%PDF-1.3 % 1 0 obj << /FormType 1 /Subtype /Form /Resources << /Font << /F3 2 0 R /F2 3 0 R >> /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] >> /Type /XObject /BBox [0 0 596 842] /Filter /FlateDecode /Length 572 /Matrix [1 0 0 1 0 0] >> stream xTjA}KWU7<D|PEć3$oU$nBYfNU&W-ӏ/ٛfnfm>=*Ąe"I)3!G|I<|<+TrE `{mZFPHg?NG-TWFcX ޿ZMã:;r}F5'tve299O).?q&hk {E܈WQnG8:zg**V dRiC;  *h5`>>c"5fD.͓~oۈ)>Ff·}2;@Y$u)5Hr2.س32odfJWL421~.VX"RoYvbr߇R"y?5}s#2G{$ծqit9@b(QĊC|ꢇ̾{ZnEqlѴHm!!cX@W' endstream endobj 2 0 obj << /Encoding /WinAnsiEncoding /Subtype /Type1 /Type /Font /BaseFont /Times-Italic >> endobj 3 0 obj << /Encoding /WinAnsiEncoding /Subtype /Type1 /Type /Font /BaseFont /Times-Roman >> endobj 4 0 obj << /Filter /FlateDecode /Length 10 >> stream x+| endstream endobj 5 0 obj << /Filter /FlateDecode /Length 43 >> stream xS**T0T0B0gbjnhiZ endstream endobj 6 0 obj << /Type /Catalog /Pages 7 0 R >> endobj 7 0 obj << /Kids [8 0 R] /Type /Pages /Count 1 >> endobj 8 0 obj << /Resources << /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] /XObject 9 0 R /ExtGState 10 0 R >> /Contents [4 0 R 11 0 R 5 0 R] /Parent 7 0 R /Type /Page /MediaBox [0 0 596.01 842.93] /CropBox [0 0 596.009 842.927] >> endobj 11 0 obj << /Filter /FlateDecode /Length 68 >> stream x+T03T0A(˥d^U`jlfg`77036Q02337U06г(Pp Ba endstream endobj 12 0 obj << /OPM 1 /Type /ExtGState >> endobj 13 0 obj << /Subtype /Image /Width 560 /Filter /DCTDecode /Height 792 /BitsPerComponent 8 /Length 15827 /ColorSpace /DeviceRGB >> stream JFIFC     C   0" M!1AQa"q2BR#Ubr$3CETd%D St4s!1 ?SƈrZSOH7iYѺdW"Nc>^c>djލysMG/ 1V.|=gx=5S(\ d#pUψy ` jʈުG[-::;ڸs_;r #97D#s۸|{dj.nmJJ_ʎ_9p`g(drdNjȆnUই4U:` p"9EEEDTTsLv~W(Vܖ-G[WP]\OPࣦ72QtKj{ Ninn64UUꪠWtAzUVW]jh27;mI9⪤ $ѯ"v,iѽ\N2:oorX` wR:[En T>P}ĵIDB-w%=|.ۯjc$KfLRM$h$Go5mTw$5N^q?&Lc@z̲ f:+欕Q oiQ25-ו%~{4}X#m.ܮS=UMN$U'oGf":'ANvQԞF#=Ti\nw.\*}ţŸ8 /r}w9&`l՞x5rEX߹rZ0TwoI'tZ#gcX'4zĿD%]>[teD\o;^ȒQ<~_oGzO6^8+aL$߱*}f?