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We recognise its potential importance )Tj T* (and )Tj 0 -1.2036 TD (relevance to general medical readers, but I am afraid that we have not )Tj 0 -1.2096 TD (yet )Tj T* (been able to reach a final decision on it. This is because several )Tj 0 -1.2036 TD (important )Tj 0 -1.2096 TD (aspects of the work still need clarifying. )Tj T* 0 Tc ( )Tj 0 -1.2036 TD -.0012 Tc (We hope very much that you will be willing and able to revise your paper )Tj 0 -1.2096 TD (as )Tj 0 -1.2036 TD (explained below in the report from the manuscript meeting, so that we )Tj 0 -1.2096 TD (will be )Tj T* (in a better position to understand your study and decide whether the BMJ )Tj 0 -1.2036 TD (is )Tj 0 -1.2096 TD (the right journal for it. We hope, too, that you will submit your )Tj T* (revised )Tj 0 -1.2036 TD (paper \(via your author area at our online editorial office )Tj 0 -1.2096 TD (http://submit.bmj.com\) within one month. )Tj T* 0 Tc ( )Tj 0 -1.2036 TD -.0012 Tc (Looking forward to hearing from you again and, we hope, to reaching a )Tj 0 -1.2096 TD (decision. )Tj 0 -1.2036 TD 0 Tc ( )Tj 0 -1.2096 TD -.0012 Tc (Best wishes )Tj T* 0 Tc ( )Tj 0 -1.2036 TD -.0012 Tc (Domhnall )Tj 0 -1.2096 TD 0 Tc ( )Tj T* -.0012 Tc (Domhnall MacAuley )Tj 0 -1.2036 TD (BMJ Editorial )Tj 0 -1.2096 TD 0 Tc ( )Tj T* ( )Tj 0 -1.2036 TD ( )Tj 0 -1.2695 TD -.0012 Tc (Report from the BMJ)Tj /TT6 1 Tf 11.3772 0 TD 0 Tc ()Tj /F2 1 Tf .5988 0 TD -.0012 Tc (s manuscript meeting )Tj -11.976 -1.2395 TD 0 Tc ( )Tj 0 -1.2096 TD -.0012 Tc (We are able to accept only a small proportion even of the good articles )Tj 0 -1.2036 TD (submitted to us. A little over 10 % of articles reach this stage, and to )Tj 0 -1.2096 TD (do so )Tj 0 -1.2036 TD (they have to have passed preliminary screening by one or more of the )Tj 0 -1.2096 TD (editors, )Tj T* (have received sufficiently positive external peer review, and have been )Tj 0 -1.2036 TD (discussed at the manuscript meeting. )Tj 0 -1.2096 TD 0 Tc ( )Tj T* -.0012 Tc (At the manuscript meeting each article is discussed by the Editor or )Tj 0 -1.2036 TD (deputy, )Tj 0 -1.2695 TD (the rest of the BMJ)Tj /TT6 1 Tf 11.3772 0 TD 0 Tc ()Tj /F2 1 Tf .5988 0 TD -.0012 Tc (s international team of research editors, and two )Tj -11.976 -1.2395 TD (invited )Tj ET endstream endobj 4 0 obj <> endobj 5 0 obj <>/Font<>/ProcSet[/PDF/Text]>> endobj 6 0 obj <>stream /GS1 gs BT /F2 1 Tf 10.02 0 0 10.02 108 712.02 Tm 0 g -.0012 Tc 0 Tw (advisers: one statistician and one clinical editorial adviser. As well )Tj 0 -1.2096 TD (as the )Tj 0 -1.2635 TD (scientific merits of the paper we take into account each paper)Tj /TT6 1 Tf 37.1258 0 TD 0 Tc ()Tj /F2 1 Tf .5988 0 TD -.0012 Tc (s )Tj -37.7246 -1.2395 TD (originality )Tj 0 -1.2096 TD (and interest to a general readership in comparison with other submitted )Tj 0 -1.2695 TD (papers. We take reviewers)Tj /TT6 1 Tf 14.9701 0 TD 0 Tc ()Tj /F2 1 Tf .5988 0 TD -.0012 Tc ( reports fully into account too, but the )Tj -15.5689 -1.2395 TD (final )Tj 0 -1.2036 TD (decision on acceptance or rejection of a paper rests with the Editor. )Tj 0 -1.2096 TD 0 Tc ( )Tj T* -.0012 Tc (These comments are an attempt to summarise the discussions at the )Tj 0 -1.2036 TD (manuscript )Tj 0 -1.2096 TD (meeting. They are not an exact transcript. )Tj T* 0 Tc ( )Tj 0 -1.2036 TD -.0012 Tc (Members of the committee were: )Tj 0 -1.2096 TD 0 Tc ( )Tj T* -.0012 Tc (Trish Groves \(Chair\), Jon Deeks \(ext Statistician\), Elizabeth Loder, )Tj 0 -1.2036 TD (Wim )Tj 0 -1.2096 TD (Weber, Tobias Kurth, Kirsten Patrick, Domhnall MacAuley. )Tj 0 -1.2036 TD (* Randomisation of spouses. There is likely to be correlation in couples )Tj 0 -1.2096 TD (so )Tj T* (should it be analysed as a cluster. The unadjusted results show little )Tj 0 -1.2036 TD (effect. There is only a benefit is when adjusted. Also no account for )Tj 0 -1.2096 TD (the )Tj T* (number of comparisons. We suspect that with adjustment , the clustering )Tj 0 -1.2036 TD (effect )Tj 0 -1.2096 TD (may disappear. The message of the paper might change. There are )Tj T* (problems in )Tj 0 -1.2036 TD (the method and clustering of spouse. )Tj /TT2 1 Tf 12 0 0 12 72 358.2 Tm .0001 Tc -.0001 Tw (We agree that correlation in couples is likel)Tj 18.725 0 TD .0003 Tc .0004 Tw [(y a)5.3(nd w)7.5(e)-.9( therefore have a)5.3(d)1.5(apted our clustering )]TJ -18.725 -1.325 TD -.0011 Tw [(of the stand)6.6(a).4(rd errors to account for this. )]TJ 17.915 0 TD -.0018 Tw [(We now)7.6( cluster standard errors both at the )]TJ -17.915 -1.32 TD 0 Tc -.0012 Tw (household and at sub-village le)Tj 13.115 0 TD .0003 Tc -.0028 Tw (vels, accounting for the possible)Tj 13.525 0 TD -.0003 Tw [( correla)5.3(t)-1.7(ion w)7.5(i)-1.9(thin couples )]TJ -26.64 -1.325 TD [(and the variation in s)4.6(e)-.8(lection prob)6.6(ability a)5.4(t)-1.6( th)6.6(at sub-villa)5.4(g).4(e leve)4.2(l. All tables have)4.2( been )]TJ 0 -1.32 TD -.0001 Tc -.0007 Tw (revised accordingly. We have also updated the )Tj 19.995 0 TD .0002 Tc -.0027 Tw (statistical methods sub-)Tj 10 0 TD .0001 Tc -.0001 Tw (section to describe )Tj -29.995 -1.325 TD .0005 Tc -.0013 Tw (this. These changes do not alter )Tj 13.89 0 TD .0001 Tc -.0001 Tw [(th)6.3(e main messages of the paper. )]TJ /F1 1 Tf 10.02 0 0 10.02 407.28 278.8201 Tm 0 Tc 0 Tw ( )Tj /TT2 1 Tf 12 0 0 12 72 252.9601 Tm .0003 Tc -.0011 Tw [(Regarding the multip)6.5(le comparison)6.5(s, w)7.5(e)-.9( had al)-6.9(w)]TJ 20.8 0 TD .0002 Tc -.0002 Tw (ays planned to look pr)Tj 9.51 0 TD .0007 Tc -.0023 Tw [(imarily a)5.7(t)-1.3( the effect )]TJ -30.31 -1.32 TD 0 Tc -.0006 Tw (after one year, i.e. at round 4, expecting that)Tj 18.885 0 TD -.0001 Tc -.0011 Tw [( the effect w)7.1(o)-5.1(uld beco)]TJ 9.215 0 TD .0003 Tc -.0019 Tw (me stronger over time )Tj -28.1 -1.325 TD .0002 Tc -.0002 Tw (during the previous rounds. We therefore do not th)Tj 21.865 0 TD .0005 Tc -.0017 Tw (ink it is necessary to)Tj 8.61 0 TD .0003 Tc -.0003 Tw ( adjust for multiple )Tj -30.475 -1.32 TD .0005 Tc -.0005 Tw [(comparison)6.7(s across rou)6.7(nds. )]TJ /F2 1 Tf 10.02 0 0 10.02 72 182.7 Tm 0 Tc 0 Tw ( )Tj 0 -1.2036 TD -.0012 Tc (* How did the authors choose the variables- is it based on the p values? )Tj 0 -1.2096 TD (More variables in the final model. There are many p values in table one but )Tj 0 -1.2036 TD (not for primary hypothesis. 