(g)-1.8(r)6(a)-3.3(mme and the World Health )]TJ -20.776 -1.153 TD .001 Tc .0004 Tw [(Organization. During pre-t)5.6(est counseling, the study coun)]TJ 22.765 0 TD .0008 Tc .0006 Tw [(selor will )5.5(describe the testing and post-test counseling )]TJ -22.765 -1.153 TD .0006 Tc .0008 Tw [(process, discuss the confidentiality)-7.6( )5.5(of te)7.3(sting and results, )]TJ 23.0328 0 TD .0007 Tw [(and individuals)-5.1( )]TJ 6.7377 0 TD .0003 Tc .0011 Tw (right to decline testing. The counselor )Tj -29.7705 -1.1475 TD .001 Tc .0004 Tw [(will provide i)5.6(n)-1.7(form)8.3(ation on HIV/AIDS )-5.4(and STIs in orde)]TJ 22.6503 0 TD .0014 Tc 0 Tw [(r to clarify m)8.7(i)-4.9(sinform)8.7(a)2.6(ti)-4.9(on and/)6(or m)8.7(i).5(sconceptions, )]TJ -22.6503 -1.153 TD .0005 Tc .0009 Tw [(ensure that any decision to )5.5(take the HIV/)-5.8(STI tests is in)]TJ 21.8689 0 TD [(formed and voluntary)-7.7(,)-.9( and )5.5(prepare the participant for a )]TJ -21.8689 -1.153 TD [(positive result. The counselor will also carry)-7.7( out a ri)]TJ 20.929 0 TD .0006 Tc .0008 Tw [(sk assessment, help the parti)5.2(c)1.8(ipant develop a risk )]TJ -20.929 -1.153 TD .0009 Tc .0005 Tw [(prevention/re)7.6(duction )5.5(plan, )5.5(and explore p)3.6(o)-1.8(tential obstacles )]TJ 23.4481 0 TD .0014 Tc 0 Tw [(and prob)4.1(lem)8.7(s)2.6( that participants )-5.4(m)8.7(a)2.6(y)-6.8( encounter when )]TJ -23.4481 -1.153 TD .0001 Tw [(im)8.6(plem)8.6(enting this plan. T)5.6(h)-1.4(i)5.9(s)2.5( will include the provision of)]TJ 23.1202 0 TD .0012 Tc .0002 Tw [( m)8.5(a)2.4(le condoms, directions for use, and inform)8.5(ation on )]TJ -23.1202 -1.153 TD .0006 Tc .0008 Tw [(contraceptive and disease prevention efficacy)-7.6(. Thus, t)5.2(h)-2.1(e pr)]TJ 23.5628 0 TD [(e-test counseling will )5.5(address the following issues at )]TJ -23.5628 -1.1475 TD -.0073 Tc .0141 Tw [(a)-6.1( mi)-8.2(n)-10(i)-13.6(mu)-15.5(m:)-13.6( )]TJ 1.6393 -1.153 TD 0 Tc 0 Tw ( )Tj /TT2 1 Tf 0 -1.1585 TD .0003 Tc (- )Tj /TT4 1 Tf 1.6393 0 TD .001 Tc .0004 Tw (Knowledge of STIs, HIV/AIDS, and )Tj 14.9454 0 TD .0006 Tc .0008 Tw (difference between HIV and AIDS )Tj /TT2 1 Tf -16.5847 -1.1585 TD .0003 Tc 0 Tw (- )Tj /TT4 1 Tf 1.6393 0 TD .0009 Tc .0005 Tw [(Modes of trans)-3.4(m)8.2(ission )]TJ /TT2 1 Tf -1.6393 -1.153 TD .0003 Tc 0 Tw (- )Tj /TT4 1 Tf 1.6393 0 TD .0008 Tc .0006 Tw [(Advantages/disadvantages )-5.4(of knowin)3.5(g o)3.5(n)-1.9(es HIV status )]TJ /TT2 1 Tf -1.6393 -1.1585 TD .0003 Tc 0 Tw (- )Tj /TT4 1 Tf 1.6393 0 TD .001 Tw [(How the tests)-3.9( work, and w)6.7(h)-2.3(at the possible results are)-3.8( )]TJ /TT2 1 Tf -1.6393 -1.153 TD 0 Tw (- )Tj /TT4 1 Tf 1.6393 0 TD .0009 Tc .0005 Tw [(Risk prevention/reduction )5.5(assessment and )]TJ 17.0874 0 TD .0011 Tc .0003 Tw [(plan, including condom)8.4( dem)8.4(onstration )]TJ /TT12 1 Tf -20.3661 -1.1585 TD 0 Tc 0 Tw ( )Tj /TT4 1 Tf 0 -1.1475 TD .0008 Tc .0006 Tw (Participants will be asked to return )Tj 14.1913 0 TD .0002 Tc .0012 Tw [(to the study)-8( station duri)4.8(ng a specified )]TJ 15.2623 0 TD .001 Tc .0004 Tw [(period of tim)8.3(e to receive their test )]TJ -29.4536 -1.153 TD .0009 Tc .0005 Tw (results and post-test counseling \(described in )Tj 18.2568 0 TD .0005 Tc .0009 Tw [(the STI/)5.1(H)1.4(IV post-counseling secti)-5.8(on below\). )]TJ -18.2568 -1.153 TD 0 Tc 0 Tw ( )Tj /TT12 1 Tf T* ( )Tj T* .0003 Tc .0011 Tw [(Specimen col)-6(l)-.6(ection procedures )]TJ /TT10 1 Tf 13.3279 0 TD 0 Tc 0 Tw ( )Tj /TT4 1 Tf -13.3279 -1.1475 TD .001 Tc .0004 Tw [(Each round )5.5(of testing, parti)5.6(c)2.2(ipants will be asked to pr)]TJ 21.4208 0 TD .0008 Tc .0006 Tw [(ovide biol)5.4(ogic)7.5(a)2(l specimens )-5.4(that will be sent to t)5.4(h)-1.9(e IHRDC )]TJ -21.4208 -1.153 TD .0003 Tc .0011 Tw [(laboratory)-7.9( for STI testing. )5.5(All speci)-6(men collection will ta)]TJ 23.0055 0 TD [(ke place at)-5.9( the study)-7.8( station during )5.5(the first visit of )]TJ -23.0055 -1.153 TD .0006 Tc .0008 Tw [(each study)-7.6( r)5.7(o)3.3(und. 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Once )-5.4(a )]TJ -21.306 -1.153 TD .0007 Tc .0007 Tw [(participant tests positive for HSV-2, he/she will not be)7.4( tested for HSV-2 again. )]TJ T* 0 Tc 0 Tw ( )Tj T* .0002 Tc .0012 Tw [(Vaginal swab)-8( sa)-4(m)7.5(p)-2.5(le \(fe)-4(males only)-8(\))-.1(:)]TJ /TT10 1 Tf 14.918 0 TD 0 Tc 0 Tw ( )Tj /TT4 1 Tf .2514 0 TD .0005 Tc .0009 Tw [(Fe)7.2(male particip)-7.7(ants will be asked to)]TJ 14.4317 0 TD .0004 Tc .001 Tw [( provi)5(d)-2.3(e a self-ad)-7.8(m)2.3(inistered vaginal )]TJ ET 57.6 216.06 94.02 .53999 re f BT 10.98 0 0 10.98 57.6 205.14 Tm .001 Tc .0004 Tw [(swab sample )-5.4(for laborator)6.1(y tests at each round.)5.1( Participants)]TJ 23.8415 0 TD .0007 Tc .0007 Tw ( will be asked to collect th)Tj 10.5191 0 TD .0005 Tc .0009 Tw [(is sam)7.8(p)-2.2(le in a private area )]TJ -34.3607 -1.1475 TD [(of the study station, using )5.5(a long Q-tip that easily)-7.7( i)5.1(n)-2.2(ser)]TJ 22.8361 0 TD .0008 Tc .0006 Tw [(ts into the vagina. 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To )]TJ 21.1694 0 TD .0009 Tc .0005 Tw [(minim)8.2(i)0(ze spillover effects )]TJ 11.377 0 TD .0004 Tc .001 Tw (across the intervention and )Tj -32.5464 -1.153 TD .0007 Tc .0007 Tw [(control gr)5.8(oups \(where 1 non-marital sex)-7.5(ual )]TJ 17.5847 0 TD [(partner is in one arm)8( & )-5.4(the other part)5.3(ner is in the other arm)8(\)).4(, we will )]TJ -17.5847 -1.153 TD .001 Tc .0004 Tw [(enroll not m)8.3(o)-1.7(re than 30% of age-eligible youth from)8.3( an)]TJ 22.224 0 TD .0004 Tc .001 Tw [(y)-7.8( one village, and we will designate some villages as )]TJ -22.224 -1.1475 TD .0007 Tc .0007 Tw (high treatment penetration villages and others as low )Tj 22.7541 0 TD [(treat)-5.6(ment penetration villages, by vary)-7.5(i)5.3(ng t)5.3(h)-2(e percent )]TJ -22.7541 -1.153 TD .0009 Tc .0005 Tw [(of the eligible)7.6( population w)7.2(ho is enrolled in the treatment arm)8.2(.)-5.9( )]TJ T* 0 Tc 0 Tw ( )Tj T* .0005 Tc .0009 Tw [(Following a )5.5(phase of co)-7.7(mm)7.8(unity)-7.7( sensitization, fieldworkers)]TJ 24.0601 0 TD .0007 Tc .0007 Tw [( will visit the households of the )5.5(random)8(ly)-7.5(-selected )]TJ -24.0601 -1.153 TD .0009 Tc .0005 Tw [(young m)8.2(e)2.1(n & women to invite them)8.2( to participate in the st)]TJ 23.4481 0 TD .0008 Tc .0006 Tw [(udy)-7.4(.)-.6( P)5(o)-1.9(t)5.4(e)2(ntial participants)]TJ 10.7377 0 TD .0013 Tc .0001 Tw [( will be given an invi)5.9(tation )]TJ -34.1858 -1.153 TD .0011 Tc .0003 Tw [(that contains inform)8.4(ation about t)5.7(h)-1.6(e stud)3.8(y, plus t)5.7(h)-1.6(e inf)6.2(o)-1.6(rm)]TJ 23.0656 0 TD [(ed consent form)8.3( to read)-7.2(, and instructi)5.6(ons to com)8.3(e)2.2( to a )]TJ -23.0656 -1.1475 TD .0005 Tc .0009 Tw [(nearby)-7.7( study station)-5.3( )5.5(the following week for screeni)]TJ 21.224 0 TD .0007 Tc .0007 Tw [(ng & potential )5.5(enrollment if they are interested in )]TJ -21.224 -1.153 TD .0005 Tc .0009 Tw [(participating )5.5(\(see below fo)-7.7(r deta)]TJ 12.9618 0 TD .0003 Tc .0011 Tw [(ils on the study)-7.9( stations\). )]TJ -12.9618 -1.153 TD 0 Tc 0 Tw ( )Tj T* .0006 Tc .0008 Tw (Qualitative sub-study )Tj ET 57.6 357.54 94.38 .53998 re f BT 10.98 0 0 10.98 57.6 346.62 Tm .0004 Tc .001 Tw [(We will recru)-7.8(it participants for the qualit)5(ative study)-7.8( at)]TJ 21.7596 0 TD .001 Tc .0004 Tw [( )5.5(two points i)5.6(n)-1.7( )5.5(time using the same recruitm)8.3(ent )-5.4(m)8.3(e)2.2(thods. )]TJ -21.7596 -1.1475 TD .0006 Tc .0008 Tw [(The first recr)-5.2(uitm)7.9(ent will t)-5.7(a)1.8(ke place during the baseline visit )]TJ 24.4863 0 TD [(to the)7.3( study)-7.6( station. At the end of this visit, an )]TJ -24.4863 -1.153 TD [(interviewer for the qualitat)5.2(i)-.3(ve study)-7.6( will)5.2( verball)5.2(y)-7.6( recr)]TJ 21.5027 0 TD .001 Tc .0004 Tw [(uit a stratified random)8.3( selection of )5.5(90-100 participants. )]TJ -21.5027 -1.153 TD .0005 Tc .0009 Tw [(The sam)7.8(p)-2.2(le o)-7.7(f).2( participants select)-5.8(ed for the qualitative s)]TJ 22.1475 0 TD .0007 Tc .0007 Tw [(ub-study)-7.5( wi)5.3(ll be stratified by)-7.5( treatment arm)8(,)-.7( gender and )]TJ -22.1475 -1.153 TD .001 Tc .0004 Tw [(marital st)-5.3(atus. In additi)5.6(on )5.5(we plan to int)5.6(e)2.2(rview approxi)]TJ 22.0109 0 TD .0003 Tc .0011 Tw [(mately)-7.9( 10 )5.5(HIV-positive participants, all in the treatment )]TJ -22.0109 -1.153 TD .0012 Tc .0002 Tw [(arm)8.5(,)-.2( and 8 participants who have s)]TJ 13.9399 0 TD .0008 Tc .0006 Tw [(pous)7.4(es also enrolled in the study. We will use purposive s)7.4(a)-3.4(m)8.1(p)-1.9(ling to meet )]TJ -13.9399 -1.1475 TD .0004 Tc .001 Tw [(these recruit)-5.9(m)2.3(ent criteria )-5.4(if the)7.1(y)-7.8( are not)5( met by)-7.8( t)5(h)-2.3(e initia)]TJ 22.6393 0 TD .0011 Tc .0003 Tw [(l random)8.4( selection of particip)]TJ 11.7978 0 TD .0006 Tc .0008 Tw (ants. All participants will )Tj -34.4372 -1.153 TD .0009 Tc .0005 Tw [(be asked if they)-7.3( woul)5.5(d be )5.5(willing to )5.5(pa)]TJ 15.5847 0 TD .0005 Tc .0009 Tw [(rticipate in the qualitative sub-study. )5.5( )]TJ -15.5847 -1.153 TD 0 Tc 0 Tw ( )Tj T* .0009 Tc .0005 Tw [(The second recruit)-5.4(m)8.2(ent wi)-5.4(ll take place at m)8.2(onth-4, during th)]TJ 24.3224 0 TD .0006 Tc .0008 Tw [(e second visit t)5.2(o)-2.1( the)7.3( study)-7.6( station. All participants )]TJ -24.3224 -1.153 TD .0004 Tc .001 Tw [(interviewed in at the baseline visit will be interviewed)-7.8( ag)]TJ 22.8962 0 TD .0008 Tc .0006 Tw [(ain at the 4-m)8.1(onth visit. In addition to these interviews, )]TJ -22.8962 -1.153 TD .0007 Tc [(i)-5.6(m)2.6(m)8(e)1.9(diat)-5.6(ely)-7.5( following their post-test counseling session, )]TJ 23.1257 0 TD .0003 Tc .0011 Tw [(an interviewer for the qualitative study)-7.9( will verbally )]TJ -23.1257 -1.1475 TD .0009 Tc .0005 Tw [(recruit a random)8.2( selection )-5.4(of 5 participa)7.6(n)-1.8(ts from)8.2( the treat)]TJ 22.8962 0 TD .001 Tc .0004 Tw [(ment arm)8.3( )-5.4(who tested positive for one )5.5(or m)8.3(o)-1.7(re STI \(and )]TJ -22.8962 -1.153 TD .0006 Tc .0008 Tw [(therefore did )5.5(not receive the cash reward)-7.6(\). These partic)]TJ 22.1093 0 TD .001 Tc .0004 Tw [(ipants will be asked if they would )5.5(be willing to )]TJ -22.1093 -1.153 TD .0003 Tc .0011 Tw [(participate in the qualitative sub-study)-7.9(.)