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180.84 145.86 14.1 0.48001 re f 180.84 175.44 14.1 0.48001 re f 180.84 659.58 14.1 0.42004 re f 180.84 750.66 14.1 0.48004 re f BT 0 9.427 -9.427 0 206.7 53.34 Tm -0.0001 Tc -0.0032 Tw [(Main results )-5645.5(16 )-1387.5(\()]TJ /TT12 1 Tf 13.8241 0 TD 0 Tc 0 Tw (a)Tj /TT10 1 Tf 0.5092 0 TD -0.0026 Tc 0.0057 Tw [(\))-4.9( )6.4(Give unadj)-11.6(u)7.3(s)-6.1(ted est)-5(i)-2.2(mat)-5(e)-7.9(s and, if )6.4(a)-7.3(p)-5.5(p)7.2(l)-2.2(i)-8.6(c)-6.2(able, co)-9.9(n)7.2(f)-2.9(ou)-5.5(nd)-5.5(er-a)]TJ 24.3895 0 TD -0.0023 Tc 0.0054 Tw [(dj)-4.9(ust)-4.7(e)-1.2(d )6.4(es)-5.8(t)-4.7(i)-1.9(mat)-4.7(e)-1.2(s and the)-7.5(i)-1.9(r )6.4(precis)-5.8(ion \()-4.6(e)-1.2(g, 95)-4.6(% confiden)-5.2(ce )]TJ -25.2042 -1.4957 TD -0.0025 Tc 0.0056 Tw [(int)-4.9(e)-1.4(rval\))-4.8(.)-11( )6.4(Make c)6.6(l)-2.1(ea)-7.2(r whic)-6.1(h c)-6.1(o)2.9(nfoun)-5.4(d)1(ers we)-7.8(re adjust)-4.9(ed for)-10.3( and )6.4(why t)-4.9(h)1(ey were in)7.4(cl)-8.5(ude)-7.8(d )]TJ 51.3503 1.4957 TD 0.001 Tc -0.0043 Tw [(9-1)5(2)-1.3(, 20)5( )-6.4(& 21 )]TJ ET 194.94 48.06 0.42001 127.86 re f 194.94 175.92 m 194.94 659.58 l 195.36 659.58 l 195.36 175.92 l f 194.94 659.58 0.42001 91.56 re f 195.36 48.06 28.26 0.41998 re f 195.36 145.86 28.26 0.48001 re f 195.36 175.44 28.26 0.48001 re f 195.36 659.58 28.26 0.42004 re f 195.36 750.66 28.26 0.48004 re f BT 0 9.427 -9.427 0 235.32 53.34 Tm 11.1731 Tc 0 Tw [( )9279.7(\()]TJ /TT12 1 Tf 13.8241 0 TD 0 Tc (b)Tj /TT10 1 Tf 0.5092 0 TD -0.0023 Tc 0.0054 Tw [(\))-4.6( )6.4(Report)-4.7( cate)-7.5(gory b)7.5(o)-3.2(un)-5.2(daries when cont)-4.7(i)-8.3(n)7.5(uo)]TJ 18.1648 0 TD 0.0007 Tc 0.0024 Tw [(u)4.2(s)3.6( v)6.8(a)-4(r)5.6(i)1.1(ables)3.6( wer)5.6(e)1.8( c)3.5(a)2.4(tegor)5.6(ized)4.2( )-20156.9(9-1)4.7(2)-1.6(, )6.4(20)4.7( &)8.2(21 )]TJ ET 223.62 48.06 0.42 127.86 re f 223.62 175.92 m 223.62 659.58 l 224.04 659.58 l 224.04 175.92 l f 223.62 659.58 0.42 91.56 re f 224.04 48.06 14.16 0.41998 re f 224.04 145.86 14.16 0.48001 re f 224.04 175.44 14.16 0.48001 re f 224.04 659.58 14.16 0.42004 re f 224.04 750.66 14.16 0.48004 re f BT 0 9.427 -9.427 0 249.96 53.34 Tm 11.1731 Tc 0 Tw [( )9279.7(\()]TJ /TT12 1 Tf 13.8241 0 TD 0 Tc (c)Tj /TT10 1 Tf 0.4073 0 TD 0.0009 Tc -0.0042 Tw [(\) I)-8.1(f)0.6( relevan)4.4(t)4.9(, )-6.4(c)3.7(o)6.3(n)4.4(s)3.8(id)4.4(er tran)4.4(s)3.8(l)1.3(at)4.9(in)4.4(g )-6.4(es)3.8(tim)4.1(a)2.6(te)8.4(s)3.8( )-6.4(of relativ)7(e)2( )-6.4(ri)7.6(s)3.8(k)3.6( )]TJ 23.5557 0 TD -0.0008 Tc 0.0039 Tw [(in)9.1(to absolute)-6.1( risk f)5.2(o)-1.7(r a meaningful)5.9( time )-6.3(period)9.1( )-7994(Not Applic)8.4(a)-11.9(b)9(le)-6( )]TJ ET 238.2 48.06 0.48001 127.86 re f 238.2 175.92 m 238.2 659.58 