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We )Tj ET endstream endobj 7 0 obj <> endobj 8 0 obj <>/Font<>/ProcSet[/PDF/Text]>> endobj 9 0 obj <>stream /GS1 gs BT /TT2 1 Tf 12 0 0 12 72 708.78 Tm 0 g .0001 Tc -.0001 Tw (also included baseline STI levels, but could )Tj 18.505 0 TD -.0021 Tw [(not include the combined prevalence measure )]TJ -18.505 -1.32 TD .0004 Tc -.0014 Tw [(at baseline because My)5.4(coplasma Genitalium wa)]TJ 20.365 0 TD -.0004 Tw [(s not tested at baselin)6.6(e due to logistical )]TJ -20.365 -1.325 TD -.0002 Tc 0 Tw (constraints. )Tj /F2 1 Tf 10.02 0 0 10.02 72 654.42 Tm 0 Tc ( )Tj 0 -1.2096 TD -.0012 Tc (*There is a potential fundamental flaw. If one tests positive in the study, )Tj 0 -1.2635 TD (one doesn)Tj /TT6 1 Tf 5.3892 0 TD 0 Tc ()Tj /F2 1 Tf .5988 0 TD -.0012 Tc (t get any benefit. If looking for the money- one could get a sample )Tj -5.988 -1.2395 TD (from someone else which may bias the study. 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We now)7.6( provide additi)]TJ 19.52 0 TD .0002 Tc -.0002 Tw (onal information on specimen collection )Tj -19.52 -1.32 TD .0006 Tc -.0014 Tw [(procedures,)5.6( more deta)5.6(il on process aspects re)]TJ 19.3 0 TD .0004 Tc -.0004 Tw [(la)5.4(ted to administer)4.2(ing th)6.6(e interv)5.4(ention, and )]TJ -19.3 -1.32 TD .0005 Tc -.0017 Tw (greater clarity around the tria)Tj 12.885 0 TD .0002 Tc -.0002 Tw (l design, the primary outcome measure and its rationale and )Tj -12.885 -1.325 TD .0001 Tc -.0008 Tw [(the pow)7.3(er c)-6.1(a).1(lculations. We have also updated )]TJ 19.915 0 TD .0004 Tc -.0004 Tw (the statistical methods )Tj 9.75 0 TD (sub-section to clarify )Tj -29.665 -1.32 TD -.0018 Tw [(the rela)5.4(t)-1.6(ive ris)4.6(k)-3.4(s reported and to describe the )]TJ 19.66 0 TD .0002 Tc -.001 Tw [(clustering o)5.2(f)-1.8( standard errors both at the )]TJ -19.66 -1.325 TD 0 Tc -.0012 Tw (household and at sub-village le)Tj 13.115 0 TD .0003 Tc -.0028 Tw (vels, accounting for the possible)Tj 13.525 0 TD -.0003 Tw [( correla)5.3(t)-1.7(ion w)7.5(i)-1.9(thin couples )]TJ -26.64 -1.32 TD .0005 Tc -.0005 Tw [(and the variation in s)4.7(e)-.7(lection prob)6.7(ability a)5.5(t)-1.5( th)6.7(at sub-villa)5.5(g).5(e leve)4.3(l.)5.5( )]TJ /F2 1 Tf 10.02 0 0 10.02 72 383.16 Tm 0 Tc 0 Tw ( )Tj 0 -1.2036 TD -.0012 Tc (* Need to know a lot more about the methods of sample collection. Authors )Tj 0 -1.2096 TD (need to be clear on be clear on the primary outcome. )Tj /TT2 1 Tf 12 0 0 12 72 329.7 Tm .0003 Tc -.0003 Tw [(Please see a)5.3(b)1.5(ove our answ)7.5(er clarify)5.3(i)-1.9(ng our methods for specimen collection and the more )]TJ 0 -1.155 TD .0001 Tc -.0015 Tw (detailed description to clarify this point in th)Tj 19.03 0 TD 0 Tc (e outcomes sub-section of)Tj 10.805 0 TD .0008 Tc -.0008 Tw [( the me)4.6(th)7(ods section.)5.8( )]TJ /F2 1 Tf 10.02 0 0 10.02 72 291.3 Tm 0 Tc 0 Tw ( )Tj 0 -1.2695 TD -.0012 Tc (Technical editor)Tj /TT6 1 Tf 9.5808 0 TD 0 Tc ()Tj /F2 1 Tf .5988 0 TD -.0012 Tc (s report )Tj -10.1796 -1.2395 TD 0 Tc ( )Tj 0 -1.2036 TD -.0012 Tc (- Please provide positions \(job titles\) for each author