-1.1( )5.5( )]TJ /TT6 1 Tf 0 -1.0929 TD 0 Tc 0 Tw ( )Tj /TT4 1 Tf 0 -1.1858 TD .0014 Tc [(Round )5.5(4 Con)4.1(t).5(rol Group \()8.1(Control-R4\) )]TJ ET 57.6 142.8 174.78 .53999 re f BT 10.98 0 0 10.98 57.6 131.88 Tm .0008 Tc .0006 Tw [(The Control-)5.9(R4 group will)5.4( be selected and recruited us)]TJ 22.082 0 TD [(ing the sam)8.1(e)-3.4( procedures described above as were used )]TJ -22.082 -1.153 TD .0007 Tc [(for the origi)5.3(n)3.4(al baseline sam)8(p)-2(l)-5.6(e)1.9(. Potentially)-7.5( eligible )]TJ 21.2295 0 TD .001 Tc .0004 Tw [(i)5.6(ndividuals will be identifie)7.7(d in the existi)5.6(ng Dem)8.3(ographic )]TJ -21.2295 -1.153 TD .0009 Tc .0005 Tw [(Surveillance Surve)7.6(y)-7.3( com)8.2(puterized da)]TJ 14.9891 0 TD .0005 Tc .0009 Tw [(tabase of village residents; st)-5.8(udy)-7.7( )]TJ 13.3333 0 TD .0012 Tc .0002 Tw [(personnel will visit the)7.9(i).3(r househol)5.8(d t)5.8(o)-1.5( )]TJ -28.3224 -1.1475 TD .0006 Tc .0008 Tw [(explain the study)-7.6( and verif)5.7(y)-2.1( eligibilit)5.2(y; )5.5(and eligibles will )]TJ 23.0109 0 TD .0011 Tc .0003 Tw [(be invite)7.8(d to com)8.4(e)2.3( to the study)-7.1( stati)5.7(on the foll)5.7(owing )]TJ -23.0109 -1.153 TD .0005 Tc .0009 Tw [(week to co)-7.7(mplete inform)7.8(e)-3.7(d)-2.2( consen)]TJ 14.0219 0 TD .0008 Tc .0006 Tw [(t and enroll if the)7.5(y)-1.9( so choose. )]TJ /TT6 1 Tf 12.3224 0 TD 0 Tc 0 Tw ( )Tj /TT2 1 Tf 10.02 0 0 10.02 57.6 69.48 Tm ( )Tj 0 -1.1497 TD ( )Tj 0 -1.1437 TD .0003 Tc -.0027 Tw [(Recr)6.2(uitmen)6.3(t Materials)5.6( )]TJ ET endstream endobj 263 0 obj <>/Font<>/ProcSet[/PDF/Text]>> endobj 266 0 obj <> endobj 267 0 obj <> endobj 268 0 obj <>stream hZ\Tו?3@01JOA(0 2D4tGm|jP ~A^C߿ O>^{HG}r : <.G2&=ы5DQ@{bCZ\"z߈ɵgr0^9зQdwE7%'dF|++ACiD?{|+?#B% t'Mtq\3Y6erϢkl2t+D ]0ɔTʦu4ړRyx=eR#f2ZMt h' {.Y;ch͡4 6c,AYC hmKo3gS>zLeml ʷ*fҰ ̖cDc~z~@?߱[me{| _I-r9| yTB`pӍ|Jt7Kߤo}$C~?ѯ7 Y %wd6r\+jVlbf#=~^H4%b|2_]X;uz+A(K3\XItY2IXc||X|\>)_U ({p &FmQTW5M62h7ua-W%3?Cv65ԃ҇l4"3ߓʳsr }Dc.SMʆ,ZV"ybJIPRJ ;J/)3 2$GI?{p7// ?f# q^о>ڌn@#[ JJGܜ[gL553>&&j7KI)ƱcnHče6,qF%ROr$[YYh\FQ:4Դ5p#d-33ئۖUV ~˓F,$5k:sj%z閆@zGي<23gT4hpzJ2%sz8cᕾV\ۊ VrKUVgf謨VP*TdLEɘF'?BN{v%W#ޮϷ󷽝ǾJ*c9Z)(.f@* Z=3byU*Մ˫ ߠΒ0ⱕsG m NlCr@ Oт-ʖKUZ==P {FDžؑg uHV׵: Tt+n\ B jXyg2GXIشG-]8iH" ^)SDilўE,^* Z4eUF)ȲW)z#=#3M}&Q7Og{CInOD둕ҪIIjlM)Y PjJ΀/Qk,@OEEW,/xxO^Z8gPT%S$p+ln5c+x2z{S`t Ter&Z+;2x\DytWZ/S~ʀGL` x7:A X #TI.eS|RDV4VqtW) PEh4U$.h4HsϔC4Jq:i>AB!^('C^$(?@N"l1~t (sT ;iXW.کRR|O:D`τ͒YL86u5G$>YkWF]ï؄F;5m?b?@ DDW;~N938c\l+Oy4UvP}'Rp|ňW*r]7jݐ\}1 {"G#:h=u?3}` ltt~ '16,;@xXU1 v*7^ Sȿ>D`Z"X~ pxC˃sN"GD~ d;5y+26řy+y"zE~ fq>T$|1F|+D 3az.L(rCI8Qęl.9+AcƙMZx: jիzsr-kh$*j8"ƹvq]j-ԎGr#BvZ'qy &÷[D+58 muゲG#uWHg,eb?=wc܅k5A32vṳVV\z 6DK vJ!C{b Hߤ޷Q[S\@{z ujTO'h =@dzw?Qǃr1TȌ: #E6%ӿcxX;X}Xxc–9H^BScL$^8F0|MpL]EП@dsA|<~F-Q7NPr>8c&7{PE VK?C&j&ϋr?fαi fb;.fe}}) ȳяZ#aj`^Ytk_@S6IAzf[ byO'|2h6h:hЉ]B--L\kmBU>NEh[HlLkuXN֞^)M{-Ve1MĞfZA<+~`d]K$dtf9u]zţf0SG(ӖKO:}1{gXK X,^,`hmgyLֻ/v+m^V)/zN4(f;wre5mD5KR1[*;pg<>dӭ9[a1U*Lu܂ϭ(tήǻ.쒻jǔ|#m ȉkŴTS5k|6Z6*a'';c'%X L(m(K%VҢXj2q:ŚfOԓjP5eKTΨLX'Y* YsR%x3 0&ěeZk-" !R"B$9Dn !"!"!X[xph@-PTv7̻C"7HR "JH)$e%{QQA2!c,·M:1uv:LMM̚yy9ٜdkcN0[̣1QfY5fn& *j566]2=*V&1W(szBZZSUCo?`B;EO(zYԲA;wW]=OXrn3&&d+ 7M(]㼙>gٿJ+ 1WU քSX /W >B%Cg0?ML;"GaN63OyN0/x):o *aD74 M5ӆ; " vZcޘo6qP{#l&->stream /GS1 gs BT /TT2 1 Tf 7.98 0 0 7.98 57.6 748.62 Tm 0 g 0 Tc 0 Tw ( )Tj 0 -89.9774 TD .0002 Tc .0002 Tw [( )-29045.1(Page 7 o)-5.5(f)2.4( 29)]TJ /TT4 1 Tf 12 0 0 12 338.28 30.6 Tm 14.61 Tc 0 Tw ( )Tj 10.98 0 0 10.98 57.6 736.6801 Tm .0008 Tc .0006 Tw [(original contr)5.9(o)-1.9(l group recruited at round 1 Control-R)6.6(1)-1.9(\))]TJ 22.9508 0 TD .0006 Tc .0008 Tw [(. This will allow us to t)5.2(est whether t)-5.7(h)-2.1(e intensive )]TJ -22.9508 -1.153 TD .0012 Tc .0002 Tw [(counseling an)3.9(d treatm)8.5(e)2.4(nt activities given to Con)3.9(t).3(rol-)6.3(R1 )]TJ 22.5082 0 TD .0009 Tc .0005 Tw [(over the fi)5.5(rst y)-7.3(ear of the)7.6( stud)3.6(y)-7.3( resulted in changed )]TJ -22.5082 -1.153 TD .0005 Tc .0009 Tw [(sexual behavior and decreased STI incidence, as co)-7.7(mpared)]TJ 23.5902 0 TD .0007 Tc .0007 Tw [( to the new Control-R4 group that )5.5(was not enrolled )]TJ -23.5902 -1.153 TD .0011 Tc .0003 Tw [(during)3.8( the fir)6.2(s)2.3(t y)-7.1(ear of the )5.5(stud)3.8(y)-7.1(.)-.3( Alth)3.8(o)3.8(ugh )5.5(not ori)5.7(g)-1.6(i)5.7(n)-1.6(a)]TJ 22.0601 0 TD .0009 Tc .0005 Tw [(lly envisio)3.6(n)-1.8(ed in the stu)3.6(d)3.6(y)-7.3( design,)5( the)7.6( decrease in STI )]TJ -22.0601 -1.153 TD .0011 Tc .0003 Tw [(incidence that we have observed am)8.4(ong the Control-R)6.9(1)-1.6( grou)]TJ 24.3716 0 TD .0007 Tc .0007 Tw [(p d)3.4(u)-2(rin)3.4(g)-2( the first eig)3.4(h)-2(t m)8(onths of the stud)3.4(y)-7.5( sug)3.4(g)-2(ests )]TJ -24.3716 -1.1475 TD .0008 Tc [(that there )-5.4(m)8.1(a)-3.4(y be im)8.1(portant scientific gains to studying )]TJ 22.3443 0 TD .0012 Tc .0002 Tw [(the Contro)3.9(l)5.8(-).9(R1 group)3.9( as an interventio)3.9(n grou)3.9(p in)3.9( an)3.9(d of )]TJ -22.3443 -1.153 TD .0008 Tc .0006 Tw [(itself. In order to do so, w)7.1(e)2( will draw a )-5.4(new random)8.1( )-5.4(sa)]TJ 22.1202 0 TD .0006 Tc .0008 Tw [(m)7.9(p)-2.1(le of co)-7.6(mmunity)-7.6( m)7.9(e)-3.6(m)7.9(b)-7.6(ers who were eligible for the )]TJ -22.1202 -1.153 TD .0012 Tc .0002 Tw [(original stud)3.9(y)3.9( recruitm)8.5(ent )-5.4(but who were not enrolled)3.9(.)-.2( )5.5( )]TJ 21.9235 0 TD [(To m)8.5(i).3(ni)-5.1(m)8.5(i).3(ze the potential )5.5(for contam)8.5(ination due to sexual )]TJ -21.9235 -1.153 TD .0009 Tc .0005 Tw [(mixing across control gr)6(oups, we will onl)5.5(y)-7.3( draw this )]TJ 21.3661 0 TD .0012 Tc .0002 Tw [(new Control-)6.3(R4 sam)8.5(p)-1.5(le an)-7(d m)8.5(a)2.4(ke )-5.4(co)-7(m)8.5(p)-7(arisons am)8.5(ong )]TJ -21.3661 -1.153 TD .0008 Tc .0006 Tw [(married individuals. To enhance power, we will only )5.5(enro)]TJ 23.5082 0 TD .0014 Tc 0 Tw [(ll one per)6.5(s)2.6(on per m)8.7(a)2.6(rital coupl)]TJ 12.2678 0 TD .0005 Tc .0009 Tw (e into this new sample. )Tj -35.776 -1.1475 TD [(Other eligibility criteria wi)-5.8(ll be identical)]TJ 16.224 0 TD .0007 Tc .0007 Tw [( to the origina)7.4(l)-.2( baseline enrollm)8(ent )]TJ 14.235 0 TD [(crit)-5.6(er)-5.1(ia: The individuals m)8(u)-2(st have )]TJ -30.459 -1.153 TD .001 Tc .0004 Tw [(been aged 18-30 and m)8.3(a)2.2(rri)-5.3(ed at the time of the initial )5.5(r)]TJ 21.8962 0 TD .0006 Tc .0008 Tw [(ecruit)-5.7(m)7.9(ent one y)-7.6(ear ago; t)5.2(h)-2.1(ey)-7.6( m)7.9(u)-2.1(st also be currentl)5.2(y)-7.6( )]TJ -21.8962 -1.153 TD .0008 Tc .0006 Tw [(living i)5.4(n)-1.9( one of the 10 study villages,)]TJ 14.918 0 TD .0011 Tc .0003 Tw [( not be pregnant, and not)5.7( be pl)5.7(anni)]TJ 13.9126 0 TD .0012 Tc .0002 Tw [(ng )5.5(on per)6.3(m)3.1(anently)-7( m)8.5(i).3(grating out )5.5(of t)5.8(h)-1.5(e )]TJ -28.8306 -1.153 TD .0004 Tc .001 Tw [(study)-7.8( area during the next)5( )5.5(y)-7.8(ear. As at baseline, potentially)]TJ 23.5355 0 TD .001 Tc .0004 Tw [( eli)5.6(g)-1.7(ible )5.5(indivi)5.6(duals will be identifi)5.6(e)2.2(d in the exist)5.6(i).1(ng )]TJ -23.5355 -1.153 TD [(Dem)8.3(ographic Surveillance Surve)7.7(y)-7.2( com)8.3(puterized database )]TJ 23.4481 0 TD .0007 Tc .0007 Tw [(of village residents; st)-5.6(udy)-7.5( )5.5(personnel will visit the)7.4(i)-.2(r )]TJ -23.4481 -1.153 TD .0008 Tw [(household to )5.5(explain the study)-7.6( and verif)5.7(y)-2.1( eligibilit)5.2(y; )5.5(and e)]TJ 23.3989 0 TD .0009 Tc .0005 Tw [(ligibles will be invite)7.6(d to com)8.2(e)2.1( to the study)-7.3( stati)5.5(on the )]TJ -23.3989 -1.1475 TD .001 Tc .0004 Tw [(following we)7.7(ek to com)8.3(p)-1.7(let)-5.3(e)2.2( informed consent and enr)6.1(o)-1.7(ll if )]TJ 23.8415 0 TD .0005 Tc .0009 Tw [(the)7.2(y)-7.7( so )5.5(choose. All Control-R4 participants wi)-5.8(ll be )]TJ -23.8415 -1.153 TD .0011 Tc .0003 Tw [(placed in the )5.5(same study)-7.1( )5.5(gr)6.2(oup, so no ra)7.8(ndom)8.4(ization w)]TJ 22.082 0 TD .0008 Tc .0006 Tw [(ill occur. The Control-R)6.6(4)-1.9( group will r)5.9(eceive free )]TJ -22.082 -1.153 TD .0009 Tc .0005 Tw [(voluntar)6(y cou)3.6(n)-1.8(seling and te)7.6(sting for HIV and the same set)]TJ 23.3388 0 TD .0002 Tc .0012 Tw [( of STIs as original study)-8( participants \(plus free )]TJ -23.3388 -1.153 TD .0006 Tc .0008 Tw [(treat)-5.7(ment and referral as is )-5.4(done for )5.5(origi)5.2(n)-2.1(al study)-7.6( enr)5.7(o)-2.1(llees\). )]TJ /TT2 1 Tf 10.02 0 0 10.02 332.52 496.32 Tm 0 Tc 0 Tw ( )Tj -27.4371 -1.1796 TD ( )Tj 0 -1.1437 TD ( )Tj 0 -1.1497 TD -.0007 Tc -.0017 Tw [(Number o)5.3(f)-3( s)4.6(ubjects)]TJ /TT6 1 Tf 10.98 0 0 10.98 150.9 461.52 Tm 0 Tc 0 Tw ( )Tj /TT4 1 Tf -8.4973 -1.1257 TD ( )Tj 0 -1.1475 TD .0014 Tc [(Main stud)4.1(y )]TJ ET 57.6 434.82 49.8 .54001 re f BT 10.98 0 0 10.98 57.6 423.9 Tm .0008 Tc .0006 Tw [(We plan to enroll a total of )5.5(3000 indi)5.4(viduals in the st)]TJ 21.1749 0 TD .0007 Tc [(udy)-7.5(. Assum)8(i)-.2(ng)-7.5( a refusal/ineligibilit)5.3(y rate of 20%, we will )]TJ -21.1749 -1.153 TD .0012 Tc .0002 Tw [(recruit 3600 i)5.8(ndivid)3.9(u)-1.5(als. )]TJ T* 0 Tc 0 Tw ( )Tj T* .0007 Tc .0007 Tw [(By)-7.5( co)3.4(nventio)3.4(n, STI preven)3.4(tion trials are often powered)]TJ 22.1475 0 TD .0008 Tc [( to detect a magnitude of )5.5(30%)3.2( difference in STI )]TJ -22.1475 -1.1475 TD .0002 Tc .0012 Tw [(incidence acr)-5.6(oss study)-8( arms. Thus, the )]TJ 15.9399 0 TD .0008 Tc .0006 Tw [(proposed stu)3.5(d)3.5(y)-7.4( has been p)3.5(o)-1.9(wered to detect differences of a )-5.4(m)8.1(a)2(gnitude of )]TJ -15.9399 -1.153 TD .0004 Tc .001 Tw [(30% between)-7.8( aggregate STI incidence rates in the treat)-5.9(m)7.7(e)1.6(nt versus )-5.4(control arm)7.7(.)