l 238.68 659.58 l 238.68 175.92 l f 238.2 659.58 0.48001 91.56 re f 238.68 48.06 14.1 0.41998 re f 238.68 145.86 14.1 0.48001 re f 238.68 175.44 14.1 0.48001 re f 238.68 659.58 14.1 0.42004 re f 238.68 750.66 14.1 0.48004 re f BT 0 9.427 -9.427 0 264.54 53.34 Tm -0.0019 Tc 0.005 Tw [(O)-8.1(t)2.1(her )6.4(a)-6.6(n)1.6(alyses)-11.8( 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145.86 17.16 0.48001 re f 267.78 175.44 17.16 0.48001 re f 267.78 659.58 17.16 0.42004 re f 267.78 750.66 17.16 0.48004 re f BT 0 9.427 -9.427 0 296.7 53.34 Tm -0.0019 Tc 0.005 Tw [(K)-4.3(e)-0.8(y )6.4(results)-5.4( )-6256.4(1)-4.2(8)-4.2( )-1381.1(Summarise k)7.2(e)-7.2(y result)-4.3(s wit)-10.6(h)1.6( reference )6.4(t)-4.3(o)-2.8( st)-4.3(u)7.9(d)-4.8(y obj)-4.5(e)-0.8(ctives)-5.4( )-27985.5(1)-4.2(3)-4.2(-)5.1(1)-4.2(6)-4.2( )]TJ ET 284.94 48.06 0.48001 127.86 re f 284.94 175.92 m 284.94 659.58 l 285.42 659.58 l 285.42 175.92 l f 284.94 659.58 0.48001 91.56 re f 285.42 48.06 14.1 0.41998 re f 285.42 145.86 14.1 0.48001 re f 285.42 175.44 14.1 0.48001 re f 285.42 659.58 14.1 0.42004 re f 285.42 750.66 14.1 0.48004 re f BT 0 9.427 -9.427 0 311.28 53.34 Tm -0.0022 Tc 0.0053 Tw [(Limita)-6.9(tions )-6173.7(1)-4.5(9)-4.5( )-1381.1(Discuss l)-8.2(i)-1.8(mitat)-4.6(i)-8.2(on)7.7(s)-5.7( )6.4(of t)-4.6(h)7.7(e)-7.5( )6.4(st)-4.6(ud)-5.1(y, ta)-6.9(k)6.9(i)-8.2(ng in)7.6(t)-4.6(o)-3.1( acco)]TJ 32.9627 0 TD -0.0024 Tc 0.0055 Tw [(u)-5.3(n)1.1(t)-4.8( sour)-10.2(ces)-5.9( of pote)-7.7(n)7.5(t)-4.8(ial b)7.4(i)-2(as)-5.9( )6.4(or imprecision.)-4.5( D)-4.5(i)-2(scuss bot)-11.1(h)1.1( dir)]TJ 24.4531 0 TD 0.0031 Tc 0 Tw [(ec)5.9(t)7.1(i)3.5(on)6.6( a)4.8(n)0.2(d)13( )]TJ -43.8972 -1.4957 TD -0.0012 Tc 0.0043 Tw [(magnitu)8.7(d)2.3(e of any)5.9( pote)-6.4(n)8.6(t)-3.6(ial )-6.3(bias )]TJ 51.3503 1.4957 TD 0.0023 Tc 0 Tw [(13-)9.3(16 )]TJ ET 299.52 48.06 0.48001 127.86 re f 299.52 175.92 m 299.52 659.58 l 300 659.58 l 300 175.92 l f 299.52 659.58 0.48001 91.56 re f 300 48.06 28.26 0.41998 re f 300 145.86 28.26 0.48001 re f 300 175.44 28.26 0.48001 re f 300 659.58 28.26 0.42004 re f 300 750.66 28.26 0.48004 re f BT 0 9.427 -9.427 0 340.02 53.34 Tm 0.001 Tc 0.0021 Tw [(I)-8(n)10.9(terp)4.5(r)5.9(e)2.1(tatio)6.4(n)4.5( )-4913.5(20 )-1381.1(G)8.1(i)1.4(ve a c)10.1(a)-3.7(u)4.5(t)5(ious)3.9( )6.4(over)5.9(al)7.7(l in)4.5(t)5(e)2.1(rpr)5.9(e)2.1(tation)10.9( of r)5.9(e)]TJ 30.7414 0 TD -0.0009 Tc 0.004 Tw [(sults considering objectiv)5.2(es,)6.8( limit)]TJ 13.404 0 TD -0.0007 Tc 0.0038 Tw [(ations, multipl)6(i)-6.7(city of)5.3( a)-5.4(n)9.2(a)-5.4(l)-0.3(ys)]TJ 11.3228 0 TD -0.0011 Tc 0.0042 Tw (es, results from )Tj -41.9496 -1.4957 TD -0.0023 Tc 0.0054 Tw [(sim)-5.4(i)4.4(lar