)Tj 0 -2.2096 TD (To do. )Tj 0 -1.2036 TD (- The abstract must be structured with regulation headings \(Objective, Design, )Tj 0 -1.2096 TD (Setting, Participants, \(Interventions,\) Main outcome measures, Results, )Tj T* (Conclusions\) )Tj /TT2 1 Tf 12 0 0 12 72 180.36 Tm .0002 Tc -.0002 Tw (We have done this.)Tj /F2 1 Tf 10.02 0 0 10.02 168.66 180.36 Tm 0 Tc 0 Tw ( )Tj -9.6467 -1.2635 TD ( )Tj 0 -1.2036 TD -.0012 Tc (- Abbreviations should not be used and should be spelt out each time \(HIV and )Tj 0 -1.2096 TD (AIDS are OK\) )Tj /TT2 1 Tf 12 0 0 12 72 118.2 Tm .0002 Tc -.0002 Tw (We have done this.)Tj /F2 1 Tf 10.02 0 0 10.02 168.66 118.2 Tm 0 Tc 0 Tw ( )Tj -9.6467 -1.3174 TD -.0012 Tc (- For all confidence intervals, use format )Tj /TT6 1 Tf 25.7485 0 TD 0 Tc ()Tj /F2 1 Tf .5988 0 TD -.0012 Tc (xx to xx)Tj /TT6 1 Tf 4.7904 0 TD 0 Tc ()Tj /F2 1 Tf .5988 0 TD -.0012 Tc ( \(not )Tj /TT6 1 Tf 3.5928 0 TD 0 Tc ()Tj /F2 1 Tf .5988 0 TD -.0012 Tc (xx )Tj /TT6 1 Tf 1.7964 0 TD 0 Tc ()Tj /F2 1 Tf .5988 0 TD -.0012 Tc ( xx)Tj /TT6 1 Tf 1.7964 0 TD 0 Tc ()Tj /F2 1 Tf .5988 0 TD -.0012 Tc (\)

)Tj ET endstream endobj 13 0 obj <> endobj 14 0 obj <>/Font<>/ProcSet[/PDF/Text]>> endobj 15 0 obj <>stream /GS1 gs BT /TT2 1 Tf 12 0 0 12 72 708.78 Tm 0 g .0002 Tc -.0002 Tw (We have done this.)Tj /F2 1 Tf 10.02 0 0 10.02 168.66 708.78 Tm 0 Tc 0 Tw ( )Tj -9.6467 -1.2575 TD -.0012 Tc (- Please restate the main findings in the first paragraph of the Discussion )Tj /TT2 1 Tf 12 0 0 12 72 680.82 Tm .0002 Tc -.0002 Tw (We have done this.)Tj /F2 1 Tf 10.02 0 0 10.02 168.66 680.82 Tm 0 Tc 0 Tw ( )Tj -9.6467 -1.2635 TD -.0012 Tc (End matter )Tj 0 -1.2036 TD (- Please provide a summary points box comprising two or three points under )Tj 0 -1.2096 TD (each of the headings "What is already known on this topic" and "What this )Tj 0 -1.2036 TD (study adds"

)Tj /TT2 1 Tf 12 0 0 12 72 606.54 Tm .0002 Tc -.0002 Tw (We have done this.)Tj /F1 1 Tf 8.055 0 TD 0 Tc 0 Tw ( )Tj /TT2 1 Tf -8.055 -5.005 TD .0002 Tc -.0002 Tw (We have done this.)Tj /F1 1 Tf 8.055 0 TD 0 Tc 0 Tw ( )Tj /TT2 1 Tf -8.055 -5.355 TD .0002 Tc -.0002 Tw (We have done this.)Tj /F2 1 Tf 10.02 0 0 10.02 72 433.32 Tm -.0012 Tc 0 Tw (by both of the reviewers. You will find these at our online editorial office )Tj 0 -1.2096 TD (\(at http://submit.bmj.com\) in your author area, under this manuscript number. )Tj T* (Please also respond to these additional comments by the committee: )Tj 0 -1.2036 TD 0 Tc ( )Tj 0 -1.2096 TD -.0012 Tc (* )Tj 0 -1.2036 TD (* )Tj 0 -1.2096 TD (* )Tj T* (* )Tj 0 -1.2036 TD (When you revise and return your manuscript, please take note of all the )Tj 0 -1.2096 TD (following points. 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ris)5.1(k)-2.9(s, i.)5.9(e.)]TJ 19.33 0 TD .0002 Tc -.0002 Tw ( the probability of bein)Tj 9.78 0 TD (g STI positive in the )Tj -29.11 -1.3 TD -.0001 Tc .0001 Tw (intervention group, divided by the probability )Tj 19.86 0 TD .0002 Tc -.0009 Tw [(of being STI positive in the treatment group)6.3(.).2( )]TJ -19.86 -1.3 TD .0005 Tc -.0012 Tw [(The term relativ)5.5(e)-.7( ris)4.7(k)-3.3( ratio can be confusin)]TJ 18.53 0 TD .0004 Tc -.0004 Tw [(g, thus w)7.6(e)-.8( now instead use the clea)5.4(rer term )]TJ -18.53 -1.3 TD [(relative ris)4.6(k)-3.4( in the )]TJ 9.055 0 TD .0001 Tc -.0001 Tw (statistical methods. )Tj /TT14 1 Tf -9.055 -1.29 TD 0 Tc 0 Tw ( )Tj /TT8 1 Tf 10.02 0 0 10.02 72 488.1 Tm -.0004 Tc .0021 Tw [(Im al)4.6(so not)4.4( sure abo)7.7(u)-2.3(t )6(the emphas)5.6(i)4.6(s)-.4( on proof)3.9( of co)7.7(ncept)4.4()3.5( i)4.6(f)-2.1( t)4.4(h)-2.3(i)4.6(s)-.4( ph)3.7(rase i)4.6(s)-.4( )]TJ 0 -1.5569 TD -.0009 Tc .0026 Tw (to be used the concept in )Tj 13.1078 0 TD -.0011 Tc .0028 Tw 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<>/Font<>/ProcSet[/PDF/Text]>> endobj 45 0 obj <>stream /GS1 gs BT /TT8 1 Tf 10.02 0 0 10.02 72 706.5 Tm 0 g -.0002 Tc .0019 Tw [(Rati)4.8(os from cohorts)5.8(.)