-1( )-5.4( )]TJ T* 0 Tc 0 Tw ( )Tj T* .0006 Tc .0008 Tw [(Power calcul)-5.7(a)1.8(tions are bas)-3.7(e)1.8(d on a com)7.9(p)-7.6(arison of aggregat)]TJ 23.2568 0 TD .0003 Tc .0011 Tw [(e STI incidence rates b)-7.9(e)1.5(tween two, e)-3.9(qual-sized study)-7.9( )]TJ -23.2568 -1.153 TD .0009 Tc .0005 Tw [(ar)-4.9(m)8.2(s)2.1( using a log rank test and assum)8.2(i)0(ng )-5.4(a two-sided alte)]TJ 22.5902 0 TD .0006 Tc .0008 Tw [(rnative hy)-7.6(pothesis. By )5.5(basing the calculations on a)7.3( )]TJ -22.5902 -1.153 TD .0004 Tc .001 Tw [(two-ar)-5.4(m)7.7( co)-7.8(mparison, we ensure sufficie)-3.8(n)-2.3(t power to )5.5(det)]TJ 22.1421 0 TD [(ect differen)-7.8(ces of a 30% )-5.4(magnitude or )5.5(greater in the )]TJ -22.1421 -1.1475 TD .0005 Tc .0009 Tw [(treat)-5.8(ment ar)-5.3(m com)7.8(p)-2.2(a)-3.7(r).2(ed to the control arm)7.8(.)-.9( Other )-5.4(ass)-3.8(um)7.8(ptions include: )]TJ 0 -1.153 TD 0 Tc 0 Tw ( )Tj T* .0006 Tc .0008 Tw [(1. )-2278.7(Annual \(aggr)5.7(egate\) incidence rates )]TJ 17.5137 0 TD .0007 Tw [(in research sit)-5.6(es will be constant; )]TJ -17.5137 -1.153 TD .0002 Tc .0012 Tw [(2. )-2278.7(\(Aggregate\) incidence rate)-4(s )-5.4(m)7.5(a)1.4(y)-8( vary)-8( be)6.9(tween 15%-20% across r)-5.6(e)1.4(s)-4.1(earch site)-4(s;)-6.1( )]TJ T* .0008 Tc .0006 Tw [(3. )-2278.7(Total trial will be 12 m)8.1(onths; )]TJ 0 -1.1475 TD .0007 Tc [(4.)4.8( )-2278.7(Overall annual censoring \(i.e., drop-)5.8(out\))5.8( rates will be )-5.4(as high as 20% per y)-7.5(ear )]TJ 0 -1.153 TD 0 Tc 0 Tw ( )Tj T* .0006 Tc .0008 Tw [(Based on these assu)-7.6(m)7.9(p)-2.1(tions, a total sample size of 3000 in)]TJ 23.4536 0 TD .0009 Tc .0005 Tw [(dividuals \(e.g., 1500 )5.5(per )-5.4(m)8.2(a)2.1(in study ar)-4.9(m)8.2(\)).6( will be )]TJ -23.4536 -1.153 TD .0007 Tc .0007 Tw (sufficient to provide at least 90% power to detect an )Tj 21.1421 0 TD .0009 Tc .0005 Tw (intervention-related reduction )Tj 12.1858 0 TD -.0002 Tc .0016 Tw [(in STI incidence as s)-4.5(m)1.7(al)-6.5(l as )]TJ -33.3279 -1.153 TD .0007 Tc .0007 Tw (24%, significant at the 5% level. 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In roun)]TJ 14.7432 0 TD .0009 Tc .0005 Tw [(d 2 we )5.5(will include five additional)5.5( )]TJ -29.2678 -1.153 TD [(interviews: three )-5.4(men and two wo)-7.3(m)8.2(e)2.1(n who have tested positiv)]TJ 25.0219 0 TD .0007 Tc .0007 Tw [(e aft)5.3(e)1.9(r 4 m)8(onths will be asked to participate in an )]TJ -25.0219 -1.153 TD .0005 Tc .0009 Tw [(in-depth interview the wee)-3.7(k)-2.2( after receivi)-5.8(ng test results. )]TJ ET endstream endobj 261 0 obj <>/Font<>/ProcSet[/PDF/Text]>> endobj 258 0 obj <>stream /GS1 gs BT /TT2 1 Tf 7.98 0 0 7.98 57.6 748.62 Tm 0 g 0 Tc 0 Tw ( )Tj 0 -89.9774 TD .0002 Tc .0002 Tw [( )-29045.1(Page 6 o)-5.5(f)2.4( 29)]TJ /TT4 1 Tf 12 0 0 12 338.28 30.6 Tm 14.61 Tc 0 Tw ( )Tj 10.98 0 0 10.98 57.6 736.6801 Tm .0002 Tc .0012 Tw [(study)-8( in )5.5(2006 to assess the )-5.4(feasibility)-8( of )5.5(this larger trial )]TJ 22.3989 0 TD .0005 Tc .0009 Tw [(in this area. 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These qualitative data )Tj -22.3716 -1.153 TD .0007 Tw [(will be further supplem)8(ented by)-7.5( Conversational Journal da)]TJ 23.5082 0 TD .0001 Tc .0013 Tw [(ta collected by)-8.1( local comm)]TJ 10.7869 0 TD .0006 Tc .0008 Tw [(unity)-7.6( diarists, following a )]TJ -34.2951 -1.153 TD .0009 Tc .0005 Tw [(methodology )5.5(successfully)-7.3( )5.5(developed by Swidler and )]TJ 21.3661 0 TD .0005 Tc .0009 Tw [(colleagues for use study)-7.7(i)-.4(ng sexual behaviors in )]TJ -21.3661 -1.1475 TD .0019 Tc -.006 Tw [(neighbori)6.5(ng Malawi. )]TJ /TT2 1 Tf 10.02 0 0 10.02 57.6 536.28 Tm 0 Tc 0 Tw ( )Tj 0 -1.1497 TD ( )Tj T* .0001 Tc -.0025 Tw [(Stud)-5.8(y)17.3( background)6.2( )]TJ /TT4 1 Tf 10.98 0 0 10.98 57.6 500.94 Tm 0 Tc 0 Tw ( )Tj 0 -1.153 TD .0008 Tc .0006 Tw [(Mass infor)-5(m)8.1(ation, education, and communication \(IE)5.1(C\) ca)]TJ 23.5902 0 TD .0005 Tc .0009 Tw [(m)7.8(p)-7.7(aigns, t)5.1(y)-7.7(picall)5.1(y)-7.7( the)7.2( centerpiece o)-7.7(f).2( countries)-5.3( A)6.8(I).2(DS )]TJ -23.5902 -1.153 TD .001 Tc .0004 Tw [(prevention str)6.1(a)2.2(tegies, have )-5.4(been shown t)5.6(o)-1.7( have had re)]TJ 21.612 0 TD [(latively)-7.2( l)5.6(ittle i)-5.3(m)8.3(pact on patterns of HIV transm)8.3(ission and )]TJ -21.612 -1.153 TD .0006 Tc .0008 Tw [(the trajectory)-7.6( )5.5(of the epidemic \(Bertrand e)-3.6(t)-.3( al., 2006\). )]TJ 21.6721 0 TD .001 Tc .0004 Tw [(Nu)-7.2(m)8.3(e)2.2(rous studies have shown )]TJ 12.4699 0 TD .0012 Tc .0002 Tw [(that inform)8.5(ation alone is )]TJ -34.1421 -1.1475 TD .0005 Tc .0009 Tw [(typically)-7.7( insufficient to change risk beha)7.2(vior. 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In Ta)7.4(nzania, the awareness of HIV prevention )]TJ -23.3115 -1.1475 TD .0013 Tc .0001 Tw [(methods in th)4(e y)-6.9(o)4(uth )5.5(pop)4(ul)5.9(ation is hig)4(h)-1.4( )5.5(but has not)5.9( fu)4(lly )]TJ 22.9563 0 TD .0009 Tc .0005 Tw [(translated into safer sexual behaviors. Alm)8.2(o)-1.8(st 80%)3.3( of )]TJ -22.9563 -1.153 TD [(young people know that )5.5(using condom)8.2(s )-5.4(re)]TJ 16.9727 0 TD [(duces the risk of contracting HIV, but )5.5(fewer than half reported us)7.5(ing a )]TJ -16.9727 -1.153 TD .0013 Tc .0001 Tw [(condom)8.6( the last tim)8.6(e)2.5( they)-6.9( had sex \(MEASURE DHS, 200)4(7\).)5.4( )]TJ T* 0 Tc 0 Tw ( )Tj T* .0005 Tc .0009 Tw [(Psy)-7.7(c)1.7(ho-social interventions)7.1(, such as peer)-5.3(-to-peer counse)]TJ 22.6393 0 TD .0014 Tc 0 Tw [(ling, have h)4.1(a)2.6(d a significant and m)8.7(e)2.6(asurable im)8.7(pact )-5.4(on )]TJ -22.6393 -1.153 TD .0007 Tc .0007 Tw [(unsafe behaviors, but )5.5(have not been shown to be cost-e)]TJ 22.0874 0 TD .0008 Tc [(ffective a)-3.4(s)2( )-5.4(a strategy)-7.4( for )5.5(reaching young people \(Hutton )]TJ -22.0874 -1.1475 TD .0006 Tc .0008 Tw [(et al., 2003\))5.7(. )5.5(These ty)-7.6(pes of interventions )-5.4(m)7.9(a)1.8(y)-7.6( be cos)]TJ 21.6175 0 TD .0005 Tc .0009 Tw [(tly when brought to scale due to the em)7.8(p)-7.7(h)-2.2(asis on an )]TJ -21.6175 -1.153 TD .0011 Tc .0003 Tw [(indivi)5.7(dualized or sm)8.4(all group therap)3.8(y)-7.1( ap)3.8(proach, altho)3.8(ugh t)5.7(h)]TJ 24.0383 0 TD .0007 Tc .0007 Tw [(ere has been some ex)-7.5(perim)8(e)1.9(ntation with m)8(o)-2(re easily)-7.5( )]TJ -24.0383 -1.153 TD .0008 Tc [(scalable, co)-7.4(mm)8.1(unity)-7.4(-based approaches. A )-5.4(m)8.1(u)-1.9(lti-country tr)]TJ 23.765 0 TD .0007 Tc [(ial of a community)-7.5(-)5.8(b)-2(ased VCT approach is currentl)5.3(y)-7.5( )]TJ -23.765 -1.153 TD .0008 Tc [(underway)-7.4( \(C)6.6(oates and Szekeres, 2006\).)4.9( )]TJ T* 0 Tc 0 Tw ( )Tj 0 -1.1475 TD .0006 Tc .0008 Tw [(One plausible explanation for the lack of )5.5(progress with beha)]TJ 24.1749 0 TD .001 Tc .0004 Tw [(vior cha)7.7(nge interventions is)]TJ 11.0984 0 TD .0007 Tc .0007 Tw ( that most interventions )Tj -35.2732 -1.153 TD .0008 Tc [(have focused exclusively)-7.4( )5.5(o)3.5(n)-1.9( AIDS prevention m)8.1(essag)]TJ 21.6393 0 TD .001 Tc .0004 Tw [(es, rather than sexual and r)6.1(e)2.2(productive h)3.7(ealth )-5.4(m)8.3(o)-1.7(re )]TJ -21.6393 -1.153 TD .0007 Tc .0007 Tw [(broadly)-7.5(.)-.7( )5.5( These single-intervention approaches to behavior)]TJ 23.5683 0 TD .0008 Tw [( change )5.5(have presu)-7.6(m)7.9(e)-3.6(d a de)]TJ 11.2623 0 TD .0007 Tw (gree of individual control )Tj -34.8306 -1.153 TD [(over decision making that )5.5(does not speak to the reality )]TJ 22.0929 0 TD .0011 Tc .0003 Tw [(of wom)8.4(e)2.3(ns and girl)5.7(s circu)-7.1(m)8.4(stances in sub-Saharan )]TJ -22.0929 -1.153 TD .0006 Tc .0008 Tw [(Africa, nor to the dilemma )-5.4(that many)-7.6( face in balancing ec)]TJ 23.1202 0 TD .0007 Tw [(onom)8(ic n)-7.5(eeds, the desi)-5.6(re to )]TJ 11.1913 0 TD .0009 Tc .0005 Tw [(bear children, and the )5.5(need )]TJ -34.3115 -1.153 TD .0008 Tc .0006 Tw [(to protect the)7.5(m)2.7(selves fro)-7.4(m HIV and oth)3.5(e)2(r STIs. Furthe)]TJ 22.2568 0 TD .0009 Tc .0005 Tw [(rm)8.2(ore, few )-5.4(interventions )]TJ 10.1257 0 TD .0012 Tc .0002 Tw (have been developed to )Tj -32.3825 -1.1475 TD .0001 Tc .0013 Tw [(explicitly)-8.1( address criti)-6.2(cal c)-4.1(h)-2.6(aracteristi)-6.2(cs )-5.4(of the risk envi)]TJ 22.3388 0 TD .0011 Tc .0003 Tw [(ronm)8.4(ent, )-5.4(most notably pove)]TJ 11.2404 0 TD .0004 Tc .001 Tw [(rty)-7.8( and )5.5(gender inequalities )]TJ -33.5792 -1.153 TD .0008 Tc .0006 Tw [(that give rise to risk)3.5(y)-7.4( beha)7.5(viors. )5.5( )]TJ T* 0 Tc 0 Tw ( )Tj T* .0007 Tc .0007 Tw [(Many)-7.5( )5.5(public health experts have argued )]TJ 16.3005 0 TD .0008 Tc [(that a )-5.4(m)8.1(o)-1.9(re a)-3.4(ggressive approach to beha)7.5(vior change in Africa is ne)-3.4(eded, )]TJ -16.3005 -1.153 TD .0004 Tc .001 Tw [(pointing out that instances)-3.9( where HIV i)-5.9(n)-2.3(fections app)]TJ 21.6175 0 TD .0005 Tc .0009 Tw [(ears to be fall)-5.8(ing [were)-9.2(]).2( linked to successful progra)-3.7(m)7.8(s )]TJ -21.6175 -1.1475 TD .0015 Tc -.0001 Tw [(aim)8.8(e)2.7(d at chan)-6.7(ging )5.5(behavior)6.6(, notabl)6.1(y)-1.2( in K)7.8(e)2.7(ny)-6.7(a, )]TJ 19.0055 0 TD .0008 Tc .0006 Tw [(Ugan)3.5(da, and Zim)8.1(b)-1.9(abwe \(Jack, 2007\). 