%PDF-1.4 % 185 0 obj <>>> endobj 182 0 obj <>stream doi:bmjopen-2017-019422 application/pdf 2018-04-28T07:20:47+01:00 2024-09-06T18:28:21-07:00 2024-09-06T18:28:21-07:00 Adobe InDesign CS6 (Windows) uuid:052616d6-1dd2-11b2-0a00-d300083cb3ff xmp.did:B2C59A163194E611BD009A7CB80B8EC7 xmp.id:1C893C49AC4AE8118097B6C8081CF0A2 proof:pdf xmp.iid:1B893C49AC4AE8118097B6C8081CF0A2 xmp.did:12BEE6AC550DE8118634A2E26D244B8E xmp.did:B2C59A163194E611BD009A7CB80B8EC7 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2018-04-28T07:20:47+01:00 2b312085-fa55-42c2-b883-c5124135a146 Adobe PDF Library 10.0.1 False endstream endobj 186 0 obj <> endobj 135 0 obj <> endobj 181 0 obj <> endobj 187 0 obj <>/Font<>/ProcSet[/PDF/Text]/Properties<>/Shading<>/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>> endobj 1 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>> endobj 14 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>> endobj 31 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>> endobj 60 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>> endobj 75 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>> endobj 76 0 obj [77 0 R 78 0 R 79 0 R 80 0 R 81 0 R 82 0 R 83 0 R 84 0 R 85 0 R 86 0 R 87 0 R 88 0 R 89 0 R 90 0 R 91 0 R 92 0 R 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R 295 0 R] endobj 292 0 obj <>stream HWms۸Ǟ:Gu,At׉\'",L _~|I)K,"Mf"I>>xً~&uOmmo:nu_lgn n n`П,EOS/CẄaTr„ԇTZeZ屉9:3Ë0TYVpLa^Ȩ>`NjKhf".Ƿ`5qoprcAfztq`ވ/3N@ ,MH (HR=ֱ1IAgog*\H=&y>;v_?cs5.f3"_y+ 0UҬ%~?jY~Pa2&qFvV]l&E} B1${l`>q=W/%7!! U8>t(a r;?6JN8F~l6HoYi.O6 阗NRkRHs V@$IV6l nG(iw\mU#WHQg \o|P@ǥrH#x(d#7F>RFQ*pQ(}<îݡ`=TOJCX *ܠYbe3 S"U|x=S~C\N|^rK7VbrݠU1]՘{a]uXhm5^p|xz|,FTIɔoU;}n[ȉt}<}QdK OaM#\A߄x2YL2SAM:^UK%tp#5!/hz:!E\ 8eE2r"pۤXJDBޫ\ Lo,y3#<4Lwղ,M$ JK1ln$yP2kK٩ĠOp(pYћ΀IY;Ɇ;qlT]_cmk+[dZzVuWw)[ !Ͽ<~SVY㫵d`X+;w5ś풝׹EF$ASq(X[뜊:d%*G}%̝w5FD=% Ī?qҊgŖn-H=yYWFC>;,uܙpAOaGs<Zͩj{$^3ɾzg Y:%fhVF:N Sfʥ;lNlcވG=b,?AGX{GiwUoz@[bߚ>\?