-1.7( It)4.6( )6(may be u)3.9(s)-.2(eful)4.8( )]TJ 19.1557 0 TD -.0013 Tc .003 Tw [(to provid)5(e some more detailed baseline )]TJ -19.1557 -1.5569 TD -.0009 Tc .0026 Tw [(data on the )6(differences )6(be)]TJ 13.1677 0 TD .0002 Tc .0015 Tw [(tween )6(vi)5.2(llages at bas)6.2(e)3.1(li)5.2(ne and )6(how )6(the )6(str)7.8(a)2(ti)5.2(fi)5.2(ed )]TJ -13.1677 -1.5569 TD -.0007 Tc .0024 Tw [(sampling might )6(have led to some o)7.4(f)-2.4( )]TJ 18.4192 0 TD -.0009 Tc .0026 Tw [(the baseline differenc)5.1(es described. )6( )]TJ -18.4192 -1.5569 TD -.0008 Tc .0025 Tw [(More on steps take)8.1(n to)7.3( )6(ensure randomis)]TJ 20.3114 0 TD .0004 Tc .0013 Tw [(ati)5.4(o)2.5(n was trul)5.4(y bl)5.4(i)5.4(n)4.5(d wo)8.5(ul)5.4(d hav)5.4(e)3.3( been )]TJ -20.3114 -1.5569 TD -.0035 Tc .0052 Tw [(u)-5.4(s)-3.5(ef)-5.2(u)-5.4(l)1.5(.)-5( As it reads it)-4.7( h)-5.4(a)4.3(s t)-4.7(h)-5.4(e pot)-4.7(e)-.6(n)-5.4(t)1.3(ia)-7.7(l t)-4.7(o)-1.4( be v)-4.5(e)-.6(ry)-4.5( easily)-4.5( in)-5.4(f)-5.2(l)-4.5(u)-5.4(e)-.6(n)-5.4(c)-3.5(ed at f)-5.2(i)7.4(eld)-9.2( )]TJ T* -.0031 Tc .0048 Tw [(lev)-4.1(e)-6.2(l.)-4.6( At)-4.3( least)-4.3( th)-5(is sh)-5(ou)-5(ld be ref)-4.8(l)1.9(ect)-4.3(e)-.2(d in)-5( t)-4.3(h)-5(e limit)-4.3(at)-4.3(ion)-5(s)-3.1(.)-4.6( )]TJ T* 0 Tc 0 Tw ( )Tj /TT2 1 Tf 12 0 0 12 72 597.78 Tm .0005 Tc -.0008 Tw [(First, w)7.7(e)-.7( note that ther)4.3(e w)7.7(ere 10 villages and 5)5.5(0).5( sub-villag)5.5(e)-.7(s. It is true)4.3( that w)7.7(e)-.7( introduced )]TJ 0 -1.3 TD .0004 Tc -.002 Tw [(indicator v)5.4(a).4(riables for each sub-village in the )]TJ 19.525 0 TD .0005 Tc -.0005 Tw [(adjusted models to acc)4.3(o).5(unt for the)4.3( differ)4.3(e)-.7(nt )]TJ -19.525 -1.3 TD .0004 Tc -.0016 Tw [(selec)4.2(t)-1.6(ion pr)4.2(obability \(a)5.4(nd potentia)5.4(lly assoc)4.2(i)-1.8(ate)4.2(d)1.6( )]TJ 20.52 0 TD .0009 Tc -.0019 Tw [(peer-effec)4.7(t)-1.1(s\) at the su)7.1(b-villag)5.9(e)-.2( le)4.7(vel. We )]TJ -20.52 -1.3 TD -.0001 Tc .0001 Tw (have added one sentence in the limitation section to account for this. )Tj T* 0 Tc 0 Tw ( )Tj T* -.0001 Tc -.0006 Tw (In order to study potential peer-effects, in ra)Tj 19.495 0 TD .0002 Tc -.0012 Tw (ndomly selected sub-villages, the probably of )Tj -19.495 -1.3 TD .0009 Tc -.0023 Tw [(selec)4.7(t)-1.1(ion in the interv)5.9(e)4.7(n)2.1(tion arm w)8.1(a).9(s 75%)5.9( and )]TJ 20.05 0 TD .0005 Tc -.0005 Tw [(in the other sub-villages, it w)7.7(a).5(s 25%)10.5(.).5( This )]TJ -20.05 -1.3 TD .0003 Tc -.0007 Tw [(might have led to baseline imbalan)6.5(ces. For this reason, we included s)4.5(ub-villag)5.3(e)-.9( indicator )]TJ T* -.0012 Tw [(variables in)6.6( the adjusted models. This might )]TJ 19.115 0 TD .0002 Tc -.0002 Tw [(explain some of the differences betw)7.4(een the )]TJ -19.115 -1.3 TD -.0018 Tw (results from the unadjusted )Tj 12.06 0 TD 0 Tc 0 Tw [(and the adjusted)6.2( models. )]TJ -12.06 -1.3 TD ( )Tj T* .0001 Tc -.0001 Tw [(Randomi)-7.1(z)8.9(a)-4.9(tion w)7.3(a).1(s no)-4.9(t blind. Participants )]TJ 18.505 0 TD .0007 Tc -.0015 Tw [(w)7.9(e)-5.5(re not blind)6.9(e)-.5(d to arm a)5.7(ssignment s)4.9(i)-1.5(nce )]TJ -18.505 -1.3 TD .0018 Tw [(aw)7.9(areness of their )7.5(elig)5.7(ibility )]TJ 12.28 0 TD -.0011 Tw [(fo)5.6(r the conditio)5.6(n)1.8(al cash tra)5.6(n)1.8(sfer w)7.8(a).6(s a critical component of )]TJ -12.28 -1.3 TD 0 Tc -.0012 Tw (the intervention. We believe )Tj 12.44 0 TD .0008 Tc -.0028 Tw [(the review)8(er refers to the p)7(o).8(ssi)]TJ 13.075 0 TD 0 Tc -.0012 Tw (bility of manipulation of the )Tj -25.515 -1.3 TD .0003 Tc -.0003 Tw [(randomiz)9.1(a).3(t)-6.7(i)-1.9(on at the field level. We think our )]TJ 19.75 0 TD [(very transp)6.5(arent procedures eliminated this )]TJ -19.75 -1.3 TD .0002 Tc -.0002 Tw [(risk. 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The )-6(results are )-6(fascinating. )]TJ ET endstream endobj 46 0 obj <> endobj 47 0 obj <>/Font<>/ProcSet[/PDF/Text]>> endobj 48 0 obj <>stream /GS1 gs BT /TT8 1 Tf 10.02 0 0 10.02 72 706.5 Tm 0 g 0 Tc 0 Tw ( )Tj 0 -1.5569 TD .0001 Tc .0016 Tw [(The i)5.1(n)-1.8(trod)6.4(u)4.2(c).1(ti)5.1(on i)5.1(s).1( fi)5.1(ne )6(al)5.1(ong wi)5.1(th )6(t)4.9(h)-1.8(e methods)6.1( and )6(the )6(tra)7.9(i)5.1(l)5.1( desi)5.1(gn, i)5.1(n)4.2(cl)5.1(udi)5.1(n)-1.8(g )6( )]TJ T* -.0001 Tc .0018 Tw [(a descri)4.9(p).2(ti)4.9(on of)4.2( the)8.8( par)7.5(t)-1.3(i)4.9(c)-.1(i)4.9(p).2(ants an)4(d i)4.9(n)-2(terventi)10.8(ons. 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We have also removed )Tj 13.165 0 TD .0006 Tc -.0006 Tw [(the s)4.8(econd decimal fro)5.6(m)-1.4( ta)5.6(ble 2. )]TJ /TT8 1 Tf 10.02 0 0 10.02 72 222.9001 Tm 0 Tc 0 Tw ( )Tj 0 -1.5569 TD -.0028 Tc .0045 Tw [(3.)-4.3( )-3215.6(T)-3.4(h)-4.7(ere is n)-4.7(o)-.7( )6(men)-4.7(t)-4(ion)-4.7( in)-4.7( th)-4.7(e st)-4(at)-4(ist)-4(i)2.2(cal met)-4(h)-4.7(ods )6(w)-4.8(h)-4.7(eth)-4.7(e).1(r an )6(in)-4.7(t)-4(e).1(n)-4.7(t)-4(ion)-4.7(-)-3.8(t)-4(o)5.3(-)-3.8(t)-4(reat)-4( )]TJ T* [(process w)-4.7(a)-.9(s f)-4.4(o)-.6(llow)-4.7(e).2(d f)-4.4(o)-.6(r t)-3.9(h)-4.6(e an)-4.6(aly)-3.7(s)-2.7(is )]TJ 19.006 0 TD .0005 Tc .0012 Tw [(and ho)8.6(w )6(mi)5.5(ssi)5.5(ng data were ha)8.3(n)4.6(d).8(l)5.5(e)3.4(d )]TJ -19.006 -1.5569 TD -.0026 Tc .0043 Tw [(\()-3.6(a)-.8(lt)-3.8(h)-4.5(o)-.5(u)-4.5(g)-2.3(h th)-4.5(ere is a sect)-3.8(ion)-4.5( describin)]TJ 18.6527 0 TD -.0006 Tc .0023 Tw [(g ho)7.5(w m)8(u)-2.5(ch missing data existe)8.3(d\). )]TJ -18.6527 -1.5569 TD 0 Tc 0 Tw ( )Tj /TT12 1 Tf T* -.0005 Tw [(We have )6(adde)5.4(d the )6(followin)5.8(g)-1.4( s)6.4(e)-.6(ntenc)7.5(e)-.6(s t)6.5(o)-2.1( the )6(be)5.4(gi)6.5(nnng )6(of th)5.8(e statis)6.4(tic)7.5(al meth)5.8(ods )]TJ T* -.0003 Tc -.0002 Tw [(section t)6.2(o)-2.4( )6(clarify th)5.5(ese two poi)6.2(n)-.5(ts: )]TJ /TT8 1 Tf 0 -1.497 TD 0 Tc 0 Tw ()Tj /TT14 1 Tf 12 0 0 12 76.62 114.3 Tm .0009 Tc -.0023 Tw [(Each ind)5.9(i)-1.3(vidual was co)5.9(ded as per th)5.9(eir initial )]TJ 18.27 0 TD .0008 Tc -.0008 Tw [(random)8.6(i)-1.4(zed as)5(signm)8.6(ent as )]TJ 10.8 0 TD .0012 Tc -.0012 Tw [(per an in)6.2(tent-to-)4.2(tre)5(a).1(t )]TJ -29.455 -1.3 TD .0002 Tc -.0002 Tw (design. However, individuals who