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Of the 2.5 m)8(illion )]TJ /TT8 1 Tf 35.9617 0 TD .0002 Tc 0 Tw (new )Tj /TT4 1 Tf 1.8634 0 TD .0004 Tc .001 Tw (HIV infections )Tj -37.8251 -1.153 TD .0012 Tc .0002 Tw [(that occur each )5.5(y)-7(ear globall)5.8(y, 80)3.9( percent occur am)8.5(ong this age grou)3.9(p. )5.5( )]TJ T* 0 Tc 0 Tw ( )Tj ET endstream endobj 255 0 obj <>/Font<>/ProcSet[/PDF/Text]>> endobj 252 0 obj <>stream /GS1 gs BT /TT2 1 Tf 7.98 0 0 7.98 57.6 748.62 Tm 0 g 0 Tc 0 Tw ( )Tj 0 -89.9774 TD .0002 Tc .0002 Tw [( )-29045.1(Page 3 o)-5.5(f)2.4( 29)]TJ /TT4 1 Tf 12 0 0 12 338.28 30.6 Tm 14.61 Tc 0 Tw ( )Tj 10.98 0 0 10.98 75.6 736.6801 Tm .0027 Tc (1.)Tj /TT2 1 Tf .7541 0 TD 0 Tc ( )Tj /TT4 1 Tf .8852 0 TD .0006 Tc .0008 Tw [(Evaluate the im)7.9(p)-7.6(act of the co)-7.6(m)7.9(b)-2.1(ined CCT/counseli)]TJ 20.5301 0 TD .0012 Tc .0002 Tw [(ng )5.5(intervention )5.5(o)3.9(n)-1.5( STI inciden)3.9(ce overall and b)3.9(y)-1.5( )]TJ -20.5301 -1.153 TD .0008 Tc .0006 Tw [(specific subgroups )5.5(during the interventi)5.4(on period. 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A baseline census was conducted between )]TJ 21.3934 0 TD .0009 Tc .0005 Tw [(Septem)8.2(ber an)-7.3(d Decem)8.2(b)-7.3(er )-5.4(1996, and each household )5.5(has )]TJ -21.3934 -1.1475 TD .0006 Tc .0008 Tw [(been visited once every)-7.6( four m)7.9(onths )]TJ 14.7978 0 TD .001 Tc .0004 Tw [(ever since. A total of 56 )5.5(village)7.7(s are covered )-5.4(with a popula)7.7(tion of about )]TJ -14.7978 -1.153 TD .0019 Tc -.0005 Tw [(95,0)4.6(00 peo)4.6(p)-.8(l)6.5(e)3.1( in 20,)6(000 )5.5(h)4.6(ouseholds.)6( )]TJ 10.02 0 0 10.02 57.6 273.0601 Tm 0 Tc 0 Tw ( )Tj 10.98 0 0 10.98 57.6 260.58 Tm .0007 Tc .0007 Tw [(In Tanzania and ot)5.3(her East African countries, the )-5.4(m)8(a)]TJ 21.1585 0 TD .0012 Tc .0002 Tw [(jo)-7(rity of new HIV infections occur am)8.5(ong youn)3.9(g peop)3.9(le, )]TJ -21.1585 -1.1475 TD .0016 Tc -.0002 Tw [(aged 15-30)4.3(,)]TJ 7.02 0 0 7.02 109.5 252.9601 Tm .0042 Tc 0 Tw (iv)Tj 10.98 0 0 10.98 115.02 247.9801 Tm .0008 Tc .0006 Tw [( a)-3.4(nd the Kilom)8.1(b)-1.9(ero/Ulanga district appears to be)]TJ 19.5027 0 TD .0001 Tc .0013 Tw [( strongly)-8.1( affected. Th)]TJ 8.8743 0 TD 0 Tc (e infection rates in the )Tj -33.6066 -1.153 TD .0008 Tc .0006 Tw [(Morogor)5.9(o region as a whol)5.4(e are higher than m)8.1(a)2(ny)-7.4( other parts )]TJ 24.8361 0 TD .0003 Tc .0011 Tw [(of the countr)5.4(y)-7.9(. At t)4.9(h)-2.4(e district level, accurate d)-7.9(a)1.5(ta )]TJ -24.8361 -1.153 TD [(are often lacking, but the )5.5(data that are av)-7.8(ailable suggest )]TJ 22.4973 0 TD .0005 Tc .0009 Tw [(a consisten)-7.7(t)-.4( pattern. Results of an ant)5.1(e)1.7(natal survey)-7.7( )5.5(of )]TJ -22.4973 -1.153 TD .0011 Tc .0003 Tw [(youn)3.8(g m)8.4(o)-1.6(thers conducted i)5.7(n)-1.6( 20)3.8(03 revealed an overall HI)]TJ 22.8087 0 TD .0006 Tc .0008 Tw [(V prevalen)-7.6(ce of 13.0%)3( for the Kilombero/Ulanga )]TJ -22.8087 -1.153 TD .0004 Tc .001 Tw [(district as a w)-4.2(hole. In Kilom)7.7(b)-7.8(ero, overall HIV prev)]TJ 20.7814 0 TD [(ale)-3.8(n)-2.3(ce was 19.2%, co)-7.8(m)7.7(p)-2.3(ared )-5.4(to 9.8% in Ulanga \(with )]TJ -20.7814 -1.153 TD .0007 Tc .0007 Tw (apparent hot spots in a few areas e.g. Lupiro\).)Tj 7.02 0 0 7.02 276.96 189.66 Tm 0 Tc 0 Tw (v)Tj 10.98 0 0 10.98 280.5 184.6801 Tm .0007 Tc .0007 Tw [( In a)7.4(ddition, a 2006 study)-7.5( )]TJ 10.7432 0 TD 0 Tc .0014 Tw [(conducted by)-8.2( our resear)-5.8(ch team)7.3( )]TJ -31.0437 -1.1475 TD .001 Tc .0004 Tw [(found an aggr)6.1(egate STI prevalence rate o)-7.2(f).7( 19% am)8.3(ongs)]TJ 22.306 0 TD .0009 Tc .0005 Tw [(t 500 )5.5(youth r)6(a)2.1(ndom)8.2(ly)-7.3( selected fro)-7.3(m)8.2( five villages in the )]TJ -22.306 -1.153 TD .0011 Tc .0003 Tw [(Kilo)-7.1(m)8.4(b)-1.6(ero/Ulanga DSS region.)]TJ 10.02 0 0 10.02 196.62 159.42 Tm 0 Tc 0 Tw ( )Tj 10.98 0 0 10.98 199.08 159.42 Tm ( )Tj -12.8852 -1.153 TD ( )Tj T* .0011 Tc .0003 Tw [(In the last qu)3.8(arter of 2005,)5.2( IHRDC added a )5.5(y)-7.1(out)5.7(h )]TJ 20.1202 0 TD .0008 Tc .0006 Tw [(sex)3.5(ual and repro)3.5(ductive health m)8.1(odule to a socio-)]TJ -20.1202 -1.153 TD .0007 Tc [(dem)8(ographic survey)-7.5( adm)8(i)-.2(nistered within the DSS area)]TJ 21.8689 0 TD .0013 Tc .0001 Tw [(. For this m)8.6(odule, appro)4(x)-1.4(i)5.9(m)3.2(ately)-6.9( 400)4(0 )5.5(youth)4( between the )]TJ -21.8689 -1.1475 TD .0006 Tc .0008 Tw [(ages of 12-24 were rando)-7.6(mly selected fr)-5.2(om)7.9( the DSS )-5.4(datab)]TJ 23.3989 0 TD .0003 Tc .0011 Tw (ase to participate in the st)Tj 10.2077 0 TD -.0003 Tc .0017 Tw [(udy)-8.5(.)-1.7( Preli)-6.6(m)7(inary)-8.5( analyses )]TJ -33.6066 -1.153 TD .0006 Tc .0008 Tw [(indicate that age at sexual )-5.4(debut is low, )5.5(frequency)-7.6( an)3.3(d c)]TJ 22.3989 0 TD .0011 Tc .0003 Tw [(oncurrency of partners i)5.7(s)2.3( high, an)3.8(d co)3.8(ndom)8.4( use is low, )]TJ -22.3989 -1.153 TD [(all indicating )5.5(the urgent ne)7.7(ed for new )5.5(y)-7.2(o)3.7(uth-focused )]TJ 21.2568 0 TD [(p)3.8(r).8(evention app)3.8(r).8(oaches. Am)8.4(o)-7.1(ng responden)3.8(t).2(s who had ev)3.8(er )]TJ -21.2568 -1.153 TD .0009 Tc .0005 Tw [(had sex, 78%)3.3( had their first sexual contact between th)]TJ 21.5902 0 TD .0013 Tc .0001 Tw [(e ages of 14 and 1)4(8)-1.4(. Am)8.6(ong fem)8.6(a)2.5(le respondents, 6)4(2)-1.4(%)3.7( did )]TJ -21.5902 -1.153 TD .0009 Tc .0005 Tw [(not use a con)3.6(dom)8.2( in their last sexual encounter, while)]TJ 21.5355 0 TD .0017 Tc -.0003 Tw [( )5.5(38%)4.1( of m)9(a)2.9(les did n)4.4(o)-1(t use condom)9(s. Among )5.5(out-of-school )]TJ -21.5355 -1.153 TD .001 Tc .0004 Tw [(youth)3.7(,)-.4( 86%)3.4( d)3.7(i).1(d not )5.5(use con)3.7(dom)8.3(s in their last sexual en)-7.2(counter. )5.5( )]TJ ET endstream endobj 253 0 obj <>/Font<>/ProcSet[/PDF/Text]>> endobj 250 0 obj <>stream /GS1 gs BT /TT2 1 Tf 7.98 0 0 7.98 57.6 748.62 Tm 0 g 0 Tc 0 Tw ( )Tj 0 -89.9774 TD .0002 Tc .0002 Tw [( )-29045.1(Page 2 o)-5.5(f)2.4( 29)]TJ /TT4 1 Tf 12 0 0 12 338.28 30.6 Tm 14.61 Tc 0 Tw ( )Tj 10.98 0 0 10.98 57.6 736.6801 Tm .0007 Tc .0007 Tw [(m)8(onitored on a regular basis for STIs and will be rewarded)]TJ 23.6448 0 TD .0003 Tc .0011 Tw [( with cash each ti)-6(m)7.6(e)1.5( t)-6(h)-2.4(eir STI test results are all )]TJ -23.6448 -1.153 TD .0009 Tc .0005 Tw (negative. )Tj T* 0 Tc 0 Tw ( )Tj T* .0008 Tc .0006 Tw [(For our study population i)5.4(n)3.5( Tanzania, cash pay)-7.4(m)8.1(ents w)]TJ 22.224 0 TD .0006 Tc .0008 Tw [(ill be linked to several STI test results: )-5.4(Chlam)7.9(y)-7.6(dia, )]TJ -22.224 -1.153 TD .0011 Tc .0003 Tw [(gonorr)6.2(h)-1.6(ea, syphilis, HSV-2, and trichom)8.4(onas. With t)5.7(h)-1.6(e exception )5.5(of HSV-2, which can be treated but not )]TJ 0 -1.1475 TD .0004 Tc .001 Tw (cured, each of these STIs is curable. This is a cr)Tj 19.3825 0 TD .0008 Tc .0006 Tw [(itical )-5.4(point, si)5.4(nce youth who test positive for a)7.5(n)-1.9( STI can )]TJ -19.3825 -1.153 TD .0005 Tc .0009 Tw [(continue to )5.5(participate in the interven)]TJ 14.9945 0 TD .001 Tc .0004 Tw [(tio)3.7(n after they)-7.2( )5.5(h)3.7(a)2.2(ve been treated and cured )5.5(of the infection. T)5.3(hus, learning )]TJ -14.9945 -1.153 TD .0007 Tc .0007 Tw [(is encouraged through positive reinforcement, and m)8(i)-5.6(st)]TJ 22.1093 0 TD .0009 Tc .0005 Tw [(akes can be corrected and overcome. For bot)5.5(h ethical and )]TJ -22.1093 -1.153 TD .0005 Tc .0009 Tw [(practical reasons, the cash transfers will )-5.4(not be tied to )]TJ 21.7268 0 TD .0006 Tc .0008 Tw (HIV status, and HIV acquisiti)Tj 11.9344 0 TD .0009 Tc .0005 Tw (on will not result in being )Tj -33.6612 -1.153 TD .0013 Tc .0001 Tw [(dropped fr)6.4(om any arm)8.6( of the stud)4(y)-6.9(.)-.1( )5.5( )]TJ 0 -1.1475 TD 0 Tc 0 Tw ( )Tj 0 -1.153 TD .0008 Tc .0006 Tw [(The proposed intervention )5.5(is also likely)-7.4( )5.5(applicable to a vari)]TJ 23.7924 0 TD .0009 Tc .0005 Tw [(ety)-7.3( of s)7.5(o)-1.8(cial and cultural settings due to the )5.5(nature of )]TJ -23.7924 -1.153 TD .0008 Tc .0006 Tw [(the interventi)5.4(on, which is )5.5(neutral about )5.5(the specific behavi)]TJ 23.4481 0 TD .0009 Tc .0005 Tw [(ors required to remain free of infection. For ex)3.6(am)8.2(ple, )]TJ -23.4481 -1.153 TD .001 Tc .0004 Tw [(indivi)5.6(duals may)-7.2( cho)3.7(o)-1.7(se to )5.5(abstain, use condom)8.3(s, or re)]TJ 21.6448 0 TD .0008 Tc .0006 Tw (duce the number and concurre)Tj 12.1312 0 TD .0007 Tc [(ncy)-7.5( )5.5(of sexual partners. )]TJ -33.776 -1.153 TD .001 Tc .0004 Tw [(While information about )5.5(how to prevent)5.6( infection will be )]TJ 23.235 0 TD .0009 Tc .0005 Tw [(provi)5.5(ded )5.5(to all participants, the specific decision will )]TJ -23.235 -1.153 TD .0005 Tc .0009 Tw [(rest in the hands of the individuals themselves.)-6.3( )]TJ 0 -1.1475 TD 0 Tc 0 Tw ( )Tj 0 -1.153 TD .0011 Tc .0003 Tw [(Recognizing t)5.7(h)-1.6(at girls and )5.5(youn)3.8(g wom)8.4(e)-3.1(n m)8.4(a)2.3(y)-7.1( lack the power )]TJ 24.8689 0 TD .0006 Tc .0008 Tw [(to activel)5.2(y)-7.6( particip)3.3(ate in decisions affecting their )]TJ -24.8689 -1.153 TD [(sexual/reproductive health, we have added a psy)-7.6(c)1.8(hosocial)]TJ 23.1749 0 TD .0008 Tc .0006 Tw ( intervention \(gender-based )Tj 11.2678 0 TD .001 Tc .0004 Tw [(counseling and l)5.6(i).1(fe-skills )]TJ -34.4426 -1.153 TD .0006 Tc .0008 Tw [(training\) to strengthen and )5.5(reinforce the effects of the )]TJ 21.6721 0 TD .0008 Tc .0006 Tw [(CCT intervention o)3.5(n)-1.9( behav)3.5(i)-.1(or change. T)5.1(h)-1.9(e psy)-7.4(c)2(h)3.5(o)-1.9(-so)3.5(c)2(ial )]TJ -21.6721 -1.153 TD .001 Tc .0004 Tw [(co)-7.2(m)8.3(ponent of)6.1( the interventi)5.6(on will thus serve to im)8.3(pr)]TJ 21.3607 0 TD .0005 Tc .0009 Tw [(o)-7.7(v)-2.2(e the decision-making capacity)-7.7( of )5.5(participants by)-7.7( )]TJ -21.3607 -1.1475 TD .0006 Tc .0008 Tw [(focusing on STI education, )5.5(gender-power im)7.9(bal)-5.7(a)1.8(nces,)]TJ 21.6612 0 TD .0007 Tw [( )-5.4(and m)8(a)1.9(king deliberate choices in the domain of )]TJ -21.6612 -1.153 TD .0009 Tc .0005 Tw [(sexual/reproductive health. Lim)8.2(ited empirical evidence )]TJ 22.8689 0 TD .0012 Tc .0002 Tw [(suggests that econom)8.5(ic interventions i)5.8(n)-1.5( com)8.5(b)-1.5(ination )]TJ -22.8689 -1.153 TD [(with ps)7.8(y)-7(c)2.4(ho-)6.3(social support)5.8( have greater im)8.5(pact )]TJ 19.1858 0 TD .0001 Tw [(than either t)5.9(y)-6.9(pe of i)5.9(n)-1.4(tervention ta)8(ken singl)5.9(y)-6.9(.)]TJ 7.02 0 0 7.02 463.56 450.72 Tm 0 Tc 0 Tw (i)Tj 10.98 0 0 10.98 465.54 445.74 Tm ( )Tj 7.02 0 0 7.02 468.24 450.72 Tm .0042 Tc (ii)Tj 10.98 0 0 10.98 472.2 445.74 Tm 0 Tc ( )Tj 7.02 0 0 7.02 474.96 450.72 Tm .0042 Tc (iii)Tj 10.98 0 0 10.98 480.9 445.74 Tm 0 Tc ( )Tj -38.5519 -1.153 TD ( )Tj 9 0 0 9 57.6 422.4 Tm (***** )Tj 0 -1.1467 TD ( )Tj 10.98 0 0 10.98 57.6 399.72 Tm .0004 Tc .001 Tw [(Because this is such a novel approach, there are )-5.4(many)-7.8( )]TJ 21.8361 0 TD .0011 Tc .0003 Tw [(unanswered questions on how an intervention )5.5(using s)7.7(u)-1.6(ch )]TJ -21.8361 -1.1475 TD .0012 Tc .0002 Tw [(an approach could )5.5(be or s)7.8(hould be )5.5(designed. Wh)]TJ 21.0109 0 TD .0007 Tc .0007 Tw [(at )5.5(is the appropr)5.8(iate target population? Adolescents? )]TJ -21.0109 -1.153 TD .0009 Tc .0005 Tw [(Geographical hot spot)5.5( areas? Set within)3.6( residential )]TJ 20.8634 0 TD .0008 Tc .0006 Tw [(communities or within social networks? )5.5(What is the )]TJ -20.8634 -1.153 TD .0011 Tc .0003 Tw [(appropriate am)8.4(ount of cash to dispense)7.8(? What i)5.7(n)-1.6(terval )]TJ 22.3388 0 TD .0012 Tc .0002 Tw [(of testing/)5.8(pay)-7(m)8.5(ent is needed? For )5.5(ho)3.9(w long sho)3.9(u)-1.5(l)5.8(d)-1.5( the )]TJ -22.3388 -1.153 TD .0001 Tw [(intervention r)6.4(un? )5.5( What ha)8(ppens when t)5.9(h)-1.4(e m)8.6(oney)-6.9( run)4(s)2.5( )]TJ 22.1694 0 TD .0003 Tc .0011 Tw [(out?)-3.9( What are the risks?)-3.9( )5.5(How do the risks differ in )]TJ -22.1694 -1.153 TD .0013 Tc .0001 Tw [(different potential target po)4(pulation )5.5(grou)4(ps? Wh)]TJ 19.6503 0 TD .0006 Tc .0008 Tw [(at epide)-3.6(m)7.9(iologic setting is m)7.9(o)-2.1(st appropriate? )]TJ -19.6503 -1.153 TD 0 Tc 0 Tw ( )Tj 0 -1.1475 TD .0003 Tc .0011 Tw [(These are )-5.4(absolutely)-7.9( critical questions that have never )]TJ 21.9235 0 TD .0009 Tc .0005 Tw [(been exam)8.2(ined in term)8.2(s of )-5.4(CCTs & STIs/HIV prevention, )]TJ -21.9235 -1.153 TD .0006 Tc .0008 Tw [(which is why we are castin)-7.6(g a wide net in this first )]TJ 21.2077 0 TD -.0001 Tc .0015 Tw [(study)-8.3( and are focusing on an )]TJ 11.7322 0 TD .0009 Tc .0005 Tw [(epidem)8.2(iological context that )]TJ -32.9399 -1.153 TD .0005 Tc .0009 Tw [(is typical)-5.3( of)5.6( the East Afri)-5.8(can areas wh)-7.7(ere y)-7.7(outh are at higher-risk of HIV. )]TJ T* 0 Tc 0 Tw ( )Tj T* .0009 Tc .0005 Tw (We have been careful in the design of)Tj 15.1639 0 TD .0006 Tc .0008 Tw [( this study)-7.6( to ensure that we exp)]TJ 12.8852 0 TD .0009 Tc .0005 Tw [(licitl)5.5(y)-7.3( cons)7.5(ider each of these fundam)8.2(e)-3.3(ntal )]TJ -28.0492 -1.1475 TD .0005 Tc .0009 Tw [(questions and ensure that we are using the best e)-3.7(m)7.8(piri)-5.8(cal)]TJ 22.7814 0 TD [( evidence )-5.4(available. In some)]TJ 11.377 0 TD -.0001 Tc .0069 Tw [( )5.4(ca)-4.3(ses, )5.4(th)-8.3(at m)7.2(eans we have )]TJ -34.1585 -1.153 TD .0008 Tc .0006 Tw [(been able to draw on em)8.1(pirical work in other areas; in)]TJ 21.6339 0 TD .0005 Tc .0009 Tw [( )-5.4(other cases it )-5.4(means that we have built the question into )]TJ -21.6339 -1.153 TD .0003 Tc .0011 Tw [(the study)-7.9( our)5.4(selves because there is little ev)]TJ 17.5519 0 TD .0011 Tc .0003 Tw [(idence to guide interve)7.8(n)-1.6(tion )5.5(design )5.5(decisions. )]TJ -17.5519 -1.153 TD 0 Tc 0 Tw ( )Tj T* .0007 Tc .0007 Tw [(In this study, )5.5(we will i)-5.6(m)8(plement the intervention f)5.8(o)-2(r one y)]TJ 23.4044 0 TD .0008 Tw [(ear in tw)6.9(o districts in )5.5(southern Tanzania and evaluate )]TJ -23.4044 -1.153 TD .0008 Tc .0006 Tw [(its i)-5.5(m)8.1(pact by)-7.4( )5.5(random)8.1(ly)-7.4( assigning 18-)5.9(30 )5.5(y)-7.4(ear old parti)5.4(c)]TJ 21.918 0 TD .0006 Tc .0008 Tw (ipants and their spouses to receive either the CCT )Tj -21.918 -1.1475 TD [(intervention )5.5(or STI testing/treat)-5.7(ment alone. 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럶럶Ꟶꟴ鞲眯㙪ޕ׏ЋɉĉůɸڹֱӪѣϞΙ͕͒͏͎΍Ό΋ΊΉ͈͈͇͇̇̇̇̆͆··Έ͈͇͇̇̆ˆʆʅȆȆȆȆȆȇȆɇʈʈˈˈ͇̈̈̇͆͆΅ͅͅ΄΄΄΄σσστσσ΃̈́̓̃̄̄˄˄˄˄˄˄˄ʄʄʄʄʄʄʄʄʄʄʄʄʄʄʄʄʄ˄˄˄˄˄˄ʄʄʄʄʄ˄˄˄˄˄˅̅̅̅̅̅̅̅̅̅̅̅˅˅˅˅˅˅˅˅˅˅˅˅˅˅˅˅˅˅˅˅˅͇̅̅̅̅̅̅̅̅̅̅͆͆͆͆̇ͅˇɅƄƒǦίԸſ~~uuxooskkoijmhjmkmonrtswzx}}•ȗΙӚ؛ۜߜᜯ䛰曰盰雱꛲뜳휴ힶ흶읶띶띶뜶ꜶꜶ霶霶靶靵ꞵꞵ략랴잴잴잴ힴힴ횷휶휶휶휶휶휶휶휷휷휷휷흷흷ힷ잷쟶쟶럵ꟳ鞲眯㘪ޔ؏ЋɉĉŮɸοڸְөѢϝΘ͔͎͑΍Ό΋ΊΉΈ͇͇͇͇̆̆̆̆͆ΈΈΉΉΉΉ͉͈̈ˇʆȆDžDžDŽƄƅƅƆdžȇɇʈˈ͇̈̈͆͆̅̅̈́̈́ͅ΄΄σσσττττ΄̓̓̃̃˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˅̅̅̅̅̅̅̅̅̅̅̄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˅͇̅̅̅̅̅̅̅̅̅̅͆͆͆ͅͅˇʇȆŅ…œǥͯԸxx{qqtmmqjkojlokmpnpsrvxw{~|Ƙ̚қ֜ڜݝ㜯囯盯蛰꛱뛲휳휵휵흵흶흶읶띶뜶ꜶꜶ霶霶靶靵ꞵꞵ략랴잴잴잴ힴힴ휷휷흷흷ힷힷ쟶쟶럵럳Ʇ蜮䘩ߔ؏ыʉʼnŮɷ;޿ڷְөѢϜΘ͓͍͐͌΋ΊΉΈ͇̆̆˅˅˅˅͇̅͆ΈωϊϊЋЋϋϊΊ͈ˇɇDžƅŃăÃÃÄąņƆȇɇʈˈ̇̆̆̅˄˄̄̄΄΄τσЃττττ΄̓̓̃̃˃˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˃˃˃˃˃˃˃˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄˄̄̄̄̄̄̄̄̄̄̄̃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˄˄˄˄˄˄̄̄̄̄̄̄̄̄̅̅͆̅̆ͅͅˆʆɆdžņ†œǤ̮Ӹyy|ssvmnrklpklplnqnqtruxwz}|ÙɛϜ՝؞ܝߝ❯䜰曰蛰雱뛲웳훴훵융휵흶휶휶윶뜶뜶ꜶꜶ霶霶霶靵ꝵꝵ띵띴이이이흴흴ힶힶ잵랳ꝱ蛮䘩ߔ؏ыʉʼnŮɷ;ݿٷկҨСΜ͉͈͇͗̓̐̍͋͊͆̅̄˄˄˄˄͇̅̆ΉϊЌьэҎҎэЍϋ͉ʈȅń„ÅņƆȇɇˆˆˆ˅ʄʄ˃˃̈́̈́΄΃σττττ΄̓̓̃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˄̄̄̄̄̄̄˄˄˄˄˃˃˃˃˃˃ʃʃʃʃʃʃ˃˃˃˃˃˃˃˃˃˄̄̄̄̄̄̄̄̄̄̄̄̅̅˅˅ʅȅdžƇć‰ÝȥήӸ¿zz}sswnorkkpjlplmroqtrtwvy|{Ȝ͞ӟ؟۟ޞ㞰坰眰霰ꜱ윲휳횳운웴훴휵휵휵휵융뜵뛶꛶꛶零零霶霴ꝴꝴ띴띴이이이이이ힴힴힵힵ잴랲ꝰ蛭嗩َҋˉƉŭɶ̽ݾٶծҧРΛ͖͉͈͇̒̏̌͊͆̄˃˃ʂʃʃʃ˄˅͇ΉЋэҎӐԑԑԑӐюόˊɇŅ…ąƆdžɆɅʅɄɃɃʃʃ̃̓΃΃σσσσσ΃͂̂̂˂˂˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃˃̃̃̃̃̃̃˃˃˃˃˂ʂʂʂʂʂʂʂʂʂʂʂʂʂʂʂʃʃ˃ʃʃʃ̃̃˃˃̃̃̄˄̄˄̄̅˅ʄɄȅƅņĈɌ‘תɦϮո{{}ttwnnrklpjjokmqmotqtwux{z}Ş̠Ѡ֡۠ޠ➰䞰東蜰ꜱ뜲횳욳웴웴웵휵훵훵웵뛵뛵꛵ꚵꚵꚵ꛵霴뜴Ꜵ뜴뜴윴윴윴윴윴흴흴흵흵흵이띲뜯隬嗨َӋ̉lj‹ŭɵ̼ܽٵխҦРΚ͖̑̎̋̊̈̆̅̄̃˂ˁʁɁɁɂʃʅ̇ΉϋюӐԒ֔ו֕ՔԒѐ΍ʊƈÄÅąƅƅDŽDŽǃǃȂɂʃ̃̓͂΃΃΂΂΂΂̂̂˂˂ʂʃʂʂʂʂʂ˂˂˂˂˂˂ʂʂʂʂʂʂ˂˂˂˂˂ʂʂʂʂʂʂ˂˂˂˂˂ʂʂʂʂʂʃ˃˃˃˃˃˃˃˃˃˃˂ʂʂʂʂʂʂʂʂʂʂʂʂʂʂʂʂʂʂʂʂʃ˃˃˃˃˃˃˃˃˃˄˄˅ɅɄDŽńąÇʍÒŘȟ˧аָ{{}stvnorjkoijoikplnsprwux{y}¡ɢУգڢݡࡱ⠰㟰垱睱靱띲흳홲왲왳뚳욳웴융휵훵훵웵뛵뚵뚵뚵ꚵꚵꚵꚵ꛴뛴뛴뛴뛳웳웳웳웳웳윳이흴훵훵훵훵훵훵훵훵횵휴휴윳윱뛯陬喨ڎԊ͈ȉËĬȵ̻ܼشԭѦϟ͚̕ˑˎˋ̉̇̅̄̃˂ʁʀɀȀȀȁȂɄˆ͉ϋЏӑԕחؘؙؙחԕѓ͏Ɍĉ„ÄÄăăĂłƂǂɃʃ˃̂͂̓͂͂͂͂̂́ˁʁʁʂʂʂʂʂʂ˂˂˂˂˂˂ʂʂʂʂʂʂ˂˂˂˂˂ʂʂʂʂʂʂ˂˂˂˂˂ʂʂʂʂʂʂ˂˂˂˂˂˂ʂʂʂʂʁʁʁʁʁʁɁɁɁɁɁɁʁʁʁʁʂʂʂʂʂʂ˂˂˂˂˂˂˃˃˃ʄɄɅȅDŽń҉ÒŘȠ̨ѱ׹ûz{|rsumnpjknhhmhjnjlqnqvsv{x{}Ƥͥӥإܤߢᢱ㠱䟱枱螲ꝱ읲홲왲뙲뚳뚳뚴웴훴휴횴횴운뚴뚴뚴뚴뙴ꙴꙴꚴ꛳뛳뛳웳웳웳웳웳웳웳웳윴휴휴휴휴휵휵훵훵훵훵훵훵훵훵훵훵훵훵훵훵훵훵훵훵훵횵횵횵횵횵횵횵횵횵훴훴웳웱뚮阫斨ᒣڍԊ͈ȈÊĬȴ˻ۻسԬѥϟ͙̕ːˍˊˈˆ˄˃˂ʁɀǀǁȃɅˈ͋ΏђӖיٜڝڞڞל՚і̓ȏȁÁāƂȃʃ˂̂̂̂́́́ˁˁˁʁʁʂʂʂʂʂʂ˂˂˂˂˂˂ʂʂʂʂʂʂ˂˂˂˂˂ʂʂʂʂʂʂ˂˂˂˂˂ʂʂʂʂʂʂ˂˂˂˂˂˂ʂʂʂʂʁʁʁʁʁʁɁɁɁɁɁɁʁʁʁʁʂʂʂʂʂʂ˂˂˂˂˂˂˃ʃʃɃǃDŽńą…“ęȠ̩ѱ׺Žyz{pqsjknghkfgkefkginkmrpsxvy~|ħ˨Ѩרۧޥᣳ㢲䠱埱瞱鞲랲ힳ홲왲뙲뚳뚳뚴뛴웴훴훴홴홴왴뙴뙴뙴뙴뙴뙴뙴뙴뚳욳욳욳욳욳욳욳욳욳욳웴훴훴훴훴훴훴훴훴훴훴훴훴훴훴훴훴훴훴훴훴훴훴훴훴훴횴횴횴횴횴횴횴횴홴횳횳욲우뙮闫敨ᑣۍՊΈɈĊīȳ˺ۺزԫѤϟ͙̕ːˍˊˈ˅˄˂ˁʁɀƀƂDŽɇʊ̎ϒҗ՛ٟڢܤܤۤ٢՞ћ̗ȔÑāƂȂʂ˂̂̂́́́ˁˁˁʁʁʁʁʂʂʂʂ˂˂˂˂˂˂ʂʂʂʂʂʂ˂˂˂˂˂ʂʂʂʂʂʂ˂˂˂˂˂ʂʂʂʂʂʂ˂˂˂˂˂˂ʂʂʂʂʁʁʁʁʁʁɁɁɁɁɁɁʁʁʁʁʂʂʂʂʂʂ˂˂̂̂̂̂˃ʃɂǃłă„ęǠ˨бֹxz{oqrhikcdhacfbcgcejginlnsruzy{ȪϫԪ٩ݨ঳⣳䢲報柱螱Ʝ잲홲왲뙲ꚳꚳꚴ꛴뛴웴웴횳횳혴혴옴똴뙴뙴뙴뙴뙴뙴왴욳욳횳횳횳횳횳횳횳횳횳횴횴횴횴횴횴횴횴횴횴횴횴횴횴횴횴횴횴횴횴횴횴횴횴횴횴횳횳횳횴횴횴횴횴홴횳횲우뙮閫攨ᐣیՉ·ɇĉĪȲ˹ۺزԫѤϞ̔͘ˏˌˉˇ˅˃ʂʁɀ~~~~~ĀłƅLjɌ̑ϗӜסڥݩޫޫݪڨ֥ѡ͝șĖĂǂȂʂ˃˂̂̂́ˁˁˀʀʀʁʁʁʁʂʂ˂˂˂˂˂˂ʂʂʂʂʂʂ˂˂˂˂˂ʂʂʂʂʂʂ˂˂˂˂˂ʂʂʂʂʂʂ˂˂˂˂˂˂ʂɂɂʂʁʁˁˁʁʁɁɁɁɁɁɁʁʁʁʁʂʂʂʂʂʁ˂˂̂̂̂̂˃ʃȂƂƒ™ƠʨϰԹy{|nqrfhj`be]^b]^b_`dbchfinmotsv{{~ƭ̮ҭ׬ܫߩ⦴㤳墲報矱螱Ʝ쟲옲똲꙲꙳陳隴隴ꚴ뚴뚴욳욳횳횳횳횳횳횳횳혴혴옴옴옴옳옳왳왳왳왳왳홳홳홳홳홳홳홳홳홳홳횳횳횳횳횳횳횳횳횳횳횳횳횳횳횳횳횳횳횳횳횳횳횳횳횳홳홳홳홳홳홳홳홱홰똭閪擧ᏢیՉ·ɆĈéDZʸοڹرԪѣϞ̔͘ˏˌˉˇ˅˃ʁʀɀ~~~~~~ÀÃÆŊȏ˕МԢاܭ߰ްۮתҧΣɟŚ~łǂɂʃʃ˂˂ˁˁˁˀʀʀɁɁɁʁʁʁˁˁˁˁˁˁʁʁʁʁʂʂ˂˂˂˂˂ʁʁʁɁʁʁʁʁˁˁʁʁʁɁɁʁʁʁˁˁˁʁʁʁɁɁʁʁʁˁˁʁʁʁʁɁɁʁʁʁˁˁʁʁʁɁʁʁʁ˂˂̂̂̃̂˃ɃǂĂġɩαԹļ|}prtfhj^acZ[_WY^Y[_\^cabgfinnpuux}}ïʰбկٮެ੶⦴䤳墲栱矰鞱랲ퟲ옲똲꙲陴陳隵隵隵ꚵꚴ뙴뙳왳왳왳왳홳홳홳홳헳엳엳옳옳옳왳왳옳혳홲홳홳홳홳홳홳홳홳홳홳홳홳홳홳홳홳홳홳홳홳홳홳홳홳홳홲홲홲홳홳홳홳홳홯옭镪擧ᏢۋՈΆȅćèǰʸξڹױӪѣΞ̔͘ˏˌˈˆ˄˃ʁʀɀ~~~~}~~ÌƓ˙Рէٮݲ޶۳ױӬΨʣŞÂłǂȃɃʂʂʁʂʁʀɀɀɀɀɁʁʁʁˁˁˁˁˁʁʁʁɁʁʂʂ˂˂˂˂˂ʁʁʁɁʁʁʁʁˁˁʁʁʁɁɁʁʁʁˁˁˁʁʁʁɁɁʁʁʁˁˁʁʁʁʁɁɁʁʁʁˁˁʁʁʁɁʁʁʁ˂˂̂̂̃˃ʃȃƂ‚¡ǩͱӹƽ~rtwgjm^aeX[^UW[TV[VY^[]b`chgjoorwwzƲͳҲױۮ߬᩶㦴夳桲栱蟰鞱랱ힲ옲똲阳陴虴虵蚵蚵蚵隴ꙴ꙳뙳뙳뙲뙲왲왲왲홲홲홲헳엳엳옲옲옲혲혳혳홲홳홳홳홳홳홳홳홳홳홳홳홳홳홳홳홳홳홳홳횱횲홲홲홲혲혲홲홲홲홲혯역镪咧ڊՇ΅ȄćçǯʷξڸװөѢΝ͗̓ˎˋˈˆ˄˃ʁʀɀ~~~}}~}~ŕʝϤԬزܷߺ߼߼޺۹ضԲЭ˧Ƣž‚ĂƂƂǂȂɁɁɀɀȀȀȀȀȁɁɁʁʁʁˁˁˁʁʁʁɁʁʂʂ˂˂˂˂˂ʁʁʁɁʁʁʁʁˁˁʁʁʁɁɁʁʁʁˁˁˁʁʁʁɁɁʁʁʁˁˁʁʁʁʁɁɁʁʁʁˁˁʁʁʁɁʁʁʁ˂˂̂̂˂ʂɃǃĂũ̲Һƿtvyiko`cgX[_SV[QTXQTZUX]Z]badihkqqtyy|óɴϵմٱܯସ⩶㦴夳桲砱韰Ʇ잱헱뗲ꗲ阳蘴瘴癵癵癵虵虴阴阳꘳꘳꘲꘲똲똲똲옲혲혲햳햳헳헲헲혲혲혲혲혲혲혲혲혲혲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愢惢烢焢無脡脡膠膠膠膠膠膠膠腠腡腡腡腡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡脡胡胡胡胡胡脡脡脡脡脡脡脡脡脡胡胡腡脡脡脡脡脡脡脡脡脡脡腡腡煡煡煡煡烡無無炡股聣聣聣肢肤肤脢焢愢僢䂡⁠{wtqqrv}ðȺֶЫ̢Șď|wusqponnmmmmmmmmmmlllmmnnoooooooooppppoonnnnoonmkh~f{dybv_t]r^rasfwn~xú{{op}dfuZ^oSWkLRiHOiGNkFNnFOqFQtGRxIU|KXN\Q`TdWgZk\n_rbucvdyf{g}giiijklllllmmmkjgd{bxauatctfulys~~øּ׸ٲڬܥݠߛᒬ⏪㍩䋨㉦㇥ㆤㅢㄢㄡ䄡䃡僡僡惡烠脠脠脠酠酠酠酠鄠鄠鄠鄠鄠脡脡脡無無無無無無無無脠脠鄠鄠鄠鄠鄠鄠鄠鄠鄠胡胡烡烡烡烢烢烢烢烢烢脡脡脡鄡酠酠酠酠酠酠酠酠鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡鄡鄡鄡鄡鄡鄡鄡鄡鄡鄡脡脡脡無無無無烡烡烡炡股聢遢遢邢那那胢烢惢僢ァ {wtqqrv|ðȺֶЫˡǘď|wtrqpnmmmmmmmmmllllllllnnnnnnnnnnnooooonnnnnnonlkig}e{cx`u^s^r_rdtjzs~Ļ~~rsgjx^aqUYmOTjJPiGNiFNmFOpFPtGRwHT{JWM[P_SbVfYi\m_patcvdxezf{h}hijjkllmmmmmmmkig~czax`u`tbsfukys~}÷ʿ׽ظٲڬܥݠޚߕᒫ⏪⌨㊧㈦㇤ㆣㅢㄡメム䂠䂠僠僠惠烠焠脠脠鄠鄠鄠鄠鄠鄠鄠鄠脡脡脡無無烡烡烡烡烡烡脠脠鄠鄠鄠鄠鄠鄠鄠鄠鄠胡胡烡烡烡烡烡烡烡烡烡脡脠脠鄠酟酟酟酟酟酟酟酟鄠鄠鄠鄠郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡鄠鄠鄠鄠鄠鄠鄠鄠鄠鄠脠脡脡無無無無烡烡烡炡股聢遢遢邢那那胢烢惢傡だ‟~zvsppqu|°ǺֶЫˡǗÎ{vtrqpnmmlllllllllllllllmmmmmmmmmmmnnnnnnnnnnnnmlkjh~f|dyav_t^r^qargwn|wüĻtuiky`csX\nQVkLRiHOjFNkFOoFPsGRwHT{JVLYO]RaUeYi\l^pascvexfyf{g|h}hijjkllmmmmmmmkif}cyaw`t`sbsfukys~}÷ʿ׽ظٲڬܥݠޚߕᎩ⌨㊧㈦㇤ㆣㅢㄡメム䂠䂠傠傠悠烠烠胠脠鄠鄠鄠鄠鄠鄠鄠鄠脡脡脡無無烡烡烡烡烡烡脠脠鄠鄠鄠鄠鄠鄠鄠鄠鄠胡胡烡烡烡烡烡烡烡烡胡脠脠鄠鄠酟酟酟酟酟酟酟酟鄠鄠鄠鄠郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡鄠鄠鄠鄠鄠鄠鄠鄠鄠鄠脠脡脡無無無無烡烡烡炡股聢遢遢邢那那胢烢惢傡だ‟~zvsppqu|°ǺֶЫˡǗÎ{vtrqpnmlllllllllkkkkkkklllllllmmmmmmmmmmmmmmmmllkjig}ezbx_u^r^q`qdtjxr}|ƿŻvwklyadsZ]nSWkMSiIPiFNjEMlFOqFQvHSzIV~LXN[Q_TcWg[k]n`rbudwfygzg|h}i~ijkklmmmmmmmmmkif}cyaw`t`sbsfukys~}÷ʿ׽ظٲڬܥݠޚߕᎩ⌨㊧㈦㇤ㅣㅢㄡメム䂠䂠傠傠悠烠烠胠脠鄠鄠鄠鄠鄠鄠鄠鄠脡脡脡無無烡烡烡烡烡烡脠脠鄠鄠鄠鄠鄠鄠鄠郠郠胡股炡炡炡炡炡炡炡烡胡脠脠鄠鄠酟酟酟酟酟酟酟鄟鄠鄠鄠鄠郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡邡邡邡邡邡邡邡邡郡郡郠鄠鄠鄠鄠鄠鄠鄠鄠鄠脠脡脡無無烡烡烡炡炡炡股聢遢遢邢那那肢炢悢傡だ‟~zvsppqu|°ǺֶϫʡƗzvsqpomllkkkkkkkkkkkkkkkkkkkkllllllmllllmmmmmmmlkjjih~f{cx`u_s^q_qbsfumyuƼwzlo{besZ]nTXkNThJPhGNiFMkENnFPsGRxIU~KXM[P^SbVeXi\m_pbtcvexgzh{g}h~i~ijkklmmnnnnnmmkif|cxaw`s`rbsfukys~}¶ɿؽٸڲڬܥݟޙߔ፩⋨㉧㇦ㆤㅣㄢメメ゠䂠䂟傟傟傠惠惠烠焠鄠鄠鄠郠郠郠郠郠胡胡胡烡烡烡烡烡烡烡烡脠脠鄠鄠鄠鄠鄠郠郠郠郠股股炡炡炡炡炡炡炡炡炡胠胠脠鄠鄟鄟鄟鄟鄟鄟鄟鄟郠郠郠郠郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡邡邡邡邡邡邡邡邡邡邡邡邡郠郠郠郠郠郠郠郠郠郠胠胡胡烡烡烡烡炡炡炡灡聡聢聢遢遢遣遣肢炢悢偡䀠}zvsppqu|°ǺնϪʠƖzusqpomlkkkkkkkkkjjjjjjjjjjkkkklllllklllllmmlllkkjjih~f|dyav_t_r_qardsiupzyľȼx{mp}cfu[^nTWkOShKQgHNhFMjEMmENqGRvHT|JWMZO]Q`UdWhZk^o`rcudxfyg{h|h~iijkkllmmnnnnnmmkie|bx`v_s_rasftkxs~}¶ɾؽٸڲ۬ܤݟޙߔ፨⋧㉦䇦䆤䄣䄢䃡䃡゠䂠䂟䁟偟偟惟悟炟烟胟胟胟胠胠郠郠郠胡胡胡胡胡胠胠胠胠胠胠脟鄟鄟鄟鄟鄟鄠郠郠邠邡邡遡聡聡聡灡灡灡灡炠炠胠胟脟鄟鄟鄟鄟鄟鄟鄟鄟郟郠郠郠郠郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡郡邡邡遡遡遡遡遡遡遡遡邡邡邠郠郠郠郠郠郠郠郠郠胠胡胡胡胡炡炡炡恡恡恡聡灢聢遢遢遣遣聢灢灢恠䀟}yvroopt{°ǺۿյϪʠƖzusqpomlkjjjjjjjkjjjiiiiiiijjkkkkkklkkkklllllllkkjjig~f|dzbw`u`s`r`rcqfslvs|}ʿôx|nr~dhw\`pUYkOTiLQgIOgGNiFMlFNpFPtHSyJVLYO]Q`ScVfYj[m_qascveyfzh|i}h~ijjkllmnnnnnnnmlkhe|bx`v_s_rasetkxs~}µɾٽڷڱ۫ܤݟޘߓጨ⋧㉦䇥䆤䄣䄢䃡䂡䂠䁠䁟䁟偟偟悟悟炟烟胟胟胟胠胠胠胠胠胠胠胠胠胠肠肠肠肠肠肠胟郟郟郟郟郟郠郠郠邠邡邡遡聡聡聡灡灡恡恡悠炠烠烟胟胟脟脟脟脟脟脟脟胠胠胠胠胠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠股聡聡聡聡聡聡聡聡股股肠胠胠胠胠胠胠胠胠胠胠胠胠胠胠炠炡炡恡恡恡灡瀡耡耡聡聢聢聡灡灡恠~|yvroopt{¯ǹۿյϪʠƖyurponlkjjjjjjjjjiiihhhhhihiijjkkkkkjjjjkkkkkkkjjiihg~f|e{bxavauas`rbqdqhrmwv}»ŷv{mq}diw\arUZmOTiLPhIOgGNiGNkFOoGPsHRxJV}LYN\Q`ScUfXiZl]o`rbtdxfzg{h}i~ijjkllmmnnnnnnnmlkhe|bx`v_s_rasetkxs~}Ⱦٽڷ۱۫ܤݞޘߓጨ⊧㈦䆥䅤䃣䃢䂡䂡䁠䁠䁟䁟偟偟悟悟炟烟胟胟胟肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠胟郟郟郟郟郟郠邠邠遠遡遡逡耡耡耡瀡瀡怡怡恠恠炠炟烟胟胟胟胟胟胟胟胟肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠聠聡耡耡耡耡耡耡耡耡聡聡聠肠肠肠肠肠肠肠肠肠肠肠肠肠肠灠灡灡怡怡怡瀡瀡瀡耡耡耢耢耡瀡瀡怠~|yvroopt{¯ǹۿյϪʠƖyurponlkjjjjjjjjjiiihhhhhhhiijjkkkkkjjjjkkkkkkkjjiihg~f|e{cybwbvbtasapbodpispxyƽɻv{kq}chv[arUZnPUjKQhINgGNhGNkGOnGPrIRwJT|LXN[P^SbUeWhZk\n^qatcveyg{h|i~j~jjjkllmmnnnnnnnmlkhe|bx`v_s_rasetkxs~}Ⱦٽڷ۱۫ܤݞޘߓጨ⊧㈦䆥䅤䃣䃢䂡䂡䁠䁠䁟䁟偟偟悟悟炟烟胟胟胟肠肠肠肠肠肠肠肠肠肠肠肠肠肠聠肠胟邟郟郟郟郟郠邠邠遠遡遡逡耡耡耡瀡瀡怡怡恠恠炠炟烟胟胟胟胟胟胟胟胟肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠肠聠聡耡耡耡耡耡耡耡耡聡聡聠肠肠肠肠肠肠肠肠肠肠肠肠肠肠灠灡灡怡怡怡瀡瀡瀡耡耡耢耢耡瀡瀡怠~|yvroopt{¯ǹۿյϪʟƕŒ~xtqonmkjiiiiiiiiihhhgggggggihjjkkkkkjjjjjjjjkkkjjiihg~f}e|dzcycxbuas`p`namdojsrz}ǿijx~lq}aguZ`pSYmOUjKQiGNhFMhFMjFNmGPqHRvJT{KWN[O^RaTeWhXj[m]p_sbudwfzh|i}i~jjkklllmmnnnnnnnmkkge{bx_u_s_rasdtjxr~|Ǿٽڷ۱۫ܤݞޘߓጧቦ⇥ㅥㄣアアちち䀠䀠䀟䀟借偟恟悟炟烟胟胟胟肠聠灠灠灠灟灟炟肟聟聠聠聠聠聠聠炟邟肟肟肟肟肠肠肠聠耠遡怟怟灠灞烞胞肞肞肞肞肞胞胞肠肠肠肠聠聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟聟耟耠耠耠耠聠聠聠聠聠灠灠灠灠灠灟炟肟肟瀟瀡瀡瀠瀠耠~|yvroopt{¯ǹ۾մЪʟƕŒ~xtqonmkjiiiiiiiiihhhggggggghhiikkkkjiiiijjjjkjjjjiigf~f}e}d{dzcycvat`p^m_lamfpmuv}úǸ}ouciwY_pSYkMTjJPhGNhELhDLjEMlFOqHQuITzLWMYO]Q`ScVgXjZm\o^r`tcweyf{i}i~jkkkklllmmmmmmmmmlkjg~e{bx_u_s_rasdtjxr~|Ǿٽڷ۱۫ܤݞޘߓጧቦ⇥ㅤㄣアァだだ䀠䀠䀟䀟借借灟灟聟肟肟肟肟肟聟灟灟灟灟灟灟灟灟灠灠瀠瀠瀠灠灟聟肟肟肟肟肟聟聟聟耠耠怟怟灟灞炞肞肞肞肞肞肞肞肞肟聟聟聟聟聟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耟耠耠耠耟聟灟灟灟聟灟灟灟灟灟灟灟灟灟瀟瀠瀠~|yvroopt{ƸִܾЩ˟ƕŒ}wspnmlkjiiiiiiiiihhhggfffgghhiijjjjjiiiijjjjjjjjjihgff}e}e|dzcycwat`p]m]k^kbnhrpyzŽȻtyfm{[brRYlMTiIPhGNhEMiDLjDMlENpGQuITzKVMYN\Q`ScUfWiZl[o]q_savdxfzg|i~jjkklllllmmmmmmmmmlkjg~d{aw_u^r^q`rdtjxq~|ǽؼٶڰڪۣܝݗޒߎቦ⇥ㅤㄢァァだ〠〠怟瀟灟聟肟肟肟肟灟灟灟灟灟灟灟灟灟瀟瀟瀟瀟瀞耞聞聞聞聞聟聟聟耟耟耠怟怟恟灞炞炞炞炞炞炞炞炞炞灟灟灟灟瀟瀟瀟瀟瀟灟灟灟灟灟灟灟灟灟灟灟灟灟灟怟怠怠~}{xvqnnoszƸִܾѩ˞Ɣ‹}wspnmljihhhhhhhhhgggfffffgghhiijjjjjiiiiiiiijjjjjihgff~e~e|e{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We w)7.9(o).7(uld )]TJ -25.545 -1.3 TD -.0012 Tw [(be even mo)5.6(re tenta)5.6(t)-1.4(ive if the results w)7.8(ere only )]TJ 19.8 0 TD .0003 Tc -.0053 Tw (statistically significan)Tj 9.195 0 TD -.0016 Tw (t during an early time )Tj -28.995 -1.3 TD -.0004 Tw [(point rathe)4.2(r)-.8( than the final time point; how)7.6(e)-.8(ver )]TJ 20.22 0 TD .0005 Tc -.0005 Tw [(the pattern)6.7( of increas)4.7(i)3.3(ng effect ov)5.5(er time is )]TJ -20.22 -1.3 TD 0 Tc 0 Tw [(consistent w)7.2(i)-2.2(th our a priori hypothesis and )]TJ 18.475 0 TD .0003 Tc -.0003 Tw [(indeed is the reason w)7.5(h)1.5(y w)7.5(e)-.9( structured the )]TJ -18.475 -1.3 TD .0002 Tc -.0012 Tw [(intervention to have multiple incentiviz)9(ed te)]TJ 18.745 0 TD -.0002 Tw (sting rounds. 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For exa)5.5(m)-1.5(ple, w)7.7(h)1.7(ere w)7.7(e)-.7( report )]TJ 18.99 0 TD .0001 Tc -.0008 Tw [(a relative risk of 0.73, the correspo)5.1(nding odds )]TJ -18.99 -1.3 TD 0 Tc -.0005 Tw [(ratio w)7.2(o)0(uld have been reported as 0.69. 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T)4.3(h)-3(e paper )6(states that )]TJ 17.8683 0 TD [(the po)7.1(wer c)5(a).8(lculation was based on an )]TJ -17.8683 -1.5569 TD -.0027 Tc .0044 Tw [(in)-4.6(ciden)-4.6(c)-2.7(e rat)-3.9(e).2( of)-4.4( 12%)-4.4(,)1.8( )6(con)-4.6(t)-3.9(roll)-3.7(in)-4.6(g for on)-4.6(e baselin)-4.6(e measu)-4.6(r)-7.1(e f)-4.4(o)-.6(r a on)-4.6(e-t)-3.9(h)-4.6(ird )]TJ T* -.0009 Tc .0026 Tw (reduction requiring 2400 individuals with)Tj 20.5749 0 TD -.0002 Tc .0019 Tw [( no)7.9( mention of a)7.6(n)3.9(y drop-o)7.9(ut. )6( )6( )]TJ -20.5749 -1.5569 TD 0 Tc 0 Tw ( )Tj /TT2 1 Tf 12 0 0 12 72 488.58 Tm .0007 Tw [(In the revised Sample siz)8.8(e)-1.2( section w)7.2(e)-1.2( have)]TJ 18.91 0 TD .0006 Tc -.0014 Tw [( now)7.8( explicitly indicated that the po)5.6(w)7.8(er )]TJ -18.91 -1.3 TD -.0026 Tw [(calcula)5.6(t)-1.4(ion presented is)4.8( an ex-post calcula)5.6(t)]TJ 18.195 0 TD .0004 Tc -.0025 Tw [(ion based on the observed properties of the )]TJ -18.195 -1.3 TD .0001 Tc -.0001 Tw (actual recruited sample and infection rates. )Tj 19.005 0 TD .0007 Tw [(In the origin)6.3(al manuscript submission w)7.3(e)-1( had )]TJ -19.005 -1.3 TD .0003 Tc -.0003 Tw [(presented the pow)7.5(er calculations from the s)4.5(t)-1.7(udy)]TJ 20.5 0 TD .0006 Tc -.0012 Tw [( protocol,)5.6( but w)7.8(ere asked to remove these. )]TJ -20.5 -1.3 TD .0004 Tc -.0004 Tw [(We agree w)7.6(i)-1.8(th the earlier review)7.6(ers that the p)6.6(o).4(w)7.6(er calculations corresponding to our )]TJ T* 0 Tc -.001 Tw (actual data analysis are most di)Tj 13.425 0 TD .0002 Tc -.0009 Tw (rectly relevant for readers. )Tj -13.425 -1.3 TD 0 Tc 0 Tw ( )Tj /TT8 1 Tf 10.02 0 0 10.02 72 378.9 Tm -.0029 Tc .0046 Tw [(2.)-4.4( )-3215.6(C)-5.3(a)-1.1(lcu)-4.8(l)2.1(at)-4.1(ion)-4.8( of)-4.6( P)-4.7(-)2.1(v)-3.9(a)-1.1(lu)-4.8(es )6(bet)-4.1(w)-4.9(een)-4.8( ran)-4.8(d)-2.6(omiz)-4.5(ed grou)-4.8(ps at basel)-3.9(i)2.1(n)-4.8(e)0( is i)-3.9(llo)-6.7(gical )-7.9( )]TJ 0 -1.5569 TD -.0002 Tc .0019 Tw [(the P)4(-val)4.8(u)-2.1(e)8.7(s)-.2( i)4.8(n)-2.1(di)4.8(cate t)4.6(h)-2.1(e probabi)4.8(l)4.8(i)-1.2(ty t)4.6(h)-2.1(at)4.6( di)4.8(ffe)8.7(rences have)8.7( occurred b)6.1(y)-1.2( cha)7.6(n)-2.1(ce )6.8( )]TJ T* -.0017 Tc .0034 Tw [(as all differ)-6.1(e)1.2(nces are crea)]TJ 12.9042 0 TD -.0006 Tc .0023 Tw [(ted by ra)7.2(ndomization, )6(they)]TJ 13.6108 0 TD [( mus)5.4(t)-1.8( ha)7.2(ve occurred by )]TJ -26.515 -1.5569 TD -.0026 Tc .0043 Tw [(ch)-4.5(an)-4.5(ce, so )6(w)-4.6(h)1.5(y)-3.6( calcu)-4.5(l)2.4(at)-3.8(e a probabilit)-3.8(y)-3.6(?)-2.1( Wh)-4.5(at is import)-3.8(an)-4.5(t is t)-3.8(h)-4.5(e magn)-4.5(it)-3.8(u)-4.5(d)-2.3(e of )]TJ T* -.0008 Tc .0025 Tw [(the differences, no)7.3(t the)8.1( P-values. )6(Please)]TJ 20.6228 0 TD -.0005 Tc .0022 Tw [( remove the )6(P-)4.5(v)4.5(a)1.3(l)4.5(u)-2.4(es from Tabl)4.5(e 1 and)5.8( )]TJ -20.6228 -1.5569 TD -.001 Tc .0027 Tw [(the baseline data sec)5(t)-2.2(ion of the)7.9( results.)]TJ 19.8862 0 TD -.0016 Tc .0033 Tw [( )6(The )6(use of 2 )6(decimal places )-6(on the )]TJ -19.8862 -1.5569 TD -.0023 Tc .004 Tw [(percen)-4.2(t)-3.5(a)-.5(ges in)-4.2( t)-3.5(h)-4.2(is )6(t)-3.5(a)-.5(ble is also n)-4.2(o)-.2(t)-3.5( ju)-4.2(st)-3.5(if)-4(ied it)-3.5( impli)-3.3(e).6(s ex)-3.3(cessiv)-3.3(e).6( precision)-4.2(.)-9.8( )]TJ T* .0017 Tc 0 Tw ( )Tj /TT2 1 Tf 12 0 0 12 72 254.58 Tm .0003 Tc -.001 Tw (We have removed the p-values from table 1 )Tj 18.78 0 TD -.0002 Tc .0002 Tw (and from the baseline data section of the )Tj -18.78 -1.3 TD 0 Tc -.0012 Tw (results. 