~[;E䲱z}zA+Z262@ڒ[[ ^&ө2f;. Eo~0tژP:#MWxsppD1+i*[|y[pB:*@k< rajx$kTr\3EnuODCSKSl1wdqQMsC=iΥ,$Eg'AqD|ATSgSmM: }ճa5yl-L1^|nܛcBsPx#3ܖ>í;ku껇k_'Q\;YJ,?LM)) T84l 5Jn~t V$sQo yvޘ7v4Nu){f4IWa ClX4+DԱ=;xJ48LJBkkdרBCAMBaLѰ~AyN("h@HQGػ8zMqYL IG)F849DpT&GE^:F1wI}EfEѮ[r/d>=` kxbxv()Nϩ}:x˭m# ÿừ1Ζ+ $)-2鐛 :U'+X$p>m{7 暭oS@jTSؾ ;ƛ$aE6&ocbъo0 y|U%cw-69/*>@,@uf.nQ74FevҎ,9o2+Y!hqO[ݽ&R"ˊ-@/c 91]'í,%-,bCIX*Ep6{Yԩ8_1TPU+uKwTRMKfiİ^9 ۧim$5+:fÜ>OY(gQB78ɩKdX2f` (hf3)Co},e[551Fs,I (|Y7"N߷w *?O}ǴEV}W" #8UZU*`o+27tR0? ^2nʊ'J5_O'pk )z`ܘa l!nv_wc94 2]\Zk9c rXشiUe+Y)ê:MxjtK]]᪪͛e%yᯆWжg3EQVX+- rEOfۦ),/D,_>/Font<>/ProcSet[/PDF/Text]>>/Subtype/Form>>stream H\AK@+Mm{jAtoU$6ZZ1w6iof I>[ ]`, _%R[Ƹismʑ,3>>>/Subtype/Form>>stream HVKn1@*'bYp ˞!v(RݯUoCbWUӽ{ssOǜE;}<}vwsIg у;bh QWqXD{ U=r/!rUFz6/+A"џ1٨0Zcn1tTB)ԆX[V?hy9Քp0y橹-9HM-, qLj40--HΆz!C}'5!0.P(bEXxP!6 weX+60g_E+ފPW=H}?v2? l`~0hգa#Pf`m DXn+QCф;sm(aZF'u˫__ֿ UG_-޶:uO](8"mIU]qb'h88V PgZ݋8>$xW_ӱJ5Go-ApMJKtͦ CV(3˱R_Lc 0- endstream endobj 205 0 obj <> endobj 129 0 obj <> endobj 127 0 obj <> endobj 125 0 obj <> endobj 208 0 obj <> endobj 126 0 obj <>stream H\j0 ~ C]v02aXpl%3,QC~[:'~Is|Na.q%086v6IHm8waBk,.6ؽ8^+9$&}=~Mg -8yЛI3#Ȋ:Ǻہ-!4>pI"0Њ ܨa߆~z^8QT{Oà][G5Uį[q endstream endobj 231 0 obj <>stream HlU PSW1'<4\. Q*J̺.Ŋ:(PGѥ$$:ۮZTXdw]Ԣ'BX]8[ˬ'ٓ`ݙys$l %Hu+"%z@FEEV"bD TGcNjO^db++(/$ -fFYaٌ¯/ּ&,h :K^(;&h.ج֡שb`lzV),hæMZ&bf̪V+jTh$vmz`4 z!K҈uCКuBOک@4ijm--ČM(b3ubhܬ5O`$f^զU"A7P6 E)(JIS5KHk)EŽBeHvK=Pk(UAS-@➲y i%l,[M'Y+:NwRt ȧc}f 5~ ?Zc/FM4aZҴ#"FqD:Y)vJhJ&VL+ßxaawY(;e)aJ$EzZOwDT*$`DlRgza0SgDr8'Bzl֯ 4]V~<Gſɿ{3/ԛvnJ^˧gssaJL V#c*F9dTB(3X l싆rǏ6ָj9shە**xsz?xΚ1[RH"t'dT!$U*q Gp"p`#l#ÝJdO҃{I\:ĺi mv4t@]}̞EwS;(`IY3F`+Q ItA=tA(D\g,JWgqűx!1X D;)vlAcċ5x<`k1cWKM1a絡=))SBGЙ$dy\& `]=*G_ +lLsrrْ U(h.{dsGɢ7-EZ<ہؾ==5Y3ʻ{9 (L*UV]̃*fa-jdG8}"ƫ35V=MO u\IӐT ;a7"tq=$D~짨ٶ:0Mvk[g u8l!Why*M b+Vc65b5s0B0yZo}+t!f`cț+F=㒫h2iP 2 x sy SD(]ƿV!NrvN?䉑9tŒtEE9 STZ4eя>@0^u<t}q >Ng\hȟ,hR6)1C=-EtU|*¡y,F}Vǫ㐽}VWi0hGV3{m!U<6Tz1WTGH>Yuđ gΚ8rxc@mDҍ)r=I/k7W״p̃Z!nrΊZy-6p̣E$Uֲa;z0),o&NPT ĔRI˚j#"]rR"$q..섄~+MriDkтwuqd *-sx:]tn0l;=(*p"6gSI&<lڠx좈h+ Pa2 (ETA2e"if.عss|l. )+*g4><Ey l 6Tw<,EM=GZkB _vtu'Jo4)' I#.ո  HŠ4~ty5~f/oԮD:`ܾ?&<óLP;ࡱ1x(-BF)UWDX!Lbմq\{izBFCQ}zayY:2a녋&[