were not pres)Tj 19.335 0 TD .0001 Tc -.0007 Tw [(ent at any given round were treated as m)7.9(i)-2.1(ssing )]TJ -19.335 -1.3 TD .0005 Tc -.0013 Tw [(and dropped from)8.3( the analysis for that )]TJ 15.525 0 TD .0002 Tc -.0002 Tw [(round due to lack of outcom)8(e data. )]TJ ET endstream endobj 88 0 obj <> endobj 89 0 obj <>/Font<>/ProcSet[/PDF/Text]>> endobj 90 0 obj <>stream /GS1 gs BT /TT12 1 Tf 10.02 0 0 10.02 72 706.5 Tm 0 g 0 Tc 0 Tw ( )Tj /TT8 1 Tf 0 -1.5569 TD -.0009 Tc .0026 Tw [(4. )-3215.6(I would )6(have expected )6(the results )6(sect)]TJ 24 0 TD -.0014 Tc .0031 Tw [(ion to )6(have reported on )6(the incidence )]TJ -24 -1.5569 TD -.0029 Tc .0046 Tw [(of)-4.6( th)-4.8(e ou)-4.8(tcome measu)-4.8(r)-1.3(e t)-4.1(h)-4.8(is is )6(not)-4.1( men)-4.8(t)-4.1(ion)-4.8(e)0(d at)-4.1( all in)-4.8( t)-4.1(h)1.2(e t)-4.1(e)0(x)-3.9(t)-4.1( an)-4.8(d i)8(s)-2.9( )]TJ T* -.0026 Tc .0043 Tw [(somew)-4.6(h)-4.5(at)-3.8( )6(cry)-3.6(p)-2.3(t)-3.8(i)2.4(cally)-3.6( re)-5.7(port)-3.8(ed in)-4.5( T)-3.2(a)5.2(ble )]TJ 19.8563 0 TD -.0012 Tc .0029 Tw [(2 \(wrongly labeled sample mean\) and)5.1( )]TJ -19.8563 -1.5569 TD (more appropriately in Table 3. 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Wi)5.1(t)4.9(h)-1.8( )6(an i)5.1(n)-1.8(ci)5.1(denc)6.1(e rate of 12)7.1(% t)4.9(h)-1.8(e fi)5.1(gur)7.7(e)3(s wi)5.1(l)5.1(l)-.9( )]TJ T* -.0014 Tc .0031 Tw [(be close to relat)-8.6(i)3.6(ve risks but th)]TJ 15.5868 0 TD -.001 Tc .0027 Tw [(ey )6(s)5(h)-2.9(ould be de)7.9(scribed properly. )]TJ -15.5868 -1.5569 TD 0 Tc 0 Tw ( )Tj /TT2 1 Tf 12 0 0 12 72 441.78 Tm .0004 Tc -.0011 Tw [(Our tables do in fact report relative ris)4.6(k)-3.4(s, )]TJ 18.035 0 TD .0001 Tc -.0007 Tw (not odds ratios. 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We w)7.9(o).7(uld )]TJ -25.545 -1.3 TD -.0012 Tw [(be even mo)5.6(re tenta)5.6(t)-1.4(ive if the results w)7.8(ere only )]TJ 19.8 0 TD .0003 Tc -.0053 Tw (statistically significan)Tj 9.195 0 TD -.0016 Tw (t during an early time )Tj -28.995 -1.3 TD -.0004 Tw [(point rathe)4.2(r)-.8( than the final time point; how)7.6(e)-.8(ver )]TJ 20.22 0 TD .0005 Tc -.0005 Tw [(the pattern)6.7( of increas)4.7(i)3.3(ng effect ov)5.5(er time is )]TJ -20.22 -1.3 TD 0 Tc 0 Tw [(consistent w)7.2(i)-2.2(th our a priori hypothesis and )]TJ 18.475 0 TD .0003 Tc -.0003 Tw [(indeed is the reason w)7.5(h)1.5(y w)7.5(e)-.9( structured the )]TJ -18.475 -1.3 TD .0002 Tc -.0012 Tw [(intervention to have multiple incentiviz)9(ed te)]TJ 18.745 0 TD -.0002 Tw (sting rounds. 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This statement )Tj -30.8802 -1.5569 TD -.0015 Tc .0032 Tw (is presumptive about there being a proven)Tj 21.4431 0 TD -.0002 Tc .0019 Tw [( ben)3.9(e)2.7(fi)4.8(t, and)6.1( on)3.9(e wonders )6(how )6(wel)4.8(l)4.8( th)3.9(e )]TJ -21.4431 -1.5569 TD -.0025 Tc .0042 Tw [(case can)-4.4( )6(be made f)-4.2(o)-.4(r a larger t)-3.7(r)-.9(ia)-6.7(l w)-4.5(h)-4.4(ich w)-4.5(o)5.6(u)-4.4(l)2.5(d be n)-4.4(eeded \()-3.5(p)-2.2(robably requ)-4.4(irin)-4.4(g )]TJ T* -.0008 Tc .0025 Tw [(over 10,000)6.2( participants\). )]TJ /TT20 1 Tf 10.98 0 0 10.98 72 413.16 Tm 0 Tc 0 Tw ( )Tj /TT2 1 Tf 12 0 0 12 72 386.94 Tm .0002 Tc -.0008 Tw [(In the abstract and the summary b)6.4(ox, w)7.4(e)-1( now )]TJ 19.775 0 TD .0001 Tc -.0001 Tw (say that the intervention is potentially )Tj -19.775 -1.325 TD .0005 Tc -.0012 Tw [(promising rather than)6.7( promising and w)7.7(e)-.7( add that)]TJ 21.7 0 TD -.0001 Tc .0001 Tw [( a larger study w)7.1(o)-5.1(uld be useful to clarify )]TJ -21.7 -1.32 TD .0006 Tc [(the effect s)4.8(i)3.4(ze, to calibrate the s)4.8(i)-1.6(z)9.4(e)-.6( of )]TJ 15.8 0 TD .0003 Tc -.0019 Tw [(the incen)6.5(tive, and to determine whether the )]TJ -15.8 -1.32 TD .0006 Tc -.0016 Tw [(interventio)5.6(n)1.8( can be delivered cos)4.8(t)-1.4( effectiv)5.6(ely.)5.6( )]TJ /TT8 1 Tf 10.02 0 0 10.02 90 314.64 Tm 0 Tc 0 Tw ( )Tj /F1 1 Tf 0 -1.006 TD ( )Tj ET endstream endobj 97 0 obj <> endobj 98 0 obj <> endobj 99 0 obj <>stream h{ \UG9U- ""K|)74@'cԸd3QMԴL:I:1Y拝qLۘjɷf~-NթSN:ԆHLDTO fʌ)`N򒪷W_Y@4D|w٪ZgJ|UK7ƌ$7Y~d .@@u5h*7ڨQY@QipKv` H)ǩ' pdB\hO7cF)"MFmJW!rM>ZIwCzI'+ƉCЩ:-vi(fh/]5c(P뉶Ԩ"hZ6X Y5՞W>jܶmێnb5ΑCG/-k1aڅx:0NƩr4h>oy/7> ~Ok~ Xb1+#4.3P9^0䃘SyNZmVi[eqv /-F[o v|mq\/n*RN/ܼV\|%Y rX|QbmۭCRͧd'Ez#1O/|,+b2"m<)vrUgco)y<|e;J.ZHEc!y| D5VKϡSCZRo1Hx)6`V)޸`6k}[5ȓ]?=vQ#9dMˡ$ߔ3GlnQ]##mV&SzsOZs UwPrAx#O@lp.'hMt=ϩN:f7\W\4i&#;ŗy|%<ǙH.@ tV5rl"gޘFAH(HtJW(P08/7f8Y @ds5'`3+lhޘ~aCs4\JdWͅqs=| 19\ߚ$+tUmhx@Y|}C^/d30Co u&yCj&jVyM9'8n5 єi1RbPTtޒܛca =ƖnA6v !#63?ò4rNA@2;1Q*󏢆Q`e ,G*a91,}zeB8/)%!OeRPC{;pqYYT8u0%1`~C9x}JQ ,u*Mj" 7 |X{K٪ωH>H#`OW>&ql/tϜW5B/lsea"I̪RjfQiRXMpGvj6~zŵn!5c\7PA 4_4!؁&: fԩG;ZpHk{8>)0q(1VAF?X8%OpM6F[q=פFHoQ5%xV$f&fo15 -ڤPWn'S3nh'չ8T8/m3s.'q>*y'8ܝO(\~z)ىW.d^)R9rQH'b}(o Ʉf{qCZA: mz&mh}g-4gᅨnl+6G*ki/ӡPR-t'mJSk,SgaJQ< /டwG4^_!1~t:bh ^pi>6Z*;I,d7bX/22U:I?Aȇx,`XC(F+x^W^HY/k!Sqa 1Ήs ;Qo&Cr; j@((@ 0C|^}2 Cr$*@KVy?ʓMnk_Ēv|E; O M.aݸ$a zlnv+-"vw|=E<{[;YO-[Lf5l>w31ªTv@;MBu$aG|f;yl[`;@T?F\^XCGEС #$6yRxm=?sYu-)ٸWN<& Jl `uH-f;@/EjJŸOWS?;ZAtS/n\Dw ݅21HwP~bN,FɁfݛC['`G8HC;c)Fކ>EћD6zoi7߁V* î&cN?p/5GO￀13>񞂽gv~3e*x (/ހ;Ko~_ 'Ӏ7ag븈Gef8SW|#/wg7nBOgx.YR!,]jrFCmeS\;ڧ'>?o?~pu0O8Xpz zM=xh~KBs^g*0mMG/"dPɉuem ֻjŨ&n2mjU]ՇsyV%X?$o#.nE>AlD"%NMЪFA;w|/c}/-2X-uMi|W|_vb37C'6'tt#BvG^Njz% ~tϮY *RvBvR1];批EI>"]X|+ʵK.~W52S?3,p}Zn@cv%ufwO̼wA+}xeBϱG4a)R)+(@d޺dAdqLk=ӌbY;^]"Ͳ)lhV y4Z.D< 0(@9!Pd3|w*>x wى!`v@ra܄r͡r\465*; uh4#DFMd{;ePRhZV;Ro7ۉMQ!Q!dGST\$;\zʄP9WiL=퓳!zE7B3aufkWxgxVWT3R% T9SN5U*grYNfQ/T9ѬOA=dU9INlM]Bf&=:B\IQ6v>3) He.RRFdx!)=HYHx86#a+7$7&t#p >r/zct[Et X+Rb=LRR=a |*@8dʎX)+"D!fH ۝iCG˛eDbfTv3] Cj{- :}(]ge0F_/&\Vk# tEJ?O?3lPM^f02dgXT٫IE5þ<&*{$>FmT""&~E GIGe iH6 7bokG$y).LL7{bvh>E_|W{zG~1?#GN9h~d3zz"?qEnvEqEpEwEuEwEfwc/ϥHO0L3e<)Ž-#AOR95nJlGqovK/v,IMR҂Eo+$l~lް-ylmm~6-kGۻ#vjNf6S5ZVM嚉G uvA8?pKf9/`qN@L>Mt7یYQ@X-ō{Q PuIצ-ĜncRzUF7nRܪFO]׾xhx<8|7#ٛ˩߲QbD^n oqKx7KsH=0HW|/ET|}TK1Rnkmt8yƙ"?55!GZsk*͟ڕ&Z #-ڛ6{֒Ӛժl%$sA@5Tdhլdp)ƕQ{!dHz٫5{RnJX29.9A;6gD~!|">Bdy1uUJvxDZd;.> E-A;Q')=R>MHK "~)=y SYS1t7i/sqAM|)J !yŁpp2h]?$%8vי΄TuB'x?pJú NNNNNNNNN ϣOƒT'{ ϴJ#ң=wd_#ߣ&#%y>_lwCWzE]j,K!!\>*[O 6*Z)^ L..A5VY!hTDJ N{ETnӨVjC\:V \%W:( \^(iPf:em xCh4`aLj6z,C9 }@Z,ȫT*LVVh^JE/GYMKAug[xLW{]iV54huqI_ߣuߺkAs**Kj+*WU%% %L/\RQj)+oу3 g/[ϪXR^[WeO~sTWN tӊ~<1T{^/.Y_^RT\7uԫK*jjEz _][ʕ+j!fͦ4n.Suc;O.[ *|)ƒƽj`W[gcި#/+Yl[}f78͖DmG{ 0Lࡧ endstream endobj 100 0 obj <> endobj 101 0 obj <> endobj 102 0 obj <>stream hz{|SU7r_sgligp[5]14^FqtRh@ѕzw :t![:!(ڂއW׉6h/ڇXߋĈ|T ېyP) zO7zWh'WOPZ/H}[ڠEh-=Aπ\kA;ОyA} 3_wAGͼ)P!ɶ(BbZwArztifv]a+fЫUK<~&Ylij/kou6xg689;tq=ik_'e:[,u80bad0r+!xW{]}%v{? 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