ɒ;.eENnk(QELj0@qDEUa#9Qʪ$N\۵w*nҴXn/*]b{m5SSeVE"~c u]ss:B?m}bi?u:Nդ-ZiIN޼?Iޮ^mYIht}g΢6,Oqmpi]civb^ 1|MXk=\_tSoԉʞUoN/$^:+cWE/'*}&(2[+]EdFk#|HFZsN.)*|-O *~DSsd8Gc EEw'4Q[ᦉ1LF5<(rUTIMek[#jnk^fW=)l6jhuQR?drjoG|ONzŶCeG;YkEs@%r"T9#1baL"VM<_Gy\]v:ǩ.W Mui$㉯|l<T XkJ}AhU1Djr/ ;u{ڊSS\OWV7JwISXhڋm +Uhr5//_z!aM;{Rf=ɪy2:ae+wiURڣx_R?촼 fs+,z^#mۙeI9|j {t8W}UTS}Wbj Z|cq«jޭ zV*k%wp2nw7<ɪs(mvq5]ev.Tߥ誙/L&Ɍ#Kk 9QlUXdrdo oʑ,ѤъG/P;ҲwGS{R뜍Dž:&mrVJGb|2@n}Hh\geduԐ|R'z/CneWG#Q̚7ƨhBNZ{]kU6)=j*Y[ 3;(X=|*@6S.W cuDײx))*dZXql/V%4Q[ॅ8bȜ-RZ.4\㵫#n}^}pk K$^3ZK9vu%GFPܵWi#&JjuJEgoZ@.XlG潎L\M[aVSZG$UD\/ڭj஥\GMpHpOgnLMCURĊ',Q[Ġ-N 5i•p&p{Z a90֣SdƃGZwpž} K4m\%OUK򫽦jt݅N1|bU\Ѝ<0K akZֵ0rA 5܊=3oeU2@몸NNUI:u f*"S@%l'LΛ|ۍ;i~E;,2+H\sjR9rW{Ukvr"ag<5ޡz;?UDEN懺H+ǧ5z*)^k*,7=C^JJX'fp5\Wu\=uK9z?~{!9~L)mޫA5WSXTzoߒG.Fj-uҶ H\j$F'$Q2zA^7vCgfQ3_siڍi} ulMIvE\M3⏵r?NHA{v"=g6sIGW@sW|E[TRk_ )\)ڟFӞy Rt1:'gQS=TQSUUp8PUuV}=qZx,TȸY\JN[GEiUvH+z5 cGoFWj如;!"sƫNm9` `Ѵ*]q7jHKvqXhA0y1KFxUU2@7᭟EHVل'VMjH *| jtյdKXJEBzhw}a@,r0E9:jcJd pOE_BsE.[յbجF])a 2JOZP~'3*kW(,ȍsʟScv 2aޙ܉MSVlRz詣eDIG/l22 մmsQ#S2V8_X*(Y 4܍) TH^NAu%BvNbX/"vӹkfb¦SO3}vo]Ǫ$Qβ,Tojr<WaɃzUomelqIHQ+[5<{CmS9SxA"s_MF떟h`w NXLznNK.Q}sn_Dm7JŸ\( _mȜԒ+:GĈ|~˗,rܧ>}uokv:Sfr@EUu e]Fiƫ)!c+QȨwة5$(x1t &KڷG9QQIץk'6\^i-EUDU_$Lw=|Z[R|TuuTȽ;5L!6z4vmY4x&ֶ=DΞJ5Crd 4R=/T ֡<>=N1m:򅖺+'UXp|QF> Zz1#/v91Ix!ͳ]6>8$cq*Y΍L9ɜed];ZE[t^Xoqk*7Ь8ңF䖍yUTHܜ kWJEmNG+`EW',UI 6 #UTG5Z¦MF-9TUvsOqvQÎ,r T jMnev7;_Sk׻ȫիX^#/zhctѫzmƕY%W;n |i +b$5=߇ ;^jj)H"?D^wi[ gjV'v0MlUQ㉒Jzw &]($YhI"zZGeusx]\; QZa{uAdLu]bV><.Avp+5妹+L{SgV᫅^5{S Jԭtqp5,*v9j5wTC6dNT[ AkOb*h'eLJμO[ aV#=l2"8'*`v-S^4cxd\="x4 uZQOPe͉NGq;c[Nҧ 轫IFx9$\B+TiܭsU?fw/}Ȋ>P흅/7Jz핱%4j>x=#վj-T-Xg6utpWMS '#xTP\Wt|{uu& SWCOEOO¹pSdw\s)-qYtU[wDͦgw>MN#;CoTQļNĨnW)漺TfudWX΍r4C$̊7I#52rKnUQhEzifs_X{^ڍL*MSaPKE-\MD&O ̉x:6u=~%;sO}czGW:ഒ.TUZeZyV#;W@܍T1jqKBӪz -S9Z#jT7iZj^]kڨ:/X&8ڈֱDC[yWSQ:yO; YYS.rƯcW)`3abGNr/)- Ҵr"nML6ȿƽn/;T:¾Z;spYҫz}%X5  ,OK 54i150D;qtm{\'U0疣e5$:9jtUu|NimW_[TqVAHɡ{x#-rxK-5TMV9-rx*\7S[tt,X\O;!ZOv}Od_6Hjsy-fSE";rrb2#ѱ?ݓ5L S9ہn#UeQZzz(i:95-Ǟ_OʞT]'wlC ,΂m!{DOf?MS5ƚMIS TJG"=E=kQɇ#k#ZU\"{&1Z8X.;m;i\~ M QS+ ajwMFT1'ѫ[9âu>UfT|Zvtܳ?Xbd5ȣL5ֱj&9"!TTQzivKSMqTmuvwNdwz-d5SHeQ{VSi&5Y$r&Q^I>Ի48_tUﰽXu@6Rn7Kk$ZZ?G4Ue5ƣZDL"', Zs]Q<$U/z (1(˦n%XSEp6,^met6Yjd_$vNcZn9+-b#$/126 /7hkK%iI 7~Qӹ:~%D٩⺾EmrQVkO1puRQAAM=4Ldq Z܈wz6 m{֞IiY9_#A=ʮLj$j%Ѹ":nh<2ۮԫIr\K 5uRץt{DtL>}\sRA{mo=:m8RY;yUyQ3rC7뷵+bOz6-GDŒ'X.ֶ[[+c" 22UE$5tSdF''5S RJiw"2SBυ '9!tމ:DʸmҢEDP%wkQ__Q-$ W,5 HQUnvfҭ=ʖZY:w'vSC5VqLm'$r'e{;t-`EQ8ZƦx2Zxk(v+ifF3LL#r|ިE좷o^tkW{NlKl1+ W~T2Z go\/X6 cn5!8|N@s@2@ pj:ZӨG+<>Rg-%lf\RQ= `c F&p~G*NWyU&F8P%CfJj HhӤPFo܇dd 28|O[5")DH(lLR*sƞ]#cEF*ݡƘfߓٯ1` _Gm/ JB&cogR9 +#NS~*H0d pc d OXmfr-Z[V)"٫ժ!nC:6f{R1*ې{$אzvD/pg%'{+\詘QLů":?iTlbUuxKd.@n :jhଂH*!dȜ/VT^ |ؽ#v)fu20 LV&;\ʶ| ac>('i-UufZ(2PݠWG.U*Z&6cÉ m;ceL:_N|˗$)3d `"`/]cerG ˕Q9E#sDTELRÙYl4tPo"w+7#NoU6?/BQZHՍ\6DEsw_/e'.>Kh!_#="OW8[¿W_/HGu.5o7 #W-:6=!Uu"e-Ӭ6ZPje4"5r"(WB""/\껯2o#c qguL_yNɏ\(_dsTr޺&]WHX=z>U̬IVzxϟT߫._|Yu"do՗_/e#{O' U+|jZ#:'\ji WEH4Cu6jd\XLcW'%f52v?vKitel|%kׯE>*bH#{Q{p^P4>V]MG>3Ϫn,|s5+–\gI0ZtNjAoӹt=f U' J:B eUr'SxuL8vkk)ыNkW3EIQ4._pKWpQ.?qkVʴ7I<\Yf[JAqynu5ڞi]ng8isnw=_Mꊾ ).V{2fw2]mHϩ1֑1J793{Jïj5^R,͡ZDkr&BmV[{mutQ *4Yl.-5r# wo˺z=(qq(ϟb/Oa[0Vr.&է$=~W;G[>WUYU2O =K0SI#9]ܼɀ(D %~ݵ%ngM]JX1pмiic8bbGlF1:!݃ mIU)QEW4n^dtGݏE W.oD-pKQFTs[˚rkF <7kb]tN6'DF9QS1;l=+I O{W9{Ԕ1} vݹr9 KfYnHGO,H&)Ĉn^7qtO޼I#fσP@#ES=?Z'4. ;S1&{̀1rJkR*I})xS~rd5T 2u‚ u%MVW:IhZUs\Q!y3<9^Jgd endstream endobj 10 0 obj << /R7 12 0 R >> endobj 9 0 obj << /R8 13 0 R /Xi0 1 0 R >> endobj 14 0 obj << /ModDate (D:20220905041901Z00'00') /CreationDate (D:20220905041901Z00'00') /Author (https://imagemagick.org) /Title (bmjopen-2021-054523supp003) /Producer (GPL Ghostscript 9.26) >> endobj xref 0 15 0000000000 65535 f 0000000015 00000 n 0000000843 00000 n 0000000945 00000 n 0000001046 00000 n 0000001130 00000 n 0000001247 00000 n 0000001298 00000 n 0000001357 00000 n 0000017806 00000 n 0000017771 00000 n 0000001595 00000 n 0000001738 00000 n 0000001786 00000 n 0000017851 00000 n trailer << /Info 14 0 R /ID [<8b48d387d06c814ac98ca42bba088680> <8b48d387d06c814ac98ca42bba088680>] /Root 6 0 R /Size 15 >> startxref 18082 %%EOF