st)-4.7(udies)-5.8(,)-7.4( )6.4(a)-7(n)1.2(d)7.6( ot)-4.7(h)7.6(e)-7.6(r re)-7.6(levant)-4.7( )6.4(e)-7.6(v)3.8(ide)-7.5(n)1.2(c)6.8(e)-13.9( )]TJ 51.3503 1.4957 TD 0.0023 Tc 0 Tw [(13-)9.3(16 )]TJ ET 328.26 48.06 0.47998 127.86 re f 328.26 175.92 m 328.26 659.58 l 328.74 659.58 l 328.74 175.92 l f 328.26 659.58 0.47998 91.56 re f 328.74 48.06 28.2 0.41998 re f 328.74 145.86 28.2 0.48001 re f 328.74 175.44 28.2 0.48001 re f 328.74 659.58 28.2 0.42004 re f 328.74 750.66 28.2 0.48004 re f BT 0 9.427 -9.427 0 368.7 53.34 Tm -0.0016 Tc 0.0047 Tw [(Genera)-6.3(l)5.1(i)-1.2(sa)-12.7(b)8.3(ility )-4366.1(21 )-1381.1(Discuss the genera)-6.3(l)5.1(i)-1.2(sa)-6.3(bility )]TJ 24.6377 0 TD -0.0005 Tc 0.0036 Tw [(\()-9.1(e)0.6(x)6.2(t)-2.9(ernal )6.4(validi)6.2(t)-9.2(y\) of the study)6.6( resul)6.2(t)-2.9(s )-24879.5(13-)6.5(16 )]TJ ET 356.94 48.06 0.48001 127.86 re f 356.94 175.92 m 356.94 659.58 l 357.42 659.58 l 357.42 175.92 l f 356.94 659.58 0.48001 91.56 re f 357.42 48.06 14.1 0.41998 re f 357.42 145.86 14.1 0.48001 re f 357.42 175.44 14.1 0.48001 re f 357.42 659.58 14.1 0.42004 re f 357.42 750.66 14.1 0.48004 re f BT /TT6 1 Tf 0 9.427 -9.427 0 386.52 53.34 Tm 0.0001 Tc 0.003 Tw [(Other in)8.5(format)9.4(ion )]TJ /TT10 1 Tf 11.3991 0.3501 TD 1.8934 Tc 0 Tw ( )Tj 53.4697 0 TD 0.0023 Tc [(13-)9.3(16 )]TJ ET 371.52 48.06 0.42001 127.86 re f 371.52 175.92 m 371.52 659.58 l 371.94 659.58 l 371.94 175.92 l f 371.52 659.58 0.42001 91.56 re f 371.94 48.06 17.16 0.41998 re f 371.94 145.86 17.16 0.48001 re f 371.94 175.44 17.16 0.48001 re f 371.94 659.58 17.16 0.42004 re f 371.94 750.66 17.16 0.48004 re f BT 0 9.427 -9.427 0 400.86 53.34 Tm -0.0017 Tc 0.0048 Tw [(F)-6.8(u)8.1(nd)-4.6(ing )-7408.4(2)-4(2)-4( )-1381.1(Give the sourc)-5.3(e)-0.6( of )6.4(funding an)-4.6(d )6.4(t)-4.1(h)1.8(e role of t)-4.1(h)1.8(e fu)8.2(nders)]TJ 35.3431 0 TD -0.0022 Tc 0.0052 Tw [( for the present st)-4.6(u)-5.1(d)1.3(y an)-5.1(d, if ap)-5.1(pli)-8.2(c)0.6(able)-7.4(, for )6.3(t)-4.6(h)1.3(e original )6.3(s)-5.7(t)]TJ 23.3393 0 TD -0.0018 Tc -0.0015 Tw [(ud)-4.7(y on )]TJ -45.1638 -1.4957 TD -0.0011 Tc 0.0042 Tw [(wh)8.8(ich the pres)-11(en)8.8(t article i)5.6(s)-4.6( )6.4(based)8.8( )]TJ 51.3503 1.4957 TD 0.0023 Tc 0 Tw (16 )Tj ET 389.1 48.06 0.47998 127.86 re f 389.1 175.92 m 389.1 659.58 l 389.58 659.58 l 389.58 175.92 l f 389.1 659.58 0.47998 91.56 re f 389.58 48.06 28.74 0.41998 re f 417.84 48.06 0.48001 97.8 re f 389.58 145.86 28.74 0.48001 re f 417.84 146.34 0.48001 29.1 re f 389.58 175.44 28.74 0.48001 re f 417.84 175.92 m 417.84 659.58 l 418.32 659.58 l 418.32 175.92 l f 389.58 659.58 28.74 0.42004 re f 417.84 660 0.48001 90.66 re f 389.58 750.66 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