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.8852 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD -.0011 Tc (be)Tj /TT17 1 Tf 1.0437 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0005 Tc (incontrovertibly)Tj /TT17 1 Tf 6.7049 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD -.0002 Tc [(link)-6.6(e).5(d)]TJ /TT17 1 Tf 2.5519 0 TD 0 Tc <0003>Tj /TT18 1 Tf .2295 0 TD -.0024 Tc (to)Tj /TT17 1 Tf .8852 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0002 Tc (risky)Tj /TT17 1 Tf 1.9563 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0051 Tc [(sex)5.6(u)6.2(a)6.9(l)]TJ /TT17 1 Tf 2.6503 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0003 Tc [(activi)-5.5(ty,)]TJ /TT17 1 Tf 3.306 0 TD 0 Tc <0003>Tj /TT18 1 Tf -37.5683 -1.4044 TD -.0012 Tc [(ther)-6.4(e)]TJ /TT17 1 Tf 2.2459 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0003 Tc (is)Tj /TT17 1 Tf .6503 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0017 Tc [(som)-4.5(e)]TJ /TT17 1 Tf 2.2623 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD -.0003 Tc [(unce)-5.1(r)0(tain)-4.7(ty)]TJ /TT17 1 Tf 4.8087 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD -.0018 Tc [(ar)-7(oun)-6.2(d)]TJ /TT17 1 Tf 3 0 TD 0 Tc <0003>Tj /TT18 1 Tf .2295 0 TD -.0004 Tc [(trans)-5.8(m)-1.1(ission)]TJ /TT17 1 Tf 10.98 0 0 10.98 321.12 538.4401 Tm 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .003 Tc [(pa)4.8(thw)4.9(a)4.8(ys.)]TJ /TT17 1 Tf 4.3005 0 TD .0034 Tc <00030003>Tj /TT18 1 Tf .4535 0 TD .0044 Tc [(Ra)6.2(th)5.5(er)]TJ /TT17 1 Tf 2.8087 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD -.0004 Tc (than)Tj /TT17 1 Tf 1.918 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD (risk)Tj /TT17 1 Tf 1.4863 0 TD <0003>Tj /TT18 1 Tf .224 0 TD .0002 Tc (penalizing)Tj /TT17 1 Tf 4.224 0 TD 0 Tc <0003>Tj /TT18 1 Tf -35.4973 -1.4044 TD -.0001 Tc (participants)Tj /TT17 1 Tf 4.9618 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .006 Tc [(fr)6.3(o)8.1(m)]TJ /TT17 1 Tf 2.0273 0 TD 0 Tc <0003>Tj /TT18 1 Tf .2295 0 TD -.001 Tc [(tes)-6.4(t)1.4(ing)]TJ /TT17 1 Tf 2.8579 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0023 Tc [(po)4.4(sit)4.7(i)2(ve)]TJ /TT17 1 Tf 3.2951 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0003 Tc (if)Tj /TT17 1 Tf .5628 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0058 Tc (it)Tj /TT17 1 Tf .5956 0 TD 0 Tc <0003>Tj /TT18 1 Tf .2295 0 TD .0035 Tc [(wa)5.3(s)]TJ /TT17 1 Tf 1.6393 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0032 Tc [(un)4.3(re)3.9(la)5(te)3.9(d)]TJ /TT17 1 Tf 4.0656 0 TD 0 Tc <0003>Tj /TT18 1 Tf .2295 0 TD -.0024 Tc (to)Tj /TT17 1 Tf .8852 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0002 Tc (risky)Tj /TT17 1 Tf 1.9563 0 TD 0 Tc <0003>Tj /TT18 1 Tf .2295 0 TD -.0003 Tc [(beh)-4.7(a)-3.9(vior,)]TJ /TT17 1 Tf 3.9454 0 TD 0 Tc <0003>Tj /TT18 1 Tf .2295 0 TD -.0019 Tc (we)Tj /TT17 1 Tf 1.2514 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0011 Tc (chose)Tj /TT17 1 Tf 2.3989 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .003 Tc (to)Tj /TT17 1 Tf .8852 0 TD 0 Tc <0003>Tj /TT18 1 Tf .2295 0 TD -.0006 Tc (use)Tj /TT17 1 Tf 1.4426 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD -.0024 Tc [(th)-6.8(e)]TJ /TT17 1 Tf 1.388 0 TD 0 Tc <0003>Tj /TT18 1 Tf -37.5519 -1.4098 TD .0003 Tc (aggregate)Tj /TT17 1 Tf 4.1257 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0002 Tc (results)Tj /TT17 1 Tf 2.7923 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0003 Tc (in)Tj /TT17 1 Tf .7869 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD -.0024 Tc [(th)-6.8(e)]TJ /TT17 1 Tf 1.388 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0078 Tc [(co)9.9(m)7.1(p)3.4(o)9.9(s)7.8(i)7.5(t)4.8(e)]TJ /TT17 1 Tf 4.3497 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0004 Tc (measure)Tj /TT17 1 Tf 3.612 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .003 Tc (to)Tj /TT17 1 Tf .8852 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0048 Tc [(in)5.9(cre)5.5(a)6.6(s)4.8(e)]TJ /TT17 1 Tf 3.4699 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0044 Tc [(po)6.5(w)6.4(e)-.4(r)]TJ /TT17 1 Tf 2.6831 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .006 Tc [(fo)8.1(r)]TJ /TT17 1 Tf 1.2131 0 TD 0 Tc <0003>Tj /TT18 1 Tf .2295 0 TD -.0018 Tc (the)Tj /TT17 1 Tf 1.388 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD -.0001 Tc [(s)-5.5(t)2.3(udy.)]TJ /TT17 1 Tf 2.5683 0 TD 0 Tc <0003>Tj /TT18 1 Tf -31.7322 -1.4044 TD .0009 Tc (We)Tj /TT17 1 Tf 1.4098 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0034 Tc [(ha)5.2(ve)]TJ /TT17 1 Tf 2.0109 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0048 Tc [(mod)5.9(i)4.5(f)4.3(i)4.5(e)5.5(d)]TJ /TT17 1 Tf 3.7486 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD -.0024 Tc [(th)-6.8(e)]TJ /TT17 1 Tf 1.388 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0041 Tc [(sen)5.2(t)6.5(en)5.2(ce)]TJ /TT17 1 Tf 3.7596 0 TD 0 Tc <0003>Tj /TT18 1 Tf .2295 0 TD -.0015 Tc [(abo)-4.9(u)-.4(t)]TJ /TT17 1 Tf 2.4536 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD -.0024 Tc [(th)-6.8(e)]TJ /TT17 1 Tf 1.388 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0041 Tc [(la)6(ck)]TJ /TT17 1 Tf 1.6448 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD -.0021 Tc (of)Tj /TT17 1 Tf .8579 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD -.0006 Tc [(f)-6.6(a)1.3(miliari)-6.4(ty)]TJ /TT17 1 Tf 4.2842 0 TD 0 Tc <0003>Tj /TT18 1 Tf .2295 0 TD -.0021 Tc (of)Tj /TT17 1 Tf .8525 0 TD 0 Tc <0003>Tj /TT18 1 Tf .2295 0 TD -.0001 Tc (participants)Tj /TT17 1 Tf 4.9618 0 TD 0 Tc <0003>Tj /TT18 1 Tf .2295 0 TD -.0015 Tc (and)Tj /TT17 1 Tf 1.5683 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0012 Tc (clinicians)Tj /TT17 1 Tf 3.7978 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD -.0022 Tc [(wi)-8(th)]TJ /TT17 1 Tf 1.8743 0 TD 0 Tc <0003>Tj /TT18 1 Tf -39.1585 -1.4098 TD (m)Tj /TT17 1 Tf .8142 0 TD <0003>Tj /TT18 1 Tf .224 0 TD -.0002 Tc (Gen,)Tj /TT17 1 Tf 1.9399 0 TD 0 Tc <0003>Tj /TT18 1 Tf 10.98 0 0 10.98 143.16 476.64 Tm .0013 Tc (and)Tj /TT17 1 Tf 1.5683 0 TD 0 Tc <0003>Tj /TT18 1 Tf .2295 0 TD .005 Tc [(re)5.7(p)6.1(l)4.7(a)6.8(c)2.7(ed)]TJ /TT17 1 Tf 3.6011 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0058 Tc (it)Tj /TT17 1 Tf .5956 0 TD 0 Tc <0003>Tj /TT18 1 Tf .2295 0 TD -.0022 Tc [(wi)-8(th)]TJ /TT17 1 Tf 1.8743 0 TD 0 Tc <0003>Tj /TT18 1 Tf .2295 0 TD -.0019 Tc (an)Tj /TT17 1 Tf 1.0328 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0001 Tc [(ex)-4.9(plan)-4.3(ati)-5.7(o)2.2(n)]TJ /TT17 1 Tf 4.9454 0 TD 0 Tc <0003>Tj /TT18 1 Tf .2295 0 TD -.0021 Tc (of)Tj /TT17 1 Tf .8525 0 TD 0 Tc <0003>Tj /TT18 1 Tf .2295 0 TD -.0015 Tc (why)Tj /TT17 1 Tf 1.7596 0 TD 0 Tc <0003>Tj /TT18 1 Tf .2295 0 TD (m)Tj /TT17 1 Tf .8142 0 TD <0003>Tj /TT18 1 Tf .224 0 TD .0007 Tc (Gen)Tj /TT17 1 Tf 1.6831 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0003 Tc (can)Tj /TT17 1 Tf 1.4536 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0044 Tc (be)Tj /TT17 1 Tf 1.0437 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD -.0009 Tc [(us)-6.3(ed)]TJ /TT17 1 Tf 1.9781 0 TD 0 Tc <0003>Tj /TT18 1 Tf .2295 0 TD -.0024 Tc (to)Tj /TT17 1 Tf .8852 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD -.0006 Tc [(inc)-8.4(r)-.3(ease)]TJ /TT17 1 Tf 3.4645 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .004 Tc [(po)6.1(we)4.7(r)]TJ /TT17 1 Tf 2.6831 0 TD 0 Tc <0003>Tj /TT18 1 Tf .2295 0 TD -.0011 Tc (but)Tj /TT17 1 Tf 1.4208 0 TD 0 Tc <0003>Tj /TT18 1 Tf -38.4863 -1.4044 TD .0003 Tc (is)Tj /TT17 1 Tf .6448 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD -.0001 Tc (less)Tj /TT17 1 Tf 1.5519 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .0004 Tc [(appr)-4.8(opriate)]TJ /TT17 1 Tf 4.9508 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD .006 Tc [(fo)8.1(r)]TJ /TT17 1 Tf 1.2186 0 TD 0 Tc <0003>Tj /TT18 1 Tf .224 0 TD -.0003 Tc [(conditi)-6.1(on)-4.7(ality.)]TJ /TT17 1 Tf 6.0273 0 TD 0 Tc <0003>Tj /TT8 1 Tf 10.02 0 0 10.02 72 432.72 Tm -.0003 Tc .002 Tw [(I al)4.7(so have )6(a questi)4.7(on )6(about samp)6(l)4.7(e)2.6( si)4.7(ze \(page 10\); )6(the d)6(e)2.6(scri)4.7(p)0(ti)4.7(on i)4.7(s)-6.2( tha)7.5(t)-1.5( a )6( )]TJ 0 -1.5569 TD -.0021 Tc .0038 Tw [(log ran)-4(k)-3.1( t)-3.3(e).8(st)-3.3( is bein)-4(g used,)-3.6( h)-4(o)6(w)-4.1(e).8(ver t)-3.3(h)-4(e resu)-4(l)8.8(t)-3.3(s/)-3.1(t)-3.3(a)-.3(bles show)-4.1( logist)-3.3(ic regression)-10( )]TJ T* -.0013 Tc .003 Tw (\(which is the entirely appr)Tj 13.1856 0 TD .0029 Tw [(opriate tool to use\) )6(- does)]TJ 13.1437 0 TD -.0032 Tc .0049 Tw [( th)-5.1(e in)-5.1(it)-4.4(ial descr)-7.6(i)-4.2(p)-2.9(t)-4.4(i)1.8(on)-5.1( )6( )]TJ -26.3293 -1.5569 TD -.0011 Tc .0028 Tw (need minor modification? )Tj T* 0 Tc 0 Tw ( )Tj /TT2 1 Tf 12 0 0 12 72 355.2 Tm .0001 Tc -.0001 Tw [(As indicated in the res)4.3(ponse to the editors )]TJ 18.39 0 TD .0005 Tc -.0005 Tw [(co)5.5(mments, th)6.7(e sample su)6.7(b-section has now)7.7( been )]TJ -18.39 -1.3 TD .0007 Tc -.0015 Tw [(revised to reflect the p)6.9(o).7(w)7.9(er calculations for )]TJ 18.69 0 TD .0004 Tc -.002 Tw [(the analysis reported. The previous pow)7.6(er )]TJ -18.69 -1.3 TD -.0003 Tw [(calcula)5.3(t)-1.7(ions)4.5( w)7.5(ere those used when the proj)]TJ 18.22 0 TD .0007 Tc -.0023 Tw [(ect w)7.9(a).7(s initially conceived)6.8(,).7( but these w)7.9(ere )]TJ -18.22 -1.3 TD .0002 Tc -.001 Tw [(updated to the currently reported pow)7.4(er calculat)]TJ 20.885 0 TD .0003 Tc [(ions du)6.5(ring the final stages of project )]TJ -20.885 -1.3 TD -.0003 Tw [(design and recruitment planning. As per the review)7.5(ers in)6.5(tuition, w)7.5(e)-.9( too had initially )]TJ T* -.0016 Tw [(considered the log ran)6.6(k)-3.4( test to be most appro)5.4(p)]TJ 19.775 0 TD .001 Tc -.0018 Tw [(riate. Ho)6(w)8.2(e)-.2(ver, field)7.2(w)8.2(ork in preparation fo)6(r )]TJ -19.775 -1.3 TD .0003 Tc -.0015 Tw [(project launch suggested the stron)6.5(g)]TJ 15.11 0 TD .0006 Tc -.0001 Tw [( possibility)5.6( of time-va)5.6(r)4.4(ying effe)4.4(ct s)4.8(i)-1.6(z)9.5(e)-.6(s, which led us to )]TJ -15.11 -1.3 TD 0 Tc 0 Tw [(instead prefer an approach that w)7.2(o)-5(uld estimate)]TJ 20.225 0 TD .0007 Tc -.0027 Tw [( separate models at e)4.5(a).7(ch post-tr)4.5(e)4.5(a).7(tment )]TJ -20.225 -1.3 TD .0009 Tc -.0009 Tw [(time po)5.9(int.)5.9( )]TJ /TT8 1 Tf 10.02 0 0 10.02 72 214.3201 Tm 0 Tc 0 Tw ( )Tj 0 -1.5569 TD -.0001 Tc .0018 Tw [(A coupl)4.9(e)2.8( of )6(questi)4.9(ons/c)5.9(o)2(mments a)7.7(b).2(out )6(the )6(ta)7.7(bl)4.9(es: )]TJ T* 0 Tc 0 Tw ( )Tj T* -.0012 Tc .0029 Tw [(Table 1: )6(Do we )6(need columns 3 & )6(5? My )]TJ 21.006 0 TD -.0009 Tc .0026 Tw [(unde)8(rstanding )6(that as these )6(are baseline )]TJ -21.006 -1.5569 TD -.0024 Tc .0041 Tw [(descript)-3.6(i)2.6(v)-3.4(e).5( resu)-4.3(lt)-3.6(s ')-3.3(P)-4.2(' valu)-4.3(es are n)-4.3(o)-.3(t)-3.6( )]TJ 18.497 0 TD -.0016 Tc .0033 Tw [(necessar)6(y)-2.6(. 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The previous pow)7.7(er calculations w)7.7(ere those used when the project w)7.7(a).5(s )]TJ T* .0003 Tc -.0019 Tw [(initially conceived, but these w)7.5(ere updated to)]TJ 19.195 0 TD -.0014 Tw [( the currently reported pow)7.6(er calculations )]TJ -19.195 -1.3 TD (during the final stages of project )Tj 14.11 0 TD .0001 Tc -.0017 Tw [(design and recruitment planning. )]TJ /TT8 1 Tf 10.02 0 0 10.02 72 276.36 Tm 0 Tc 0 Tw ( )Tj /TT2 1 Tf 12 0 0 12 72 251.22 Tm .0004 Tc -.0004 Tw [(In the abstract, w)7.6(e)-.8( now clearly sta)5.4(t)3.4(es the 4 se)]TJ 19.165 0 TD .0005 Tc -.0005 Tw [(x)5.5(u)1.7(ally trans)4.7(m)-1.5(itted infe)4.3(c)4.3(t)-1.5(ions comb)6.6(ined for the )]TJ -19.165 -1.325 TD .0006 Tc -.0016 Tw [(primary ou)6.8(tcome measure both in th)]TJ 15.695 0 TD .0004 Tc -.0004 Tw [(e method)6.6(s and the results headin)6.6(gs. )]TJ /F2 1 Tf 10.02 0 0 10.02 72 212.7001 Tm 0 Tc 0 Tw ( )Tj 0 -1.2096 TD -.0012 Tc (*Abstract- says is a proof of concept study. )Tj /TT2 1 Tf 12 0 0 12 72 171.3 Tm .0001 Tc -.0011 Tw (By identifying this as a proof)Tj 12.64 0 TD .0006 Tc -.0006 Tw [( of concept stud)6.8(y, w)7.8(e)-.6( hoped to acknow)7.8(ledge the importance )]TJ -12.64 -1.15 TD [(of tes)4.8(t)-1.4(ing o)5.6(n)1.8( a small s)4.8(c)4.4(ale w)7.8(h)1.8(ether individuals)4.8( w)7.8(ill respond to financial incent)3.6(i)-1.6(ve)4.4(s to change )]TJ T* .0004 Tc -.0004 Tw [(their sexua)5.4(l)3.2( behavior before eva)5.4(l)-1.8(u)6.6(a).4(ting w)7.6(h)1.6(ether the intervention can)6.5( be delivered on a )]TJ T* .0002 Tc -.0002 Tw [(larger scale. 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As well )Tj 0 -1.2096 TD (as the )Tj 0 -1.2635 TD (scientific merits of the paper we take into account each paper)Tj /TT6 1 Tf 37.1258 0 TD 0 Tc ()Tj /F2 1 Tf .5988 0 TD -.0012 Tc (s )Tj -37.7246 -1.2395 TD (originality )Tj 0 -1.2096 TD (and interest to a general readership in comparison with other submitted )Tj 0 -1.2695 TD (papers. We take reviewers)Tj /TT6 1 Tf 14.9701 0 TD 0 Tc ()Tj /F2 1 Tf .5988 0 TD -.0012 Tc ( reports fully into account too, but the )Tj -15.5689 -1.2395 TD (final )Tj 0 -1.2036 TD (decision on acceptance or rejection of a paper rests with the Editor. )Tj 0 -1.2096 TD 0 Tc ( )Tj T* -.0012 Tc (These comments are an attempt to summarise the discussions at the )Tj 0 -1.2036 TD (manuscript )Tj 0 -1.2096 TD (meeting. They are not an exact transcript. )Tj T* 0 Tc ( )Tj 0 -1.2036 TD -.0012 Tc (Members of the committee were: )Tj 0 -1.2096 TD 0 Tc ( )Tj T* -.0012 Tc (Trish Groves \(Chair\), Jon Deeks \(ext Statistician\), Elizabeth Loder, )Tj 0 -1.2036 TD (Wim )Tj 0 -1.2096 TD (Weber, Tobias Kurth, Kirsten Patrick, Domhnall MacAuley. )Tj 0 -1.2036 TD (* Randomisation of spouses. There is likely to be correlation in couples )Tj 0 -1.2096 TD (so )Tj T* (should it be analysed as a cluster. The unadjusted results show little )Tj 0 -1.2036 TD (effect. There is only a benefit is when adjusted. Also no account for )Tj 0 -1.2096 TD (the )Tj T* (number of comparisons. We suspect that with adjustment , the clustering )Tj 0 -1.2036 TD (effect )Tj 0 -1.2096 TD (may disappear. The message of the paper might change. There are )Tj T* (problems in )Tj 0 -1.2036 TD (the method and clustering of spouse. )Tj /TT2 1 Tf 12 0 0 12 72 358.2 Tm .0001 Tc -.0001 Tw (We agree that correlation in couples is likel)Tj 18.725 0 TD .0003 Tc .0004 Tw [(y a)5.3(nd w)7.5(e)-.9( therefore have a)5.3(d)1.5(apted our clustering )]TJ -18.725 -1.325 TD -.0011 Tw [(of the stand)6.6(a).4(rd errors to account for this. )]TJ 17.915 0 TD -.0018 Tw [(We now)7.6( cluster standard errors both at the )]TJ -17.915 -1.32 TD 0 Tc -.0012 Tw (household and at sub-village le)Tj 13.115 0 TD .0003 Tc -.0028 Tw (vels, accounting for the possible)Tj 13.525 0 TD -.0003 Tw [( correla)5.3(t)-1.7(ion w)7.5(i)-1.9(thin couples )]TJ -26.64 -1.325 TD [(and the variation in s)4.6(e)-.8(lection prob)6.6(ability a)5.4(t)-1.6( th)6.6(at sub-villa)5.4(g).4(e leve)4.2(l. All tables have)4.2( been )]TJ 0 -1.32 TD -.0001 Tc -.0007 Tw (revised accordingly. We have also updated the )Tj 19.995 0 TD .0002 Tc -.0027 Tw (statistical methods sub-)Tj 10 0 TD .0001 Tc -.0001 Tw (section to describe )Tj -29.995 -1.325 TD .0005 Tc -.0013 Tw (this. These changes do not alter )Tj 13.89 0 TD .0001 Tc -.0001 Tw [(th)6.3(e main messages of the paper. )]TJ /F1 1 Tf 10.02 0 0 10.02 407.28 278.8201 Tm 0 Tc 0 Tw ( )Tj /TT2 1 Tf 12 0 0 12 72 252.9601 Tm .0003 Tc -.0011 Tw [(Regarding the multip)6.5(le comparison)6.5(s, w)7.5(e)-.9( had al)-6.9(w)]TJ 20.8 0 TD .0002 Tc -.0002 Tw (ays planned to look pr)Tj 9.51 0 TD .0007 Tc -.0023 Tw [(imarily a)5.7(t)-1.3( the effect )]TJ -30.31 -1.32 TD 0 Tc -.0006 Tw (after one year, i.e. at round 4, expecting that)Tj 18.885 0 TD -.0001 Tc -.0011 Tw [( the effect w)7.1(o)-5.1(uld beco)]TJ 9.215 0 TD .0003 Tc -.0019 Tw (me stronger over time )Tj -28.1 -1.325 TD .0002 Tc -.0002 Tw (during the previous rounds. We therefore do not th)Tj 21.865 0 TD .0005 Tc -.0017 Tw (ink it is necessary to)Tj 8.61 0 TD .0003 Tc -.0003 Tw ( adjust for multiple )Tj -30.475 -1.32 TD .0005 Tc -.0005 Tw [(comparison)6.7(s across rou)6.7(nds. )]TJ /F2 1 Tf 10.02 0 0 10.02 72 182.7 Tm 0 Tc 0 Tw ( )Tj 0 -1.2036 TD -.0012 Tc (* How did the authors choose the variables- is it based on the p values? )Tj 0 -1.2096 TD (More variables in the final model. There are many p values in table one but )Tj 0 -1.2036 TD (not for primary hypothesis. We need more explanation of how the variables )Tj 0 -1.2096 TD (were selected etc )Tj /TT2 1 Tf 12 0 0 12 72 109.0201 Tm .0003 Tc -.0009 Tw [(For Table 1 and adjusted models, w)7.5(e)-.9( chose st)]TJ 19.25 0 TD -.0003 Tw [(andard socio-demographic variab)6.5(l)-1.9(es such as )]TJ -19.25 -1.325 TD .0002 Tc -.0002 Tw (age, gender, education, marital status, soci)Tj 18.09 0 TD .0001 Tc -.0001 Tw [(o-economic status and income w)7.3(h)1.3(ich are )]TJ -18.09 -1.32 TD .0004 Tc -.0012 Tw [(expected to influence b)6.6(e)-.8(haviors. \(We did not )]TJ 19.17 0 TD 0 Tc -.0007 Tw (choose these variables based on p-values\). We )Tj ET endstream endobj 414 0 obj <>/Font<>/ProcSet[/PDF/Text]>> endobj 411 0 obj <>stream /GS1 gs BT /TT2 1 Tf 12 0 0 12 108 708.84 Tm 0 g 0 Tc 0 Tw (1\))Tj /TT4 1 Tf .835 0 TD ( )Tj /F1 1 Tf 10.02 0 0 10.02 126 708.84 Tm -.0012 Tc (First round decision letter and our answers in bold. )Tj /F2 1 Tf -1.7964 -2.4132 TD (MS ID#: BMJ/2011/883504 )Tj 0 -1.2096 TD (MS TITLE: Incentivizing safe sex: A randomized trial of conditional cash )Tj T* (transfers \(CCTs\) for HIV/STI prevention in rural Tanzania )Tj 0 -1.2036 TD 0 Tc ( )Tj 0 -1.2096 TD -.0012 Tc (Thank you for sending us this paper, which we were pleased to have the )Tj 0 -1.2036 TD (chance )Tj 0 -1.2096 TD (to consider, and enjoyed reading. We recognise its potential importance )Tj T* (and )Tj 0 -1.2036 TD (relevance to general medical readers, but I am afraid that we have not )Tj 0 -1.2096 TD (yet )Tj T* (been able to reach a final decision on it. This is because several )Tj 0 -1.2036 TD (important )Tj 0 -1.2096 TD (aspects of the work still need clarifying. )Tj T* 0 Tc ( )Tj 0 -1.2036 TD -.0012 Tc (We hope very much that you will be willing and able to revise your paper )Tj 0 -1.2096 TD (as )Tj 0 -1.2036 TD (explained below in the report from the manuscript meeting, so that we )Tj 0 -1.2096 TD (will be )Tj T* (in a better position to understand your study and decide whether the BMJ )Tj 0 -1.2036 TD (is )Tj 0 -1.2096 TD (the right journal for it. We hope, too, that you will submit your )Tj T* (revised )Tj 0 -1.2036 TD (paper \(via your author area at our online editorial office )Tj 0 -1.2096 TD (http://submit.bmj.com\) within one month. )Tj T* 0 Tc ( )Tj 0 -1.2036 TD -.0012 Tc (Looking forward to hearing from you again and, we hope, to reaching a )Tj 0 -1.2096 TD (decision. )Tj 0 -1.2036 TD 0 Tc ( )Tj 0 -1.2096 TD -.0012 Tc (Best wishes )Tj T* 0 Tc ( )Tj 0 -1.2036 TD -.0012 Tc (Domhnall )Tj 0 -1.2096 TD 0 Tc ( )Tj T* -.0012 Tc (Domhnall MacAuley )Tj 0 -1.2036 TD (BMJ Editorial )Tj 0 -1.2096 TD 0 Tc ( )Tj T* ( )Tj 0 -1.2036 TD ( )Tj 0 -1.2695 TD -.0012 Tc (Report from the BMJ)Tj /TT6 1 Tf 11.3772 0 TD 0 Tc ()Tj /F2 1 Tf .5988 0 TD -.0012 Tc (s manuscript meeting )Tj -11.976 -1.2395 TD 0 Tc ( )Tj 0 -1.2096 TD -.0012 Tc (We are able to accept only a small proportion even of the good articles )Tj 0 -1.2036 TD (submitted to us. 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